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Advances in the research of the role of macrophage/microglia polarization-mediated inflammatory response in spinal cord injury

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

Quercetin prevents necroptosis of oligodendrocytes by inhibiting macrophages/microglia polarization to M1 phenotype after spinal cord injury in rats

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MSC-secreted TGF-β regulates lipopolysaccharide-stimulated macrophage M2-like polarization via the Akt/FoxO1 pathway

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STEM CELL RESEARCH & THERAPY (2019)

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Exosomes Derived From M2b Macrophages Attenuate DSS-Induced Colitis

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FRONTIERS IN IMMUNOLOGY (2019)

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Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation

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Review Cell Biology

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MicroRNAs in contusion spinal cord injury: pathophysiology and clinical utility

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Long noncoding RNAs: a missing link in osteoporosis

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γdT cells provide the early source of IFN-γ to aggravate lesions in spinal cord injury

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Melatonin improves quality and longevity of chronic neural recording

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Preconditioning influences mesenchymal stem cell properties in vitro and in vivo

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Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3

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Transcriptional Regulation of Macrophages Polarization by MicroRNAs

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Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity

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EBIOMEDICINE (2018)

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Hypoxic preconditioned bone mesenchymal stem cells ameliorate spinal cord injury in rats via improved survival and migration

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INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2018)

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Exosomes Produced from 3D Cultures of MSCs by Tangential Flow Filtration Show Higher Yield and Improved Activity

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Chemokine-Induced Macrophage Polarization in Inflammatory Conditions

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FRONTIERS IN IMMUNOLOGY (2018)

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Preconditioning of bone marrow-derived mesenchymal stem cells highly strengthens their potential to promote IL-6-dependent M2b polarization

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Adipogenic miR-27a in adipose tissue upregulates macrophage activation via inhibiting PPARγ of insulin resistance induced by high-fat diet-associated obesity

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MiR-124 contributes to M2 polarization of microglia and confers brain inflammatory protection via the C/EBP-α, pathway in intracerebral hemorrhage

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Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Attenuates Apoptosis, Inflammation, and Promotes Angiogenesis after Spinal Cord Injury in Rats

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NEUROCHEMICAL RESEARCH (2017)

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PPAR-γ agonist rosiglitazone reduces autophagy and promotes functional recovery in experimental traumaticspinal cord injury

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NEUROSCIENCE LETTERS (2017)

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Effect of modulation of PPAR-γ activity on Kupffer cells M1/M2 polarization in the development of non-alcoholic fatty liver disease

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MicroRNA 26a (miR-26a)/KLF4 and CREB-C/EBPβ regulate innate immune signaling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection

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Mesenchymal Stem Cell-Derived Extracellular Vesicles as Mediators of Anti-Inflammatory Effects: Endorsement of Macrophage Polarization

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NATURE REVIEWS DISEASE PRIMERS (2017)

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IL-4 Drives Microglia and Macrophages Toward a Phenotype Conducive for Tissue Repair and Functional Recovery After Spinal Cord Injury

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MiR-130b promotes obesity associated adipose tissue inflammation and insulin resistance in diabetes mice through alleviating M2 macrophage polarization via repression of PPAR-γ

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IMMUNOLOGY LETTERS (2016)

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Nanoparticle-Delivered IRF5 siRNA Facilitates M1 to M2 Transition, Reduces Demyelination and Neurofilament Loss, and Promotes Functional Recovery After Spinal Cord Injury in Mice

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miR-155 Deletion in Mice Overcomes Neuron-Intrinsic and Neuron-Extrinsic Barriers to Spinal Cord Repair

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NADPH oxidase isoform expression is temporally regulated and may contribute to microglial/macrophage polarization after spinal cord injury

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Reactive astrocytes undergo M1 microglia/macrohpages- induced necroptosis in spinal cord injury

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MOLECULAR NEURODEGENERATION (2016)

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MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response

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SHOCK (2016)

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Reprogramming macrophage orientation by microRNA 146b targeting transcription factor IRF5

