期刊
FRONTIERS IN ENDOCRINOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2022.1095711
关键词
Wnt16; bone homeostasis; osteoblast; osteoclast; osteoarthritis; chondrocytes
资金
- National Natural Science Foundation of China (NSFC)
- Pearl River S&T Nova Program of Guangzhou
- [81600888]
- [201806010012]
Wnt16, a member of the Wnt family, plays an important role in bone density, bone strength, and osteoarthritis. Recent studies have shown that Wnt16 acts as a positive regulator of bone mass and a protective regulator of osteoarthritis progression, and the mechanisms of its signaling have been illustrated.
Wnts are secreted cysteine-rich glycoproteins involved in joint development and skeletal homeostasis and have been implicated in the occurrence of osteoarthritis. Over the past decade, Wnt16, a member of the Wnt family, has received widespread attention for its strong association with bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. In recent years, further studies have shed light on the role of Wnt16 a positive regulator of bone mass and protective regulator of osteoarthritis progression. Transduction mechanisms and crosstalk involving Wnt16 signaling have also been illustrated. More importantly, local Wnt16 treatment has been shown to ease osteoarthritis, inhibit bone resorption, and promote new bone formation in bone defect models. Thus, Wnt16 is now a potential therapeutic target for skeletal diseases and osteoarthritis. This paper reviews our current understanding of the mechanisms by which Wnt16 signaling regulates bone homeostasis and osteoarthritis.
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