4.4 Article

The Short-chain Fatty Acid Propionic Acid Activates the Rcs Stress Response System Partially through Inhibition of d-Alanine Racemase

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Microbiology

Staphylococcus aureus Overcomes Anaerobe-Derived Short-Chain Fatty Acid Stress via FadX and the CodY Regulon

Joshua R. Fletcher et al.

Summary: This study investigates the impact of the abundant CRS anaerobe Fusobacterium nucleatum on the growth kinetics and transcriptome of Staphylococcus aureus, demonstrating that propionate and butyrate produced by F. nucleatum may influence the growth and gene expression of S. aureus.

JOURNAL OF BACTERIOLOGY (2022)

Article Multidisciplinary Sciences

Gut-derived butyrate suppresses ocular surface inflammation

Laura Schaefer et al.

Summary: Dry eye is a common ocular inflammatory disorder characterized by tear film instability and reduced tear production. The interaction between the intestinal microbiota and the ocular surface, mediated by microbially produced small molecules such as butyrate, plays a potential role in maintaining ocular surface homeostasis. In this study, it was found that the SCFA transporter SLC5A8 is expressed in murine conjunctival and corneal epithelium, and pretreatment with phenylbutyrate (PBA) reduced inflammation in corneal epithelial cultures and dendritic cells. The protective effect of PBA requires SLC5A8. Oral treatment with tributyrin, a prodrug form of butyrate, reduced inflammation at the ocular surface in mice undergoing desiccating stress, partially through the involvement of SLC5A8.

SCIENTIFIC REPORTS (2022)

Article Immunology

IgaA Protein, GumB, Has a Global Impact on the Transcriptome and Surface Proteome of Serratia marcescens

Nicholas A. Stella et al.

Summary: This study investigates the role of the Rcs stress response system in a clinical keratitis isolate of Serratia marcescens. The results show that the GumB gene has a global impact on S. marcescens gene expression, and measurable effects on bacterial cytotoxicity and surface adhesin production.

INFECTION AND IMMUNITY (2022)

Article Virology

Supplementing the Diet with Sodium Propionate Suppresses the Severity of Viral Immuno-inflammatory Lesions

Deepak Sumbria et al.

Summary: This study demonstrates that changing the diet to include increased levels of short-chain fatty acid (SCFA) salt sodium propionate can diminish the severity of ocular infections caused by herpes simplex virus. By inhibiting the involvement of inflammatory T cells, the inclusion of SCFA in the diet could be a useful approach to reducing the impact of recurrent herpetic lesions in humans.

JOURNAL OF VIROLOGY (2021)

Article Microbiology

The Rcs stress response inversely controls surface and CRISPR-Cas adaptive immunity to discriminate plasmids and phages

Leah M. Smith et al.

Summary: Bacteria have multiple immune mechanisms against phages and foreign genetic elements. The study found that pathways like the Rcs pathway can simultaneously regulate innate and adaptive CRISPR-Cas immunity to suppress phage infection and facilitate plasmid acquisition.

NATURE MICROBIOLOGY (2021)

Article Biochemistry & Molecular Biology

Structure-based analyses of Salmonella RcsB variants unravel new features of the Rcs regulon

Juanjo Huesa et al.

Summary: RcsB is a transcriptional regulator in enteric bacteria that controls gene expression through binding to target gene promoters in an active dimeric conformation, with DNA binding potentially stabilizing an active conformation in unphosphorylated RcsB. Phosphorylation contributes to gene regulation and RcsB may play a role in controlling iron metabolism. The RcsB box for active dimeric binding to DNA was identified as TN(G/A)GAN(4)TC(T/C)NA, found in promoter, intergenic, and intragenic regions to facilitate both increased or decreased gene transcription.

NUCLEIC ACIDS RESEARCH (2021)

Review Microbiology

The Rcs System in Enterobacteriaceae: Envelope Stress Responses and Virulence Regulation

Jiao Meng et al.

