Copper Mediated Direct Amination: Synthesis of 1,2,3,15 a-tetrahydro-14H-pyrrolo[1,2-a]quinazolino[3,2-c]quinazolin-14-onederivatives via 2-(2-bromophenyl)quinazolin-4(3H)-ones

A convenient one pot method developed for synthesisof fused pyrroloquinazolinone and amino quinazolinone derivatives starting from 2-bromo benzaldehyde, anthranilamide through in situ formation of2-(2-bromophenyl)quinazolin-4(3H)-one and subsequent reaction withdifferent amino acids/cyclic secondary amines under aerobic conditions. The multicomponent protocol mediated by copper (II) salt involves direct amination with 2-(2-bromophenyl)quinazolin-4(3H)-one, decarboxylation and cyclization to obtain polycyclic fused quinazolinone or aminated quinazolinone derivatives with the acceptable yields.

Automated summary

A convenient one-pot method has been developed for the synthesis of fused pyrroloquinazolinone and amino quinazolinone derivatives. The method involves the in situ formation of 2-(2-bromophenyl)quinazolin-4(3H)-one and subsequent reaction with different amino acids/cyclic secondary amines under aerobic conditions. The protocol mediated by copper (II) salt results in the direct amination, decarboxylation, and cyclization to obtain polycyclic fused quinazolinone or aminated quinazolinone derivatives with satisfactory yields.