☆ 4.7 Article

Implications of hydrogen sulfide in colorectal cancer: Mechanistic insights and diagnostic and therapeutic strategies

REDOX BIOLOGY (2023)

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Synthesis and evaluation of potent novel inhibitors of human sulfide: quinone oxidoreductase

Simon D. P. Baugh et al.

Summary: The study reports the first small-molecule inhibitors of human sulfide:quinone oxidoreductase (SQOR), which decrease the rate of breakdown of hydrogen sulfide (H2S). These inhibitors may offer a new approach for the treatment of heart failure with reduced ejection fraction.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2021)

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Article Biochemistry & Molecular Biology

Imaging Hydrogen Sulfide in Hypoxic Tissue with [99mTc]Tc-Gluconate

Yongkyoung Kweon et al.

Summary: This study demonstrates the detection of endogenous hydrogen sulfide generated in hypoxic tissue using [Tc-99m]Tc-gluconate, a novel imaging agent that can be used both in vitro and in vivo.

MOLECULES (2021)

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Review Biochemistry & Molecular Biology

Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics

Bindu D. Paul et al.

Summary: Hydrogen sulfide (H2S) was once thought to be only toxic, but is now known to also act as an endogenous signaling molecule. The effects of H2S on cellular physiology are dose-dependent, with lower concentrations being beneficial and higher concentrations being cytotoxic. In particular, H2S has contrasting effects on mitochondrial function, inhibiting the electron transport chain at higher concentrations and stimulating bioenergetics at lower concentrations.

REDOX BIOLOGY (2021)

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Review Cell Biology

Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells

Csaba Szabo

Summary: H2S, previously known as a toxic gas and environmental hazard, has been found to play multiple biological regulatory roles in mammalian cells as an endogenously produced gaseous transmitter. Its effects in mitochondria serve as an electron transport stimulator in physiological concentrations, particularly significant in cancer cells where it helps maintain mitochondrial organization and DNA repair.

CELLS (2021)

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Article Biochemistry & Molecular Biology

The multifaceted roles of sulfane sulfur species in cancer-associated processes

Karim Zuhra et al.

Summary: Sulfane sulfur species, which include various biologically relevant compounds and proteins, play a significant role in cancer biology by modulating cell bioenergetics and contributing to metabolic reprogramming. They achieve this by binding to target proteins or sulfidating specific cysteine residues, thereby regulating cellular functions and exhibiting anti-tumoral properties.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2021)

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Review Pharmacology & Pharmacy

The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species

Brandan Pedre et al.

Summary: Originally used as a mucolytic, N-acetylcysteine (NAC) is now a standard treatment for paracetamol poisoning and a widely used antioxidant. In addition to its traditional mechanisms, a newly discovered mechanism involves the conversion of NAC into hydrogen sulfide and sulfane sulfur species, which may explain many of its effects.

PHARMACOLOGY & THERAPEUTICS (2021)

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Article Pharmacology & Pharmacy

Pharmacological induction of mesenchymal-epithelial transition via inhibition of H2S biosynthesis and consequent suppression of ACLY activity in colon cancer cells

Kelly Ascencao et al.

Summary: Hydrogen sulfide (H2S) is an important endogenous gaseous transmitter mediator that regulates cellular functions. In cancer cells, overproduction of H2S has been linked to processes such as metabolism stimulation and cell proliferation. By inhibiting H2S biosynthesis in colon cancer cells, a shift towards MET was induced, potentially contributing to anti-cancer effects.

PHARMACOLOGICAL RESEARCH (2021)

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Review Chemistry, Multidisciplinary

Smart Nanogatekeepers for Tumor Theranostics

Xunfa Zhang et al.

Summary: Nanoparticulate drug delivery systems face challenges in reaching tumor sites and minimizing off-target side effects. Nanogatekeepers designed with structure-transformable and stable strategies can undergo transformation in tumor microenvironments. Intelligent structure-stable nanogatekeepers with reversible activation and individualized receptors aim to improve drug delivery systems.

SMALL (2021)

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Article Multidisciplinary Sciences

In vitro anticancer activity of hydrogen sulfide and nitric oxide alongside nickel nanoparticle and novel mutations in their genes in CRC patients

Zjwan Housein et al.

Summary: This study assessed the impact of nickel nanoparticles and scorpion venom on colorectal cancer cells, as well as the influence of 5-FU, H2S, and NO, revealing that H2S enhances the anticancer efficiency of 5-FU in the presence of NiNPs, while NO exhibits antiapoptotic activity in CRC cell lines.

SCIENTIFIC REPORTS (2021)

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Article Chemistry, Physical

Mechanistically Diverse Pathways for Sulfoquinovose Degradation in Bacteria

Jiayi Liu et al.

