☆ 4.8 Review

Exosomes: A potential tool for immunotherapy of ovarian cancer

FRONTIERS IN IMMUNOLOGY (2023)

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Article Obstetrics & Gynecology

Evaluation of circulating microRNAs as non-invasive biomarkers in the diagnosis of ovarian cancer: a case-control study

Kai Berner et al.

Summary: Ovarian cancer is a significant global health issue, with a high mortality rate. This study focused on identifying potential biomarkers for early detection of ovarian cancer by analyzing microRNA expression levels in different cell lines and urine samples. The results showed promise for using specific microRNAs as circulating biomarkers in liquid biopsies for ovarian cancer detection.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Preclinical evaluation of [99mTc]Tc-labeled anti-EpCAM nanobody for EpCAM receptor expression imaging by immuno-SPECT/CT

Tianyu Liu et al.

Summary: In this study, a site-specifically labeled EpCAM-targeted nanobody was synthesized and evaluated for the noninvasive imaging of EpCAM expression using SPECT/CT. The results showed high EpCAM specificity and the potential for clinical translation.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

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Article Chemistry, Multidisciplinary

Potential Application of Exosomes in Vaccine Development and Delivery

Md Nurul Huda et al.

Summary: This review summarizes the crucial role of exosomes in immune modulation, cell-cell communication, and disease progression, and discusses the potential of exosomes as vaccine delivery vehicles.

PHARMACEUTICAL RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Dynamic metabolic change of cancer cells induced by natural killer cells at the single-cell level studied by label-free mass cytometry

Zizheng Shen et al.

Summary: This study used label-free mass cytometry to analyze the metabolites in human hepatocellular carcinoma cells at the single-cell level after interaction with NK cells. Several metabolites and metabolic pathways were identified to be involved in cell apoptosis, providing new insights into the heterogeneity of cell apoptosis and evaluating the cytotoxicity of NK cells.

CHEMICAL SCIENCE (2022)

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Article Immunology

Development of a Dendritic Cell/Tumor Cell Fusion Cell Membrane Nano-Vaccine for the Treatment of Ovarian Cancer

Lei Zhang et al.

Summary: A new tumor vaccine, FCM-NPs, was developed by fusing DCs and OC cells and coating them onto nanoparticles, showing promising results in promoting immune responses and inhibiting tumor metastasis.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Multidisciplinary Sciences

Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy

Jiahui Zhang et al.

Summary: In this study, it was found that neutrophil-derived exosomes (N-Ex) can induce tumor cell apoptosis by delivering cytotoxic proteins and activating caspase signaling pathway. By decorating N-Ex with superparamagnetic iron oxide nanoparticles (SPIONs), a higher tumor-targeting therapeutic effect can be achieved. Moreover, exosome-like nanovesicles (NNVs) were fabricated with high yield. Compared to liposome-loaded doxorubicin (DOX) and natural NNVs, DOX-loaded NNVs showed improved inhibition of tumor cell proliferation. Additionally, DOX-loaded, SPION-decorated NNVs selectively accumulated at tumor sites under an external magnetic field, effectively restraining tumor growth and significantly prolonging survival rate in mice.

SCIENCE ADVANCES (2022)

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Article Oncology

Immunotherapy for Colorectal Cancer: Mechanisms and Predictive Biomarkers

Lindsey Carlsen et al.

Summary: This review discusses preclinical and clinical studies on immunotherapy for colorectal cancer, including various treatment methods and predictive biomarkers for treatment response. Despite certain limitations, immunotherapy provides hope for improving patient outcomes and quality of life.

CANCERS (2022)

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Review Cell Biology

Exosome as a Delivery Vehicle for Cancer Therapy

Bohyun Moon et al.

Summary: Exosomes are naturally produced extracellular vesicles that have the potential to serve as effective delivery vehicles for cancer therapy, improving drug selectivity and stability.

CELLS (2022)

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Review Pharmacology & Pharmacy

Exosomes in cancer immunoediting and immunotherapy

Yarong Zhao et al.

Summary: As an important means of communication among cells, exosomes are increasingly studied, especially in the context of cancer immunotherapy. Exosomes derived from tumor cells and different immune cells have complex and changeable physiological functions due to carrying different proteins and nucleic acids from the source cells. Based on the role of exosomes in intercellular communication, cancer treatment methods are continuously being researched. This review briefly introduces the molecular composition of exosomes and its secretion mechanism, summarizes the role of exosomes encapsulating different information molecules, and provides a detailed introduction to the role of exosomes in the three phases of tumor immunoediting and the relevant literature of exosomes in the tumor immune microenvironment.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

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Review Oncology

Role of Exosomes in Immune Microenvironment of Hepatocellular Carcinoma

Xiaojing Chen et al.

Summary: This paper reviews the multiple roles of tumor-associated exosomes in the progression of HCC, with a particular focus on how exosomes regulate the tumor immune microenvironment (TIME) and how exosomal cargos affect the progression of HCC.

JOURNAL OF ONCOLOGY (2022)

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Article Cell Biology

Impact on NK cell functions of acute versus chronic exposure to extracellular vesicle-associated MICA: Dual role in cancer immunosurveillance

Elisabetta Vulpis et al.

Summary: This study investigated the immunomodulatory properties of the NKG2D ligand MICA*008 associated with different populations of extracellular vesicles (sEVs and mEVs). The results showed that MICA*008 is present on both vesicle populations, and NKG2D is involved in the uptake of vesicles expressing its cognate ligand. MICA*008-expressing sEVs and mEVs can activate NK cells, but prolonged stimulation leads to NKG2D downmodulation and impaired NKG2D-mediated functions. Additionally, MICA*008 can be transferred by vesicles to NK cells, causing fratricide. The accumulation of NKG2D ligands associated with vesicles in the tumor microenvironment may suppress NK cell activity.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

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Review Cell Biology

Exosomes as Drug Carriers in Anti-Cancer Therapy

Lan Chen et al.

Summary: Exosomes as potential drug carriers in cancer therapy have attracted a high demand, but their development still faces challenges. This article summarizes the current applications of exosomes derived from different cells as drug carriers in anti-cancer therapy in vitro and in vivo, and discusses the challenges and prospects of exosome-based drug delivery systems in cancer therapy.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Immunology

Neoantigen Cancer Vaccines: Generation, Optimization, and Therapeutic Targeting Strategies

Carson R. Reynolds et al.

Summary: Neoantigen-based immunotherapeutic approaches have become an effective and highly tolerable therapeutic option in the rapidly evolving field of cancer treatment.

VACCINES (2022)

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Review Biochemistry & Molecular Biology

Tumor-Derived Extracellular Vesicles Regulate Cancer Progression in the Tumor Microenvironment

Qianqian Bao et al.

Summary: Extracellular vesicles (EVs) are nanosized particles released by cells, which play an important role in cell-to-cell communication and disease diagnosis and treatment. They contain various biomolecules and can transmit functional molecules between cells, influencing the tumor microenvironment. Tumor-derived EVs have significant effects on cell function, drug resistance, and immune response in tumor progression.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Review Oncology

Current Perspectives on the Unique Roles of Exosomes in Drug Resistance of Hepatocellular Carcinoma

Dongdong Xue et al.

Summary: This review summarizes and discusses the underlying relationship between exosomes and drug resistance in HCC, and suggests that exosomes may serve as candidate biomarkers for predicting and monitoring drug responses, as well as potential targets or vectors to reverse drug resistance in HCC.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2022)

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Article Chemistry, Medicinal

In vitro evaluation of the pogostone effects on the expression of PTEN and DACT1 tumor suppressor genes, cell cycle, and apoptosis in ovarian cancer cell line

Mansour Homayoun et al.

