Self-assembled polylactic acid (PLA): Synthesis, properties and biomedical applications

The surface morphology and topography of cell culture substrates play an important role in cell proliferation and growth. Regulation of the surface microstructure allows the development of tissue culture media suitable for different cells. Polylactic acid (PLA) is a biobased and biodegradable (under defined conditions) polymer with low immunogenicity, non-toxicity, and good mechanical properties, which have facilitated their pharmaceutical and biomedical applications. This review summarizes recent advances in the synthesis and self-assembly of surface microstructure based on PLA materials and discusses their biomedical applications such as cell culturing and tissue engineering.

Automated summary

The surface morphology and topography of cell culture substrates are crucial for cell proliferation and growth. Polylactic acid (PLA), a biobased and biodegradable polymer, has been extensively studied for its biomedical applications. This review highlights the recent progress in the synthesis and self-assembly of surface microstructures based on PLA materials and discusses their applications in cell culturing and tissue engineering.