4.7 Article

Potential genetic biomarkers predict adverse pregnancy outcome during early and mid-pregnancy in women with systemic lupus erythematosus

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Rheumatology

Evaluation of lupus anticoagulant, damage, and remission as predictors of pregnancy complications in systemic lupus erythematosus: the French GR2 study

Maddalena Larosa et al.

Summary: The specific roles of remission status, lupus low disease activity state (LLDAS), and damage accrual on the prognosis of pregnancies in women with SLE are unknown. This study found that damage at conception and lupus anticoagulant were significantly associated with adverse pregnancy outcomes, while hypocomplementemia in the first trimester was associated with maternal flares later in pregnancy.

RHEUMATOLOGY (2022)

Review Biotechnology & Applied Microbiology

Using Machine Learning to Predict Complications in Pregnancy: A Systematic Review

Ayleen Bertini et al.

Summary: Through analyzing 98 articles, 31 were selected for predicting perinatal complications with main features of electronic medical records, medical images, and biological markers. The studies mainly focus on pre-eclampsia and prematurity, using AUC as the main precision metric for accuracy measurement.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

Article Obstetrics & Gynecology

Value of second-trimester uterine artery pulsatility index in pregnancies with systemic lupus erythematosus and/or antiphospholipid syndrome

Maria J. Canto et al.

Summary: Abnormal second-trimester uterine artery Doppler evaluation is highly predictive for adverse perinatal outcome in pregnancies affected by SLE or APS.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2022)

Review Biochemistry & Molecular Biology

Transcription factor networks in trophoblast development

Henrieta Papuchova et al.

Summary: The placenta is crucial for the development of the embryo and the success of pregnancy. It serves as a site for exchange between the mother and the embryo, has immune functions, and acts as an important endocrine organ. Specialized trophoblast cell types, including syncytiotrophoblast and extravillous trophoblast, are responsible for these diverse functions of the placenta. Transcription factors play a vital role in regulating the emergence, specialization, and identity of these cells, and their coordinated actions determine the specific characteristics of each cell type. This article provides an overview of transcription factors involved in the development and function of human trophoblast and discusses their similarities and differences to their counterparts in mice. The establishment of human in vitro models combined with -omics approaches has greatly advanced our understanding of the human trophoblast field.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

Review Immunology

Monocytes and macrophages in pregnancy: The good, the bad, and the ugly

Heather True et al.

Summary: A successful human pregnancy involves precise immune adaptations to support fetal growth while protecting the mother and fetus from microbial challenges. The first trimester is characterized by increased innate immune activity for successful implantation and placental development. As pregnancy progresses, an immunosuppressive environment develops to promote fetal tolerance and prevent complications. Prior to labor, an inflammatory environment is reinstated triggering childbirth. Monocytes in maternal circulation and tissue-resident macrophages play critical roles in maintaining this balance.

IMMUNOLOGICAL REVIEWS (2022)

Article Immunology

The dynamics of Th17 / Treg ratio in SLE patients during pregnancy

Antonio Braga et al.

Summary: In SLE patients, the count of peripheral Treg cells does not decrease during pregnancy, while the count of Th17 cells remains stable. In contrast, in healthy pregnant women, the Treg/Th17 ratio decreases. These changes may be due to the pro-inflammatory state present throughout pregnancy in SLE patients.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2022)

Article Medicine, General & Internal

Predictors Associated with Adverse Pregnancy Outcomes in a Cohort of Women with Systematic Lupus Erythematosus from Romania-An Observational Study (Stage 2)

Petronela Vicoveanu et al.

Summary: This study provides a comprehensive analysis of the most important predictors for adverse pregnancy outcomes in pregnant patients with SLE, which could serve as a basis for further research.

JOURNAL OF CLINICAL MEDICINE (2022)

Article Cell Biology

G-Protein Coupled Receptor Dysregulation May Play Roles in Severe Preeclampsia-A Weighted Gene Correlation Network Analysis of Placental Gene Expression Profile

Manuel S. Vidal Jr et al.

