Highly Specific Antibiotic Detection on Water-Stable Black Phosphorus Field-Effect Transistors

Two-dimensional (2D) black phosphorus (BP) has been reported to have appealing semiconducting properties as the sensing channel in field-effect transistor (FET) sensors. However, the intrinsic instability of BP in water greatly hinders its application, and little is known about its sensing performance and mechanism in aqueous medium. Herein, a water-stable BP FET sensor for antibiotic detection is reported. A novel surface engineering strategy with Ag+ coordination and melamine cyanurate (MC) supramolecular passivation is utilized to enhance the stability and transistor performance of BP. With molecularly imprinted polymers (MIPs) as the detection probe for tetracycline, the BPAg(+)/MC/MIPs sensor shows high sensitivity to tetracycline with a detection limit of 7.94 nM and a quick response within 6 s as well as high selectivity against other antibiotics with similar molecular structures. A new sensing mechanism relying on the conjugation effect of the probe structure is proposed, and new knowledge about alkalinity-enhanced and ionic strength-related response from the electrostatic gating effect is given based on the solution chemistry impact study. This work offers an efficient surface engineering strategy to enable the application of 2D BP for antibiotic detection in aqueous medium and presents a new sensing mechanism in chemical analysis by FET sensors.

Automated summary

A water-stable BP FET sensor for antibiotic detection is developed by employing a surface engineering strategy with Ag+ coordination and MC supramolecular passivation. The BPAg(+)/MC/MIPs sensor shows high sensitivity, low detection limit, and rapid response to tetracycline, as well as high selectivity against other antibiotics. A new sensing mechanism based on the probe structure and the electrostatic gating effect is proposed. This work enables the application of 2D BP for antibiotic detection in aqueous medium and reveals a new sensing mechanism in chemical analysis by FET sensors.