期刊
CHEMISTRYSELECT
卷 7, 期 48, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202204173
关键词
amino acids; anthranilamide; 2-bromo benzaldehyde; decarboxylative cyclisation and N-arylation
资金
- DST
- CSIR
A convenient one-pot method has been developed for the synthesis of fused pyrroloquinazolinone and amino quinazolinone derivatives. The method involves the in situ formation of 2-(2-bromophenyl)quinazolin-4(3H)-one and subsequent reaction with different amino acids/cyclic secondary amines under aerobic conditions. The protocol mediated by copper (II) salt results in the direct amination, decarboxylation, and cyclization to obtain polycyclic fused quinazolinone or aminated quinazolinone derivatives with satisfactory yields.
A convenient one pot method developed for synthesisof fused pyrroloquinazolinone and amino quinazolinone derivatives starting from 2-bromo benzaldehyde, anthranilamide through in situ formation of2-(2-bromophenyl)quinazolin-4(3H)-one and subsequent reaction withdifferent amino acids/cyclic secondary amines under aerobic conditions. The multicomponent protocol mediated by copper (II) salt involves direct amination with 2-(2-bromophenyl)quinazolin-4(3H)-one, decarboxylation and cyclization to obtain polycyclic fused quinazolinone or aminated quinazolinone derivatives with the acceptable yields.
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