Summary: This study used weighted gene correlated network analysis (WGCNA) to investigate dysregulated gene networks in placental tissues from severe preeclamptic pregnancies. The study identified a gene module enriched for G-protein-coupled receptor (GPCR)-related genes, which may play key roles in preeclampsia. Some of these genes are involved in angiogenesis and vasodilation or vasoconstriction.
Article Biochemistry & Molecular Biology

Identification of LOC101927355 as a Novel Biomarker for Preeclampsia

Reyna Penailillo et al.

Summary: This study aimed to identify potential lncRNA biomarkers for preeclampsia by analyzing the expression of lncRNAs in the placentas and plasma of patients. Six lncRNAs were validated and differentially expressed in preeclampsia placentas, two of which were also detected in maternal plasma, indicating their potential use as biomarkers for the disease.

BIOMEDICINES (2022)

Article Immunology

How do pre-pregnancy endometrial macrophages contribute to pregnancy?

Huan Ma et al.

Summary: This review focuses on the phenotypes of endometrial macrophages, their interactions with other endometrial cells, their effects on subsequent pregnancies, and the pregnancy complications and disorders associated with endometrial macrophages.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2022)

Review Medicine, General & Internal

B cells in systemic lupus erythematosus: Targets of new therapies and surveillance tools

Ioannis Parodis et al.

Summary: The hyperactivity of B cells in SLE has led to the development of various B cell altering agents for treatment, with belimumab being the first biological agent to be licensed for SLE. B cell depletion, especially with rituximab, has shown promise in refractory cases, while experimental therapies targeting terminally differentiated B cells are also being explored. B and plasma cells have potential as surveillance markers for monitoring SLE patients undergoing B cell altering therapies, aiding in personalized precision treatment strategies.

FRONTIERS IN MEDICINE (2022)

Article Endocrinology & Metabolism

Thyroid autoimmunity and adverse pregnancy outcomes: a prospective cohort study

Fausta Beneventi et al.

ENDOCRINE (2022)

Article Biochemistry & Molecular Biology

Downregulated ribosomal protein L39 inhibits trophoblast cell migration and invasion by targeting E-cadherin in the placenta of patients with preeclampsia

Qiuling Jie et al.

Summary: The study found that RPL39 is significantly downregulated in early-onset PE placental tissues, and its knockdown can inhibit proliferation, migration, and invasion of trophoblast cells by targeting E-cadherin to affect cell functions.

FASEB JOURNAL (2021)

Article Immunology

The role of decidual regulatory T cells in the induction and maintenance of fetal antigen-specific tolerance: Imbalance between regulatory and cytotoxic T cells in pregnancy complications

Sayaka Tsuda et al.

Summary: Fetal antigen-specific tolerance is crucial for maintaining allogeneic pregnancies, with a key role played by Treg cells. Insufficient or dysfunctional Treg cells may contribute to the pathogenesis of complications such as miscarriage and preeclampsia in pregnancy.

HUMAN IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation

Zhongde Ye et al.

Summary: In this study, it was shown that CD4(+) T cells from patients with RA and PsA have increased expression of the pore-forming calcium channel component ORAI3 due to reduced IKAROS expression, leading to increased ARC channel activity and sensitivity to arachidonic acid. This heightened activity may contribute to chronic inflammation in these conditions, indicating a potential mechanism for the pathogenesis of RA and PsA.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Complement and coagulation cascades activation is the main pathophysiological pathway in early-onset severe preeclampsia revealed by maternal proteomics

Lina Youssef et al.

Summary: Proteomics analysis revealed significant differences at the protein level between early-onset severe preeclampsia and uncomplicated pregnancies, with activation of complement and coagulation cascades identified as important pathways. The study suggests potential therapeutic targets within the complement and coagulation pathway for early-onset severe preeclampsia.

SCIENTIFIC REPORTS (2021)

Article Oncology

Weighted-Support Vector Machine Learning Classifier of Circulating Cytokine Biomarkers to Predict Radiation-Induced Lung Fibrosis in Non-Small-Cell Lung Cancer Patients

Hao Yu et al.

Summary: Background radiation-induced lung fibrosis (RILF) is a late toxicity in patients with non-small-cell lung cancer (NSCLC) after radiotherapy (RT) which can impact quality of life and cause non-cancer related death. This study used machine learning algorithms to predict RILF risk based on pre-treatment plasma cytokine levels and dosimetric/clinical characteristics, validating the accuracy of a weighted-SVM classifier with CCL4 as a key feature. Further research with larger sample sizes is needed to confirm the role of CCL4 and the SVM classifier in RILF risk prediction.

