4.7 Article

Microbiota-induced lipid peroxidation impairs obeticholic acid-mediated antifibrotic effect towards nonalcoholic steatohepatitis in mice

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Gastroenterology & Hepatology

PUFA-Induced Metabolic Enteritis as a Fuel for Crohn's Disease

Julian Schwaerzler et al.

Summary: This study provides evidence that excessive intake of polyunsaturated fatty acids (PUFAs) in a Western diet can induce gut inflammation and worsen the course of Crohn's disease (CD). The findings suggest a potential role for targeted nutritional therapy.

GASTROENTEROLOGY (2022)

Article Gastroenterology & Hepatology

Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity

Ahmed Ghallab et al.

Summary: This study revealed the mechanism by which acetaminophen overdose causes a breach of the blood-bile barrier, resulting in futile cycling of BAs and hepatocyte death.

JOURNAL OF HEPATOLOGY (2022)

Review Biochemistry & Molecular Biology

Dietary lipids from body to brain

Custers et al.

Summary: Dietary habits have changed in Western societies over the last few decades, with certain fatty acids being linked to metabolic disorders and brain disorders. Neuroinflammation may result from unhealthy diets, with different fatty acids playing a role in either increasing or decreasing inflammation and affecting neuronal function.

PROGRESS IN LIPID RESEARCH (2022)

Review Pharmacology & Pharmacy

Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases

Baoyi Guan et al.

Summary: Cardiometabolic disease (CMD) is a leading cause of death and disability, characterized by metabolic disorder triggered cardiovascular events. Bile acids (BAs) play multifaceted roles in CMD development, directly modulating the immune system, maintaining communication between the host and microbiota, and regulating metabolic homeostasis. The BAs axis is a core coordinator in integrating systemic immunometabolism in CMD.

ACTA PHARMACEUTICA SINICA B (2022)

Review Chemistry, Multidisciplinary

FXR: structures, biology, and drug development for NASH and fibrosis diseases

Si-yu Tian et al.

Summary: The nuclear receptor FXR plays an essential role in maintaining bile acid, glucose, and lipid levels, and is associated with diseases such as obesity and type 2 diabetes. FXR has potential as a therapeutic drug target for enterohepatic diseases, but currently only obeticholic acid (OCA) is approved for primary biliary cholangitis (PBC) treatment.

ACTA PHARMACOLOGICA SINICA (2022)

Article Toxicology

Farnesoid X receptor (FXR) agonists induce hepatocellular apoptosis and impair hepatic functions via FXR/SHP pathway

Tianwei Zhang et al.

Summary: This study found that FXR agonists, obeticholic acid (OCA) and Px-102, reduced mitochondrial function in hepatocytes and promoted cell apoptosis. Inhibiting FXR or SHP genes alleviated the cytotoxic effects of OCA and Px-102. The dose-related liver damage caused by OCA and Px-102 was confirmed in a high-fat diet mouse model. OCA or Px-102 led to a decrease in hepatocyte-specific genes and augmenter of liver regeneration in the liver.

ARCHIVES OF TOXICOLOGY (2022)

Article Cell Biology

Mesenchymal stem cells protect against ferroptosis via exosome-mediated stabilization of SLC7A11 in acute liver injury

Feiyan Lin et al.

Summary: This study investigates the protective effect of mesenchymal stem cells (MSCs) and MSC-derived exosomes (MSC-Exo) on carbon tetrachloride (CCl4)-induced acute liver injury (ALI). It proposes a novel therapeutic strategy for ferroptosis-induced ALI by maintaining the function of SLC7A11 protein.

CELL DEATH & DISEASE (2022)

Article Cell Biology

Cooperative action of gut-microbiota-accessible carbohydrates improves host metabolic function

Sawako Tomioka et al.

Summary: This study found that L-arabinose and sucrose interact with gut microbiota and have anti-obesogenic effects. L-arabinose inhibits diet-induced obesity in the presence of sucrose and this effect is abolished in mice lacking SCFA receptors.

