期刊
JOURNAL OF PSYCHOPHARMACOLOGY
卷 30, 期 10, 页码 994-999出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0269881116658988
关键词
NMDA; motor learning; d-cycloserine
资金
- Medical Research Council
- Oxfordshire Health Services Research Committee
- MRC [MR/J011878/1, MR/N014448/1] Funding Source: UKRI
- Medical Research Council [MR/J011878/1, MR/N014448/1] Funding Source: researchfish
Rationale: There has recently been increasing interest in pharmacological manipulations that could potentially enhance exposure-based cognitive behaviour therapy for anxiety disorders. One such medication is the partial NMDA agonist d-cycloserine. It has been suggested that d-cycloserine enhances cognitive behaviour therapy by making learning faster. While animal studies have supported this view of the drug accelerating learning, evidence in human studies has been mixed. We therefore designed an experiment to measure the effects of d-cycloserine on human motor learning. Methods: Fifty-four healthy human volunteers were randomly assigned to a single dose of 250mg d-cycloserine versus placebo in a double-blind design. They then performed a motor sequence learning task. Results: D-cycloserine did not increase the speed of motor learning or the overall amount learnt. However, we noted that participants on d-cycloserine tended to respond more carefully (shifting towards slower, but more correct responses). Conclusion: The results suggest that d-cycloserine does not exert beneficial effects on psychological treatments via mechanisms involved in motor learning. Further studies are needed to clarify the influence on other cognitive mechanisms.
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