Summary: The study showed that pogostone can inhibit cell proliferation and increase apoptosis rate in ovarian cancer cell lines. By inducing the expression of specific genes and regulating the activity of related genes, pogostone exerts anti-cancer effects.

RESEARCH IN PHARMACEUTICAL SCIENCES (2022)

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Article Obstetrics & Gynecology

Serum exosomal miRNA from endometriosis patients correlates with disease severity

Yahong Wu et al.

Summary: The study compared the miRNA expression profile of serum exosomes from women with endometriosis to normal controls, revealing 26 up-regulated and 19 down-regulated genes in endometriosis patients. These differentially expressed miRNAs are mainly involved in the regulation of cellular development, metabolism, and the MAPK and PI3k-Akt pathways. Further analysis indicates that these miRNAs in serum exosomes may play a role in the pathogenesis of endometriosis and are associated with the severity and certain symptoms of the disease.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2022)

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Review Chemistry, Medicinal

Function and therapeutic development of exosomes for cancer therapy

Sang Bum Kim

Summary: Exosomes are extracellular vesicles containing intracellular components that play a significant role in intercellular communication and the tumor microenvironment. They have been extensively studied for their involvement in immune control and cancer development. Researchers are developing exosome-related drugs, including inhibitors of exosomal release and engineered exosomes, to target cancer.

ARCHIVES OF PHARMACAL RESEARCH (2022)

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Article Biophysics

Three-dimensional hierarchical plasmonic nano-architecture based label-free surface-enhanced Raman spectroscopy detection of urinary exosomal miRNA for clinical diagnosis of prostate cancer

Woo Hyun Kim et al.

Summary: Urinary exosomal miRNAs have emerged as valuable biomarkers for early-stage diagnosis and prognosis of prostate cancer due to their non-invasiveness, stability, and representation of cell status. However, developing an accurate detection method for urinary exosomal miRNAs is challenging due to their low abundance and sequence homology. In this study, a label-free miRNA sensing platform using surface-enhanced Raman scattering (SERS) was developed, based on a three-dimensional hierarchical plasmonic nano-architecture, for the detection of urinary exosomal miRNAs. Clinical validation using urinary samples demonstrated that the SERS sensor achieved high diagnostic accuracy for distinguishing prostate cancer patients from healthy controls based on differential expression of urinary exosomal miRNAs. This study highlights the potential of the SERS sensor for facile and accurate measurement of miRNA expression and its importance in disease diagnosis.

BIOSENSORS & BIOELECTRONICS (2022)

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Review Oncology

Emerging role of circular RNAs in the pathogenesis of ovarian cancer

Soudeh Ghafouri-Fard et al.

Summary: Circular RNAs (circRNAs) play a crucial role in the evolution and progression of ovarian cancer, serving as potential tumor markers and regulators of cancer cell metastasis and chemoresistance.

CANCER CELL INTERNATIONAL (2022)

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Review Oncology

Exosomes reveal the dual nature of radiotherapy in tumor immunology

Xinru Hu et al.

Summary: This review explores the dual effects of radiotherapy on the immune system and the role of exosomes in mediating these effects. It discusses how radiation-induced changes in exosomes can either inhibit or activate the immune system, leading to immunosuppression or immune clearance. By analyzing the relationship between exosome-derived molecules and immunity, this review sheds light on the potential of using exosomes to improve the treatment and prognosis of cancer patients.

CANCER SCIENCE (2022)

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Review Genetics & Heredity

Unleashing the power of NK cells in anticancer immunotherapy

Meike Vogler et al.

Summary: NK cells play a crucial role in cancer treatment, with their killing capacity determined by signals between NK cells and targeted tumor cells. Combining NK cell therapy with other agents can enhance therapeutic efficacy.

JOURNAL OF MOLECULAR MEDICINE-JMM (2022)

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Article Biochemistry & Molecular Biology

Isolation of Platelet-Derived Exosomes from Human Platelet-Rich Plasma: Biochemical and Morphological Characterization

Miquel Saumell-Esnaola et al.

Summary: This study explored the molecular and morphological characteristics of platelet-derived exosomes and validated a method for isolating highly pure platelet exosomes. It was found that activated platelets released more exosomes, which exhibited the molecular and morphological features of platelet exosomes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Medicine, Research & Experimental

Roles and clinical application of exosomal circRNAs in the diagnosis and treatment of malignant tumors

Dong Ye et al.

Summary: Exosomal circRNAs are nucleic acid molecules found in microvesicles secreted by cells, playing important roles in intercellular communication and gene expression regulation. They can modulate tumor growth and metastasis in tumors and can be used as biomarkers for tumor diagnosis and treatment.

JOURNAL OF TRANSLATIONAL MEDICINE (2022)

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Review Biochemistry & Molecular Biology

Potential clinical utility of liquid biopsies in ovarian cancer

Jie Wei Zhu et al.

Summary: Liquid biopsy, a novel sampling method analyzing tumor components in the peripheral circulation, has the potential to improve the clinical management of ovarian cancer by enabling early diagnosis, predicting prognosis, detecting recurrence, and monitoring treatment response. Its advantages include non-invasiveness, feasibility, and the ability to capture dynamic tumor changes over time.

MOLECULAR CANCER (2022)

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Review Immunology

Hypoxia Induced Changes of Exosome Cargo and Subsequent Biological Effects

Hongxia Jiang et al.

Summary: Exosomes are small vesicles that mediate intercellular communication by transferring various components. Hypoxia influences the content and effects of exosomes. Hypoxic exosomes derived from tumor cells lead to different biological effects depending on the recipient units. Understanding the characteristics of hypoxic exosomes provides new insight into the pathogenesis of hypoxia-related diseases.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

CAR-T Cell Performance: How to Improve Their Persistence?

Gina Lopez-Cantillo et al.

Summary: CAR-T cell therapy has shown great success in treating hematological neoplasms, but its effectiveness in solid tumors is limited. Strategies to improve CAR-T cell persistence, function, and anti-tumor activity are being studied, including cell culture optimization, modulation of cell metabolism, and manipulation of signaling pathways involved in T-cell differentiation.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Oncology

Nucleic acids and proteins carried by exosomes of different origins as potential biomarkers for gynecologic cancers

Miaomiao Ye et al.

Summary: This review focuses on the potential roles of exosomes in gynecologic cancers, particularly their regulatory functions of non-coding RNAs in carcinogenesis. Investigating the applications of exosomes in cancer diagnosis and prediction can help uncover the molecular mechanisms of cancer development.

MOLECULAR THERAPY-ONCOLYTICS (2022)

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Article Cell Biology

T Lymphocyte and CAR-T Cell-Derived Extracellular Vesicles and Their Applications in Cancer Therapy

Victor Calvo et al.

Summary: Extracellular vesicles (EV) are diverse cell-derived vesicles that participate in intercellular communication and cargo delivery. Specific EV released by certain cells can be used for cell-free, EV-dependent cancer therapy.

CELLS (2022)

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Article Cell Biology

The Role of Exosomes in Inflammatory Diseases and Tumor-Related Inflammation

Yuan Tian et al.

