☆ 4.8 Review

Natural killer cells in sepsis: Friends or foes?

FRONTIERS IN IMMUNOLOGY (2023)

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Review Cell Biology

Immune dysregulation and RNA N6-methyladenosine modification in sepsis

Hongyan Chen et al.

Summary: Sepsis is a life-threatening syndrome caused by immune dysfunction in response to infection. It is a highly heterogeneous condition with complex mechanisms. The immune response to sepsis includes both hyper-inflammatory and immune-suppressive phases, and dysregulated m6A modifications play a significant role in immune cell changes during sepsis.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2023)

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Review Pharmacology & Pharmacy

The pathophysiology of sepsis-2021 update: Part 2, organ dysfunction and assessment

Judith Jacobi

Summary: This article reviews the dysfunction of major organ systems in sepsis, including cardiovascular, respiratory, renal, hematologic, hepatic, and neurologic dysfunction, as well as the scoring systems used for identification. Timely recognition and a complete understanding of the pathophysiologic mechanisms are crucial for improving patient outcomes.

AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY (2022)

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Article Biotechnology & Applied Microbiology

Tim-3 regulates sepsis-induced immunosuppression by inhibiting the NF-κB signaling pathway in CD4 T cells

Siyuan Huang et al.

Summary: Immunosuppression in response to severe sepsis is a significant concern in human health. CD4 T cells, particularly those expressing Tim-3, play a critical role in sepsis-induced immunosuppression. Tim-3 inhibits the NF-kappa B signaling pathway in CD4 T cells during sepsis, contributing to the immunosuppressive effect.

MOLECULAR THERAPY (2022)

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Review Pediatrics

Mechanisms and modulation of sepsis-induced immune dysfunction in children

Leena B. Mithal et al.

Summary: Immunologic responses during sepsis vary significantly among patients and evolve over the course of illness, leading to a spectrum of immunoparalysis that can increase morbidity and mortality. Current research focuses on immune dysregulation and immunomodulatory therapies in sepsis, with future emphasis on personalized treatments involving gene expression.

PEDIATRIC RESEARCH (2022)

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Review Immunology

All About (NK Cell-Mediated) Death in Two Acts and an Unexpected Encore: Initiation, Execution and Activation of Adaptive Immunity

Ariel Ramirez-Labrada et al.

Summary: In this article, the available experimental evidence on how NK cells kill target cells is reviewed and discussed, with a special focus on the different cell death modalities that have been found to be activated during NK cell-mediated cytotoxicity, including apoptosis and more inflammatory pathways like necroptosis and pyroptosis. Based on this new evidence, NK cell-induced cell death is proposed as a new regulatory mechanism linking innate immune response with the activation of tumor adaptive T cell responses.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Medicine, General & Internal

The hypothalamus-pituitary-adrenal axis in sepsis- and hyperinflammation-induced critical illness: Gaps in current knowledge and future translational research directions

Greet Van den Berghe et al.

Summary: The traditional model of increased systemic glucocorticoid availability in response to sepsis and hyperinflammation-induced critical illness has been challenged in recent research, revealing a more complex and time-dependent set of responses. Cortisol production driven by ACTH is only temporarily increased, followed by orchestrated peripheral adaptations to maintain increased cortisol availability for target tissues without the need for continued production, along with changes at target tissues to guide cortisol action according to tissue-specific needs.

EBIOMEDICINE (2022)

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Review Medicine, General & Internal

Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options

Di Liu et al.

Summary: Sepsis is a common complication of combat injuries and trauma, characterized by life-threatening organ dysfunction caused by a dysregulated host response to infection. Immunosuppression, one of the major causes of septic death, can be reversed and host resistance can be established by targeting it.

MILITARY MEDICAL RESEARCH (2022)

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Review Oncology

Exploring the NK cell platform for cancer immunotherapy

Jacob A. Myers et al.

Summary: NK cells have innate potential to kill cancer cells, leading to the development of various NK cell-based therapies for cancer treatment. The main focus of NK cell therapy research is on optimizing sources of therapeutic NK cells and enhancing their cytotoxicity and persistence in the body.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Review Cell & Tissue Engineering

Generating natural killer cells for adoptive transfer: expanding horizons

Soumyadipta Kundu et al.

