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Regulation of bone health through physical exercise: Mechanisms and types

期刊

FRONTIERS IN ENDOCRINOLOGY
卷 13, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2022.1029475

关键词

osteoporosis; bone mass; exercise; cytokines; irisin; Piezo1; PCs

资金

  1. Science Fund of the National Natural Science Foundation of China
  2. [31870910]
  3. [82071789]

向作者/读者索取更多资源

This article summarizes the mechanisms of exercise on osteoporosis and provides new proposals for the prevention and treatment of osteoporosis.
Osteoporosis, characterized by bone mineral density reduction, bone mass loss, increased bone fragility, and propensity to fractures, is a common disease in older individuals and one of the most serious health problems worldwide. The imbalance between osteoblasts and osteoclasts results in the predominance of bone resorption and decreased bone formation. In recent years, it has been found that regular and proper exercise not only helps prevent the occurrence of osteoporosis but also adds benefits to osteoporosis therapy; accordingly, bone homeostasis is closely associated with mechanical stress and the intricate crosstalk between osteoblasts and osteoclasts. In this review, we summarize the mechanisms of exercise on osteoporosis and provide new proposals for the prevention and treatment of osteoporosis.

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