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Association Between Blood Eosinophils and Neutrophils With Clinical Features in Adult-Onset Asthma

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DOI: 10.1016/j.jaip.2022.11.025

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This study aims to assess the association between blood eosinophil and neutrophil counts and clinical and molecular features in patients with adult-onset asthma. The findings showed that patients can be divided into four groups (pauci-granulocytic, neutrophilic, eosinophilic, and mixed granulocytic) based on their eosinophil and neutrophil levels.
BACKGROUND: Asthma is a disease that can be separated into different phenotypes and endotypes based on the clinical characteristics and the molecular mechanisms of the condition, respectively. OBJECTIVE: To assess the association between blood eosinophil and neutrophil counts with clinical and molecular features in patients with adult-onset asthma. METHODS: Blood eosinophil and neutrophil counts were measured from 203 patients who took part in the Seinajoki Adult Asthma Study and attended the 12-year follow-up visit. The patients were then divided into four groups (pauci-granulocytic [n = 108], neutrophilic [n = 60], eosinophilic [n = 21], and mixed granulocytic [n = 14]), according to eosinophil and neutrophil levels. The cutoff values used to define

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