CELL REPORTS (2022)

Review Medicine, Research & Experimental

An overview of ferroptosis in non-alcoholic fatty liver disease

Shendong Wang et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is a global public health problem with no specific drug to reverse it. Ferroptosis has been implicated in the progression of NAFLD, although its mechanism of action remains poorly understood.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Article Biochemistry & Molecular Biology

Chenodeoxycholic acid suppresses AML progression through promoting lipid peroxidation via ROS/p38 MAPK/DGAT1 pathway and inhibiting M2 macrophage polarization

Jinting Liu et al.

Summary: Our study revealed that CDCA suppresses AML progression by synergistically promoting LDs accumulation and lipid peroxidation via the ROS/p38 MAPK/DGAT1 pathway caused by mitochondrial dysfunction in leukemia cells, as well as inhibiting M2 macrophage polarization.

REDOX BIOLOGY (2022)

Article Nanoscience & Nanotechnology

Fluorescent Egg White-Based Carbon Dots as a High-Sensitivity Iron Chelator for the Therapy of Nonalcoholic Fatty Liver Disease by Iron Overload in Zebrafish

Lidong Yu et al.

Summary: This paper reports the Fe3+ chelation and therapy of iron overload nonalcoholic fatty liver disease (NAFLD) using fluorescent egg white-based carbon dots (EWCDs) obtained through microwave-assisted pyrolysis method. The high-sensitivity sensor EWCDs show a high correlation between fluorescence emission and Fe3+ concentration in low concentration ranges, with high biocompatibility and specific binding of Fe3+ both in vivo and in vitro. As a novel nano-iron-chelator, EWCDs can successfully attenuate the production of lethal reactive oxygen species, prevent hepatocyte apoptosis, regulate fatty acid metabolism, and alleviate inflammation. Ultimately, they alleviate NAFLD induced by iron overload in zebrafish.

ACS APPLIED MATERIALS & INTERFACES (2021)

Editorial Material Gastroenterology & Hepatology

Nonalcoholic fatty liver disease: another leap forward

Manal F. Abdelmalek

Summary: In 2020, there were significant advances in nonalcoholic fatty liver disease, including new insights into pathophysiology, advancements in non-invasive diagnostics, and the publication of interim results from the first phase III trial showing improvement in hepatic fibrosis.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Review Oncology

Broadening horizons: the role of ferroptosis in cancer

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, and can be induced by various agents to suppress tumor growth while also potentially triggering inflammation-associated immunosuppression. The extent of ferroptosis's impact on tumor biology and its interactions with other signaling pathways are still under investigation.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Review Gastroenterology & Hepatology

The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer

Lulu Sun et al.

Summary: FXR plays a crucial role in metabolic diseases and gastrointestinal and liver cancers by regulating bile acid synthesis and enterohepatic circulation, influencing glucose and lipid homeostasis. Targeting FXR signaling and bile acid metabolites may provide potential strategies for prevention and treatment of gastrointestinal and liver cancers.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Review Biochemistry & Molecular Biology

Mechanisms and disease consequences of nonalcoholic fatty liver disease

Rohit Loomba et al.

Summary: NAFLD and NASH are leading chronic liver diseases worldwide, causing progressive liver injury that can lead to cirrhosis and hepatocellular carcinoma. These diseases are associated with hepatic glucose and lipid metabolism, and are influenced by genetic, epigenetic, and environmental factors.
Review Gastroenterology & Hepatology

Cross-talk between hepatic stellate cells and T lymphocytes in liver fibrosis

Hao Li et al.

Summary: The interaction between T lymphocytes and hepatic stellate cells plays a crucial role in regulating the progression of liver fibrosis, influencing inflammation, HSC activation, and the course of fibrosis. Understanding this communication process can provide insights into the pathological mechanisms underlying liver fibrosis.

HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL (2021)

Review Biochemistry & Molecular Biology

Nonalcoholic Fatty Liver Disease: Focus on New Biomarkers and Lifestyle Interventions

Maria Notarnicola et al.

Summary: NAFLD is considered as a hepatic manifestation of metabolic syndrome, characterized by excessive lipid accumulation and oxidative stress leading to liver injury. The identification of genetic and epigenetic modifications contributing to NAFLD pathogenesis is crucial, while lifestyle modifications remain the main prevention and treatment approach.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell Biology

FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption

Bethan L. Clifford et al.

Summary: FXR agonists are used to treat NAFLD by controlling hepatic lipid absorption and fatty acid synthesis, specifically reducing levels of MUFA and PUFA in the liver. This reduction is mediated by repression of specific genes and is independent of other regulatory factors like SHP and SREBP1c. Additionally, tissue-specific FXR KO mice studies show that hepatic FXR controls lipogenic genes while intestinal FXR controls lipid absorption.

CELL METABOLISM (2021)

Article Cell Biology

Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects

Emeline Dierge et al.

Summary: Excess uptake of specific polyunsaturated fatty acids can selectively induce ferroptosis in cancer cells under acidic conditions, potentially serving as an adjuvant antitumor modality to complement pharmacological approaches.

CELL METABOLISM (2021)

Article Endocrinology & Metabolism

A new mechanism of obeticholic acid on NASH treatment by inhibiting NLRP3 inflammasome activation in macrophage

Suling Huang et al.

Summary: This study reveals that OCA inhibits NLRP3 inflammasome activation in BMDMs by impacting the activation stage and disrupting ASC oligomerization, leading to potential therapeutic effects on NASH. The findings were validated in murine models and in vitro experiments.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

Article Biochemistry & Molecular Biology

HP1021 is a redox switch protein identified in Helicobacter pylori

Piotr Szczepanowski et al.

Summary: HP1021 functions as a redox switch protein in Helicobacter pylori, playing an important role in the bacterium's response to oxidative stress. The protein contains sensitive cysteine residues that affect its DNA-binding activity and affinity towards template DNA, making it a potential target for control strategies against H. pylori.

NUCLEIC ACIDS RESEARCH (2021)

Review Gastroenterology & Hepatology

Advances in paediatric nonalcoholic fatty liver disease: Role of lipidomics

Anna Di Sessa et al.

Summary: NAFLD, closely related to obesity, has become a global health issue. Lipotoxicity and the role of different lipid classes in NAFLD have gained attention. Lipidomic studies offer insights for innovative therapeutic approaches in NAFLD treatment.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

Article Medicine, Research & Experimental

Co-administration of obeticholic acid and simvastatin protects against high-fat diet-induced non-alcoholic steatohepatitis in mice

Wen-Cong Li et al.

Summary: The combination of obeticholic acid (OCA) and simvastatin (SIM) showed promising therapeutic effects in a high-fat diet-induced model of non-alcoholic steatohepatitis (NASH), reducing liver inflammation and steatosis, preventing weight gain and fat accumulation.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

Article Multidisciplinary Sciences

SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis

Jiyu Zhou et al.

NATURE COMMUNICATIONS (2020)

Article Gastroenterology & Hepatology

A randomized, placebo-controlled, phase II study of obeticholic acid for primary sclerosing cholangitis

Kris Kowdley et al.

JOURNAL OF HEPATOLOGY (2020)

Article Gastroenterology & Hepatology

Targeted lipidomics reveals extensive changes in circulating lipid mediators in patients with acutely decompensated cirrhosis

Cristina Lopez-Vicario et al.

JOURNAL OF HEPATOLOGY (2020)

Review Gastroenterology & Hepatology

Lytic cell death in metabolic liver disease

Jeremie Gautheron et al.