Summary: Inflammation plays a crucial role in tumorigenesis and tumor development, and exosomes have been found to regulate inflammatory processes and tumor-related inflammation. This review focuses on the functions of exosomes in modulating the inflammatory microenvironment and discusses their potential as targets and tools for treating inflammation-related diseases and tumor-related inflammation.

CELLS (2022)

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Review Oncology

Nano Drug Delivery System for Tumor Immunotherapy: Next-Generation Therapeutics

Lili Zhou et al.

Summary: Tumor immunotherapy is a powerful strategy for treating cancer by stimulating the immune system. However, the heterogeneity of tumors and immunosuppressive microenvironment make it difficult for immunotherapy to be effective. With the advancements in materials science and nanotechnology, innovative biomaterials and drug delivery systems can enhance the effectiveness of immunotherapy.

FRONTIERS IN ONCOLOGY (2022)

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Review Cell Biology

Key Players of the Immunosuppressive Tumor Microenvironment and Emerging Therapeutic Strategies

Kevin Park et al.

Summary: The tumor microenvironment is a battlefield for immune cells and tumor cells, and immune checkpoint inhibitors have shown promise in cancer treatment. However, response rates are low and resistance is common. Understanding the tumor microenvironment is crucial for developing strategies to overcome resistance, and ongoing clinical trials are investigating combination treatments targeting specific tumor and microenvironment characteristics.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Cell Biology

Molecular Characterization Clinical and Immunotherapeutic Characteristics of m5C Regulator NOP2 Across 33 Cancer Types

Taisheng Liu et al.

Summary: This study comprehensively explored the clinical and immunotherapeutic values of NOP2 in cancers. The results showed that NOP2 was upregulated in most cancers and was closely associated with poor prognosis and immunotherapy inactivation.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Health Care Sciences & Services

Comparison of Human Urinary Exosomes Isolated via Ultracentrifugation Alone versus Ultracentrifugation Followed by SEC Column-Purification

Kun Huang et al.

Summary: This study compared two methods, ultracentrifugation and size exclusion chromatography, for isolating exosomes from urine. The findings showed that exosomes isolated using size exclusion chromatography had higher levels of exosome-positive marker and no detectable contamination, indicating that this method is effective for collecting contaminant-free human urinary exosomes.

JOURNAL OF PERSONALIZED MEDICINE (2022)

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Review Biochemistry & Molecular Biology

Current Knowledge on Exosome Biogenesis, Cargo-Sorting Mechanism and Therapeutic Implications

Shenmin Xie et al.

Summary: Extracellular vesicles, specifically exosomes, are nanoscale membrane vesicles released by cells and have the potential to uncover unknown cellular and molecular mechanisms in intercellular communication and disease. They are effective drug delivery systems and display complexity in their formation, release, and bioengineering.

MEMBRANES (2022)

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Article Medicine, General & Internal

Exosome-Derived miRNAs as Potential Biomarkers for Prostate Bone Metastasis

Zhenquan Lu et al.

Summary: The study aimed to identify potential exosome-derived miRNAs related to prostate cancer bone metastasis. Two datasets were collected and analyzed to identify differentially expressed miRNAs. The study identified four miRNAs that may serve as biomarkers for prostate cancer bone metastasis. However, further research is needed to understand the role of these miRNAs in the development and progression of bone metastasis in prostate cancer.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2022)

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Article Surgery

Expression of Enhancer-Binding Protein CEBPA mRNA and Protein in Ovarian Cancer and Its Relationship With Pathobiological Characteristics

Shufang Mi et al.

Summary: Ovarian cancer is difficult to diagnose early due to its hidden onset and lack of specific symptoms. The expression of CEBPA in patients with ovarian borderline tumor and ovarian cancer is high, and its high expression is valuable for the diagnosis of ovarian cancer and is also a poor prognostic factor.

FRONTIERS IN SURGERY (2022)

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Article Biochemistry & Molecular Biology

Exosomal RNAs in diagnosis and therapies

Pranay Narang et al.

Summary: The field of extracellular vesicles, particularly exosomes, has been rapidly advancing. Exosomes, ranging from 40 to 160 nm in diameter, are released by most cells in the body and carry molecules that reflect their cell of origin. Of particular importance are the various RNA molecules found in exosomes, which have been linked to regulating biological processes and diseases in the central nervous system, cardiovascular system, metabolism, cancer, and immune system. Furthermore, exosomes also show potential as therapeutic agents for tissue regeneration and conditions resulting from excessive inflammation. Further research is needed to fully understand exosome formation, their biological effects, and their potential as biomarkers and therapeutics.

NON-CODING RNA RESEARCH (2022)

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Article

Progress of exosome research in systemic lupus erythematosus

Jie Shen et al.

Cytokine: X (2022)

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Article Pharmacology & Pharmacy

Extracellular vesicles: emerging anti-cancer drugs and advanced functionalization platforms for cancer therapy

Manling Wu et al.

Summary: Increasing evidence shows that unmodified extracellular vesicles (EVs) can effectively inhibit the malignant progression of different types of tumors by delivering bioactive molecules, making them a promising emerging anticancer drug. Researchers are actively exploring ways to engineer EVs as a translational therapy platform, broadening their therapeutic capability and enhancing specificity and effectiveness through targeted modifications. This review focuses on the latest research progress of functionalized EVs and highlights their superior biological functions and therapeutic potential, aiming to inspire new design concepts and develop next-generation nanomedicine therapeutic platforms.

DRUG DELIVERY (2022)

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Review Oncology

Roles of small extracellular vesicles in the development, diagnosis and possible treatment strategies for hepatocellular carcinoma (Review)

Shuyue Yang et al.

Summary: sEVs, small extracellular vesicles, play a role in intercellular communication and have been implicated in the initiation and progression of hepatocellular carcinoma (HCC). They have the potential to be used for diagnosis and targeted drug delivery in HCC treatment.

INTERNATIONAL JOURNAL OF ONCOLOGY (2022)

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Review Gastroenterology & Hepatology

Gastric cancer and genomics: review of literature

Takumi Onoyama et al.

Summary: Gastric cancer is a major health concern, and genomics has become an indispensable tool for its treatment. Genomics can help identify new therapeutic targets and provide personalized treatment for patients. Additionally, genomics can predict the anti-tumor effects of immune checkpoint inhibitors and select suitable patients for treatment. Liquid biopsy analysis is also helpful in predicting the genomic status of gastric cancer.

JOURNAL OF GASTROENTEROLOGY (2022)

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Article Oncology

Exosomes: Insights and therapeutic applications in cancer

Anita Raj Panigrahi et al.

Summary: Cancer is a disease characterized by the uncontrolled division of abnormal cells, and it is the second leading cause of death worldwide. Engineered exosomes, as messengers between cells, can be used as drug delivery vehicles to achieve targeted treatment.

TRANSLATIONAL ONCOLOGY (2022)

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Correction Cell Biology

Tumor-associated macrophage-derived exosomes transmitting miR-193a-5p promote the progression of renal cell carcinoma via TIMP2-dependent vasculogenic mimicry (vol 13, 382, 2022)

Qing Liu et al.

CELL DEATH & DISEASE (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

A predictive model for recurrence after upfront surgery in patients with resectable pancreatic ductal adenocarcinoma (PDAC) by using preoperative clinical data and CT characteristics

Ningzi Tian et al.

Summary: A predictive model based on preoperative clinical data and CT characteristics was developed to estimate recurrence risk in patients with resectable pancreatic ductal adenocarcinoma (PDAC) after upfront surgery. The model showed good discrimination capability and may aid clinicians in selecting optimal candidates for treatment.

