☆ 4.6 Article

Molecular and Clinical Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Isolates at a Tertiary Hospital in Wuhan, China

INFECTION AND DRUG RESISTANCE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Immunology

Prediction of Prognosis in Adult Patients With Carbapenem-Resistant Klebsiella pneumoniae Infection

Jihui Chen et al.

Summary: This study analyzed the clinical information of adult patients with carbapenem-resistant Klebsiella pneumoniae (CRKP) infection, established a nomogram for predicting mortality risk, and determined the effectiveness of different antimicrobial regimens. The results can help clinicians identify high-risk adult patients with CRKP infection, improve treatment outcomes, and reduce mortality.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

添加到收藏夹

Article Immunology

Carbapenemase Production and Epidemiological Characteristics of Carbapenem-Resistant Klebsiella pneumoniae in Western Chongqing, China

Wan Huang et al.

Summary: This study aimed to determine the molecular characteristics of carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates in a hospital in western Chongqing, southwestern China. The findings provide new insights into the genomic features, resistance patterns, and virulence factors of CRKP, which can contribute to the clinical empirical use of antibiotics.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

添加到收藏夹

Article Microbiology

Transporter Genes and fosA Associated With Fosfomycin Resistance in Carbapenem-Resistant Klebsiella pneumoniae

Yu-Ping Wang et al.

Summary: This study investigated the fosfomycin resistance mechanism of carbapenem-resistant Klebsiella pneumoniae (CRKP). The study found that the genes fosA(KP) I91V and transporter deficiencies were two common mechanisms leading to resistance. The study highlights the need for new therapeutic agents for CRKP infections in Taiwan.

FRONTIERS IN MICROBIOLOGY (2022)

添加到收藏夹

Article Microbiology

Within-Host Genotypic and Phenotypic Diversity of Contemporaneous Carbapenem-Resistant Klebsiella pneumoniae from Blood Cultures of Patients with Bacteremia

Shaoji Cheng et al.

Summary: This study is the first genome-wide analysis of within-host diversity of Klebsiella pneumoniae strains recovered from individual patients with bloodstream infections (BSIs). Our finding challenges the single-organism hypothesis and suggests that at least some BSIs are caused by mixed bacterial populations that are unrecognized by the clinical laboratory. The data support a model of pathogenesis in which pressures in vivo select for strain variants with particular antibiotic resistance or virulence attributes and raise questions about laboratory protocols and treatment decisions directed against single strains.

MBIO (2022)

添加到收藏夹

Article Microbiology

Molecular epidemiology and mechanism of Klebsiella pneumoniae resistance to ertapenem but not to other carbapenems in China

Dongliang Wang et al.

Summary: This study investigated the molecular epidemiology and resistance mechanism of K. pneumoniae strains that are susceptible to meropenem and imipenem but resistant only to ertapenem. It was found that ramR mutation may be related to ertapenem resistance, and mutations in ramR cause efflux pump inhibition and over-expression of outer membrane protein OmpK35 in some strains.

FRONTIERS IN MICROBIOLOGY (2022)

添加到收藏夹

Article Infectious Diseases

Molecular Epidemiology, Clinical Characteristics and Risk Factors for Bloodstream Infection of Multidrug-Resistant Klebsiella pneumoniae Infections in Pediatric Patients from Tianjin, China

Mengzhu Hou et al.

Summary: This study investigated the molecular epidemiology and drug resistance mechanism of pediatric Multidrug-Resistant Klebsiella pneumoniae infections. The results showed that ST11 was the prevalent clone, and ST11 CRKP strains carrying blaNDM-5 and blaKPC-2 genes were resistant to most tested antibiotics. CRKP infections mainly occurred in young immunocompromised patients, with chemotherapy for hematological malignancies being an independent risk factor for bloodstream infections.

INFECTION AND DRUG RESISTANCE (2022)

添加到收藏夹

Review Infectious Diseases

A global perspective on the convergence of hypervirulence and carbapenem resistance in Klebsiella pneumoniae

Peng Lan et al.