Summary: NK cells are a unique type of innate lymphoid cells with therapeutic potential in cancer immunotherapy. They can be obtained from various sources and expanded ex vivo for therapeutic use. Developing ex vivo NK cell expansion techniques can lead to higher cell doses and application of genetic engineering methods.

CYTOTHERAPY (2021)

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Article Immunology

The SIRPα-CD47 immune checkpoint in NK cells

Tobias Deuse et al.

Summary: The study reveals that disruption of the SIRP alpha-CD47 immune checkpoint may enhance NK cell antitumor responses, and that elevated CD47 expression may prevent NK cell-mediated killing of allogeneic and xenogeneic tissues.

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Review Oncology

NK cell-based cancer immunotherapy: from basic biology to clinical development

Sizhe Liu et al.

Summary: NK cells, as a specialized immune effector cell type, play a critical role in immune activation against abnormal cells. Unlike T cell activation, NK cell activation is governed by interactions between NK receptors and target cells, leading to significant attention in cancer immunotherapy. Many efforts are focused on developing and engineering NK cell-based cancer immunotherapy.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Review Biochemistry & Molecular Biology

Toll-Like Receptors (TLRs), NOD-Like Receptors (NLRs), and RIG-I-Like Receptors (RLRs) in Innate Immunity. TLRs, NLRs, and RLRs Ligands as Immunotherapeutic Agents for Hematopoietic Diseases

Katarzyna Wicherska-Pawlowska et al.

Summary: The innate immune system recognizes pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) through pattern recognition receptors (PRRs), activating immune cells and initiating inflammatory and immune responses. This system also plays a role in cancer immunosurveillance, with potential for natural and synthetic agonists of PRRs to be used as adjuvants in cancer immunotherapies.

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Article Cell Biology

Cell-Type-Specific Immune Dysregulation in Severely Ill COVID-19 Patients

Changfu Yao et al.

Summary: Recent studies have shown immunologic dysfunction in severely ill patients with COVID-19, particularly in those with ARDS, where defective antigen presentation and interferon responsiveness were observed in monocytes. There was also suppressed cytotoxic activity in NK cells and CD8 T lymphocytes, along with deficient B cell activation, indicating delayed viral clearance in severely ill patients. These findings suggest an immune imbalance in COVID-19 patients with ARDS, potentially contributing to a more severe disease course.

CELL REPORTS (2021)

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Article Biochemistry & Molecular Biology

Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19

Can Liu et al.

Summary: This study longitudinally assessed various factors in single peripheral immune cells of COVID-19 patients and identified primary correlates of disease severity and outcome. Timing was emphasized as crucial in the analysis, clinical monitoring, and therapeutic intervention of COVID-19.

CELL (2021)

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Review Pharmacology & Pharmacy

Key Challenges in Providing Effective Antibiotic Therapy for Critically Ill Patients with Bacterial Sepsis and Septic Shock

Cornelia B. Landersdorfer et al.

Summary: Early initiation of effective antibiotic therapy is essential for critically ill patients with sepsis or septic shock, but current guidelines are lacking. Renal function is a key determinant for achieving the required antibiotic exposure. Model-informed approaches are suggested to individualize treatment regimens and adjust them based on monitoring antibiotic concentrations and other clinical data during treatment.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

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Review Immunology

Biological effects of IL-15 on immune cells and its potential for the treatment of cancer

Shuling Zhang et al.

Summary: IL-15 has emerged as a novel immunomodulatory cytokine in cancer immunotherapy, with the potential to reject and destroy cancer cells by expanding and activating immune cells. Preclinical studies and clinical trials have shown promising outcomes, suggesting a possible future clinical application of IL-15-based therapy in combination with other treatments. Understanding the biological characteristics of IL-15 is crucial for maximizing therapeutic benefits.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Immunology

NK Cell-Derived IL-10 Supports Host Survival during Sepsis

Isaac J. Jensen et al.

Summary: NK cells play a critical role in host survival during sepsis by limiting the scope and duration of the cytokine storm, with NK cell-derived IL-10 being crucial for survival in septic patients. This demonstrates the beneficial regulatory mechanisms of NK cells in controlling systemic inflammation during dysregulated infection-induced inflammatory responses.

JOURNAL OF IMMUNOLOGY (2021)

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Article Immunology

The Inflammatory Factors Associated with Disease Severity to Predict COVID-19 Progression

Wei Huang et al.

