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Circulating Tumor Cells in Cancer Diagnostics and Prognostics by Single-Molecule and Single-Cell Characterization

ACS SENSORS (2023)

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ACS SENSORS (2019)

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Article Multidisciplinary Sciences

High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes

Mandeep Singh et al.

NATURE COMMUNICATIONS (2019)

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Article Cell Biology

S100-EPISPOT: A New Tool to Detect Viable Circulating Melanoma Cells

Laure Cayrefourcq et al.

CELLS (2019)

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Article Medical Laboratory Technology

Circulating Tumor Cells as a Prognostic Factor in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: The CIRCUTEC Prospective Study

Renaud Garrel et al.

CLINICAL CHEMISTRY (2019)

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Article Biophysics

Dual-antibody Modified PLGA Nanofibers for Specific Capture of Epithelial and Mesenchymal CTCs

Hui Liu et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Review Biotechnology & Applied Microbiology

EpCAMlow Circulating Tumor Cells: Gold in the Waste

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DISEASE MARKERS (2019)

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Review Biochemistry & Molecular Biology

The Need for Multi-Omics Biomarker Signatures in Precision Medicine

Michael Olivier et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Medicine, Research & Experimental

The role of collagen in cancer: from bench to bedside

Shuaishuai Xu et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2019)

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Article Medicine, General & Internal

A Novel Ex Vivo System Using 3D Polymer Scaffold to Culture Circulating Tumor Cells from Breast Cancer Patients Exhibits Dynamic E-M Phenotypes

Tamasa De et al.

JOURNAL OF CLINICAL MEDICINE (2019)

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Article Chemistry, Multidisciplinary

Label-Free Detection of Post-translational Modifications with a Nanopore

Laura Restrepo-Perez et al.

NANO LETTERS (2019)

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Article Biotechnology & Applied Microbiology

Analysis of short tandem repeat expansions and their methylation state with nanopore sequencing

Pay Giesselmann et al.

NATURE BIOTECHNOLOGY (2019)

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3D Bioprinted In Vitro Metastatic Models via Reconstruction of Tumor Microenvironments

Fanben Meng et al.

ADVANCED MATERIALS (2019)

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Review Oncology

Single-Cell Analysis of Circulating Tumor Cells: Why Heterogeneity Matters

Su Bin Lim et al.

CANCERS (2019)

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BulkVis: a graphical viewer for Oxford nanopore bulk FAST5 files

Alexander Payne et al.

BIOINFORMATICS (2019)

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A Nanopore Phosphorylation Sensor for Single Oligonucleotides and Peptides

Yi-Lun Ying et al.

RESEARCH (2019)

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Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding

Sofia Gkountela et al.

CELL (2019)

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Review Cell Biology

New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer

Anushka Dongre et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Review Oncology

Circulating Tumor Cell-Derived Pre-Clinical Models for Personalized Medicine

Marta Tellez-Gabriel et al.

CANCERS (2019)

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Article Nanoscience & Nanotechnology

Topotactic Fibrillogenesis of Freeze-Cast Microridged Collagen Scaffolds for 3D Cell Culture

Clement Rieu et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Multidisciplinary Sciences

New Labyrinth Microfluidic Device Detects Circulating Tumor Cells Expressing Cancer Stem Cell Marker and Circulating Tumor Microemboli in Hepatocellular Carcinoma

Shanshan Wan et al.

SCIENTIFIC REPORTS (2019)

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Detection of circulating sarcoma tumor cells using a microfluidic chip-type cell sorter

Nobuhiko Hasegawa et al.

SCIENTIFIC REPORTS (2019)

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Article Chemistry, Multidisciplinary

Label-Free Multiplexed Electrical Detection of Cancer Markers on a Microchip Featuring an Integrated Fluidic Diode Nanopore Array

Lian Duan et al.

