Maternal serum NGAL in the first trimester of pregnancy is a potential biomarker for the prediction of gestational diabetes mellitus

Article Multidisciplinary Sciences

Neutrophil gelatinase-associated lipocalin as a prognostic biomarker of severe acute respiratory distress syndrome

Eunjeong Son et al.

Summary: NGAL levels are elevated in ARDS patients and are associated with survival rates and ICU mortality. Serum and BAL levels of NGAL have good predictive value for ICU mortality in ARDS patients.

SCIENTIFIC REPORTS (2022)

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Article Multidisciplinary Sciences

Urinary neutrophil gelatinase-associated lipocalin (NGAL) can potentially predict vascular complications and reliably risk stratify patients with peripheral arterial disease

Mehroz Ehsan et al.

Summary: This study found that urine NGAL levels are associated with the worsening status of peripheral arterial disease (PAD) and major adverse limb events (MALE), indicating the potential of urine NGAL for risk-stratification of PAD patients.

SCIENTIFIC REPORTS (2022)

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Article Medicine, General & Internal

Predictive Value of Elevated Neutrophil Gelatinase-Associated Lipocalin (NGAL) Levels for Assessment of Cardio-Renal Interactions among ST-Segment Elevation Myocardial Infarction Patients

David Zahler et al.

Summary: Elevated NGAL levels have prognostic utility for renal and clinical outcomes among STEMI patients undergoing primary PCI, independent of traditional inflammatory markers. High NGAL is associated with increased short-term adverse outcomes, such as acute kidney injury, lower left ventricular ejection fraction, higher 30-day mortality, and higher incidence of MACE.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Immunology

Lipocalin-2 does not influence EAE clinical score but it increases inflammation in central nervous system

Sofia P. das Neves et al.

Summary: The contribution of lipocalin-2 (LCN2) to multiple sclerosis (MS) remains controversial. In this study, we induced experimental autoimmune encephalomyelitis (EAE) in LCN2-null and wild-type mice, and found that LCN2-null EAE mice had decreased expression of interferon gamma and less demyelination in the cerebellum. Both genotypes showed similar alterations in thymocyte and splenocyte populations. In MS patients, higher levels of LCN2 in cerebrospinal fluid (CSF) at diagnosis may be associated with faster disease progression, but further studies are needed to confirm this, as the association disappeared after controlling for other factors.

JOURNAL OF NEUROIMMUNOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Relationship between Neutrophil Gelatinase-Associated Lipocalin, Eosinophil Cationic Protein, Cytokines, and Atopic Sensitization in Patients with Allergic Diseases

Jong Weon Choi et al.

Summary: The effect of neutrophil gelatinase-associated lipocalin (NGAL) on eosinophil activation, atopic sensitization, and systemic inflammation in allergic diseases has rarely been investigated. This study found that NGAL may be more closely linked to allergic inflammation and possible fibrotic changes in the airways rather than the severity of eosinophil activation and atopic sensitization.

BIOMED RESEARCH INTERNATIONAL (2022)

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Article Endocrinology & Metabolism

Lower ATG7 Levels are Associated with a Higher Risk of Gestational Diabetes Mellitus: A Cross-Sectional Study

Ling Lu et al.

Summary: This study found that ATG7 levels are significantly lower in pregnant women with gestational diabetes mellitus (GDM) compared to those without GDM, and lower ATG7 levels are associated with a higher risk of GDM. ATG7 levels are also negatively associated with insulin resistance. Autophagy deficiency, caused by lower ATG7 levels, may play a role in mediating insulin resistance in the development of GDM.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2022)

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Review Medical Laboratory Technology

Sample size, power and effect size revisited: simplified and practical approaches in pre-clinical, clinical and laboratory studies

Ceyhan Ceran Serdar et al.

Summary: Calculating sample size in scientific studies is crucial for scientific contribution, impacting hypothesis and study design. Incorrect sample size may lead to inadequate results, time and cost losses, and ethical issues. This review aims to highlight the importance of sample size and provide researchers with tools to estimate it accurately.