JOURNAL OF HEPATOLOGY (2020)

Article Multidisciplinary Sciences

PEBP1 acts as a rheostat between prosurvival autophagy and ferroptotic death in asthmatic epithelial cells

Jinming Zhao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Medicine, General & Internal

Primary biliary cholangitis

Ana Lleo et al.

LANCET (2020)

Article Gastroenterology & Hepatology

Obeticholic acid may increase the risk of gallstone formation in susceptible patients

Samer Al-Dury et al.

JOURNAL OF HEPATOLOGY (2019)

Review Endocrinology & Metabolism

Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies

Norbert Stefan et al.

LANCET DIABETES & ENDOCRINOLOGY (2019)

Editorial Material Medicine, General & Internal

Obeticholic acid: towards first approval for NASH

Mohammed Eslam et al.

LANCET (2019)

Article Pharmacology & Pharmacy

Combined obeticholic acid and apoptosis inhibitor treatment alleviates liver fibrosis

Jiyu Zhou et al.

ACTA PHARMACEUTICA SINICA B (2019)

Article Urology & Nephrology

FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity

Xiaoxin X. Wang et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

Review Gastroenterology & Hepatology

Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

Wei Jia et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

Article Pharmacology & Pharmacy

Obeticholic acid raises LDL-cholesterol and reduces HDL-cholesterol in the Diet-Induced NASH (DIN) hamster model

Francois Briand et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2018)

Article Biochemistry & Molecular Biology

Increased serum concentration of ceramides in obese children with nonalcoholic fatty liver disease

Natalia Wasilewska et al.

LIPIDS IN HEALTH AND DISEASE (2018)

Article Biochemistry & Molecular Biology

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

Marcus Grohmann et al.

Article Biochemistry & Molecular Biology

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

Lulu Sun et al.

NATURE MEDICINE (2018)

Article Gastroenterology & Hepatology

Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease

Yaron Rotman et al.

Article Biochemistry & Molecular Biology

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Valerian E. Kagan et al.

NATURE CHEMICAL BIOLOGY (2017)

Review Biochemistry & Molecular Biology

Redox signaling mediated by the gut microbiota

Rheinallt M. Jones et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Review Gastroenterology & Hepatology

Mechanisms of hepatic stellate cell activation

Takuma Tsuchida et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

Article Endocrinology & Metabolism

Effects of obeticholic acid on lipoprotein metabolism in healthy volunteers

R. Pencek et al.

DIABETES OBESITY & METABOLISM (2016)

Review Biotechnology & Applied Microbiology

Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies

Giovanni Musso et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

Article Multidisciplinary Sciences

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Changtao Jiang et al.

NATURE COMMUNICATIONS (2015)

Review Neurosciences

Polyunsaturated fatty acids and their metabolites in brain function and disease

Richard P. Bazinet et al.

NATURE REVIEWS NEUROSCIENCE (2014)

Review Endocrinology & Metabolism

Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome

Hannele Yki-Jarvinen

LANCET DIABETES & ENDOCRINOLOGY (2014)

Review Gastroenterology & Hepatology

The role of the gut microbiota in nonalcoholic fatty liver disease

Ahmed Abu-Shanab et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2010)

Article Gastroenterology & Hepatology

The Plasma Lipidomic Signature of Nonalcoholic Steatohepatitis

Puneet Puri et al.

HEPATOLOGY (2009)

Article Gastroenterology & Hepatology

A lipidomic analysis of nonalcoholic fatty liver disease

Puneet Puri et al.

HEPATOLOGY (2007)

Article Medicine, Research & Experimental

Farnesoid X receptor is essential for normal glucose homeostasis

K Ma et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Gastroenterology & Hepatology

Design and validation of a histological scoring system for nonalcoholic fatty liver disease

DE Kleiner et al.

HEPATOLOGY (2005)

Article Multidisciplinary Sciences

The gut microbiota as an environmental factor that regulates fat storage

F Bäckhed et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)