ACS NANO (2018)

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Review Pharmacology & Pharmacy

Clinical applications of the CellSearch platform in cancer patients

Sabine Riethdorf et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

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Article Medical Laboratory Technology

Effect of Blood Collection Tube Type and Time to Processing on the Enumeration and High-Content Characterization of Circulating Tumor Cells Using the High-Definition Single-Cell Assay

Mariam Rodriguez-Lee et al.

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (2018)

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Article Biochemical Research Methods

A Microfluidic Chip Integrated with Hyaluronic Acid-Functionalized Electrospun Chitosan Nanofibers for Specific Capture and Nondestructive Release of CD44-Overexpressing Circulating Tumor Cells

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BIOCONJUGATE CHEMISTRY (2018)

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Article Oncology

Isolation and molecular analysis of circulating tumor cells from lung cancer patients using a microfluidic chip type cell sorter

Masaru Watanabe et al.

CANCER SCIENCE (2018)

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Ice-templating beet-root pectin foams: Controlling texture, mechanics and capillary properties

Sarah Christoph et al.

CHEMICAL ENGINEERING JOURNAL (2018)

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Article Medical Laboratory Technology

Evaluation of Preanalytical Conditions and Implementation of Quality Control Steps for Reliable Gene Expression and DNA Methylation Analyses in Liquid Biopsies

Martha Zavridou et al.

CLINICAL CHEMISTRY (2018)

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Review Biochemistry & Molecular Biology

Platforms for Single-Cell Collection and Analysis

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Method for Dynamically Detecting Secretions from Single Cells Using a Nanopore

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NANO LETTERS (2018)

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A comparison of methods to assess cell mechanical properties

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NATURE METHODS (2018)

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Engineering precision biomaterials for personalized medicine

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SCIENCE TRANSLATIONAL MEDICINE (2018)

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Recent Advances in Magnetic Levitation: A Biological Approach from Diagnostics to Tissue Engineering

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ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Article Materials Science, Biomaterials

Recent Advances in Magnetic Levitation: A Biological Approach from Diagnostics to Tissue Engineering

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ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Label-Free Sensing of Human 8-Oxoguanine DNA Glycosylase Activity with a Nanopore

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ACS SENSORS (2018)

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Review Nanoscience & Nanotechnology

Biofabrication strategies for 3D in vitro models and regenerative medicine

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Hydrogel microenvironments for cancer spheroid growth and drug screening

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SCIENCE ADVANCES (2018)

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Review Nanoscience & Nanotechnology

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NATURE NANOTECHNOLOGY (2018)

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Article Multidisciplinary Sciences

Design and MinION testing of a nanopore targeted gene sequencing panel for chronic lymphocytic leukemia

Paola Orsini et al.

SCIENTIFIC REPORTS (2018)

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Article Multidisciplinary Sciences

Autologous cell lines from circulating colon cancer cells captured from sequential liquid biopsies as model to study therapy-driven tumor changes

Alexandra Soler et al.

SCIENTIFIC REPORTS (2018)

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Article Health Care Sciences & Services

Health economic impact of liquid biopsies in cancer management

Maarten J. IJzerman et al.

EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH (2018)

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Review Biochemical Research Methods

DEPArray™ system: An automatic image-based sorter for isolation of pure circulating tumor cells

Mariano Di Trapani et al.

CYTOMETRY PART A (2018)

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Article Biochemical Research Methods

VyCAP's puncher technology for single cell identification, isolation, and analysis

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CYTOMETRY PART A (2018)

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3D Bioprinting of Breast Cancer Models for Drug Resistance Study

Ying Wang et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Article Chemistry, Analytical

Proteome Profiling of 1 to 5 Spiked Circulating Tumor Cells Isolated from Whole Blood Using Immunodensity Enrichment, Laser Capture Microdissection, Nanodroplet Sample Processing, and Ultrasensitive nanoLC-MS

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ANALYTICAL CHEMISTRY (2018)

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Article Medical Laboratory Technology

Multiplex Gene Expression Profiling of In Vivo Isolated Circulating Tumor Cells in High-Risk Prostate Cancer Patients

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CLINICAL CHEMISTRY (2018)