FRONTIERS IN ONCOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Identification of Potential Biomarkers and Immune Infiltration Characteristics in Idiopathic Pulmonary Arterial Hypertension Using Bioinformatics Analysis

Haowei Zeng et al.

Summary: HBB, RNASE2, S100A9, and IL1R2 were identified as potential biomarkers to discriminate IPAH from the control group. There was a significant difference in immune infiltration between patients with IPAH and the normal group, with higher levels of certain immune cells observed in IPAH patients.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Article Genetics & Heredity

The Emergence and Global Spread of Noninvasive Prenatal Testing

Vardit Ravitsky et al.

Annual Review of Genomics and Human Genetics (2021)

Review Immunology

Macrophage Polarization and Plasticity in Systemic Lupus Erythematosus

Mariame Mohamed Ahamada et al.

Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease that primarily affects adults, especially females and non-Caucasian individuals. Despite numerous studies on SLE, the exact pathogenesis remains unclear and there is no specific drug for effective treatment. The involvement of macrophages in the development of SLE is increasingly recognized, suggesting a potential for macrophage-centered therapeutic approaches.

FRONTIERS IN IMMUNOLOGY (2021)

Article Endocrinology & Metabolism

Quantifying the Impacts of Pre- and Post-Conception TSH Levels on Birth Outcomes: An Examination of Different Machine Learning Models

Yuantong Sun et al.

Summary: This study utilized machine learning models to analyze predictive features such as pre- and post-conception serum TSH levels in pregnant women. The XGBoost model showed superior performance in predicting characteristics and polytomous variables, while abnormal preconception TSH or not-well-controlled TSH had strong predictive ability for birth outcomes.

FRONTIERS IN ENDOCRINOLOGY (2021)

Article Immunology

The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases

Wen Q. Qiu et al.

Summary: The Sez6 family members are novel complement regulators that inhibit C3 convertases with varying degrees of efficacy in the classical and alternative pathways, promoting C3b degradation. Sez6L2, as a representative member, accelerates the dissociation of C3 convertases and functions as a cofactor for Factor I to facilitate C3b cleavage, with no cofactor activity toward C4b.

FRONTIERS IN IMMUNOLOGY (2021)

Review Biotechnology & Applied Microbiology

Using machine learning approaches for multi-omics data analysis: A review

Parminder S. Reel et al.

Summary: With the advancement of high-throughput omics technologies, it is crucial for biomedical research to adopt integrative approaches to analyze diverse omics data using machine learning algorithms. This can lead to the discovery of novel biomarkers and improve disease prediction and precision medicine delivery.-Methods in machine learning have enabled researchers to gain a deeper insight into biological systems and provide recommendations for interdisciplinary professionals looking to incorporate machine learning skills in multi-omics studies.

BIOTECHNOLOGY ADVANCES (2021)

Article Multidisciplinary Sciences

Permutation-based identification of important biomarkers for complex diseases via machine learning models

Xinlei Mi et al.

Summary: The study outlines the challenges of human disease research, proposes a computationally efficient Permutation-based Feature Importance Test to assist in interpreting and selecting individual features in complex machine learning models for complex disease analysis, and demonstrates its practical usage in identifying important biomarkers and boosting model prediction performance.

NATURE COMMUNICATIONS (2021)

Article Genetics & Heredity

Identification of Potential Biomarkers for Psoriasis by DNA Methylation and Gene Expression Datasets

Yong Liu et al.

Summary: This study aimed to identify biomarkers of psoriasis by analyzing gene expression and methylation datasets of psoriatic skin tissues. Through multiple computational approaches, it was found that the majority of hypermethylated and downregulated genes were enriched in pathways related to glucose homeostasis and lipid storage. Possible targets like IRS1, ARHGEF10, and RAI14 were identified for future studies of psoriasis.

FRONTIERS IN GENETICS (2021)

Article Medicine, General & Internal

Maternal Systemic Lupus Erythematosus (SLE) High Risk for Preterm Delivery and Not for Long-Term Neurological Morbidity of the Offspring

Dora Davidov et al.

