期刊
FRONTIERS IN GENETICS
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2022.1037190
关键词
growth factor; osteonecrosis of the femoral head; gene polymorphism; tissue engineering; genetic engineering
资金
- Department of Science and Technology of Jilin Province
- Health Science and Technology Capacity Improvement Project of Jilin Province
- [20200201327JC]
- [2021JC019]
Osteonecrosis of the femoral head is a orthopedic condition that often requires total hip arthroplasty. Dysregulated growth factor-related genes may play a role in its development. Tissue and genetic engineering may be potential treatment strategies.
Osteonecrosis of the femoral head (ONFH) is a potentially disabling orthopedic condition that requires total hip arthroplasty in most late-stage cases. However, mechanisms underlying the development of ONFH remain unknown, and the therapeutic strategies remain limited. Growth factors play a crucial role in different physiological processes, including cell proliferation, invasion, metabolism, apoptosis, and stem cell differentiation. Recent studies have reported that polymorphisms of growth factor-related genes are involved in the pathogenesis of ONFH. Tissue and genetic engineering are attractive strategies for treating early-stage ONFH. In this review, we summarized dysregulated growth factor-related genes and their role in the occurrence and development of ONFH. In addition, we discussed their potential clinical applications in tissue and genetic engineering for the treatment of ONFH.
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