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Article Nanoscience & Nanotechnology

Ethanol-dispersed and antibody-conjugated polymer nanofibers for the selective capture and 3-dimensional culture of EpCAM-positive cells

Junghyo Yoon et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

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Electro-osmotic capture and ionic discrimination of peptide and protein biomarkers with FraC nanopores

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NATURE COMMUNICATIONS (2017)

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Profiling protein expression in circulating tumour cells using microfluidic western blotting

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NATURE COMMUNICATIONS (2017)

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Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers

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NATURE COMMUNICATIONS (2017)

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Mapping and phasing of structural variation in patient genomes using nanopore sequencing

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NATURE COMMUNICATIONS (2017)

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Promoting Cell Migration in Tissue Engineering Scaffolds with Graded Channels

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ADVANCED HEALTHCARE MATERIALS (2017)

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Hyaluronic acid-functionalized electrospun PLGA nanofibers embedded in a microfluidic chip for cancer cell capture and culture

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BIOMATERIALS SCIENCE (2017)

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Article Nanoscience & Nanotechnology

Functionalized Solid-State Nanopore Integrated in a Reusable Microfluidic Device for a Better Stability and Nanoparticle Detection

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ACS APPLIED MATERIALS & INTERFACES (2017)

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Sequencing and phasing cancer mutations in lung cancers using a long-read portable sequencer

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DNA RESEARCH (2017)

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Direct sensing of cancer biomarkers in clinical samples with a designed nanopore

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CHEMICAL COMMUNICATIONS (2017)

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Atomic Force Microscopy: A Powerful Tool to Address Scaffold Design in Tissue Engineering

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JOURNAL OF FUNCTIONAL BIOMATERIALS (2017)

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Article Engineering, Biomedical

Development of three-dimensional collagen scaffolds with controlled architecture for cell migration studies using breast cancer cell lines

Jonathan J. Campbell et al.

BIOMATERIALS (2017)

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Elasticity, Adhesion, and Tether Extrusion on Breast Cancer Cells Provide a Signature of Their Invasive Potential

Georges Smolyakov et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

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Article Chemistry, Multidisciplinary

Single-Molecule DNA Methylation Quantification Using Electro-optical Sensing in Solid-State Nanopores

Tal Gilboa et al.

ACS NANO (2016)

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Article Chemistry, Analytical

Protein Counting in Single Cancer Cells

Stephanie M. Schubert et al.

ANALYTICAL CHEMISTRY (2016)

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Article Oncology

Nanopore sequencing detects structural variants in cancer

Alexis L. Norris et al.

CANCER BIOLOGY & THERAPY (2016)

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TP53 gene mutation analysis in chronic lymphocytic leukemia by nanopore MinION sequencing

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DIAGNOSTIC PATHOLOGY (2016)

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Real-time, portable genome sequencing for Ebola surveillance

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NATURE (2016)

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Review Multidisciplinary Sciences

Metastatic colonization by circulating tumour cells

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NATURE (2016)

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Review Biochemical Research Methods

A practical guide to hydrogels for cell culture

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NATURE METHODS (2016)

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Epigenetic Determinants of Cancer

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COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)

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Short term ex-vivo expansion of circulating head and neck tumour cells

Arutha Kulasinghe et al.

ONCOTARGET (2016)

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Article Oncology

TGF-β signal rewiring sustains epithelial-mesenchymal transition of circulating tumor cells in prostate cancer xenograft hosts

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ONCOTARGET (2016)

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Discrimination Between Normal and Cancerous Cells Using AFM

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BIONANOSCIENCE (2016)

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Nanopore-Based Assay for Detection of Methylation in Double-Stranded DNA Fragments

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ACS NANO (2015)

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Levitational Image Cytometry with Temporal Resolution

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ADVANCED MATERIALS (2015)

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Review Oncology

Ex Vivo Culture of CTCs: An Emerging Resource to Guide Cancer Therapy

Shyamala Maheswaran et al.