Summary: Sulfoquinovose (SQ) is a polar headgroup of sulfolipids found in plants and other photosynthetic organisms, and bacterial degradation of SQ is crucial for the global sulfur cycle. Six sulfoglycolysis pathways have been discovered, showcasing the diversity of mechanisms through which bacteria utilize this ubiquitous organosulfur compound.

ACS CATALYSIS (2021)

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Article Chemistry, Multidisciplinary

Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis

Mahima Sharma et al.

Summary: This study investigates the core steps of sulfoglycolysis and the function and specificity of regulating enzymes, revealing unique catalytic properties and regulatory mechanisms distinct from traditional glycolysis pathways.

ACS CENTRAL SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Engineering a Hydrogen-Sulfide-Based Nanomodulator to Normalize Hyperactive Photothermal Immunogenicity for Combination Cancer Therapy

Jie Li et al.

Summary: The gas-modulated photothermal immunogenicity strategy, which integrates a polysulfide-based hydrogen sulfide donor with a conjugated polymer, shows great potential in inhibiting tumor growth and limiting inflammation.

ADVANCED MATERIALS (2021)

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Review Biochemistry & Molecular Biology

Glycyl Radical Enzymes and Sulfonate Metabolism in the Microbiome

Yifeng Wei et al.

Summary: Bacteria play important roles in the biogeochemical sulfur cycle by degrading sulfonates to obtain sulfur, carbon, and energy for growth. Cleavage of the inert sulfonate C-S bond involves various enzymes, cofactors, and both oxygen-dependent and oxygen-independent catalytic mechanisms. Recent discoveries in strictly anaerobic bacteria show that sulfonate degradation occurs through O2-sensitive free radical chemistry, catalyzed by glycyl radical enzymes (GREs), enriching our understanding of sulfonate metabolism in the anaerobic biosphere.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 90, 2021 (2021)

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Article Biotechnology & Applied Microbiology

Zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer

Xiang Pan et al.

Summary: In colorectal cancer, the excessive concentration of H2S can be effectively reduced by a zinc oxide coated virus-like silica nanoparticles (VZnO), leading to tumor inhibition through activating ferroptosis. This nanoplatform shows low toxicity and high safety in colorectal cancer treatment, and does not have therapeutic effects on other non H2S rich cancers.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Biochemistry & Molecular Biology

A H2S-Specific Ultrasensitive Fluorogenic Probe Reveals TMV-Induced H2S Production to Limit Virus Replication

Zhili Pang et al.

Summary: Understanding the role of H2S in antiviral host defense mechanisms and developing selective probes for its detection in vivo can provide opportunities for the development of potential antivirals against RNA viruses.

CHEMBIOCHEM (2021)

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Article Ecology

Sulfoquinovose is a select nutrient of prominent bacteria and a source of hydrogen sulfide in the human gut

Buck T. Hanson et al.

Summary: The study reveals that sulfoquinovose (SQ) derived from green vegetables serves as an exclusive microbial nutrient in the human gut, metabolized by specific bacteria such as Eubacterium rectale and Bilophila wadsworthia to produce hydrogen sulfide (H2S), impacting host health. This highlights the importance of individual dietary compounds and organosulfur metabolism on microbial activity and suggests potential for precision editing of gut microbiota through dietary and prebiotic interventions.

ISME JOURNAL (2021)

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Article Chemistry, Medicinal

Novel Aryl-Substituted Pyrimidones as Inhibitors of 3-Mercaptopyruvate Sulfurtransferase with Antiproliferative Efficacy in Colon Cancer

Marina Bantzi et al.

Summary: A study identified a novel 3-MST inhibitor HMPSNE with micromolar potency, along with derivatives, showing inhibitory effects on colon cancer cell proliferation.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Chemistry, Physical

Fabrication of Cu2O/Bi2S3 heterojunction photocatalysts with enhanced visible light photocatalytic mechanism and degradation pathways of tetracycline

Rui Zhang et al.

Summary: A novel Cu2O/Bi2S3 p-n heterojunction photocatalyst was prepared and showed higher catalytic activity for the degradation of tetracycline (TC) under visible light, with a degradation rate of up to 95%. The enhancement in photocatalytic activity was attributed to the formation of heterojunctions that expand visible light absorption and effective electron-hole separation. The research provided new insights into the development of efficient photocatalysts for treating organic pollutants.

JOURNAL OF MOLECULAR STRUCTURE (2021)

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Article Medicine, General & Internal

Association Between the Sulfur Microbial Diet and Risk of Colorectal Cancer

Yiqing Wang et al.

Summary: Sulfur-metabolizing bacteria that reduce dietary sulfur to hydrogen sulfide have been associated with colorectal cancer risk. A dietary pattern characterized by high sulfur microbial content was found to increase the risk of CRC, potentially mediated by sulfur-metabolizing bacteria.

JAMA NETWORK OPEN (2021)

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Article Oncology

Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells

Shanwen Chen et al.

