☆ 4.5 Article

Case Report: A case of recurrent thrombosis in pediatric antiphospholipid syndrome associated with pediatric onset systemic lupus

FRONTIERS IN PEDIATRICS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Rheumatology

Panel sequencing links rare, likely damaging gene variants with distinct clinical phenotypes and outcomes in juvenile-onset SLE

Amandine Charras et al.

Summary: This study identified highly penetrant damaging gene variants associated with juvenile-onset systemic lupus erythematosus (jSLE) in a large national cohort. Patients with "genetic" SLE exhibited distinct clinical features and were younger at onset compared to other SLE patients. Routine sequencing could allow for patient stratification and targeted treatment.

RHEUMATOLOGY (2023)

添加到收藏夹

Article Medicine, General & Internal

Risk of Arterial Thromboembolism, Venous Thromboembolism, and Bleeding in Patients with Nephrotic Syndrome: A Population-Based Cohort Study

Soren Viborg Vestergaard et al.

Summary: Adults with nephrotic syndrome have a higher risk of arterial thromboembolism, venous thromboembolism, and bleeding compared to the general population, especially in the first year with a significant increase in risk.

AMERICAN JOURNAL OF MEDICINE (2022)

添加到收藏夹

Article Pediatrics

Pediatric antiphospholipid syndrome: clinical features and therapeutic interventions in a single center retrospective case series

Jacqueline A. Madison et al.

Summary: This case series of pediatric antiphospholipid syndrome (APS) provides important insights into the disease phenotypes displayed by children with APS. The high prevalence of non-criteria clinical manifestations highlights the need to consider these characteristics when developing pediatric-specific classification criteria and when considering this relatively rare diagnosis in pediatric practice.

PEDIATRIC RHEUMATOLOGY (2022)

添加到收藏夹

Review Rheumatology

Work participation in patients with systematic lupus erythematosus: a systematic review

Birgit S. Blomjous et al.

Summary: This systematic review identified variables associated with work participation outcomes in patients with systematic lupus erythematosus (SLE). Factors such as age, ethnicity, educational level, disease activity score, disease duration, disease manifestations, physical functioning, cognitive functioning were found to be predictors for work outcomes. It was also found that certain demographic and disease-related factors were associated with unfavorable work outcomes.

RHEUMATOLOGY (2022)

添加到收藏夹

Article Immunology

Cardiovascular disease risk in antiphospholipid syndrome: Thrombo-inflammation and atherothrombosis

Maria G. Tektonidou

Summary: Antiphospholipid syndrome (APS), an autoimmune disorder, primarily affects young adults and is characterized by the presence of antiphospholipid antibodies along with vascular manifestations. The pathogenesis of cardiovascular disease (CVD) in APS involves factors such as platelet activation, thrombosis, and the role of oxidized low-density lipoprotein. In addition, traditional risk factors including smoking, hypertension, hyperlipemia, and obesity are associated with subclinical atherosclerosis and cardiovascular events in APS.

JOURNAL OF AUTOIMMUNITY (2022)

添加到收藏夹

Review Rheumatology

Endothelial function and endothelial progenitor cells in systemic lupus erythematosus

Anselm Mak et al.

Summary: The excessive cardiovascular mortality observed in patients with SLE compared to the general population has led to in-depth investigations of non-traditional, SLE-related risk factors such as endothelial dysfunction and reduced EPC levels. Challenges in defining and assessing EPCs pose difficulties in translating them into prognostic markers for CVD in SLE patients.

NATURE REVIEWS RHEUMATOLOGY (2022)

添加到收藏夹

Review Medicine, General & Internal

Laboratory Diagnosis of Antiphospholipid Syndrome: Insights and Hindrances

Arne Vandevelde et al.

Summary: The diagnosis and risk stratification of antiphospholipid syndrome (APS) are complex and require various laboratory tests. Efforts to standardize and optimize these tests are ongoing to improve diagnostic accuracy and repeatability. There are challenges in laboratory testing, such as interference by anticoagulation therapy for LAC detection and high variability due to different reagents and detection techniques.

JOURNAL OF CLINICAL MEDICINE (2022)

添加到收藏夹

Editorial Material Medicine, General & Internal

Adults with first-time nephrotic syndrome had increased risk for thromboembolic events, higher near time of diagnosis

Siraj Mithoowani et al.

ANNALS OF INTERNAL MEDICINE (2022)

添加到收藏夹

Letter Rheumatology

Determination of the minimal clinically important difference (MCID) of the physician global assessment (PGA) in SLE

Erik W. Anderson et al.