Summary: COVID-19 is associated with immune dysregulation and cytokine storm, leading to altered levels of various immune cells and cytokines in the body. Some specific factors could potentially be used as biomarkers for predicting disease severity and progression.

JOURNAL OF IMMUNOLOGY (2021)

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Review Immunology

NK Cells in Autoimmune Diseases: Protective or Pathogenic?

Meifang Liu et al.

Summary: Autoimmune diseases result from the loss of self-tolerance and can be categorized into organ-specific and systemic types. Genetic and environmental factors play a role in autoimmunity development, while innate immunity has been shown to contribute to the onset of autoimmune diseases. NK cells have dual roles in autoimmunity, and their varied effects in different disease contexts suggest their potential as therapeutic targets.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

The Role of Natural Killer Cells in Autoimmune Diseases

Umut Can Kucuksezer et al.

Summary: NK cells are a subset of innate lymphoid cells that play important roles in anti-tumor immune responses and immune regulation, with different subgroups showing cytotoxic functions or cytokine production. Their activation is influenced by a variety of factors, including cell surface receptors and cytokines, and their dysregulation can contribute to various immune-mediated diseases. Further research on NK cell biology and their potential therapeutic applications is necessary for better understanding and treatment of inflammatory disorders.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

Immune Checkpoints: Novel Therapeutic Targets to Attenuate Sepsis-Induced Immunosuppression

Margaret A. McBride et al.

Summary: Sepsis is a leading cause of death in intensive care units, with survivors often experiencing immunosuppression and recurrent infections. Current treatment relies on supportive care and with the increasing incidence of antibiotic-resistant microbes, there is a need to discover novel therapeutics. Studies have shown that specific cell surface inhibitory immune checkpoint receptors and ligands play crucial roles in mediating the balance between host immune competency and immunosuppression in sepsis. Targeting these immune checkpoints may improve host resistance to infection and serve as a means of individualized therapy for septic patients.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

Immune Deregulation in Sepsis and Septic Shock: Reversing Immune Paralysis by Targeting PD-1/PD-L1 Pathway

Yuki Nakamori et al.

Summary: Sepsis is a disease characterized by a dysregulated host response to infection, with both inflammation and immune suppression occurring, and no specific treatment has been validated. The challenge lies in the complexity and heterogeneity of sepsis, requiring the selection of homogenous sepsis subgroups for testing experimental therapies. Artificial intelligence may help in identifying the most suitable subgroup for specific pathway inhibitors.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Nursing

Sepsis

Michael H. Ackerman et al.

CRITICAL CARE NURSING CLINICS OF NORTH AMERICA (2021)

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Review Immunology

Innate Lymphoid Cells and Natural Killer Cells in Bacterial Infections: Function, Dysregulation, and Therapeutic Targets

Noha Mousaad Elemam et al.

Summary: Infectious diseases, particularly bacterial infections, pose a significant global medical challenge, with the innate lymphoid cells (ILCs) playing a crucial role in defense against these infections. However, bacteria have evolved methods to evade the host immune system, leading to infection spread and tissue damage.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Review Immunology

Current Perspectives on Off-The-Shelf Allogeneic NK and CAR-NK Cell Therapies

Erica L. Heipertz et al.

Summary: Natural killer (NK) cells are a crucial part of the immune system, with the ability to kill virally infected and malignant cells. Current research is focused on testing the efficacy of NK cell therapy for cancer and exploring the use of CAR-NK for treatment.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Human NK cells: From development to effector functions.

Arosh Shavinda Perera Molligoda Arachchige

Summary: NK cells, the major lymphocyte subset of the innate immune system, mediate antiviral and anti-tumor responses through natural cytotoxicity, cytokine stimulation, and Ab-dependent cellular cytotoxicity. Research on human NK cells has made significant progress in areas such as ontogeny, maturation, receptor diversity, types of responses, and effector functions.

INNATE IMMUNITY (2021)

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Review Pharmacology & Pharmacy

Targeting Neutrophils in Sepsis: From Mechanism to Translation

Xiaofei Shen et al.