BMC MEDICAL IMAGING (2022)

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Review Immunology

The Effect of Hypoxia-Induced Exosomes on Anti-Tumor Immunity and Its Implication for Immunotherapy

Wenwen Guo et al.

Summary: Hypoxia is a critical feature of solid tumors, which can promote tumorigenesis and progression. One of the mechanisms by which hypoxia promotes tumor growth is through affecting the secretion of exosomes, which are extracellular vesicles involved in various cellular processes. Hypoxia-induced exosome alterations not only exist in tumor cells, but also in other cells within the tumor microenvironment, and these altered exosomes have been found to negatively regulate anti-tumor immune responses.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

Potentiality of Exosomal Proteins as Novel Cancer Biomarkers for Liquid Biopsy

Chunmiao Hu et al.

Summary: Liquid biopsy, with its non-invasive and real-time sampling advantages, has rapidly developed in cancer prognosis and diagnosis. Exosomes, nanosized extracellular vesicles, carry diverse cargos and transmit regulatory signals. Exosomal proteins and some nucleic acids can be used as targets for exosome isolation and potential diagnostic markers in liquid biopsy.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Oncology

Effect of Exosomes from Patients with Grade One Cervical Intraepithelial Neoplasia on Cell Cultures: A Preliminary Study

Luz Eugenia Alcantara-Quintana et al.

Summary: This study examined the effect of exosomes obtained from self-taken vaginal samples on the viability of HeLa cells. It found that exosomes have a protective effect on cells from patients without injury, but promote cell viability in injured patients. This suggests that exosomes can potentially serve as biomarkers for the early diagnosis of cervical cancer and as a treatment option.

CANCER MANAGEMENT AND RESEARCH (2022)

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Review Oncology

Effects of Exosomal Viral Components on the Tumor Microenvironment

Jing Li et al.

Summary: Oncogenic viral infection can affect the tumor microenvironment through exosomes, promoting tumor progression. Exosomes are extracellular membrane vesicles that contain lipids, nucleic acids, and proteins, and they can exchange information between cells. Many studies have shown that various tumor-associated viruses can exert their biological functions through exosomes.

CANCERS (2022)

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Review Cell Biology

Biological Features of Extracellular Vesicles and Challenges

Ye Zeng et al.

Summary: Extracellular vesicles (EVs) are lipid bilayer membrane vesicles containing DNA, RNA, lipids and proteins, which play important roles in the pathophysiological processes of various diseases. This study discusses the advantages of EVs and the challenges associated with their application, proposing solutions to facilitate their clinical use.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Veterinary Sciences

Association of Systemic Inflammatory and Immune Indices With Survival in Canine Patients With Oral Melanoma, Treated With Experimental Immunotherapy Alone or Experimental Immunotherapy Plus Metronomic Chemotherapy

Jessica Soares Garcia et al.

Summary: This study aimed to evaluate the impact of inflammatory indices in dogs with oral melanoma before treatment. The results suggest that CRP/ALB ratio and frequency of circulating Tregs may serve as potential prognostic markers in canine patients with oral melanoma.

FRONTIERS IN VETERINARY SCIENCE (2022)

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Review Chemistry, Medicinal

Tumor-Derived Membrane Vesicles: A Promising Tool for Personalized Immunotherapy

Jiabin Xu et al.

Summary: Tumor-derived membrane vesicles (TDMVs) are non-invasive, chemotactic, and easily obtained, containing various tumor-derived substances. They are widely used in drug loading, membrane fusion, and vaccine preparation. Personalized vectors prepared using editable properties of cells can aid in designing personalized vaccines. This review focuses on recent research on TDMV technology and its application in personalized immunotherapy, highlighting the strengths and challenges of TDMVs for their transition from theory to clinical practice.

PHARMACEUTICALS (2022)

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Article Immunology

Natural killer cell-related prognosis signature characterizes immune landscape and predicts prognosis of HNSCC

Hao Chi et al.

Summary: This study established a reliable signature based on genes related to NK cells in HNSCC, providing a new perspective for assessing immunotherapy response and prognosis. The 17-NRGs signature demonstrated excellent predictive performance and offered new perspectives for evaluating pre-immune efficacy, facilitating future precision immuno-oncology research.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

IL-7: A promising adjuvant ensuring effective T cell responses and memory in combination with cancer vaccines?

Yue Zhao et al.

Summary: Cancer vaccines have shown specificity, effectiveness, and safety as an alternative immunotherapeutic strategy. However, maintaining long-term immune memory, especially T cell memory, after vaccination is still a challenge. IL-7, as an adjuvant, has potential in the development of cancer vaccines.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Medicine, General & Internal

Antibody-mediated allograft rejection is associated with an increase in peripheral differentiated CD28-CD8

Hoa Le Mai et al.

Summary: The study found that the percentage and absolute number of CD28-CD8+ T cells were significantly increased in kidney transplant patients with antibody-mediated rejection (ABMR). Moreover, CD28-CD8+ T cells from patients with ABMR showed a more rigorous response to stimulation compared to their CD28+ counterparts. These findings suggest that differentiated CD28-CD8+ T cells, with increased frequency, number, and function, may play a role in the pathobiology of ABMR.

EBIOMEDICINE (2022)

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Article Cell Biology

MicroRNA-4516 in Urinary Exosomes as a Biomarker of Premature Ovarian Insufficiency

Zobia Umair et al.

Summary: This study collected urine samples from participants in Korea and found that hsa-miR-4516 is upregulated in patients with premature ovarian insufficiency (POI), regardless of the presence of Turner syndrome. The upregulation of miR-4516 in the ovary was confirmed in a mouse model of POI, accompanied by a decrease in the predicted target protein STAT3. These findings suggest that miR-4516 may serve as a diagnostic marker for POI.

CELLS (2022)

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Review Oncology

Tumor-derived exosomes: immune properties and clinical application in lung cancer

Jing Wu et al.

Summary: Lung cancer is a major cause of cancer-related death worldwide, with poor overall survival rates. Exosomes, small vesicles secreted by various cells, play a role in cellular communication. Tumor-derived exosomes (TEXs) carry immunosuppressive and immunostimulatory molecules, and can be used as biomarkers for prognosis, diagnosis, and treatment response in lung cancer. TEXs may interfere with immunotherapies but also hold potential as adjuvants and antigenic components in lung cancer vaccines.

CANCER DRUG RESISTANCE (2022)

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Review Oncology

Roles of exosomes as drug delivery systems in cancer immunotherapy: a mini-review

Zhen Fang et al.

Summary: Exosomes, as carriers of cancer therapeutic drugs, have the potential for future cancer immunotherapy, but the clinical application still faces challenges.

DISCOVER ONCOLOGY (2022)

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Review Medicine, Research & Experimental

Antibody-based drug delivery systems for cancer therapy: Mechanisms, challenges, and prospects

Zhoujiang Chen et al.

Summary: Antibody-based cancer therapy has emerged as an efficient therapeutic strategy with diverse clinical manifestations and applications. Various drug delivery platforms have been developed to enhance therapeutic efficacy. Antibody-based drug delivery systems play an important role in cancer therapy by addressing the current challenges of antibody application and utilizing advanced drug delivery technologies.

THERANOSTICS (2022)

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Review Pharmacology & Pharmacy

Combining therapeutic vaccines with chemo- and immunotherapies in the treatment of cancer

Matthew D. Kerr et al.