Summary: The study identified a reciprocal regulation between xCT and the transsulfuration pathway, which presents a targetable metabolic vulnerability. CTH derived H2S increased the stability of xCT through persulfidation of OTU domain-containing ubiquitin aldehyde-binding protein 1 at cysteine 91. Treatment with AOAA and Erastin resulted in synthetic lethality both in vitro and in vivo, primarily through increased ferroptosis and apoptosis.

NEOPLASIA (2021)

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Article Nanoscience & Nanotechnology

Novel Multifunctional Stimuli-Responsive Nanoparticles for Synergetic Chemo-Photothermal Therapy of Tumors

Xing-Qun Pu et al.

Summary: A novel class of multifunctional responsive nanoparticles was designed and fabricated as drug nanocarriers for synergetic chemo-photothermal therapy of tumors. These nanoparticles demonstrated good biocompatibility and outstanding photothermal conversion efficiency, with controlled drug release under low pH and high temperature conditions. Experimental results showed that the nanoparticles were phagocytosed by tumor cells and released drugs in acidic environments, with higher efficacy in combined chemo and photothermal therapy compared to individual treatments.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Analytical

A H2S-Triggered Dual-Modal Second Near-Infrared/Photoacoustic Intelligent Nanoprobe for Highly Specific Imaging of Colorectal Cancer

Shenghui Bi et al.

Summary: The study introduces an endogenous H2S-triggered SiO2@Ag nanoprobe for in situ dual-modal NIR-II/PA imaging of colorectal cancer. The designed dual-modal nanoprobe can be converted to SiO2@Ag2S after in situ biosynthesis via a sulfuration reaction with the over-expressed endogenous H2S in the colorectal tumor. The designed SiO2@Ag nanoprobe exhibits high sensitivity and specificity for diagnosing colorectal cancer in vivo via dual-modal NIR-II/PA imaging, providing a new dual-modal imaging strategy for noninvasive intelligent detection of colorectal cancer.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Analytical

In Situ Activatable Ratiometric NIR-II Fluorescence Nanoprobe for Quantitative Detection of H2S in Colon Cancer

Chenlu Wang et al.

Summary: A novel in situ H2S-activatable ratiometric nanoprobe with two NIR-II emission signals was developed for the detection of H2S and illumination of colon cancer. This nanoprobe successfully enabled the accurate quantitative detection of H2S and the precise localization of colon cancer through an endogenous H2S-induced in situ reduction reaction to form Ag2S QDs. These findings provide a new strategy for specific molecule detection and disease diagnosis using an in situ-activatable NIR-II ratiometric FL nanoprobe.

ANALYTICAL CHEMISTRY (2021)

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Article Gastroenterology & Hepatology

The Sulfur Microbial Diet Is Associated With Increased Risk of Early-Onset Colorectal Cancer Precursors

Long H. Nguyen et al.

Summary: The study found that in a cohort of young women, dietary interactions with gut sulfur-metabolizing bacteria may play a role in early-onset colorectal carcinogenesis, possibly beginning in adolescence.

GASTROENTEROLOGY (2021)

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Review Biochemistry & Molecular Biology

The Hidden Role of Hydrogen Sulfide Metabolism in Cancer

Rong-Hsuan Wang et al.

Summary: Hydrogen sulfide, while important for physiological functions, is also associated with aberrant expression in cancer development; understanding the roles of tumor-derived H2S in cancer provides opportunities for targeted therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

Gut microbiota-derived metabolites in CRC progression and causation

Nishu Dalal et al.

Summary: Recent research suggests that dysbiosis and improper concentrations of microbial metabolites in the gut may lead to the carcinogenesis of colorectal cancer. Specific bacteria, such as Fusobacterium nucleaturm, Streptococcus bovis, Helicobacter pylori, Bacteroides fragilis and Clostridium septicum, have been implicated in CRC development by producing metabolites that promote inflammation and cancer progression. Metabolites derived from gut microbiota are now considered as potential factors in CRC diagnosis, prognosis, and therapy based on recent studies.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2021)

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Article Chemistry, Multidisciplinary

Real-Time Imaging of Hepatic Inflammation Using Hydrogen Sulfide-Activatable Second Near-Infrared Luminescent Nanoprobes

Qin Liu et al.

Summary: The study introduces a turn-on second near-infrared (NIR-II) luminescent approach for sensitive, real-time, and in situ detection of hydrogen sulfide (H2S) in vivo. This method relies on the competitive absorption between H2S-responsive chromophores and NIR-II luminescent lanthanide nanoparticles, allowing for the monitoring of endogenous H2S in lipopolysaccharide-induced liver inflammation.

NANO LETTERS (2021)

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Article Oncology

Systems Biomedicine of Primary and Metastatic Colorectal Cancer Reveals Potential Therapeutic Targets

Mehran Piran et al.