CANCER RESEARCH (2015)

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Establishment and Characterization of a Cell Line from Human Circulating Colon Cancer Cells

Laure Cayrefourcq et al.

CANCER RESEARCH (2015)

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Review Pathology

Liquid biopsy in cancer patients: advances in capturing viable CTCs for functional studies using the EPISPOT assay

Catherine Alix-Panabieres et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2015)

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Magnetic levitation of single cells

Naside Gozde Durmus et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Review Chemistry, Physical

Bioinspired structural materials

Ulrike G. K. Wegst et al.

NATURE MATERIALS (2015)

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Article Biochemistry & Molecular Biology

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

Dong Gao et al.

CELL (2014)

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A novel technique for scaffold fabrication: SLUP (salt leaching using powder)

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CURRENT APPLIED PHYSICS (2014)

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Article Chemistry, Multidisciplinary

Nanopores Discriminate among Five C5-Cytosine Variants in DNA

Zachary L. Wescoe et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

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Article Oncology

Circulating Tumor Cells Predict Survival in Early Average-to-High Risk Breast Cancer Patients

Brigitte Rack et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2014)

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Article Biotechnology & Applied Microbiology

Single-molecule site-specific detection of protein phosphorylation with a nanopore

Christian B. Rosen et al.

NATURE BIOTECHNOLOGY (2014)

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Review Cell Biology

Three-dimensional organotypic culture: experimental models of mammalian biology and disease

Eliah R. Shamir et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

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Article Endocrinology & Metabolism

Nanomechanical Biomarkers of Single Circulating Tumor Cells for Detection of Castration Resistant Prostate Cancer

Pawel Osmulski et al.

PROSTATE (2014)

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Article Multidisciplinary Sciences

Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility

Min Yu et al.

SCIENCE (2014)

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Article Oncology

Expansion of CTCs from early stage lung cancer patients using a microfluidic co-culture model

Zhuo Zhang et al.

ONCOTARGET (2014)

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Article Oncology

International study on inter-reader variability for circulating tumor cells in breast cancer

Michail Ignatiadis et al.

BREAST CANCER RESEARCH (2014)

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Article Chemistry, Multidisciplinary

Engineered Nanopore of Phi29 DNA-Packaging Motor for Real-Time Detection of Single Colon Cancer Specific Antibody in Serum

Shaoying Wang et al.

ACS NANO (2013)

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Article Engineering, Biomedical

An ice-templated, linearly aligned chitosan-alginate scaffold for neural tissue engineering

Nicola L. Francis et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2013)

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Review Biochemical Research Methods

Multiparametric imaging of biological systems by force-distance curve-based AFM

Yves F. Dufrene et al.

NATURE METHODS (2013)

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Article Endocrinology & Metabolism

Single-cell analysis of circulating tumor cells identifies cumulative expression patterns of EMT-related genes in metastatic prostate cancer

Chun-Liang Chen et al.

PROSTATE (2013)

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Article Cell Biology

Inertial Focusing for Tumor Antigen-Dependent and -Independent Sorting of Rare Circulating Tumor Cells

Emre Ozkumur et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

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Article Cell Biology

The Identification and Characterization of Breast Cancer CTCs Competent for Brain Metastasis

Lixin Zhang et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

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Article Biochemistry & Molecular Biology

Cancer cell detection in tissue sections using AFM

Malgorzata Lekka et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2012)

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Review Chemistry, Multidisciplinary

Disease Detection and Management via Single Nanopore-Based Sensors

Joseph E. Reiner et al.

CHEMICAL REVIEWS (2012)

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Article Nanoscience & Nanotechnology

The nanomechanical signature of breast cancer

Marija Plodinec et al.

NATURE NANOTECHNOLOGY (2012)

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Article Multidisciplinary Sciences

Single Cell Profiling of Circulating Tumor Cells: Transcriptional Heterogeneity and Diversity from Breast Cancer Cell Lines

Ashley A. Powell et al.

PLOS ONE (2012)

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Article Multidisciplinary Sciences

Cell Stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells

Wenwei Xu et al.