Summary: A deeper understanding of the immunostimulatory properties of cytoreductive therapies has supported their utility in combination therapies involving cancer vaccines to induce a durable anti-tumor immune response. Combination therapies may have synergies depending on the identity of the cytotoxic agent, vaccine target, dosing schedule, and cancer type, suggesting that combining cancer vaccines with immunomodulatory cytoreductive therapy is a promising strategy for cancer therapy.

EXPERT OPINION ON DRUG DISCOVERY (2021)

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Review Biochemistry & Molecular Biology

The implication of IL-6 in the invasiveness and chemoresistance of ovarian cancer cells. Systematic review of its potential role as a biomarker in ovarian cancer patients

Izabela Szulc-Kielbik et al.

Summary: IL-6 plays multiple roles in ovarian cancer, including promoting cell proliferation, inhibiting apoptosis, enhancing cell migration and invasion, and correlating with chemotherapy resistance. Its elevated levels in serum and ascites of ovarian cancer patients suggest it as a potential biomarker for distinguishing malignant and nonmalignant tumors and predicting chemotherapy response. IL-6 also serves as a potential target in anti-cancer therapy.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

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Review Biochemistry & Molecular Biology

The role of exosomal lncRNAs in cancer biology and clinical management

Wuwen Zhang et al.

Summary: Exosomes play a crucial role in cell-cell communication within the cancer microenvironment. Exosomal long noncoding RNAs (lncRNAs) are key regulators in cancer development, involved in processes such as cancer cell proliferation, metastasis, drug resistance, and immunomodulation. Changes in exosomal lncRNAs levels often correlate with cancer occurrence and progression, making them valuable biomarkers for cancer diagnosis and prognosis.

EXPERIMENTAL AND MOLECULAR MEDICINE (2021)

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Review Oncology

Extracellular vesicles and oncogenic signaling

Antonia Schubert et al.

Summary: Extracellular vesicles (EVs) have emerged as potential diagnostic and prognostic markers for cancer therapy, yet much remains unknown about their exact mechanisms of signaling specificity and cargo transfer. Several signaling cascades utilize EVs for signaling in tumor-stroma interaction, including key pathways such as Wnt and TGF-beta, which are tightly associated with tumor progression and metastasis. Multiple mechanisms of how EVs interplay with signaling cascades to mediate complex processes have been described, shedding light on the potential therapeutic applications and gaps in knowledge.

MOLECULAR ONCOLOGY (2021)

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Article Plant Sciences

Targeting CD155 by rediocide-A overcomes tumour immuno-resistance to natural killer cells

Wanyi Ng et al.

Summary: Red-A enhances NK cell-mediated lysis of NSCLC cells, promotes degranulation and IFN-gamma production, and down-regulates tumor immune-resistance by decreasing CD155 expression. This suggests the potential of checkpoint inhibitors targeting TIGIT/CD155 signaling to overcome cancer immune-resistance.

PHARMACEUTICAL BIOLOGY (2021)

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Review Oncology

Mechanisms underlying low-clinical responses to PD-1/PD-L1 blocking antibodies in immunotherapy of cancer: a key role of exosomal PD-L1

Zi Yin et al.

Summary: Exosomes, specifically those derived from cancer cells, contain immunosuppressive proteins such as PD-L1, which can hinder immune responses and promote tumor progression. Blocking the interaction between PD-1 and PD-L1 can enhance the efficacy of cancer treatment by restoring anti-tumor immunity.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Oncology

The Interplay of Exosomes and NK Cells in Cancer Biology

Ines A. Batista et al.

Summary: Cancer is the second most common cause of death globally, with an expected rise of about 50% in incidence and mortality in the coming decades. Immunotherapy has shown the best results for cancer treatment, highlighting the importance of studying anti-tumor immune response in cancer research.

CANCERS (2021)

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Review Oncology

Current status of research on exosomes in general, and for the diagnosis and treatment of kidney cancer in particular

Weipu Mao et al.

Summary: Kidney cancer is a common urological tumour with high malignancy and poor treatment efficacy. Exosomes, as mediators of intercellular communication in the tumor microenvironment, play an important role in the diagnosis and treatment of kidney cancer.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Review Veterinary Sciences

Exploiting Microfluidics for Extracellular Vesicle Isolation and Characterization: Potential Use for Standardized Embryo Quality Assessment

Bahram Talebjedi et al.

Summary: In recent decades, research on extracellular vesicles (EVs) has grown significantly, particularly in their role in cellular communication and potential as biomarkers of health and disease. However, the importance of embryonic EVs is still limited due to small sample volumes, low EV concentrations, and complex isolation procedures. The use of microfluidics technologies shows promise in optimizing the isolation and characterization of embryonic EVs.

FRONTIERS IN VETERINARY SCIENCE (2021)

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Review Biochemistry & Molecular Biology

Application of CAR-T Cell Therapy beyond Oncology: Autoimmune Diseases and Viral Infections

Ekaterina Zmievskaya et al.

Summary: Adoptive cell transfer (ACT) has been at the forefront of the battle against cancer, with the success of novel CAR-T cell technologies expanding its potential applications to other diseases. This brings new hope and possibilities to the medical field.

BIOMEDICINES (2021)

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Review Pharmacology & Pharmacy

Extracellular Vesicles in Oncology: from Immune Suppression to Immunotherapy

Akhil Srivastava et al.

Summary: Exosomes play important roles in cell-to-cell communication and cellular physiology, particularly in cancer research. They are utilized as a resource in liquid biopsy to identify molecules associated with immune therapy. Research suggests that exosomes have potential roles in immune modulation and diagnosis.

AAPS JOURNAL (2021)

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Article Cell Biology

Role and Function of T Cell-Derived Exosomes and Their Therapeutic Value

Yuanyuan Shao et al.

MEDIATORS OF INFLAMMATION (2021)

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Review Biochemistry & Molecular Biology

mRNA in cancer immunotherapy: beyond a source of antigen

Lien Van Hoecke et al.

Summary: mRNA therapeutics have become a focus in molecular medicine research, particularly in the field of immuno-oncology. The versatility and advantages of mRNA go beyond cancer vaccine development, with potential for endless therapeutic applications through smart design and pharmaceutical formulations. Novel immunotherapeutic strategies are now exploring the use of mRNA beyond tumor antigens as a source, showing promise for clinical applications.

MOLECULAR CANCER (2021)

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Article Biotechnology & Applied Microbiology

M2 Macrophage-Derived Exosomes Promote Angiogenesis and Growth of Pancreatic Ductal Adenocarcinoma by Targeting E2F2

Yuhan Yang et al.

Summary: The study revealed that exosomes derived from M2 macrophages can promote angiogenesis in PDAC, leading to accelerated tumor growth. By transferring miR-155-5p and miR-221-5p to endothelial cells, the interaction between TAMs and angiogenesis in PDAC was further confirmed. Targeting exosomal miRNAs from TAMs may provide diagnostic and therapeutic strategies for PDAC.

MOLECULAR THERAPY (2021)

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Article Cell Biology

Exosomes in ovarian cancer ascites promote epithelial-mesenchymal transition of ovarian cancer cells by delivery of miR-6780b-5p

Jing Cai et al.

Summary: Poor prognosis of ovarian cancer is mainly due to metastasis, with ascites-derived exosomes playing a role in promoting metastasis through epithelial-mesenchymal transition. The key microRNA miR-6780b-5p in ADEs facilitates cancer metastasis by promoting EMT in ovarian cancer cells, indicating a potential mechanism for ovarian cancer progression.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

TCF4 enhances hepatic metastasis of colorectal cancer by regulating tumor-associated macrophage via CCL2/CCR2 signaling

Wei Tu et al.

