期刊
ORGANIC CHEMISTRY FRONTIERS
卷 10, 期 1, 页码 189-192出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2qo01540d
关键词
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资金
- Shenzhen Science and Technology Innovation Committee [GXWD20201231165807007-20200812100115001, JCYJ20180504165454447]
- Shenzhen Science and Technology Program [KQTD20190929174023858]
- Shenzhen Bay Laboratory Open Research Program [SZBL2019062801010]
- National Natural Science Foundation of China [21871018, 21732001, 21901014, 22231003, 22271008]
- Guangdong Science and Technology Program [2017B030314002]
- Industry and Information Technology Bureau of Shenzhen Municipality [201806151622209330]
- Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions [2019SHIBS0004]
- Third Foster Plan in 2019 Molecular Imaging Probe Preparation and Characterization of Key Technologies and Equipment [ZDKJ20190305003]
- National Ten Thousand Talent Program
A nine-step asymmetric total synthesis of (+)-tubingensin A has been achieved, featuring intramolecular Heck reaction for establishing the key vicinal quaternary stereocenter motif present in the natural product and late-stage Zweifel olefination for side chain elongation.
A nine-step asymmetric total synthesis of (+)-tubingensin A has been realized. The synthesis features (a) an intramolecular Heck reaction to install the C20 quaternary carbon center thus establishing the key vicinal quaternary stereocenter motif present in the natural product and (b) a late-stage Zweifel olefination applied to side chain elongation.
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