Summary: Sepsis is a life-threatening condition with a lack of specific treatment, and neutrophils play a crucial role during sepsis. Impairment in neutrophil function may lead to inappropriate responses to infection and increased susceptibility to secondary infection. Restoring neutrophil function could promote bacterial clearance and improve sepsis outcome.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Immunology

Natural Killer Cells Generated From Human Induced Pluripotent Stem Cells Mature to CD56brightCD16+NKp80+/- In-Vitro and Express KIR2DL2/DL3 and KIR3DL1

Johanna Euchner et al.

Summary: The study focused on generating CD56(+)CD16(+)CD3(-) NK lymphocytes from hiPSC, and characterized the development of NK cells by examining the surface expression of NK-lineage markers. Through hematopoietic priming, high purity CD56(bright)CD16(-) and CD56(bright)CD16(+) NK cells were efficiently differentiated. The generated NK cells exhibited functional cytotoxicity, degranulation, and antibody-dependent cell-mediated cytotoxicity, confirming their maturity up to stage 4b.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Targeting Cytokines, Pathogen-Associated Molecular Patterns, and Damage-Associated Molecular Patterns in Sepsis via Blood Purification

Kazuhiro Moriyama et al.

Summary: Sepsis is a condition characterized by dysregulated immune response to infections, leading to organ dysfunction and even death. Immune system overactivation, triggered by pathogen-associated molecular patterns binding to pattern recognition receptors, results in cellular dysfunction and inflammatory cytokine elevation. Neutrophils, once antimicrobial protectors, can become mediators of tissue injury and organ dysfunction during sepsis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Parasitology

The role of IL-12 in stimulating NK cells against Toxoplasma gondii infection: a mini-review

Sepideh Mahmoudzadeh et al.

Summary: Natural Killer cells play a crucial protective role during Toxoplasma gondii infection by releasing interferon gamma. Interleukin 12 is a critical cytokine for generating IFN-gamma-producing NK cells, and IL-2 is an important stimulatory factor for NK cells. Factors affecting the stimulation of interleukin-12 production by T. gondii tachyzoites were also discussed in the review.

PARASITOLOGY RESEARCH (2021)

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Review Immunology

The role of natural killer cells in liver inflammation

A. J. Highton et al.

Summary: NK cells are a major immune subset within the liver, playing important roles in the immune responses against hepatotropic viral infections, autoimmune liver diseases, and fatty liver disease. Understanding the involvement of NK cells in liver inflammation is crucial for effective treatment and future immunotherapeutic targeting in these disease settings.

SEMINARS IN IMMUNOPATHOLOGY (2021)

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Article Immunology

A Novel Single Cell RNA-seq Analysis of Non-Myeloid Circulating Cells in Late Sepsis

Dijoia B. Darden et al.

Summary: Late after sepsis, circulating lymphoid cells show a unique transcriptomic pattern reflecting immunosuppression and low-grade inflammation, with differences identified between patients with bacterial and fungal sepsis. This highlights a potential role for precision medicine-guided immunomodulatory therapy in post-sepsis patients with chronic critical illness.

FRONTIERS IN IMMUNOLOGY (2021)

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AI-guided discovery of the invariant host response to viral pandemics

Debashis Sahoo et al.

Summary: The study used an AI-based approach to define the host immune response in viral pandemics, particularly the cytokine storm associated with fatal COVID-19. It found that a specific gene signature could help determine disease severity and set therapeutic goals.

EBIOMEDICINE (2021)

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Article Medicine, Research & Experimental

TIGIT modulates sepsis-induced immune dysregulation in mice with preexisting malignancy

Wenxiao Zhang et al.

Summary: TIGIT is an inhibitory receptor that is upregulated in cancer and contributes to impaired antitumor immunity, but its role in sepsis is unclear. Experiments showed that anti-TIGIT antibody reversed T cell apoptosis in cancer septic mice, leading to significant survival benefits for these patients. This suggests that anti-TIGIT therapy may be a potential immunotherapy to improve outcomes in septic cancer patients.

JCI INSIGHT (2021)

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Review Biochemistry & Molecular Biology

iPSC-Derived Natural Killer Cells for Cancer Immunotherapy

Peter Karagiannis et al.

Summary: The discovery of human pluripotent stem cells (PSCs) has led to the exploration of induced pluripotent stem cells (iPSCs) as a potential universal cell source for therapies, including cancer immunotherapies using natural killer (NK cells). iPSCs offer advantages in quality and flexibility compared to primary NK cells, and there are various protocols for genetic modification and differentiation into NK cells. However, there are challenges that need to be addressed before iPSC-based NK cell immunotherapies can become mainstream in clinical settings.