Summary: Colorectal cancer liver metastasis is a significant clinical problem, and tumor-associated macrophage (TAM) recruitment and M2 polarization are closely associated with elevated TCF4 expression in the metastatic site. TCF4 deficiency reduces TAM infiltration and M2 polarization, mediated by the regulated CCL2 and CCR2 expression. These findings suggest that the TCF4-CCL2-CCR2 axis plays a crucial role in CRC liver metastasis by enhancing TAMs recruitment and M2 polarization.

CELL DEATH & DISEASE (2021)

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Article Chemistry, Multidisciplinary

On-Chip Biogenesis of Circulating NK Cell-Derived Exosomes in Non-Small Cell Lung Cancer Exhibits Antitumoral Activity

Yoon-Tae Kang et al.

Summary: NK cells and their derived exosomes play a crucial role in cancer immunotherapy, as they exhibit high stability and lower immunogenicity, providing possibilities for personalized treatments. A novel microfluidic system for collecting patient-specific NK cells and NK-exosomes on chips offers potential applications in cancer therapies.

ADVANCED SCIENCE (2021)

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Review Endocrinology & Metabolism

Stem Cell-Based Clinical Trials for Diabetes Mellitus

Eleonora de Klerk et al.

Summary: Intraportal allogeneic cadaveric islet transplantation shows promise for Type I Diabetes patients, but is limited by issues like cadaveric islet availability and immunosuppressive drug dependence. Mesenchymal stem cell and human embryonic stem cell approaches are explored as alternatives, but still face challenges such as immune rejection. Protective immune strategies and innovative technologies are being developed to address these challenges.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Oncology

M2 macrophage-derived exosomal microRNA-155-5p promotes the immune escape of colon cancer by downregulating ZC3H12B

Yu-Shui Ma et al.

Summary: The study investigates the role of M2 macrophage-derived exosomal miR-155-5p in immune escape of colon cancer cells. They found that miR-155-5p could be transferred to cancer cells, targeting ZC3H12B and promoting proliferation and antiapoptosis abilities. Additionally, the miRNA reduced ZC3H12B-mediated IL-6 stability, leading to immune escape and tumor formation.

MOLECULAR THERAPY-ONCOLYTICS (2021)

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Article Multidisciplinary Sciences

Plasma cells shape the mesenchymal identity of ovarian cancers through transfer of exosome-derived microRNAs

Zhengnan Yang et al.

Summary: The study found that plasma cells are enriched in high-grade serous ovarian cancers (HGSCs) and are associated with the mesenchymal phenotype switch of tumor cells. Exosome-derived miR-330-3p released by plasma cells induced noncanonical JAM-B expression in nonmesenchymal ovarian cancer cells. Depletion of plasma cells reversed mesenchymal characteristics of ovarian cancer and inhibited in vivo tumor growth.

SCIENCE ADVANCES (2021)

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Review Oncology

Modulation of the Vascular-Immune Environment in Metastatic Cancer

Bo He et al.

Summary: This review highlights the impact of abnormal blood vessels on immune cell access and anti-cancer immune responses, as well as the importance of vascular features in the pre-metastatic niche for potential therapies. It also discusses the challenges posed by different maturation status of blood vessels in treating metastatic lesions.

CANCERS (2021)

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Review Immunology

The Roles of Exosomes in Immunoregulation and Autoimmune Thyroid Diseases

Junli Zou et al.

Summary: Exosomes are small extracellular vesicles released from cells that contain various bioactive molecules and play a crucial role in cell-to-cell communication. Studies have shown that exosomes are involved in the pathogenesis of autoimmune thyroid diseases, but further exploration is still needed.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Gastroenterology & Hepatology

Tumor-Secreted Extracellular Vesicles Regulate T-Cell Costimulation and Can Be Manipulated To Induce Tumor-Specific T-Cell Responses

Xianda Zhao et al.

Summary: This study reveals the critical role of tumor-secreted extracellular vesicles (EVs) containing microRNA miR-424 in suppressing antitumor immune response and leading to resistance to immune checkpoint blockade therapies in colorectal cancer. Modified tumor-secreted EVs with miR-424 knocked down enhance T-cell-mediated antitumor immune response and increase the efficacy of immune checkpoint blockade. Intravenous injections of modified tumor-secreted EVs induce tumor antigen-specific immune responses and boost the immune checkpoint blockade efficacy in late-stage colorectal cancer models.

GASTROENTEROLOGY (2021)

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Review Endocrinology & Metabolism

The Utility of Exosomes in Diagnosis and Therapy of Diabetes Mellitus and Associated Complications

Yaoxiang Sun et al.

Summary: The research focuses on the multiple effects of exosomes in the pathology and therapy of diabetes mellitus and diabetic complications, providing new insights into reflecting individual physiological status, regulating metabolism, and repairing damaged tissues.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Review Oncology

(In)Distinctive Role of Long Non-Coding RNAs in Common and Rare Ovarian Cancers

Maja Sabol et al.

Summary: Ovarian cancers are the most lethal form of gynecological tumors, with rare OCs having distinct molecular characteristics, prognosis, and therapeutic approaches. Late diagnosis due to the lack of specific symptoms is a common problem for all ovarian malignancies.

CANCERS (2021)

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Review Oncology

The Breast Tumor Microenvironment: A Key Player in Metastatic Spread

Lucas E. L. Terceiro et al.

Summary: The tumor microenvironment is crucial in the development and metastasis of various cancers, including breast cancer. Interactions between breast cancer cells and neighboring cells regulate metastasis through cell-to-cell contact or the release of signaling factors. Exosomes and circulating tumor cells also play roles in breast cancer metastasis. Markers associated with stromal cells in the breast tumor environment have potential to predict patient survival and guide treatment, while advancements in technology may lead to more effective therapies for breast cancer patients.

CANCERS (2021)

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Review Oncology

NK Cells in the Tumor Microenvironment as New Potential Players Mediating Chemotherapy Effects in Metastatic Melanoma

Cinzia Garofalo et al.

Summary: Chemotherapy has been the standard treatment for metastatic cutaneous melanoma, but the introduction of immune checkpoint inhibitors (ICIs) has significantly improved the outcome. However, some patients are unresponsive to ICIs, and recent studies suggest that chemotherapy may enhance NK cells' anti-tumor cytotoxicity within the tumor microenvironment. The use of nanocarriers loaded with chemotherapeutics is a promising approach to deliver therapeutic molecules effectively.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Positive Reciprocal Feedback of lncRNA ZEB1-AS1 and HIF-1α Contributes to Hypoxia-Promoted Tumorigenesis and Metastasis of Pancreatic Cancer

Yan Jin et al.

Summary: The research revealed that ZEB1-AS1 was significantly upregulated in pancreatic cancer cells under hypoxia conditions, correlating with poor prognosis in patients. ZEB1-AS1 facilitates the transcription of ZEB1 and stabilization of HIF-1α, promoting metastasis in pancreatic cancer cells.

FRONTIERS IN ONCOLOGY (2021)

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Review Oncology

Emerging Functions and Clinical Applications of Exosomal ncRNAs in Ovarian Cancer

Yu Zhang et al.

Summary: Exosomal noncoding RNAs play a crucial role in ovarian cancer development and may become valuable tools for diagnosis and treatment.