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EBIOMEDICINE (2016)

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Silencing MicroRNA-155 Attenuates Cardiac Injury and Dysfunction in Viral Myocarditis via Promotion of M2 Phenotype Polarization of Macrophages

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Donor variability among anti-inflammatory pre-activated mesenchymal stromal cells

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Crucial Role of Lateral Size for Graphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals

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Macrophage silica nanoparticle response is phenotypically dependent

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Endothelial cells suppress monocyte activation through secretion of extracellular vesicles containing antiinflammatory microRNAs

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Astrocytic TYMP and VEGFA drive blood-brain barrier opening in inflammatory central nervous system lesions

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Adoptive transfer of M2 macrophages promotes locomotor recovery in adult rats after spinal cord injury

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Macrophage activation and its role in repair and pathology after spinal cord injury

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CELLULAR AND MOLECULAR LIFE SCIENCES (2015)

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Age decreases macrophage IL-10 expression: Implications for functional recovery and tissue repair in spinal cord injury

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Diffuse and persistent blood-spinal cord barrier disruption after contusive spinal cord injury rapidly recovers following intravenous infusion of bone marrow mesenchymal stem cells

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Myeloid Cell-Derived Reactive Oxygen Species Externally Regulate the Proliferation of Myeloid Progenitors in Emergency Granulopoiesis

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Azithromycin drives alternative macrophage activation and improves recovery and tissue sparing in contusion spinal cord injury

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Temporal kinetics of macrophage polarization in the injured rat spinal cord

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Soy Isoflavones Promote Radioprotection of Normal Lung Tissue by Inhibition of Radiation-Induced-Activation-of Macrophages-and-Neutrophils

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Neurotrauma and Inflammation: CNS and PNS Responses

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MEDIATORS OF INFLAMMATION (2015)

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miR-130a regulates macrophage polarization and is associated with non-small cell lung cancer

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ONCOLOGY REPORTS (2015)

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Hypoxia Precondition Promotes Adipose-Derived Mesenchymal Stem Cells Based Repair of Diabetic Erectile Dysfunction via Augmenting Angiogenesis and Neuroprotection

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miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program

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NATURE COMMUNICATIONS (2015)

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Mesenchymal Stromal Cells Affect Disease Outcomes via Macrophage Polarization

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STEM CELLS INTERNATIONAL (2015)

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Microglial and macrophage polarization -new prospects for brain repair

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NATURE REVIEWS NEUROLOGY (2015)

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MicroRNA 21 Is a Homeostatic Regulator of Macrophage Polarization and Prevents Prostaglandin E2-Mediated M2 Generation

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Regulation of IL-4 Receptor Signaling by STUB1 in Lung Inflammation

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AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)

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The effect of inflammatory cell-derived MCP-1 loss on neuronal survival during chronic neuroinflammation

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BIOMATERIALS (2014)

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Early administration of tumor necrosis factor-alpha antagonist promotes survival of transplanted neural stem cells and axon myelination after spinal cord injury in rats

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BRAIN RESEARCH (2014)

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CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease

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JOURNAL OF CLINICAL INVESTIGATION (2014)

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Review Immunology

Neutrophil contribution to spinal cord injury and repair

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MiR-146b is a regulator of human visceral preadipocyte proliferation and differentiation and its expression is altered in human obesity

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MOLECULAR AND CELLULAR ENDOCRINOLOGY (2014)

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Transcriptomic Profiling of the Development of the Inflammatory Response in Human Monocytes In Vitro

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PLOS ONE (2014)

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TRENDS IN NEUROSCIENCES (2014)

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Human Bone Marrow-Derived Mesenchymal Stem Cells Display Enhanced Clonogenicity but Impaired Differentiation With Hypoxic Preconditioning

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STEM CELLS TRANSLATIONAL MEDICINE (2014)

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CLINICAL EPIDEMIOLOGY (2014)

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An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD

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Angiogenic capacity of M1-and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9

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ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages

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CELL RESEARCH (2013)

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MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines

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CELL RESEARCH (2013)

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MicroRNA in Cardiovascular Calcification Focus on Targets and Extracellular Vesicle Delivery Mechanisms

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IL-17-Mediated M1/M2 Macrophage Alteration Contributes to Pathogenesis of Bisphosphonate-Related Osteonecrosis of the Jaws

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Late blocking of peripheral TNF-α is ineffective after spinal cord injury in mice

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Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function

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MicroRNA let-7c Regulates Macrophage Polarization

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M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

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NATURE NEUROSCIENCE (2013)

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Effect of Infliximab Combined With Methylprednisolone on Expressions of NF-κB, TRADD, and FADD in Rat Acute Spinal Cord Injury

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SPINE (2013)

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Review Neurosciences

Managing Inflammation after Spinal Cord Injury through Manipulation of Macrophage Function

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NEURAL PLASTICITY (2013)

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MiR-34a inhibits lipopolysaccharide-induced inflammatory response through targeting Notch1 in murine macrophages

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EXPERIMENTAL CELL RESEARCH (2012)

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MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages

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JOURNAL OF CLINICAL INVESTIGATION (2012)

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Blockade of interleukin-6 signaling inhibits the classic pathway and promotes an alternative pathway of macrophage activation after spinal cord injury in mice

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JOURNAL OF NEUROINFLAMMATION (2012)

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Transplantation of Mesenchymal Stem Cells Promotes an Alternative Pathway of Macrophage Activation and Functional Recovery after Spinal Cord Injury

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Human MSC Suppression Correlates With Cytokine Induction of Indoleamine 2,3-Dioxygenase and Bystander M2 Macrophage Differentiation

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MOLECULAR THERAPY (2012)

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Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

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NATURE IMMUNOLOGY (2012)

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Inducible MicroRNA-223 Down-Regulation Promotes TLR-Triggered IL-6 and IL-1β Production in Macrophages by Targeting STAT3

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PLOS ONE (2012)

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Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Adoptive transfer of Th1-conditioned lymphocytes promotes axonal remodeling and functional recovery after spinal cord injury

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CELL DEATH & DISEASE (2012)

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MicroRNA-125b Potentiates Macrophage Activation

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JOURNAL OF IMMUNOLOGY (2011)

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Obstacles and opportunities for understanding macrophage polarization

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JOURNAL OF LEUKOCYTE BIOLOGY (2011)

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Deficient CX3CR1 Signaling Promotes Recovery after Mouse Spinal Cord Injury by Limiting the Recruitment and Activation of Ly6Clo/iNOS+ Macrophages

Dustin J. Donnelly et al.

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Repertoire of microglial and macrophage responses after spinal cord injury

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NATURE REVIEWS NEUROSCIENCE (2011)

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Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment

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BRAIN (2010)

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Review Biochemistry & Molecular Biology

Macrophage Diversity Enhances Tumor Progression and Metastasis

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CELL (2010)

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MicroRNA-27b Contributes to Lipopolysaccharide-mediated Peroxisome Proliferator-activated Receptor γ (PPARγ) mRNA Destabilization

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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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Pro-Inflammatory Cytokines, IFNγ and TNFα, Influence Immune Properties of Human Bone Marrow and Wharton Jelly Mesenchymal Stem Cells Differentially

S. Jyothi Prasanna et al.

PLOS ONE (2010)

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Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

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SCIENCE (2010)

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The PPAR gamma agonist Pioglitazone improves anatomical and locomotor recovery after rodent spinal cord injury

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EXPERIMENTAL NEUROLOGY (2007)

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Review Immunology

Astrocytes are active players in cerebral innate immunity

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TRENDS IN IMMUNOLOGY (2007)

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15d-prostaglandin J2 activates peroxisome proliferator-activated receptor-γ, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats

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JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2006)

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Letter Immunology

Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells

G Raes et al.

JOURNAL OF IMMUNOLOGY (2005)

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Bone marrow chimeric rats reveal the unique distribution of resident and recruited macrophages in the contused rat spinal cord

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