Summary: The Rcs system is a crucial mechanism for bacterial response to envelope stress and regulation of virulence, helping bacteria adapt to environmental pressures through signal transduction and control mechanisms.

FRONTIERS IN MICROBIOLOGY (2021)

Review Immunology

Short-Chain Fatty Acid and FFAR2 Activation - A New Option for Treating Infections?

Katja Schlatterer et al.

Summary: SCFAs play a crucial role in immune response against bacterial infections, with FFAR2 acting as the receptor that detects SCFAs in both intestinal and skin microbiomes. Activation of FFAR2 has shown potential in reducing susceptibility to various bacterial and viral infections.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Article Immunology

The Rcs Stress Response System Regulator GumB Modulates Serratia marcescens-Induced Inflammation and Bacterial Proliferation in a Rabbit Keratitis Model and Cytotoxicity In Vitro

Eric G. Romanowski et al.

Summary: The study showed that GumB regulates the production of virulence factors through the Rcs system, and the overall stress response system is a key factor in a bacterium's ability to induce vision-threatening keratitis.

INFECTION AND IMMUNITY (2021)

Article Multidisciplinary Sciences

High-throughput suppressor screen demonstrates that RcsF monitors outer membrane integrity and not Bam complex function

Muralidhar Tata et al.

Summary: The Rcs regulator is a complex signaling cascade that monitors gram-negative cell envelope integrity by interacting with the Bam complex and OMPs. Contrary to previous belief, the absence of nonessential component BamE inhibits the function of central component BamA, leading to the discovery that RcsF/OMP assembly plays a crucial role in sensing OM stress and activating the Rcs signaling pathway.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Chemistry, Medicinal

Impacts of Metabolism and Organic Acids on Cell Wall Composition and Pseudomonas aeruginosa Susceptibility to Membrane Active Antimicrobials

Giorgia Manzo et al.

Summary: Reliable antimicrobial susceptibility testing is crucial in clinical antibiotic therapy decisions and new antibiotic development. This study investigated the response of Escherichia coli and Pseudomonas aeruginosa to different growth media using NMR metabolomics and electron microscopy, to determine metabolic strategies and susceptibility to antimicrobials. The results showed that different media can affect the metabolic strategies of bacteria and their susceptibility to antimicrobial drugs.

ACS INFECTIOUS DISEASES (2021)

Article Chemistry, Medicinal

Combining Cell Envelope Stress Reporter Assays in a Screening Approach to Identify BAM Complex Inhibitors

Maurice Steenhuis et al.

Summary: Researchers identified potential BAM complex inhibitors as novel targets for antibiotics, which induced cell envelope sigma(E) and Rcs stress in bacteria. Two of the compounds showed characteristics of known BAM complex inhibitors, including reducing the abundance of OMPs and disrupting OM integrity.

ACS INFECTIOUS DISEASES (2021)

Article Infectious Diseases

Antibiotics Used in Empiric Treatment of Ocular Infections Trigger the Bacterial Rcs Stress Response System Independent of Antibiotic Susceptibility

Nathaniel S. Harshaw et al.

Summary: The Rcs phosphorelay is a bacterial stress response system that influences multiple pathogenic phenotypes and drug tolerance. Different classes of antibiotics can activate the Rcs system to varying degrees, regardless of the susceptibility status of the bacterium.

ANTIBIOTICS-BASEL (2021)

Article Biochemistry & Molecular Biology

Short-Chain Fatty Acids Modulate Metabolic Pathways and Membrane Lipids in Prevotella bryantii B14

Andrej Trautmann et al.

PROTEOMES (2020)

Article Infectious Diseases

Stress-Based High-Throughput Screening Assays to Identify Inhibitors of Cell Envelope Biogenesis

Maurice Steenhuis et al.

ANTIBIOTICS-BASEL (2020)

Article Biochemical Research Methods

mCloverBlaster: A tool to make markerless deletions and fusions using lambda red and I-SceI in Gram-negative bacterial genomes

Kara M. Lehner et al.