Summary: The researchers conducted an analysis of differentially expressed genes in colorectal cancer to propose potential mechanisms influencing tumor progression and metastasis, such as downregulation of mitochondrial genes and augmentation of antioxidants. They also identified potential therapeutic targets and combinatory mechanisms inhibiting EMT and cell migration, which need further experimental validation.

FRONTIERS IN ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

Efficacy of Novel Aminooxyacetic Acid Prodrugs in Colon Cancer Models: Towards Clinical Translation of the Cystathionine β-Synthase Inhibition Concept

Mark R. Hellmich et al.

Summary: The upregulation of CBS in cancer cells has been identified as a tumor-promoting factor, leading to the synthesis of a novel CBS-targeting prodrug YD0251 with higher efficacy in inhibiting tumor growth compared to the prototypical CBS inhibitor AOAA. The prodrug was successful in suppressing tumor growth in vivo with low toxicity, and a potential plasma marker for CBS-expressing tumors was identified for potential future theranostic applications to match CBS inhibitor therapy with high-CBS expressors.

BIOMOLECULES (2021)

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Review Chemistry, Multidisciplinary

Sulfoglycolysis: catabolic pathways for metabolism of sulfoquinovose

Alexander J. D. Snow et al.

Summary: Sulfoquinovose (SQ) is a derivative of glucose produced by photosynthetic organisms, and its degradation plays a key role in the global sulfur and carbon biogeochemical cycles. Bacteria degrade SQ through two main pathways: one involves breaking down the 6-carbon skeleton of SQ into two fragments, while the other involves complete metabolism through desulfonylation to release sulfite and glucose. Discovery of sulfoglycolytic pathways has revealed novel enzymes and binding proteins, shedding light on how the sulfonate group is recognized and its relationship to glycolysis pathways.

CHEMICAL SOCIETY REVIEWS (2021)

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Article Nanoscience & Nanotechnology

A Unique Multifunctional Luminescent Probe for Self-Monitoring Photodynamic Therapy by Detecting H2S in Cancer Cells

Jie Yuan et al.

Summary: A multifunctional hydrogen sulfide (H2S) probe Ru-NBD was developed for reporting the therapeutic effect during the PDT process by detecting hydrogen sulfide. The probe could serve as an effective PDT reagent before and after H2S activation, as well as for real-time monitoring of the therapeutic effect via restored luminescence. The luminescent signal of Ru-NBD changes accordingly as the phototherapy process progresses, showing a correlation between luminescence intensity and cell inhibition rate.

ACS APPLIED BIO MATERIALS (2021)

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Review Pathology

Molecular Functions of Hydrogen Sulfide in Cancer

Rodney E. Shackelford et al.

Summary: Hydrogen sulfide plays a complex role in various human malignancies, promoting multiple cancer-related processes and impacting prognosis. Investigating the function of H2S in cancer is crucial for understanding its molecular mechanisms and intervening in cancer development.

PATHOPHYSIOLOGY (2021)

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Article Chemistry, Multidisciplinary

A covalent organic framework-based nanoagent for H2S-activable phototherapy against colon cancer

Jie Feng et al.

Summary: In this study, a Cu(ii)-porphyrin-derived nanoscale COF was developed for PDT against H2S-enriched colon tumors, with controllable singlet oxygen release. The in situ generated CuS can also be used synchronously as a photothermal agent for PTT.

CHEMICAL COMMUNICATIONS (2021)

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Review Chemistry, Multidisciplinary

Radiolabelling of nanomaterials for medical imaging and therapy

Juan Pellico et al.

Summary: Nanomaterials have unique properties for medical imaging and therapy, and efforts have been made to translate nanomedicines into clinical practice. Studying biodistribution and pharmacokinetics of nanomedicinal-drugs from early stages is crucial for effective clinical translation. Radiolabelling nanomaterials enables in vivo tracking for imaging and therapy, but selection of appropriate radiolabelling method is critical for robust information during development.

CHEMICAL SOCIETY REVIEWS (2021)

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Review Chemistry, Multidisciplinary

Second near-infrared photothermal materials for combinational nanotheranostics

Cheng Xu et al.

Summary: Second near-infrared photothermal therapy (NIR-II PTT) has advantages of deeper penetration and less toxicity, but faces challenges of suboptimal photothermal conversion and limited therapeutic efficacy. To improve efficacy, multifunctional NIR-II photothermal inorganic or organic materials have been developed for combination with other therapeutic modalities.

CHEMICAL SOCIETY REVIEWS (2021)

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Review Biotechnology & Applied Microbiology

The roles of microbial products in the development of colorectal cancer: a review

Yongkun Fang et al.

Summary: A large number of microbes in the gut play a role in processing ingested food, and their products are implicated in the development of colorectal cancer. The molecular mechanisms linking gut microbial products to CRC are not fully understood, with some products having controversial roles in CRC. Investigating the effects of gut microbiota products on CRC and their mechanisms is crucial for prevention and treatment.

