期刊
ADVANCED MATERIALS
卷 28, 期 1, 页码 86-+出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201502902
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资金
- Leona M. and Harry B. Helmsley Charitable Trust [2014PG-T1D002]
- National Institutes of Health through Ruth L. Kirschstein National Research Service Award [F32DK101335]
- Wellcome Trust-MIT Postdoctoral Fellowship
Dynamically restructuring pH-responsive hydrogels are synthesized, employing dynamic covalent chemistry between phenylboronic acid and cis-diol modified poly(ethylene glycol) macromonomers. These gels display shear-thinning behavior, followed by a rapid structural recovery (self-healing). Size-dependent in vitro controlled and glucose-responsive release of proteins from the hydrogel network, as well as the biocompatibility of the gels, are evaluated both in vitro and in vivo.
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