Summary: The study found that although SLE is associated with preterm delivery, maternal SLE is not significantly associated with long-term neurological disease in offspring. This suggests that children born to mothers with SLE do not have a higher risk of long-term neurological disease compared to children born to mothers without SLE.

JOURNAL OF CLINICAL MEDICINE (2021)

Review Biochemistry & Molecular Biology

Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy

Jian Kang et al.

Summary: This article discusses the importance of ribosome biogenesis and protein synthesis in cell growth and proliferation, as well as the extra-ribosomal functions of ribosomal proteins in stress response. It also explores the connections between ribosomopathies and cancer, recent advances in research, and potential therapies. Insights into resistance mechanisms to ribosome biogenesis-targeting therapies provide new perspectives on cancer susceptibility in ribosomopathies and potential implications for cancer treatment.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Review Pediatrics

Immunological pathogenesis and treatment of systemic lupus erythematosus

Lu Pan et al.

WORLD JOURNAL OF PEDIATRICS (2020)

Article Biochemistry & Molecular Biology

ALDH1A3-regulated long non-coding RNA NRAD1 is a potential novel target for triple-negative breast tumors and cancer stem cells

Dejan Vidovic et al.

CELL DEATH AND DIFFERENTIATION (2020)

Article Biochemistry & Molecular Biology

Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3

Martina Pigoni et al.

EMBO JOURNAL (2020)

Article Multidisciplinary Sciences

Early-pregnancy transcriptome signatures of preeclampsia: from peripheral blood to placenta

Aishwarya P. Yadama et al.

SCIENTIFIC REPORTS (2020)

Article Immunology

CD206+M2-Like Macrophages Are Essential for Successful Implantation

Yosuke Ono et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Biochemistry & Molecular Biology

CD4 T Helper Cell Subsets and Related Human Immunological Disorders

Xiaoliang Zhu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Cardiac & Cardiovascular Systems

A brain natriuretic peptide-based prediction model for atrial fibrillation after thoracic surgery: Development and internal validation

David Amar et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2019)

Article Biochemistry & Molecular Biology

Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy

Avinash Das Sahu et al.

MOLECULAR SYSTEMS BIOLOGY (2019)

Article Immunology

Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy

Seunghee Hong et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Article Immunology

Placental expression of lysophosphatidic acid receptors in normal pregnancy and preeclampsia

Tatsuya Fujii et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2019)

Review Biochemistry & Molecular Biology

Arachidonic Acid Metabolism and Kidney Inflammation

Tianqi Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Rheumatology

TLR4+CXCR4+ plasma cells drive nephritis development in systemic lupus erythematosus

Kongyang Ma et al.

ANNALS OF THE RHEUMATIC DISEASES (2018)

Article Rheumatology

Real-world incidence and prevalence of systemic lupus erythematosus in Alberta, Canada

Francis Fatoye et al.

RHEUMATOLOGY INTERNATIONAL (2018)

Article Biochemical Research Methods

SVM-RFE: selection and visualization of the most relevant features through non-linear kernels

Hector Sanz et al.

BMC BIOINFORMATICS (2018)

Article Cell Biology

The cohesin complex prevents Myc-induced replication stress

Sara Rohban et al.

CELL DEATH & DISEASE (2017)

Article Biochemical Research Methods

Robust enumeration of cell subsets from tissue expression profiles

Aaron M. Newman et al.

NATURE METHODS (2015)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Review Immunology

Monocytes and macrophages in pregnancy and pre-eclampsia

Marijke M. Faas et al.

FRONTIERS IN IMMUNOLOGY (2014)

Article Nutrition & Dietetics

5-Methyltetrahydrofolate and thiamine diphosphate in cord-blood erythrocytes of preterm versus term newborns

D. Weber et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2013)

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

Article Biochemical Research Methods

WGCNA: an R package for weighted correlation network analysis

Peter Langfelder et al.

BMC BIOINFORMATICS (2008)

Review Medicine, General & Internal

Mechanisms of disease: Systemic lupus erythematosus

Anisur Rahman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Biochemical Research Methods

Gene selection and classification of microarray data using random forest -: art. no. 3

R Díaz-Uriarte et al.

BMC BIOINFORMATICS (2006)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)