BIOENGINEERED (2021)

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Review Biochemistry & Molecular Biology

Role of hydrogen sulfide donors in cancer development and progression

Ebenezeri Erasto Ngowi et al.

Summary: There are numerous potential cancer therapeutic targets emerging recently, with hydrogen sulfide playing a role in regulating cellular activities. However, the outcome of treating cancer cells with H2S donors depends on multiple factors. Various signaling pathways have been reported to be altered following treatments with H2S donors, suggesting their potential in cancer treatment.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Chemistry, Medicinal

Eruca sativa Mill. seed extract promotes anti-obesity and hypoglycemic effects in mice fed with a high-fat diet

Eugenia Piragine et al.

Summary: Studies have shown that extracts from Brassicaceae vegetables have positive metabolic effects on obesity models, reducing weight gain, improving glucose metabolism, and enhancing the metabolism of adipocytes.

PHYTOTHERAPY RESEARCH (2021)

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Article Biochemistry & Molecular Biology

S-Persulfidation: Chemistry, Chemical Biology, and Significance in Health and Disease

Chun-tao Yang et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

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Review Chemistry, Multidisciplinary

Sorbents for hydrogen sulfide capture from biogas at low temperature: a review

Dongjing Liu et al.

ENVIRONMENTAL CHEMISTRY LETTERS (2020)

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Review Pharmacology & Pharmacy

Signalling by hydrogen sulfide and polysulfides via protein S-sulfuration

Hideo Kimura

BRITISH JOURNAL OF PHARMACOLOGY (2020)

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Review Chemistry, Multidisciplinary

Two-Dimensional Nanomaterials for Photothermal Therapy

Shuang Liu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Review Biochemistry & Molecular Biology

The Benefits of Macromolecular/Supramolecular Approaches in Hydrogen Sulfide Delivery: A Review of Polymeric and Self-Assembled Hydrogen Sulfide Donors

Kuljeet Kaur et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

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Article Chemistry, Medicinal

Hydrogen sulfide releasing oridonin derivatives induce apoptosis through extrinsic and intrinsic pathways

Haonan Li et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Article Gastroenterology & Hepatology

Association Between Sulfur-Metabolizing Bacterial Communities in Stool and Risk of Distal Colorectal Cancer in Men

Long H. Nguyen et al.

GASTROENTEROLOGY (2020)

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Review Pharmacology & Pharmacy

Potential role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H2S) pathway in cancer cells

Fiona Augsburger et al.

PHARMACOLOGICAL RESEARCH (2020)

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Article Multidisciplinary Sciences

H2S-activatable near-infrared afterglow luminescent probes for sensitive molecular imaging in vivo

Luyan Wu et al.

NATURE COMMUNICATIONS (2020)

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Article Chemistry, Physical

Dynamic Structural Changes Accompany the Production of Dihydroxypropanesulfonate by Sulfolactaldehyde Reductase

Mahima Sharma et al.

ACS CATALYSIS (2020)

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Article Chemistry, Analytical

Magnetic-Photoacoustic Dual-Mode Probe for the Visualization of H2S in Colorectal Cancer

Chenglin Yan et al.

ANALYTICAL CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

SG1002 and Catenated Divalent Organic Sulfur Compounds as Promising Hydrogen Sulfide Prodrugs

Gabriel Gojon et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

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Article Biotechnology & Applied Microbiology

A Sulfoglycolytic Entner-Doudoroff Pathway in Rhizobium leguminosarum bv. trifolii SRDI565

Jinling Li et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2020)

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Review Chemistry, Multidisciplinary

Multifluorinated Aryl Azides for the Development of Improved H2S Probes, and Fast Strain-promoted Azide-Alkyne Cycloaddition and Staudinger Reactions

Xueying Kang et al.

CHEMISTRY-AN ASIAN JOURNAL (2020)

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Review Cell Biology

Recent Advances in Metabolic Pathways of Sulfate Reduction in Intestinal Bacteria

Ivan Kushkevych et al.

CELLS (2020)

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Review Biochemistry & Molecular Biology

Synergisms, Discrepancies and Interactions between Hydrogen Sulfide and Carbon Monoxide in the Gastrointestinal and Digestive System Physiology, Pathophysiology and Pharmacology

Urszula Glowacka et al.

BIOMOLECULES (2020)

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Article Biochemistry & Molecular Biology

Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells

Fiona Augsburger et al.

BIOMOLECULES (2020)

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Review Biochemistry & Molecular Biology

Cystathionine-beta-synthase: Molecular Regulation and Pharmacological Inhibition

Karim Zuhra et al.