FRONTIERS IN ONCOLOGY (2021)

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Review Cell Biology

Research Progress of circRNAs in Glioblastoma

Xu Guo et al.

Summary: Circular RNAs (circRNAs) exhibit specific expression patterns in GBM, showing potential as novel biomarkers and providing new insights for treatment.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Cell Biology

The Emerging Role of Exosomes in Cancer Chemoresistance

Jing Li et al.

Summary: Exosomes play critical roles in promoting chemoresistance in cancer through various mechanisms. Due to their stability, specificity, and sensitivity, exosomes can serve as biomarkers in liquid biopsies to monitor the current status and progression of cancer chemoresistance.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Oncology

Novel insights into exosomal circular RNAs: Redefining intercellular communication in cancer biology

Huimin Lin et al.

Summary: Exosomal circRNAs are important mediators of intercellular communication in cancer, participating in various aspects of cancer biology and potentially holding promise for future clinical applications. Their biogenesis, properties, functions, and roles in the tumor microenvironment are areas of active research and interest.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Medicine, Research & Experimental

TAM-derived extracellular vesicles containing microRNA-29a-3p explain the deterioration of ovarian cancer

Lili Lu et al.

Summary: This study elucidated the role of TAM-derived exosomal miR-29a-3p in ovarian cancer (OC). The findings demonstrated that TAM-EVs enhanced OC cell proliferation through the FOXO3-AKT/GSK313 pathway and upregulation of PD-L1 expression, facilitating tumor immune escape.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Review Materials Science, Biomaterials

Potential Use of Exosomes as Diagnostic Biomarkers and in Targeted Drug Delivery: Progress in Clinical and Preclinical Applications

Md Nurul Huda et al.

Summary: Exosomes are cell-derived vesicles containing various active biomolecules, with potential for drug delivery and early disease diagnosis.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Review Cell Biology

Exosomal Non-coding RNAs-Mediated Crosstalk in the Tumor Microenvironment

Qi Chen et al.

Summary: Exosomes play important roles in the modulation of tumor cells and immune cells through the secretion of ncRNAs, such as miRNAs, lncRNAs, and circRNAs. Understanding the functions of exosomal ncRNAs may lead to their potential use as biomarkers for cancer diagnosis, prognosis, and as targets for novel therapy.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Engineering, Biomedical

Inflammatory tumor microenvironment responsive neutrophil exosomes-based drug delivery system for targeted glioma therapy

Jun Wang et al.

Summary: NEs-Exos system exhibits neutrophil-like chemotactic function and BBB penetration capability, efficiently suppressing tumor growth and prolonging survival time in a glioma mouse model.

BIOMATERIALS (2021)

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Article Multidisciplinary Sciences

Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution

Luize G. Lima et al.

Summary: Exosomes secreted by cancer cells play a crucial role in metastasis, with cytokines in the tumor microenvironment binding to exosomes and promoting their uptake by specific cell lineages and organs to enhance metastatic dissemination. This interaction between exosomes and cytokines is a key determinant of cancer progression.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Exosomal hsa-miR-21-5p is a biomarker for breast cancer diagnosis

Min Liu et al.

Summary: The study utilized comprehensive bioinformatics analysis and experimental validation to identify hsa-miR-21-5p as significantly up-regulated in breast cancer tissues, cells, and exosomes. Further investigations confirmed the diagnostic value of plasma exosomal hsa-miR-21-5p in distinguishing healthy individuals from breast cancer patients, with a sensitivity of 86.7% and specificity of 93.3%.

PEERJ (2021)

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Review Immunology

Exosomes and Melatonin: Where Their Destinies Intersect

Adriana Alonso Novais et al.

Summary: Exosomes and melatonin play important roles in cell-to-cell communication, and their combination can improve various pathological processes, including inflammation, hepatic metabolic disturbance, immunosuppression, etc.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

L2pB1 Cells Contribute to Tumor Growth Inhibition

Varuna Shibad et al.

Summary: L2pB1 cells, a subpopulation of B-1 B cells capable of producing nIgM, have anti-cancer effects by recognizing and inducing tumor cell death, making them potential candidates in overcoming drug resistance associated with tumor heterogeneity.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

CXCR6 is required for antitumor efficacy of intratumoral CD8+ T cell

Binglin Wang et al.

Summary: This study revealed that CXCR6 is exclusively expressed on intratumoral CD8(+) T cells, which are more immunocompetent and possess stronger antitumor activity. Additionally, CXCR6 may serve as a biomarker for tumor immunotherapy.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Oncology

Exosomes Promote Pre-Metastatic Niche Formation in Gastric Cancer

Jing Gao et al.

Summary: Exosomes play a crucial role in the formation of pre-metastatic niches in gastric cancer, facilitating tumor metastasis by establishing a supportive environment remotely. The cell components in pre-metastatic niches secrete exosomes that interact with each other, providing signals that promote tumor growth.

FRONTIERS IN ONCOLOGY (2021)

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Review Biochemistry & Molecular Biology

The Role and Clinical Interest of Extracellular Vesicles in Pregnancy and Ovarian Cancer

Nazanin Yeganeh Kazemi et al.

Summary: Ovarian cancer and pregnancy expose the immune system to novel antigens, with both tumors and placenta utilizing extracellular vesicles (EVs) for cell-to-cell communication. EVs play a crucial role in promoting cell division and invasion, immunosuppression, and angiogenesis in both cancer and pregnancy.

BIOMEDICINES (2021)

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Review Oncology

Engineering stem cells for cancer immunotherapy

Yan-Ruide Li et al.

Summary: Engineering stem cells offer a promising approach for cancer immunotherapy by stably expressing chimeric antigen receptors or T-cell receptors against tumor-associated antigens. They can engraft for long-term immune cell generation, provide sustained tumor-specific effector cells, and serve as off-the-shelf cellular products to avoid the need for personalized therapies.

TRENDS IN CANCER (2021)

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Article Medicine, General & Internal

Human Leukocyte Antigens-DQA1 and -DQB1 Alleles in Patients With Common Warts

Grazia Sanchez-Barrientos et al.

Summary: The alleles DQA1*03:01:01, DQB1*03:02, DQA1*04:01, and DQB1*04:02 were found to be associated with susceptibility to common warts, while DQA1*05:01 was significantly diminished in them. Haplotypes DQA1*04:01-DQB1*04:02 and DQA1*03:01:01-DQB1*03:02 were associated with susceptibility, while DQA1*05:01-DQB1*03:01 increased significantly in controls.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

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Article Medical Laboratory Technology

Coupling size exclusion chromatography to ultracentrifugation improves detection of exosomal proteins from human plasma by LC-MS

Sara Alameldin et al.

Summary: The study found that using the UC + SEC method can more effectively enrich proteins in exosomes, and coupling UC and SEC can reduce plasma protein contamination by 98.8% compared to using UC alone.

PRACTICAL LABORATORY MEDICINE (2021)

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Review Health Care Sciences & Services

Tracking the CAR-T Revolution: Analysis of Clinical Trials of CAR-T and TCR-T Therapies for the Treatment of Cancer (1997-2020)

Nikola A. Ivica et al.

Summary: CAR-T/TCR-T cellular immunotherapies have shown remarkable success in treating refractory B-cell malignancies. The increase in clinical trials is driven by the development of different CAR-T products, with China and the US being major innovators in the field. This industry exhibits a robust response to competitor products, with the term "bioparallels" coined to describe similar therapeutic approaches.

