期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.1057602
关键词
telomere length; periodontal disease; Mendelian randomization; causality; genome-wide association studies; biological aging; inflammation
类别
资金
- Science and technology fund project of Guizhou provincial health commission
- Science and Technology Plan Project of Guiyang in 2014 [gzwkj2022-161]
- [[2014]003]
- [[2019]9-7-13]
This study investigated the causal relationship between periodontitis and shortened telomere lengths (TL) using a two-sample Mendel randomized (MR) study. The results showed that a genetic prediction of short TL was causally associated with a higher risk of periodontitis, while periodontitis had no significant effect on TL. No pleiotropy was detected in sensitivity analysis.
BackgroundObservational studies have demonstrated a link between shortened telomere lengths(TL) and chronic periodontitis. However, whether the shortened TL is the cause or the result of periodontitis is unknown.Therefore, our objective was to investigate a bidirectional causal relationship between periodontitis and TL using a two-sample Mendel randomized (MR) study. MethodsA two-sample bidirectional MR analysis using publicly available genome-wide association study (GWAS) data was used. As the primary analysis, inverse variance weighting (IVW) was employed. To identify pleiotropy, we used leave-one-out analysis, MR-Egger, Weighted median, Simple mode, Weighted mode, and MR pleiotropy residual sum and outlier (MR-PRESSO). ResultsIn reverse MR results, a genetic prediction of short TL was causally associated with a higher risk of periodontitis (IVW: odds ratio [OR]: 1.0601, 95% confidence interval [CI]: 1.0213 to 1.1002; P =0.0021) and other complementary MR methods. In the forward MR analysis, periodontitis was shown to have no significant effect on TL (IVW: p = 0.7242), with consistent results for the remaining complementary MR. No pleiotropy was detected in sensitivity analysis (all P>0.05). ConclusionOur MR studies showed a reverse causal relationship, with shorten TL being linked to a higher risk of periodontitis, rather than periodontitis shorten that TL. Future research is needed to investigate the relationship between cell senescence and the disease.
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