MOLECULES AND CELLS (2021)

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Article Cell Biology

Integrated immune dynamics define correlates of COVID-19 severity and antibody responses

Marios Koutsakos et al.

Summary: The study found that the immune response in COVID-19 patients differs between the acute phase and convalescent phase, with more severe immune activation and cellular hyperactivation in critically ill patients. The research also revealed the crucial role of activated CXCR3(+)cT(FH)1 cells in predicting antibody levels and neutralization activity.

CELL REPORTS MEDICINE (2021)

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Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis

Marcela Garzon-Tituana et al.

Summary: Granzyme A plays a key role in the inflammatory response during abdominal sepsis and shows potential therapeutic effects for the treatment of this severe pathology. GzmA is mainly expressed by NK cells and influences the expression of proinflammatory mediators IL-6 and TNF alpha.

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Enli Liu et al.

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Martha A. L. Boening et al.

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In Vivo Efficacy of Umbilical Cord Blood Stem Cell-Derived NK Cells in the Treatment of Metastatic Colorectal Cancer

John P. Veluchamy et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Review Immunology

Natural Killer Cell Memory: Progress and Implications

Hui Peng et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Critical Care Medicine

Assessment of Global Incidence and Mortality of Hospital-treated Sepsis

Carolin Fleischmann et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2016)

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Article Medicine, General & Internal

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Mervyn Singer et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

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Article Cell Biology

Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1

Andriani C. Patera et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2016)

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Review Pharmacology & Pharmacy

Immunotherapy: A promising approach to reverse sepsis-induced immunosuppression

Naeem K. Patil et al.

PHARMACOLOGICAL RESEARCH (2016)

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Article Multidisciplinary Sciences

IL-15 Superagonist Expands mCD8+T, NK and NKT Cells after Burn Injury but Fails to Improve Outcome during Burn Wound Infection

Naeem K. Patil et al.

PLOS ONE (2016)

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Article Microbiology

Bacterial Manipulation of NK Cell Regulatory Activity Increases Susceptibility to Listeria monocytogenes Infection

Sarah E. Clark et al.

PLOS PATHOGENS (2016)

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Article Oncology

Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain

Se Jeong Lee et al.

BMC CANCER (2015)

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Review Biochemistry & Molecular Biology

NK cells and interferons

Rossella Paolini et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2015)

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Article Immunology

IL-15 Superagonist-Mediated Immunotoxicity: Role of NK Cells and IFN-γ

Yin Guo et al.

JOURNAL OF IMMUNOLOGY (2015)

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Article Immunology

NK and NKT Cell Depletion Alters the Outcome of Experimental Pneumococcal Pneumonia: Relationship with Regulation of Interferon-γ Production

Eirini Christaki et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2015)

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Review Immunology

NK cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma

Cheng Sun et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2015)

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Article Biochemistry & Molecular Biology

A disturbed interaction with accessory cells upon opportunistic infection with Pseudomonas aeruginosa contributes to an impaired IFN-γ production of NK cells in the lung during sepsis-induced immunosuppression

Eva Pastille et al.

INNATE IMMUNITY (2015)

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Review Medicine, Research & Experimental

A panoramic spectrum of complex interplay between the immune system and IL-32 during pathogenesis of various systemic infections and inflammation

Babar Khawar et al.

EUROPEAN JOURNAL OF MEDICAL RESEARCH (2015)

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Review Oncology

Advantages and clinical applications of natural killer cells in cancer immunotherapy

Erik Ames et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2014)

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Article Immunology

NK Cells with KIR2DS2 Immunogenotype Have a Functional Activation Advantage To Efficiently Kill Glioblastoma and Prolong Animal Survival

Andrea Gras Navarro et al.

JOURNAL OF IMMUNOLOGY (2014)

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Review Cell Biology

Tissue-specific NK cell populations and their origin

Tatyana Lysakova-Devine et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2014)

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Article Cell Biology

NK cells kill mycobacteria directly by releasing perforin and granulysin

Chia-Chen Lu et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2014)

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Article Multidisciplinary Sciences

Tim-3 Negatively Mediates Natural Killer Cell Function in LPS-Induced Endotoxic Shock

Hongyan Hou et al.

