4.8 Article

Advances in the research of the role of macrophage/microglia polarization-mediated inflammatory response in spinal cord injury

期刊

FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.1014013

关键词

macrophages; spinal cord injury; polarization; inflammatory response; miRNA; mesenchymal stem cells; microglia

资金

  1. National Natural Science Foundation of China
  2. Guizhou Provincical Science and Technology Foundation
  3. [81960299]
  4. [1Y324]

向作者/读者索取更多资源

Regulating macrophage/microglia polarization, particularly from an M1 to M2 phenotype, is crucial for the regression of inflammation and tissue repair following spinal cord injury (SCI). Understanding the role of the inflammatory response and macrophages/microglia in SCI and repair can provide insights into potential therapeutic strategies for SCI.
It is often difficult to regain neurological function following spinal cord injury (SCI). Neuroinflammation is thought to be responsible for this failure. Regulating the inflammatory response post-SCI may contribute to the recovery of neurological function. Over the past few decades, studies have found that macrophages/microglia are one of the primary effector cells in the inflammatory response following SCI. Growing evidence has documented that macrophages/microglia are plastic cells that can polarize in response to microenvironmental signals into M1 and M2 macrophages/microglia. M1 produces pro-inflammatory cytokines to induce inflammation and worsen tissue damage, while M2 has anti-inflammatory activities in wound healing and tissue regeneration. Recent studies have indicated that the transition from the M1 to the M2 phenotype of macrophage/microglia supports the regression of inflammation and tissue repair. Here, we will review the role of the inflammatory response and macrophages/microglia in SCI and repair. In addition, we will discuss potential molecular mechanisms that induce macrophage/microglia polarization, with emphasis on neuroprotective therapies that modulate macrophage/microglia polarization, which will provide new insights into therapeutic strategies for SCI.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据