Rapid-onset dystonia-parkinsonism is associated with reduced cerebral blood flow without gray matter changes

Purpose: Previous research showed discrete neuropathological changes associated with rapid-onset dystonia-parkinsonism (RDP) in brains from patients with an ATP1A3 variant, specifically in areas that mediate motor function. The purpose of this study was to determine if magnetic resonance imaging methodologies could identify di erences between RDP patients and variant-negative controls in areas of the brain that mediate motor function in order to provide biomarkers for future treatment or prevention trials. Methods: Magnetic resonance imaging voxel-based morphometry and arterial spin labeling were used to measure gray matter volume and cerebral blood flow, respectively, in cortical motor areas, basal ganglia, thalamus, and cerebellum, in RDP patients with ATP1A3 variants (n = 19; mean age = 37 +/- 14 years; 47% female) and variant-negative healthy controls (n = 11; mean age = 34 +/- 19 years; 36% female). Results: We report age and sex-adjusted between group di erences, with decreased cerebral blood flow among patients with ATP1A3 variants compared to variant-negative controls in the thalamus (p = 0.005, Bonferroni alpha level <0.007 adjusted for regions). There were no statistically significant between-group di erences for measures of gray matter volume. Conclusions: There is reduced cerebral blood flow within brain regions in patients with ATP1A3 variants within the thalamus. Additionally, the lack of corresponding gray matter volume di erences may suggest an underlying functional etiology rather than structural abnormality.

Automated summary

The purpose of this study was to determine whether there are differences between patients with rapid-onset dystonia-parkinsonism (RDP) and variant-negative controls in brain areas that mediate motor function using magnetic resonance imaging (MRI) methodologies. The results showed decreased cerebral blood flow in the thalamus of patients with ATP1A3 variants compared to the control group. However, there were no significant differences in gray matter volume between the two groups. This suggests that ATP1A3 variants may lead to reduced cerebral blood flow in the thalamus, indicating a functional rather than a structural abnormality.