JOURNAL OF MICROBIOLOGICAL METHODS (2020)

Article Biotechnology & Applied Microbiology

Non-invasive, ratiometric determination of intracellular pH in Pseudomonas species using a novel genetically encoded indicator

Alejandro Arce-Rodriguez et al.

MICROBIAL BIOTECHNOLOGY (2019)

Review Biochemistry & Molecular Biology

The Complex Rcs Regulatory Cascade

Erin Wall et al.

ANNUAL REVIEW OF MICROBIOLOGY, VOL 72 (2018)

Article Pharmacology & Pharmacy

Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells

Meng Li et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2018)

Article Biotechnology & Applied Microbiology

An IgaA/UmoB Family Protein from Serratia marcescens Regulates Motility, Capsular Polysaccharide Biosynthesis, and Secondary Metabolite Production

Nicholas A. Stella et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2018)

Article Immunology

Free Fatty Acids Profiles Are Related to Gut Microbiota Signatures and Short-Chain Fatty Acids

Javier Rodriguez-Carrio et al.

FRONTIERS IN IMMUNOLOGY (2017)

Article Biotechnology & Applied Microbiology

Visualizing Bdellovibrio bacteriovorus by Using the tdTomato Fluorescent Protein

Somdatta Mukherjee et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2016)

Article Genetics & Heredity

The Rcs regulon in Proteus mirabilis: implications for motility, biofilm formation, and virulence

Kristen E. Howery et al.

CURRENT GENETICS (2016)

Article Microbiology

Regulation of the Swarming Inhibitor disA in Proteus mirabilis

Bree A. Szostek et al.

JOURNAL OF BACTERIOLOGY (2013)

Article Biotechnology & Applied Microbiology

Serratia marcescens Quinoprotein Glucose Dehydrogenase Activity Mediates Medium Acidification and Inhibition of Prodigiosin Production by Glucose

James E. Fender et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2012)

Article Biochemistry & Molecular Biology

Genome-Wide Identification of Genes Regulated by the Rcs Phosphorelay System in Erwinia amylovora

Dongping Wang et al.

MOLECULAR PLANT-MICROBE INTERACTIONS (2012)

Review Microbiology

The Rcs phosphorelay: more than just a two-component pathway

David J. Clarke

FUTURE MICROBIOLOGY (2010)

Article Microbiology

Cyclic AMP negatively regulates prodigiosin production by Serratia marcescens

Eric J. Kalivoda et al.

RESEARCH IN MICROBIOLOGY (2010)

Article Microbiology

Comparative functional analysis of the RcsC sensor kinase from different Enterobacteriaceae

Ya-Hui Huang et al.

FEMS MICROBIOLOGY LETTERS (2009)

Article Biochemistry & Molecular Biology

Acetyl phosphate-sensitive regulation of flagellar biogenesis and capsular biosynthesis depends on the Rcs phosphorelay

Christine E. Fredericks et al.

MOLECULAR MICROBIOLOGY (2006)

Article Biotechnology & Applied Microbiology

Saccharomyces cerevisiae-based molecular tool kit for manipulation of genes from gram-negative bacteria

Robert M. Q. Shanks et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2006)

Article Microbiology

Killing by ampicillin and ofloxacin induces overlapping changes in Escherichia coli transcription profile

M Kaldalu et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)

Article Microbiology

β-lactam induction of colanic acid gene expression in Escherichia coli

FC Sailer et al.

FEMS MICROBIOLOGY LETTERS (2003)

Article Agriculture, Dairy & Animal Science

Perspectives on the use of organic acids and short chain fatty acids as antimicrobials

SC Ricke

POULTRY SCIENCE (2003)

Article Multidisciplinary Sciences

The etiology of white pox, a lethal disease of the Caribbean elkhorn coral, Acropora palmata

KL Patterson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Multidisciplinary Sciences

One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products

KA Datsenko et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

Article Biochemistry & Molecular Biology

Evidence against a direct antimicrobial role of H2O2 in the infection of plants by Erwinia chrysanthemi

E Miguel et al.

MOLECULAR PLANT-MICROBE INTERACTIONS (2000)