4.5 Review

Cofilin Acts as a Booster for Progression of Malignant Tumors Represented by Glioma

期刊

CANCER MANAGEMENT AND RESEARCH
卷 14, 期 -, 页码 3245-3269

出版社

DOVE MEDICAL PRESS LTD
DOI: 10.2147/CMAR.S389825

关键词

cofilin; glioma; malignant tumor; migration; invasion; apoptosis

类别

资金

  1. National Natural Science Foundation of China
  2. Heilongjiang Provincial Health Commission
  3. [81974452]
  4. [2019-393]

向作者/读者索取更多资源

Cofilin plays a crucial role in actin structural reorganization and dynamic regulation. It has the potential to serve as a biomarker for predicting tumor metastasis and prognosis in malignant tumors. Targeting cofilin regulating kinases and the cofilin-mediated mitochondrial pathway could be effective options for the development of novel anti-malignant tumor drugs.
Cofilin, as a depolymerization factor of actin filaments, has been widely studied. Evidences show that cofilin has a role in actin structural reorganization and dynamic regulation. In recent years, several studies have demonstrated a regulatory role for cofilin in the migration and invasion mediated by cell dynamics and epithelial to mesenchymal transition (EMT)/EMT-like process, apoptosis, radiotherapy resistance, immune escape, and transcriptional dysregulation of malignant tumor cells, particularly glioma cells. On this basis, it is practical to evaluate cofilin as a biomarker for predicting tumor metastasis and prognosis. Targeting cofilin regulating kinases, Lin11, Isl-1 and Mec-3 kinases (LIM kinases/LIMKs) and their major upstream molecules inhibits tumor cell migration and invasion and targeting cofilin-mediated mitochondrial pathway induces apoptosis of tumor cells represent effective options for the development of novel anti-malignant tumor drug, especially anti-glioma drugs. This review explores the structure, general biological function, and regulation of cofilin, with an emphasis on the critical functions and prospects for clinical therapeutic applications of cofilin in malignant tumors represented by glioma.

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