4.4 Article

Metal-free organic transformation: 2,6-Pyridine dicarboxylic acid catalyzed synthesis of 5-substituted-1H-tetrazoles and β-aminoketones

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CHEMISTRYSELECT
卷 7, 期 46, 页码 -

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202202943

关键词

2; 6-Pyridine dicarboxylic acid; 5-substituted-1H-tetrazoles; beta-aminoketones; (E)-N; 1-bis(4-ethoxyphenyl) methanimine; Mannich reaction

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  1. Sona College of Technology

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A highly efficient metal-free one-pot synthesis of 5-substituted-1H-tetrazoles has been established using click chemistry and Mannich reaction with 2,6-pyridine dicarboxylic acid (PDCA) as an organocatalyst. The method offers excellent yields and advantages such as short reaction time, low impetus stacking %, a multi-component approach, and metal-free ecobenign synthesis.
A highly efficient, clean, and easy technique for the one-pot metal-free synthesis of 5-substituted-1H-tetrazoles through click chemistry approach and beta-aminoketones via Mannich reaction employing 2,6-pyridine dicarboxylic acid (PDCA) as an organocatalyst has been established. These conversions occur under gentle reaction conditions to give excellent to superior yields. This methodology offers benefits such as short reaction time, a low impetus stacking %, a multi-component approach, and metal-free ecobenign synthesis.

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