4.7 Article

Bromine radical enhanced stoichiometric pyridylation of alkylarenes and diarylmethanes at room temperature

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ORGANIC CHEMISTRY FRONTIERS
卷 10, 期 4, 页码 890-897

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ROYAL SOC CHEMISTRY
DOI: 10.1039/d2qo01908f

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A method for the radical-radical couplings of alkylarenes and diarylmethanes with 4-cyanopyridine has been developed at room temperature. The reactions were promoted by combining photoredox catalysis and hydrogen atom transfer catalysis. A wide range of diarylmethanes and triarylmethanes with heteroaryl groups were synthesized with good to excellent yields. The pyridine moiety was also successfully introduced into bioactive molecules and complex compounds.
The radical-radical couplings of readily available alkylarenes and diarylmethanes with cheap and abundant 4-cyanopyridine in a stoichiometric manner at room temperature have been developed. This method employed broadly applicable petroleum-derived toluene derivatives as latent alkylating reagents, promoted by the merger of photoredox catalysis and hydrogen atom transfer catalysis. A wide range of diarylmethanes and triarylmethanes with heteroaryl groups were synthesized in good to excellent yields. Given the stoichiometric and mild conditions, the pyridine moiety was also successfully introduced into bioactive molecules and complex compounds. Mechanistic investigations reveal that the bromine radical serves as a selective hydrogen atom transfer (HAT) reagent to rapidly abstract a hydrogen atom from benzyl C-H bonds.

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