PLOS ONE (2014)

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Article Microbiology

HMGB1-Promoted and TLR2/4-Dependent NK Cell Maturation and Activation Take Part in Rotavirus-Induced Murine Biliary Atresia

Yinrong Qiu et al.

PLOS PATHOGENS (2014)

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Article Biology

Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells

Dorothy K. Sojka et al.

ELIFE (2014)

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Article Critical Care Medicine

Immunotherapy for the Adjunctive Treatment of Sepsis: From Immunosuppression to Immunostimulation Time for a Paradigm Change?

Jenneke Leentjens et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)

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Article Immunology

The functional role of natural killer cells early in clinical sepsis

George Giannikopoulos et al.

APMIS (2013)

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Review Medical Laboratory Technology

Biomarkers of sepsis

James D. Faix

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2013)

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Article Cell & Tissue Engineering

Intraperitoneal delivery of human natural killer cells for treatment of ovarian cancer in a mouse xenograft model

Melissa A. Geller et al.

CYTOTHERAPY (2013)

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Article Allergy

Natural killer cell biology: An update and future directions

Kerry S. Campbell et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

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Review Critical Care Medicine

Bench-to-bedside review: Natural killer cells in sepsis - guilty or not guilty?

Fernando Souza-Fonseca-Guimaraes et al.

CRITICAL CARE (2013)

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Article Critical Care Medicine

Regulation of Lymphocyte Trafficking by CXC Chemokine Receptor 3 during Septic Shock

Daniela S. Herzig et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)

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Review Infectious Diseases

The immune response to severe bacterial infections: consequences for therapy

Evangelos J. Giamarellos-Bourboulis et al.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2012)

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Article Immunology

Interleukin-32 enhances cytotoxic effect of natural killer cells to cancer cells via activation of death receptor 3

Mi H. Park et al.

IMMUNOLOGY (2012)

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Review Immunology

IL-12 family cytokines: immunological playmakers

Dario A. A. Vignali et al.

NATURE IMMUNOLOGY (2012)

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Article Critical Care Medicine

NEUTRALIZATION OF IL-10 RESTORES THE DOWNREGULATION OF IL-18 RECEPTOR ON NATURAL KILLER CELLS AND INTERFERON-γ PRODUCTION IN SEPTIC MICE, THUS LEADING TO AN IMPROVED SURVIVAL

Shuichi Hiraki et al.

SHOCK (2012)

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Review Immunology

Activation of Natural Killer cells during microbial infections

Amir Horowitz et al.

FRONTIERS IN IMMUNOLOGY (2012)

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Article Immunology

Natural killer cell distribution and trafficking in human tissues

Paolo Carrega et al.

FRONTIERS IN IMMUNOLOGY (2012)

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Article Critical Care Medicine

Therapeutic efficacy of CXCR3 blockade in an experimental model of severe sepsis

Daniela S. Herzig et al.

CRITICAL CARE (2012)

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Letter Critical Care Medicine

The predictive role of early activation of natural killer cells in septic shock

Raul de Pablo et al.

CRITICAL CARE (2012)

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Article Critical Care Medicine

A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis

Jonathan S. Boomer et al.

CRITICAL CARE (2012)

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Article Critical Care Medicine

The late phase of sepsis is characterized by an increased microbiological burden and death rate

Gordon P. Otto et al.

CRITICAL CARE (2011)

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Article Critical Care Medicine

Early natural killer cell counts in blood predict mortality in severe sepsis

David Andaluz-Ojeda et al.

CRITICAL CARE (2011)

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Review Biochemistry & Molecular Biology

Pattern Recognition Receptors and Inflammation

Osamu Takeuchi et al.

CELL (2010)

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Article Cell Biology

CD16 cross-linking induces increased expression of CD56 and production of IL-12 in peripheral NK cells

Maria-Elena Marquez et al.

CELLULAR IMMUNOLOGY (2010)

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Article Immunology

Murine CXCR3+CD27bright NK cells resemble the human CD56bright NK-cell population

Nicole Marquardt et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2010)

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Article Immunology

IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis

Shigeaki Inoue et al.