Summary: Hypervirulence and carbapenem resistance have emerged as two distinct evolutionary directions for Klebsiella pneumoniae, posing a great threat in clinical settings. CR-hvKP strains, integrating both phenotypes, have become increasingly prevalent globally, primarily in Asia. The mechanisms for the emergence of CR-hvKP can be summarised by three patterns, and continued surveillance of their dissemination should be highly prioritised.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2021)

添加到收藏夹

Article Infectious Diseases

Clinical Characteristics and Risk Factors for Critically Ill Patients with Carbapenem-Resistant Klebsiella pneumoniae (CrKP): A Cohort Study from Developing Country

Ying-Yi Luan et al.

Summary: The study identified lactic acid, APACHE II score, and tigecycline combined with fosfomycin as independent risk factors for 28-day mortality in patients with CrKP infection. Combining lactic acid with APACHE II score could predict mortality. Treatment strategies focusing on improving these factors may contribute to better outcomes in patients with CrKP infection.

INFECTION AND DRUG RESISTANCE (2021)

添加到收藏夹

Article Infectious Diseases

Resistance Phenotype and Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae Isolates in Shanghai

Wen-Xia Zhang et al.

Summary: This study collected 133 CRKP isolates from patients in Shanghai, China, and found that these isolates exhibited high resistance to cephalosporins and carbapenems. The majority of strains were isolated from ICUs, with the prevalent subtype being ST11, clustered into seven different clonal groups.

MICROBIAL DRUG RESISTANCE (2021)

添加到收藏夹

Article Infectious Diseases

Carbapenem-Resistant Klebsiella pneumoniae in Southwest China: Molecular Characteristics and Risk Factors Caused by KPC and NDM Producers

Zhaoyinqian Li et al.

Summary: This study evaluated the molecular characteristics and risk factors of CRKP infection, revealing different genetic environments of KPC-2 and NDM-1 genes on various plasmids, as well as common risk factors like hematological disease and tracheal cannula usage. The detection of novel strains and the need for preventive measures against further dissemination of CRKP isolates were emphasized.

INFECTION AND DRUG RESISTANCE (2021)

添加到收藏夹

Article Infectious Diseases

Transmission and evolution of OXA-48-producing Klebsiella pneumoniae ST11 in a single hospital in Taiwan

Min-Chi Lu et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Treatment Outcome of Bacteremia Due to Non-Carbapenemase-producing Carbapenem-Resistant Klebsiella pneumoniae Bacteremia: Role of Carbapenem Combination Therapy

Nan-Yao Lee et al.

CLINICAL THERAPEUTICS (2020)

添加到收藏夹

Article Infectious Diseases

Molecular epidemiology of Carbapenem-resistant Klebsiella pneumoniae in a paediatric hospital in China

Bingjie Wang et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

添加到收藏夹

Article Public, Environmental & Occupational Health

Risk factors for carbapenem-resistant Klebsiella pneumoniae infection relative to two types of control patients: a systematic review and meta-analysis

Wei-min Zhu et al.

ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL (2020)

添加到收藏夹

Article Infectious Diseases

Outbreak of KPC-2-Producing Klebsiella pneumoniae ST76 Isolates in an Intensive Care Unit and Neurosurgery Unit

Shanshan Su et al.

MICROBIAL DRUG RESISTANCE (2020)

添加到收藏夹

Review Infectious Diseases

Virulence evolution, molecular mechanisms of resistance and prevalence of ST11 carbapenem-resistant Klebsiella pneumoniae in China: A review over the last 10 years

Wenjian Liao et al.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2020)

添加到收藏夹

Article Genetics & Heredity

Epigenomics, genomics, resistome, mobilome, virulome and evolutionary phylogenomics of carbapenem-resistant Klebsiella pneumoniae clinical strains

Katlego Kopotsa et al.

MICROBIAL GENOMICS (2020)

添加到收藏夹

Article Immunology

Prevalence, risk factors and molecular epidemiology of carbapenem-resistantKlebsiella pneumoniaein patients from Zhejiang, China, 2008-2018

Yanyan Hu et al.