BIOMOLECULES (2020)

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Article Nanoscience & Nanotechnology

Endogenous Hydrogen Sulfide-Triggered MOF-Based Nanoenzyme for Synergic Cancer Therapy

Yite Li et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Colorectal Tumor Microenvironment-Activated Bio-Decomposable and Metabolizable Cu2O@CaCO3Nanocomposites for Synergistic Oncotherapy

Mengyu Chang et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Aggregation Enhanced Responsiveness of Rationally Designed Probes to Hydrogen Sulfide for Targeted Cancer Imaging

Rongchen Wang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Biochemistry & Molecular Biology

A transaldolase-dependent sulfoglycolysis pathway in Bacillus megaterium DSM 1804

Yinbo Liu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Review Pharmacology & Pharmacy

Hydrogen sulfide: An endogenous regulator of the immune system

Nahzli Dilek et al.

PHARMACOLOGICAL RESEARCH (2020)

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Article Multidisciplinary Sciences

Two radical-dependent mechanisms for anaerobic degradation of the globally abundant organosulfur compound dihydroxypropanesulfonate

Jiayi Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Chemistry, Multidisciplinary

H2S-Scavenged and Activated Iron Oxide-Hydroxide Nanospindles for MRI-Guided Photothermal Therapy and Ferroptosis in Colon Cancer

Yangyang Li et al.

SMALL (2020)

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Article Biochemistry & Molecular Biology

Green tea polyphenolic antioxidants oxidize hydrogen sulfide to thiosulfate and polysulfides: A possible new mechanism underpinning their biological action

Kenneth R. Olson et al.

REDOX BIOLOGY (2020)

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Article Multidisciplinary Sciences

Environmental and Intestinal Phylum Firmicutes Bacteria Metabolize the Plant Sugar Sulfoquinovose via a 6-Deoxy-6-sulfofructose Transaldolase Pathway

Benjamin Frommeyer et al.

ISCIENCE (2020)

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Article Pharmacology & Pharmacy

Mechanism of cystathionine-β-synthase inhibition by disulfiram: The role of bis(N,N-diethyldithiocarbamate)-copper(II)

Karim Zuhra et al.

BIOCHEMICAL PHARMACOLOGY (2020)

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Article Nanoscience & Nanotechnology

Endogenous H2S-Activable Liposomal Nanoplatform for Synergistic Colorectal Tumor Ablation at Mild Apparent Temperature

Jingyan Sun et al.

ACS APPLIED BIO MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Highly efficient H2S scavengers via thiolysis of positively-charged NBD amines

Ismail Ismail et al.

CHEMICAL SCIENCE (2020)

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Article Materials Science, Biomaterials

Rational design of water-dispersible and biocompatible nanoprobes with H2S-triggered NIR emission for cancer cell imaging

Hengyan Liu et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Medicine, Research & Experimental

Ellagic acid-Fe@BSA nanoparticles for endogenous H2S accelerated Fe(III)/Fe(II) conversion and photothermal synergistically enhanced chemodynamic therapy

Qingqing Tian et al.

THERANOSTICS (2020)

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Article Oncology

Aminooxyacetic acid (AOAA) sensitizes colon cancer cells to oxaliplatin via exaggerating apoptosis induced by ROS

Taohua Yue et al.

JOURNAL OF CANCER (2020)

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Review Pharmacology & Pharmacy

Regulators of the transsulfuration pathway

Juan I. Sbodio et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

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Review Chemistry, Multidisciplinary

Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reactions

Zhongmin Tang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Article Multidisciplinary Sciences

A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia

Spencer C. Peck et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Biochemistry & Molecular Biology

Biochemical and structural investigation of taurine:2-oxoglutarate aminotransferase from Bifidobacterium kashiwanohense

Mengya Li et al.

BIOCHEMICAL JOURNAL (2019)

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Article Multidisciplinary Sciences

A generic approach towards afterglow luminescent nanoparticles for ultrasensitive in vivo imaging

Yuyan Jiang et al.

NATURE COMMUNICATIONS (2019)

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Article Chemistry, Multidisciplinary

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Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells

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Theranostic Nanoplatform with Hydrogen Sulfide Activatable NIR Responsiveness for Imaging-Guided On-Demand Drug Release

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Self-Assembled Copper Amino Acid Nanoparticles for in Situ Glutathione AND H2O2 Sequentially Triggered Chemodynamic Therapy

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Ratiometric photoacoustic nanoprobes for monitoring and imaging of hydrogen sulfide in vivo

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H2S oxidation by nanodisc-embedded human sulfide quinone oxidoreductase

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H2S-Activable MOF Nanoparticle Photosensitizer for Effective Photodynamic Therapy against Cancer with Controllable Singlet-Oxygen Release

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H2S-induced S-sulfhydration of lactate dehydrogenase a (LDHA) stimulates cellular bioenergetics in HCT116 colon cancer cells

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Review Biochemistry & Molecular Biology