PLOS ONE (2012)

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Article Oncology

mRNA and microRNA Expression Profiles in Circulating Tumor Cells and Primary Tumors of Metastatic Breast Cancer Patients

Anieta M. Sieuwerts et al.

CLINICAL CANCER RESEARCH (2011)

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Article Chemistry, Multidisciplinary

Discrimination of Methylcytosine from Hydroxymethylcytosine in DNA Molecules

Meni Wanunu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

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Article Nanoscience & Nanotechnology

Nanopore-based detection of circulating microRNAs in lung cancer patients

Yong Wang et al.

NATURE NANOTECHNOLOGY (2011)

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Letter Oncology

Circulating Tumor Cells and Sample Size: The More, the Better

Zarina S. Lalmahomed et al.

JOURNAL OF CLINICAL ONCOLOGY (2010)

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Article Nanoscience & Nanotechnology

Rapid electronic detection of probe-specific microRNAs using thin nanopore sensors

Meni Wanunu et al.

NATURE NANOTECHNOLOGY (2010)

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Article Instruments & Instrumentation

Application of AFM in Microbiology: A Review

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SCANNING (2010)

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Dense fibrillar collagen matrices for tissue repair

Marie Madeleine Giraud Guille et al.

SOFT MATTER (2010)

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Cell proliferation and migration in silk fibroin 3D scaffolds

Biman B. Mandal et al.

BIOMATERIALS (2009)

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Article Oncology

Tumor suppressor protein SMAR1 modulates the roughness of cell surface: combined AFM and SEM study

Ruchika Kaul-Ghanekar et al.

BMC CANCER (2009)

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Review Chemistry, Multidisciplinary

Nanopore analytics: sensing of single molecules

Stefan Howorka et al.

CHEMICAL SOCIETY REVIEWS (2009)

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Review Biochemistry & Molecular Biology

Force probing surfaces of living cells to molecular resolution

Daniel J. Mueller et al.

NATURE CHEMICAL BIOLOGY (2009)

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Article Nanoscience & Nanotechnology

Atomic force microscopy detects differences in the surface brush of normal and cancerous cells

S. Iyer et al.

NATURE NANOTECHNOLOGY (2009)

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Article Biochemistry & Molecular Biology

AFM indentation study of breast cancer cells

Q. S. Li et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

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Review Nanoscience & Nanotechnology

Atomic force microscopy as a multifunctional molecular toolbox in nanobiotechnology

Daniel J. Mueller et al.

NATURE NANOTECHNOLOGY (2008)

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Article Multidisciplinary Sciences

Circulating microRNAs as stable blood-based markers for cancer detection

Patrick S. Mitchell et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Article Nanoscience & Nanotechnology

Nanomechanical analysis of cells from cancer patients

Sarah E. Cross et al.

NATURE NANOTECHNOLOGY (2007)

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Article Cell & Tissue Engineering

In vitro assessment of axonal growth using dorsal root ganglia explants in a novel three-dimensional collagen matrix

Ahmet Bozkurt et al.

TISSUE ENGINEERING (2007)

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Review Microscopy

Atomic force microscopy: Determination of unbinding force, off rate and energy barrier for protein-ligand interaction

Chih-Kung Lee et al.

MICRON (2007)

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Article Oncology

Circulating tumor cells versus imaging - Predicting overall survival in metastatic breast cancer

G. Thomas Budd et al.

CLINICAL CANCER RESEARCH (2006)

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Review Oncology

MicroRNA signatures in human cancers

George A. Calin et al.

NATURE REVIEWS CANCER (2006)

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Article Biochemistry & Molecular Biology

Matrix elasticity directs stem cell lineage specification

Adam J. Engler et al.

CELL (2006)

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Article Oncology

Circulating tumor cells in patients with breast cancer dormancy

SD Meng et al.

CLINICAL CANCER RESEARCH (2004)

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Article Oncology

Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases

WJ Allard et al.

CLINICAL CANCER RESEARCH (2004)

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