期刊
CHEMISTRYSELECT
卷 7, 期 48, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202203791
关键词
Leucine Rich Repeat; Shoc2; Cancer; HawkDock; X-ray crystallography and Structure-Function Relationship
The structural advancement in Shoc2 protein suggests that it may exhibit a dimer or higher order oligomer structure during its scaffolding activity, providing a new perspective for drug development in treating cancer and other diseases.
The structural advancement in Shoc, a prototypical Leucine rich protein, involved in MAPK pathway has added a new dimension in the development of drugs and therapeutics in treatment of cancer and other diseases. Here we have used computational studies to show that Shoc2 protein likely exhibits a dimer or even higher order oligomer structure during its scaffolding activity. The new perspective needs to be further explored for development of effective treatment against cancer, and other diseases.
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