JOURNAL OF IMMUNOLOGY (2010)

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Article Immunology

A Role for Granzyme M in TLR4-Driven Inflammation and Endotoxicosis

Desiree A. Anthony et al.

JOURNAL OF IMMUNOLOGY (2010)

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Review Cell Biology

Human defensins and LL-37 in mucosal immunity

Mona Doss et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2010)

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Article Multidisciplinary Sciences

Interleukin-32β Propagates Vascular Inflammation and Exacerbates Sepsis in a Mouse Model

Hanako Kobayashi et al.

PLOS ONE (2010)

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Article Critical Care Medicine

Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection

Charalambos Gogos et al.

CRITICAL CARE (2010)

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Article Hematology

Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity

Petter S. Woll et al.

BLOOD (2009)

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Review Hematology

The phenotypic and functional characteristics of umbilical cord blood and peripheral blood natural killer cells

Michael R. Verneris et al.

BRITISH JOURNAL OF HAEMATOLOGY (2009)

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Article Microbiology

Systemic but Not Local Infections Elicit Immunosuppressive IL-10 Production by Natural Killer Cells

Georgia Perona-Wright et al.

CELL HOST & MICROBE (2009)

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Review Immunology

CD56bright natural killer (NK) cells: an important NK cell subset

Aurelie Poli et al.

IMMUNOLOGY (2009)

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Review Immunology

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress

Luke A. J. O'Neill

IMMUNOLOGICAL REVIEWS (2008)

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Article Immunology

NK cells play a critical protective role in host defense against acute extracellular Staphylococcus aureus bacterial infection in the lung

Cherrie-Lee Small et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Critical Care Medicine

Depletion of NK cells in a murine polytrauma model is associated with improved outcome and a modulation of the inflammatory response

Tanja Barkhausen et al.

SHOCK (2008)

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Article Immunology

Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs

Todd A. Fehniger et al.

IMMUNITY (2007)

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Article Microbiology

Cross-talk with myeloid accessory cells regulates human natural killer cell interferon-γ responses to malaria

Kirsty C. Newman et al.

PLOS PATHOGENS (2006)

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Article Immunology

MyD88-dependent IFN-γ production by NK cells is key for control of Legionella pneumophila infection

R Spörri et al.

JOURNAL OF IMMUNOLOGY (2006)

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Article Physiology

Differential effect of imipenem treatment on wild-type and NK cell-deficient CD8 knockout mice during acute intra-abdominal injury

VT Enoh et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2006)

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Article Critical Care Medicine

Early changes of CD4-positive lymphocytes and NK cells in patients with severe Gram-negative sepsis

Evangelos J. Giamarellos-Bourboulis et al.

CRITICAL CARE (2006)

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Article Immunology

Contribution of natural killer cells to the pathogenesis of septic shock induced by Streptococcus pyogenes in mice

O Goldmann et al.

JOURNAL OF INFECTIOUS DISEASES (2005)

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Article Physiology

β2-microglobulin knockout mice treated with anti-asialoGM1 exhibit improved hemodynamics and cardiac contractile function during acute intra-abdominal sepsis

W Tao et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2004)

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Article Medicine, Research & Experimental

Mice depleted of CD8+ T and NK cells are resistant to injury caused by cecal ligation and puncture

ER Sherwood et al.

LABORATORY INVESTIGATION (2004)

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Article Critical Care Medicine

β2 microglobulin knockout mice are resistant to lethal intraabdominal sepsis

ER Sherwood et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2003)

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Article Immunology

IL-21 in synergy with IL-15 or IL-18 enhances IFN-γ production in human NK and T cells

M Strengell et al.

JOURNAL OF IMMUNOLOGY (2003)

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Article Surgery

Natural killer cells contribute to the lethality of a murine model of Escherichia coli infection

B Badgwell et al.

SURGERY (2002)

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Article Immunology

Granulysin, a T cell product, kills bacteria by altering membrane permeability

WA Ernst et al.

JOURNAL OF IMMUNOLOGY (2000)

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Article Infectious Diseases

Changes in lymphocyte subpopulations and CD3+/DR+ expression in sepsis

M Holub et al.

CLINICAL MICROBIOLOGY AND INFECTION (2000)

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Article Surgery

IL-4-induced activation of the Stat6 pathway contributes to the suppression of cell-mediated immunity and death in sepsis

GY Song et al.

SURGERY (2000)

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