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Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer

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S-Sulfhydration of ATP synthase by hydrogen sulfide stimulates mitochondrial bioenergetics

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Profound Chemopreventative Effects of a Hydrogen Sulfide-Releasing NSAID in the APCMin/+ Mouse Model of Intestinal Tumorigenesis

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Taurocholic acid metabolism by gut microbes and colon cancer

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Review Biochemistry & Molecular Biology

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Polymorphic Variants of Human Rhodanese Exhibit Differences in Thermal Stability and Sulfur Transfer Kinetics

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Positional isomerism markedly affects the growth inhibition of colon cancer cells by NOSH-aspirin: COX inhibition and modeling

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NOSH-Aspirin Inhibits Colon Cancer Cell Growth: Effects Of Positional Isomerism

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Biosynthesis of a Central Intermediate in Hydrogen Sulfide Metabolism by a Novel Human Sulfurtransferase and Its Yeast Ortholog

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Organization of the Human Mitochondrial Hydrogen Sulfide Oxidation Pathway

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Sulphoglycolysis in Escherichia coli K-12 closes a gap in the biogeochemical sulphur cycle

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Semiconducting polymer nanoparticles as photoacoustic molecular imaging probes in living mice

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Enhanced chemopreventive effects of a hydrogen sulfide-releasing anti-inflammatory drug (ATB-346) in experimental colorectal cancer

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Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-β-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro

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S-Aroylthiooximes: A Facile Route to Hydrogen Sulfide Releasing Compounds with Structure-Dependent Release Kinetics

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ORGANIC LETTERS (2014)

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A Ratiometric Fluorescent Probe for Rapid Detection of Hydrogen Sulfide in Mitochondria

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Identification of Cystathionine -Synthase Inhibitors Using a Hydrogen Sulfide Selective Probe

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Selectivity of commonly used pharmacological inhibitors for cystathionine synthase (CBS) and cystathionine lyase (CSE)

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BRITISH JOURNAL OF PHARMACOLOGY (2013)

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Microbial regulation of host hydrogen sulfide bioavailability and metabolism

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Functional Near Infrared-Emitting Cr3+/Pr3+ Co-Doped Zinc Gallogermanate Persistent Luminescent Nanoparticles with Superlong Afterglow for in Vivo Targeted Bioimaging

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MOLECULAR CANCER (2013)

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Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Cell-trappable fluorescent probes for endogenous hydrogen sulfide signaling and imaging H2O2-dependent H2S production

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells

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NATURE COMMUNICATIONS (2013)

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Detoxification of H2S by Differentiated Colonic Epithelial Cells: Implication of the Sulfide Oxidizing Unit and of the Cell Respiratory Capacity

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ANTIOXIDANTS & REDOX SIGNALING (2012)

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Article Biochemistry & Molecular Biology

NOSH-aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid is a potent inhibitor of colon cancer cell growth in vitro and in a xenograft mouse model

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Hydrogen sulfide-releasing aspirin modulates xenobiotic metabolizing enzymes in vitro and in vivo

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BIOCHEMICAL PHARMACOLOGY (2012)

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Article Pharmacology & Pharmacy

Hydrogen sulfide-releasing NSAIDs inhibit the growth of human cancer cells: A general property and evidence of a tissue type-independent effect

Mitali Chattopadhyay et al.

BIOCHEMICAL PHARMACOLOGY (2012)

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Article Biochemistry & Molecular Biology

Human Sulfide:Quinone Oxidoreductase Catalyzes the First Step in Hydrogen Sulfide Metabolism and Produces a Sulfane Sulfur Metabolite

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BIOCHEMISTRY (2012)

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Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells

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Article Pharmacology & Pharmacy

Sulphide quinone reductase contributes to hydrogen sulphide metabolism in murine peripheral tissues but not in the CNS

D. R. Linden et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

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Upconversion nanophosphors for small-animal imaging

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CHEMICAL SOCIETY REVIEWS (2012)

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Generation of gaseous sulfur-containing compounds in tumour tissue and suppression of gas diffusion as an antitumour treatment

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Article Biochemistry & Molecular Biology

Characterization of Patient Mutations in Human Persulfide Dioxygenase (ETHE1) Involved in H2S Catabolism

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Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice

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NATURE (2012)

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Review Physiology

PHYSIOLOGICAL IMPLICATIONS OF HYDROGEN SULFIDE: A WHIFF EXPLORATION THAT BLOSSOMED

Rui Wang

PHYSIOLOGICAL REVIEWS (2012)

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Diallyl sulfide, diallyl disulfide and diallyl trisulfide affect drug resistant gene expression in colo 205 human colon cancer cells in vitro and in vivo

Kuang-Chi Lai et al.

