期刊
JOURNAL OF PSYCHOPHARMACOLOGY
卷 30, 期 4, 页码 344-353出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0269881116628430
关键词
Altered states of consciousness; lysergic acid diethylamide; psychedelics; mental time travel; episodic past memory; mentation reports; default-mode network; self
资金
- Safra Foundation
- Beckley Foundation
- Walacea crowd-funding campaign
- Medical Research Council (MRC)
This paper reports on the effects of LSD on mental time travel during spontaneous mentation. Twenty healthy volunteers participated in a placebo-controlled crossover study, incorporating intravenous administration of LSD (75 g) and placebo (saline) prior to functional magnetic resonance imaging (fMRI). Six independent, blind judges analysed mentation reports acquired during structured interviews performed shortly after the functional magnetic resonance imaging (fMRI) scans (approximately 2.5 h post-administration). Within each report, specific linguistic references to mental spaces for the past, present and future were identified. Results revealed significantly fewer mental spaces for the past under LSD and this effect correlated with the general intensity of the drug's subjective effects. No differences in the number of mental spaces for the present or future were observed. Consistent with the previously proposed role of the default-mode network (DMN) in autobiographical memory recollection and ruminative thought, decreased resting-state functional connectivity (RSFC) within the DMN correlated with decreased mental time travel to the past. These results are discussed in relation to potential therapeutic applications of LSD and related psychedelics, e.g. in the treatment of depression, for which excessive reflection on one's past, likely mediated by DMN functioning, is symptomatic.
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