BIOCHEMIA MEDICA (2021)

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Article Medicine, Research & Experimental

Lipocalin-2: Structure, function, distribution and role in metabolic disorders

Saeeda Al Jaberi et al.

Summary: Lipocalin-2 (LCN-2) is a circulating protein responsible for transporting small molecules to target organs, and has been used as a biomarker for renal injury. It has antibacterial, anti-inflammatory, and cell protection functions, and is associated with metabolic disorders such as obesity and type 2 diabetes. The precise role of LCN-2 in metabolic pathways is still unclear.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Endocrinology & Metabolism

2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2021

Summary: The American Diabetes Association's Standards of Medical Care in Diabetes provides clinical practice recommendations, treatment goals, guidelines, and tools for evaluating care quality. It is updated annually by a multidisciplinary expert committee, and readers are invited to comment on the standards at professional.diabetes.org/SOC.

DIABETES CARE (2021)

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Article Endocrinology & Metabolism

Putrescine as a Novel Biomarker of Maternal Serum in First Trimester for the Prediction of Gestational Diabetes Mellitus: A Nested Case-Control Study

Cheng Liu et al.

Summary: This study found that women with GDM had elevated levels of serum putrescine in the first trimester. Circulating putrescine may serve as a valuable predictive biomarker for GDM.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Endocrinology & Metabolism

The Clinical Values of Afamin, Triglyceride and PLR in Predicting Risk of Gestational Diabetes During Early Pregnancy

Xuechun Wang et al.

Summary: Maternal age, early pregnancy afamin level, triglycerides, and platelet/lymphocyte ratio were identified as independent risk factors for gestational diabetes. A model was established with good discrimination ability, and combining these factors can help in prediction and early diagnosis of GDM.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Endocrinology & Metabolism

A Novel Nomogram for Predicting Gestational Diabetes Mellitus During Early Pregnancy

Mei Kang et al.

Summary: This study established a novel predictive nomogram for GDM, showing significant differences in blood indexes between GDM and normal pregnant women. The nomogram had an AUC value of 0.772 and demonstrated good performance in calibration curves and decision curve analysis.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Endocrinology & Metabolism

CircRNA circVEGFC is Highly Expressed in Gestational Diabetes Mellitus (GDM) and It is Correlated with Multiple Adverse Events

Wenjing She et al.

Summary: This study found that circVEGFC is highly expressed in GDM and is correlated with multiple adverse events.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2021)

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Article Immunology

Regulatory role of Apelin-13-mediated PI3K/AKT signaling pathway in the glucose and lipid metabolism of mouse with gestational diabetes mellitus

Xiao-Dan Zheng et al.

Summary: Compared to the Control group, mice in the GDM group showed continuous increase in FBG levels and significant decrease in FINS levels. Apelin-13 treatment in GDM mice significantly improved glucose and lipid metabolism, reduced oxidative stress and inflammatory reaction, and protected pancreatic islets. The improvement was reversed by LY294002 treatment.

IMMUNOBIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Lipid Metabolism Is Dysregulated before, during and after Pregnancy in a Mouse Model of Gestational Diabetes

Samuel Furse et al.

Summary: The study tested the hypothesis that maternal lipid metabolism is modulated during normal pregnancy and altered in gestational diabetes mellitus (GDM) using a mouse model of diet-induced obesity and a novel lipid analysis tool. The results showed differences in lipid metabolism between healthy pregnancies and those with GDM, suggesting that lipid metabolism plays a role in glucose tolerance and the development of GDM.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Endocrinology & Metabolism

Increased lipocalin 2 levels in adolescents with type 2 diabetes mellitus

Junji Takaya et al.

Summary: This study aimed to explore the association between bone and glucose metabolism in adolescents with obesity and type 2 diabetes mellitus. The results showed higher LCN2 levels in patients with DM2 but not in those with obesity. Serum LCN2 was positively correlated with the Model Assessment of Insulin Resistance score and body mass index, and negatively correlated with adiponectin. Further investigations are warranted to determine whether LCN2 may act as a sensitive indicator of early-stage insulin resistance.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2021)

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Article Endocrinology & Metabolism