EMERGING MICROBES & INFECTIONS (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Carbapenem-Resistant Klebsiella pneumoniae Infections among ICU Admission Patients in Central China: Prevalence and Prediction Model

Yi Li et al.

BIOMED RESEARCH INTERNATIONAL (2019)

添加到收藏夹

Article Infectious Diseases

A Study of the Virulence Traits of Carbapenem-Resistant Klebsiella pneumoniae Isolates in a Galleria mellonella Model

Mahmoud A. F. Khalil et al.

MICROBIAL DRUG RESISTANCE (2019)

添加到收藏夹

Review Infectious Diseases

Epidemiology of carbapenem-resistant Gram-negative infections globally

Adrian J. Brink

CURRENT OPINION IN INFECTIOUS DISEASES (2019)

添加到收藏夹

Article Infectious Diseases

Genomic Analysis Of A KPC-2-Producing Klebsiella Pneumoniae ST11 Outbreak From A Teaching Hospital In Shandong Province, China

Xiaohui Chi et al.

INFECTION AND DRUG RESISTANCE (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Molecular characterization of carbapenem-resistant Klebsiella pneumoniae isolates with focus on antimicrobial resistance

Xiaoling Yu et al.

BMC GENOMICS (2019)

添加到收藏夹

Article Public, Environmental & Occupational Health

Clinical, microbiological, and molecular epidemiological characteristics of Klebsiella pneumoniae-induced pyogenic liver abscess in southeastern China

Siqin Zhang et al.

ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL (2019)

添加到收藏夹

Article Immunology

The Colonization of Carbapenem-Resistant Klebsiella pneumoniae: Epidemiology, Resistance Mechanisms, and Risk Factors in Patients Admitted to Intensive Care Units in China

Xiaohua Qin et al.

JOURNAL OF INFECTIOUS DISEASES (2019)

添加到收藏夹

Article Microbiology

Identification of Biomarkers for Differentiation of Hypervirulent Klebsiella pneumoniae from Classical K-pneumoniae

Thomas A. Russo et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Carbapenem Nonsusceptible Klebsiella pneumoniae in Taiwan: Dissemination and Increasing Resistance of Carbapenemase Producers During 2012-2015

Sheng-Kang Chiu et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Immunology

Phenotypic and Genotypic Characterization of Carbapenem-resistant Enterobacteriaceae: Data From a Longitudinal Large-scale CRE Study in China (2012-2016)

Qi Wang et al.

CLINICAL INFECTIOUS DISEASES (2018)

添加到收藏夹

Editorial Material Critical Care Medicine

Treatment and mortality of Klebslella pneumoniae infections in critically ill patients: should we do and predict them better?

Matteo Bassetti et al.

INTENSIVE CARE MEDICINE (2018)

添加到收藏夹

Article Genetics & Heredity

Genetic diversity, mobilisation and spread of the yersiniabactin-encoding mobile element ICEKp in Klebsiella pneumoniae populations

Margaret M. C. Lam et al.

MICROBIAL GENOMICS (2018)

添加到收藏夹

Review Microbiology

Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance

Shiri Navon-Venezia et al.

FEMS MICROBIOLOGY REVIEWS (2017)

添加到收藏夹

Article Infectious Diseases

Hypervirulent Klebsiella pneumoniae induced ventilator-associated pneumonia in mechanically ventilated patients in China

Q. Yan et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2016)

添加到收藏夹

Article Microbiology

Outbreak of plasmid-mediated NDM-1-producing Klebsiella pneumoniae ST105 among neonatal patients in Yunnan, China

Rui Zheng et al.

ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding

Liang Chen et al.

TRENDS IN MICROBIOLOGY (2014)

添加到收藏夹

Article Immunology

Carbapenem-Resistant Enterobacteriaceae: Epidemiology and Prevention

Neil Gupta et al.

CLINICAL INFECTIOUS DISEASES (2011)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.