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Article Chemistry, Medicinal

NOSH-Aspirin: A Novel Nitric Oxide-Hydrogen Sulfide-Releasing Hybrid: A New Class of Anti-inflammatory Pharmaceuticals

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ACS MEDICINAL CHEMISTRY LETTERS (2012)

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Article Nutrition & Dietetics

Epigallocatechin Gallate (EGCG) Is the Most Effective Cancer Chemopreventive Polyphenol in Green Tea

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NUTRIENTS (2012)

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Review Physiology

Microbial pathways in colonic sulfur metabolism and links with health and disease

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FRONTIERS IN PHYSIOLOGY (2012)

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Large-Scale Synthesis of Bi2S3 Nanodots as a Contrast Agent for In Vivo X-ray Computed Tomography Imaging

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ADVANCED MATERIALS (2011)

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Review Biochemistry & Molecular Biology

Epigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises?

Derliz Mereles et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2011)

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Meeting Abstract Oncology

Relationship of pro-angiogenic factor Cyr61to colorectal cancer development and prognosis.

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JOURNAL OF CLINICAL ONCOLOGY (2011)

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Article Chemistry, Multidisciplinary

Controlling Electron Trap Depth To Enhance Optical Properties of Persistent Luminescence Nanoparticles for In Vivo Imaging

Thomas Maldiney et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

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Article Multidisciplinary Sciences

The Slow-Releasing Hydrogen Sulfide Donor, GYY4137, Exhibits Novel Anti-Cancer Effects In Vitro and In Vivo

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PLOS ONE (2011)

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H2S: A Universal Defense Against Antibiotics in Bacteria

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SCIENCE (2011)

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Review Biochemistry & Molecular Biology

Luminal sulfide and large intestine mucosa: friend or foe?

Francois Blachier et al.

AMINO ACIDS (2010)

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Review Biochemistry & Molecular Biology

Endogenous Production of H2S in the Gastrointestinal Tract: Still in Search of a Physiologic Function

David R. Linden et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

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Effectiveness of topical zinc oxide application on hypertrophic scar development in rabbits

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BURNS (2010)

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Hydrogen sulfide induces human colon cancer cell proliferation: role of Akt, ERK and p21

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CELL BIOLOGY INTERNATIONAL (2010)

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Review Chemistry, Multidisciplinary

Molecular Imaging by Means of Multispectral Optoacoustic Tomography (MSOT)

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CHEMICAL REVIEWS (2010)

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Going deeper than microscopy: the optical imaging frontier in biology

Vasilis Ntziachristos

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Article Biochemistry & Molecular Biology

3-Mercaptopyruvate Sulfurtransferase Produces Hydrogen Sulfide and Bound Sulfane Sulfur in the Brain

Norihiro Shibuya et al.

ANTIOXIDANTS & REDOX SIGNALING (2009)

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Article Biochemistry & Molecular Biology

Loss of ETHE1, a mitochondrial dioxygenase, causes fatal sulfide toxicity in ethylmalonic encephalopathy

Valeria Tiranti et al.

NATURE MEDICINE (2009)

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Article Multidisciplinary Sciences

No facilitator required for membrane transport of hydrogen sulfide

John C. Mathai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Article Biochemistry & Molecular Biology

H2S Signals Through Protein S-Sulfhydration

Asif K. Mustafa et al.

SCIENCE SIGNALING (2009)

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Article Oncology

CYR61 and αVβ5 integrin cooperate to promote invasion and metastasis of tumors growing in preirradiated stroma

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CANCER RESEARCH (2008)

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Article Cardiac & Cardiovascular Systems

Characterization of a novel, water-soluble hydrogen sulfide - Releasing molecule (GYY4137): New insights into the biology of hydrogen sulfide

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CIRCULATION (2008)

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Review Biotechnology & Applied Microbiology

Hydrogen sulphide and its therapeutic potential

Csaba Szabo

NATURE REVIEWS DRUG DISCOVERY (2007)

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Development of radioimmunotherapeutic and diagnostic antibodies: an inside-out view

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NUCLEAR MEDICINE AND BIOLOGY (2007)

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Article Biochemistry & Molecular Biology

Sulfide, the first inorganic substrate for human cells

Marc Goubern et al.

FASEB JOURNAL (2007)

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Review Biochemistry & Molecular Biology

ERK1/2 MAP kinases in cell survival and apoptosis

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IUBMB LIFE (2006)

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Article Gastroenterology & Hepatology

Sulfide-detoxifying enzymes in the human colon are decreased in cancer and upregulated in differentiation

S. Ramasamy et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)

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An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles

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NATURE MATERIALS (2006)

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Article Gastroenterology & Hepatology

Hydrogen sulfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocyanate induced apoptosis

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WORLD JOURNAL OF GASTROENTEROLOGY (2005)

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Review Chemistry, Multidisciplinary

Upconversion and anti-stokes processes with f and d ions in solids

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CHEMICAL REVIEWS (2004)

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