期刊
ORGANIC CHEMISTRY FRONTIERS
卷 10, 期 5, 页码 1173-1181出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2qo01754g
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A new metal-free electron donor-acceptor (EDA) complex photocatalysis strategy is developed for the alkylative [3 + 2] annulation of N-alkyl isoquinolin-2-ium salts with common alkynes. This method, utilizing the catalytic isoquinoline-based EDA complex, shows excellent site selectivity, tolerance of various functional groups, and uses aqueous media without expensive external photocatalysts and promotors. Mechanistic study suggests that the EDA complex is formed by the association of a catalytic isoquinoline with N-alkyl isoquinolin-2-ium salts.
A new, metal-free electron donor-acceptor (EDA) complex photocatalysis strategy for alkylative [3 + 2] annulation of N-alkyl isoquinolin-2-ium salts with common alkynes in ethyl actate/H2O to assemble highly functionalized pyrrolo[2,1-a]isoquinolines is presented. Upon photoinducing reactivity using the catalytic isoquinoline-based EDA complex, this method enables incorporation of alkynes as two-carbon units to achieve alkylative [3 + 2] annulation of N-alkyl isoquinolin-2-ium salts, and is notable for its excellent site selectivity, tolerance of a wide range of functional groups, the use of aqueous media and avoidance of the need for expensive external photocatalysts and basic or acidic promotors. Mechanistic study indicates that the EDA complex is generated from association of a catalytic isoquinoline with N-alkyl isoquinolin-2-ium salts to photoinduce reactivity.
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