ANNALS OF THE RHEUMATIC DISEASES (2022)

添加到收藏夹

Review Immunology

Epigenetics-mediated pathological alternations and their potential in antiphospholipid syndrome diagnosis and therapy

Yuan Tan et al.

Summary: APS is a systemic autoimmune disease characterized by thrombosis and poor pregnancy outcomes, which is partly attributed to elevated antiphospholipid antibodies (aPL) and increased production of prothrombotic and proinflammatory molecules. Dysfunctions in endothelial cells, monocytes, platelets, trophoblasts, and neutrophils, particularly their epigenetic variations, are key contributors to APS progression. Epigenetic alterations, including DNA methylation, histone modifications, and noncoding RNAs, affect gene expression and play a role in inflammation, thrombosis, autoimmune activation, and adverse pregnancy outcomes in APS. Understanding the underlying epigenetic mechanisms of APS could lead to novel diagnostic, therapeutic, and prognostic strategies.

AUTOIMMUNITY REVIEWS (2022)

添加到收藏夹

Article Immunology

Urine ALCAM, PF4 and VCAM-1 Surpass Conventional Metrics in Identifying Nephritis Disease Activity in Childhood-Onset Systemic Lupus Erythematosus

Samar A. Soliman et al.

Summary: This study evaluated the performance of ten urine protein markers in distinguishing disease activity in childhood-onset Systemic Lupus Erythematosus (cSLE). The results showed that urinary ALCAM, PF4, and VCAM-1 are potential biomarkers for predicting kidney disease activity in cSLE, and they hold potential as surrogate markers of nephritis flares in these patients.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Medicine, General & Internal

Pregnancy and Management in Women with Rheumatoid Arthritis, Systemic Lupus Erythematosus, and Obstetric Antiphospholipid Syndrome

Adela Castro-Gutierrez et al.

MEDICAL CLINICS OF NORTH AMERICA (2021)

添加到收藏夹

Article Rheumatology

Pediatric Antiphospholipid Syndrome: from Pathogenesis to Clinical Management

Silvia Rosina et al.

Summary: Understanding the multifaceted nature of pediatric APS is crucial to avoid underdiagnosis and undertreatment. Recent insights into the pathogenesis of APS may lead to new opportunities for pediatric APS management.

CURRENT RHEUMATOLOGY REPORTS (2021)

添加到收藏夹

Article Hematology

Anti-dsDNA Antibodies Increase the Cardiovascular Risk in Systemic Lupus Erythematosus Promoting a Distinctive Immune and Vascular Activation

Alejandra Maria Patino-Trives et al.

Summary: The presence of anti-double stranded DNA (anti-dsDNA) antibodies in patients with systemic lupus erythematosus is associated with an increased cardiovascular risk. This is possibly due to alterations in key molecular processes that drive immune and vascular activation, leading to endothelial dysfunction, proatherogenic dyslipidemia, and accelerated atherosclerosis.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Immune Thrombocytopenia in Antiphospholipid Syndrome: Is It Primary or Secondary?

Riccardo Tomasello et al.

Summary: Antiphospholipid syndrome (APS) is often linked with mild thrombocytopenia, while some patients may develop secondary immune thrombocytopenia (ITP) leading to severe thrombocytopenia with risks of major bleeding. It is important to assess the presence of antiphospholipid antibodies (aPL) in patients with ITP to stratify the risk of thrombosis and to define appropriate treatment strategies.

BIOMEDICINES (2021)

添加到收藏夹

Article Urology & Nephrology

Primary antiphospholipid syndrome associated with anti-phospholipase A2 receptor antibody-positive membranous nephropathy

Maxime Teisseyre et al.

BMC NEPHROLOGY (2020)

添加到收藏夹

Article Immunology

The treatment of anti-phospholipid syndrome: A comprehensive clinical approach

Cecilia Beatrice Chighizola et al.

JOURNAL OF AUTOIMMUNITY (2018)

添加到收藏夹

Article Rheumatology

Prevalence, persistence and clinical correlations of classic and novel antiphospholipid antibodies in systemic lupus erythematosus

Tess Marchetti et al.

RHEUMATOLOGY (2018)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Pulmonary Embolism and Renal Vein Thrombosis in Patients with Nephrotic Syndrome: Prospective Evaluation of Prevalence and Risk Factors with CT

Long Jiang Zhang et al.

RADIOLOGY (2014)

添加到收藏夹

Article Hematology

Thrombosis in Nephrotic Syndrome

Biagio Barbano et al.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2013)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.