Homoallyl alcohol as an allylation reagent for termination of the Catellani-Lautens reaction via retro-allylation

A palladium/norbornene-catalyzed ortho-amination/allylation of aryl iodides was developed for the construction of ortho-aminated allylbenzene by using N-benzoyloxyamine as the amination reagent and homoallyl alcohol as the allylation reagent. The reaction showed good functional group tolerance and broad substrate scope.

Automated summary

A palladium/norbornene-catalyzed ortho-amination/allylation reaction of aryl iodides was developed, which enabled the construction of ortho-aminated allylbenzene using N-benzoyloxyamine as the amination reagent and homoallyl alcohol as the allylation reagent. The reaction exhibited good functional group tolerance and a wide substrate scope.