Asprosin in health and disease, a new glucose sensor with central and peripheral metabolic effects

Adipose tissue malfunction leads to altered adipokine secretion which might consequently contribute to an array of metabolic diseases spectrum including obesity, diabetes mellitus, and cardiovascular disorders. Asprosin is a novel diabetogenic adipokine classified as a caudamin hormone protein. This adipokine is released from white adipose tissue during fasting and elicits glucogenic and orexigenic effects. Although white adipose tissue is the dominant source for this multitask adipokine, other tissues also may produce asprosin such as salivary glands, pancreatic B-cells, and cartilage. Significantly, plasma asprosin levels link to glucose metabolism, lipid profile, insulin resistance (IR), and beta-cell function. Indeed, asprosin exhibits a potent role in the metabolic process, induces hepatic glucose production, and influences appetite behavior. Clinical and preclinical research showed dysregulated levels of circulating asprosin in several metabolic diseases including obesity, type 2 diabetes mellitus (T2DM), polycystic ovarian syndrome (PCOS), non-alcoholic fatty liver (NAFLD), and several types of cancer. This review provides a comprehensive overview of the asprosin role in the etiology and pathophysiological manifestations of these conditions. Asprosin could be a promising candidate for both novel pharmacological treatment strategies and diagnostic tools, although developing a better understanding of its function and signaling pathways is still needed.

Automated summary

Adipose tissue malfunction results in altered adipokine secretion, particularly asprosin, which contributes to various metabolic diseases including obesity, diabetes mellitus, and cardiovascular disorders. Asprosin, a novel adipokine, is released from white adipose tissue during fasting and has gluconeogenic and orexigenic effects. Dysregulated levels of asprosin are found in obesity, type 2 diabetes, polycystic ovarian syndrome, non-alcoholic fatty liver, and certain types of cancer. Understanding the role and signaling pathways of asprosin could lead to potential therapeutic targets and diagnostic tools.