HEALTHCARE (2021)

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Article Medicine, Research & Experimental

CD45RO(-)CD8(+) T cell-derived exosomes restrict estrogen-driven endometrial cancer development via the ER beta/miR-765/PLP2/Notch axis

Wen-Jie Zhou et al.

Summary: The study investigated the molecular mechanisms underlying the interaction between estrogen signaling and CD8(+) T cells, and identified the regulatory value of the ER beta/miR-765/PLP2/Notch signaling axis in uterine corpus endometrial cancer.

THERANOSTICS (2021)

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Review Oncology

Natural Killer Cell-Derived Vesicular miRNAs: A New Anticancer Approach?

Muller Fabbri

CANCER RESEARCH (2020)

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Article Medical Laboratory Technology

Molecular immune mechanisms of HPV-infected HaCaT cells in vitro based on toll-like receptors signaling pathway

Zuolin Ying et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2020)

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Article Infectious Diseases

Impaired consciousness and decreased glucose concentration of CSF as prognostic factors in immunocompetent patients with cryptococcal meningitis

Chen Zhang et al.

BMC INFECTIOUS DISEASES (2020)

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Editorial Material Immunology

The omentum, a niche for premetastatic ovarian cancer

Xiaojing Ma

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Review Cell Biology

Role of microRNAs as Clinical Cancer Biomarkers for Ovarian Cancer: A Short Overview

Cristina Elena Staicu et al.

CELLS (2020)

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Article Biochemistry & Molecular Biology

Neutrophil-derived exosome from systemic sclerosis inhibits the proliferation and migration of endothelial cells

Liya Li et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Medicine, Research & Experimental

circCELSR1 (hsa-circ-0063809) Contributes to Paclitaxel Resistance of Ovarian Cancer Cells by Regulating FOXR2 Expression via miR-1252

Shu Zhang et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Review Biochemistry & Molecular Biology

Inducible Polarized Secretion of Exosomes in T and B Lymphocytes

Victor Calvo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Oncology

Exosomal miRNAs in tumor microenvironment

Shiming Tan et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Oncology

Efficacy of B7-H3-Redirected BiTE and CAR-T Immunotherapies Against Extranodal Nasal Natural Killer/T Cell Lymphoma

Meijun Zheng et al.

TRANSLATIONAL ONCOLOGY (2020)

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Review Oncology

Chimeric Antigen Receptor Cell Therapy: Overcoming Obstacles to Battle Cancer

Amy J. Petty et al.

CANCERS (2020)

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Review Oncology

Clinical Relevance of Liquid Biopsy in Melanoma and Merkel Cell Carcinoma

Magali Boyer et al.

CANCERS (2020)

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Article Oncology

Characterization of Human NK Cell-Derived Exosomes: Role of DNAM1 Receptor in Exosome-Mediated Cytotoxicity against Tumor

Anna Laura Di Pace et al.

CANCERS (2020)

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Review Oncology

You Have Got a Fast CAR: Chimeric Antigen Receptor NK Cells in Cancer Therapy

Aline Pfefferle et al.

CANCERS (2020)

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Article Oncology

Clinical Value of lncRNA MEG3 in High-Grade Serous Ovarian Cancer

Marianna Buttarelli et al.

CANCERS (2020)

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Review Cell Biology

Emerging Role of Exosomes in Diagnosis and Treatment of Infectious and Inflammatory Bowel Diseases

Anais Larabi et al.

CELLS (2020)

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Review Cell Biology

Pathophysiological Role and Potential Therapeutic Exploitation of Exosomes in Ovarian Cancer

Aasa Shimizu et al.

CELLS (2020)

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Article Oncology

Exosomes released from M2 macrophages transfer miR-221-3p contributed to EOC progression through targeting CDKN1B

Xiaoduan Li et al.

CANCER MEDICINE (2020)

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Article Oncology

Targeting PD-L1 in non-small cell lung cancer using CAR T cells

Ming Liu et al.

ONCOGENESIS (2020)

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Article Oncology

MicroRNAs and Their Targetomes in Tumor-Immune Communication

Sunglim Cho et al.

CANCERS (2020)

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Review Cell Biology

Tumor Microenvironment in Ovarian Cancer: Function and Therapeutic Strategy

Yanfei Yang et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Cell Biology

Circ-0001068 is a novel biomarker for ovarian cancer and inducer of PD1 expression in T cells

Xinchen Wang et al.

AGING-US (2020)

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Article Oncology

Circulating MicroRNAs and Extracellular Vesicle-Containing MicroRNAs as Response Biomarkers of Anti -programmed Cell Death Protein 1 or Programmed Death-Ligand 1 Therapy in NSCLC

Takehito Shukuya et al.

JOURNAL OF THORACIC ONCOLOGY (2020)

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Article Oncology

XIST lost induces ovarian cancer stem cells to acquire taxol resistance via a KMT2C-dependent way

Ruili Huang et al.

CANCER CELL INTERNATIONAL (2020)

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Review Medicine, Research & Experimental

The regulatory role of exosomes in leukemia and their clinical significance

Wei Deng et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2020)

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Review Biochemistry & Molecular Biology

The potential roles of exosomes in pancreatic cancer initiation and metastasis

Wei Sun et al.

MOLECULAR CANCER (2020)

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Article Biotechnology & Applied Microbiology

circKRT7-miR-29a-3p-COL1A1 Axis Promotes Ovarian Cancer Cell Progression

Qiang An et al.

ONCOTARGETS AND THERAPY (2020)

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Review Medicine, Research & Experimental

Emerging Function and Clinical Significance of Exosomal circRNAs in Cancer

Man Wang et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Review Oncology

Circulating Extracellular Vesicles in Gynecological Tumors: Realities and Challenges

Carolina Herrero et al.

FRONTIERS IN ONCOLOGY (2020)

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Review Oncology

Tumor-Associated Macrophages in Human Breast, Colorectal, Lung, Ovarian and Prostate Cancers

Irina Larionova et al.

FRONTIERS IN ONCOLOGY (2020)

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Review Biotechnology & Applied Microbiology

The Role of Exosomes in the Female Reproductive System and Breast Cancers

Yuqi Bai et al.

ONCOTARGETS AND THERAPY (2020)

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Article Oncology

Untargeted Metabolomic Characterization of Ovarian Tumors

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CANCERS (2020)

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Extracellular Vesicles Orchestrate Immune and Tumor Interaction Networks

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CANCERS (2020)

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The Emerging Role of CD24 in Cancer Theranostics-A Novel Target for Fluorescence Image-Guided Surgery in Ovarian Cancer and Beyond

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JOURNAL OF PERSONALIZED MEDICINE (2020)

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Exosomes and breast cancer drug resistance

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CELL DEATH & DISEASE (2020)

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Proteome Analysis of Human Natural Killer Cell Derived Extracellular Vesicles for Identification of Anticancer Effectors

Jung-Won Choi et al.

MOLECULES (2020)

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Exosome-based immunotherapy: a promising approach for cancer treatment

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MOLECULAR CANCER (2020)

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Natural Killer Lytic-Associated Molecule (NKLAM): An E3 Ubiquitin Ligase With an Integral Role in Innate Immunity

Donald W. Lawrence et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Drug screening model meets cancer organoid technology

Chen Liu et al.

TRANSLATIONAL ONCOLOGY (2020)

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Article Oncology

Combining Bioinformatics and Experiments to Identify and Verify Key Genes with Prognostic Values in Endometrial Carcinoma

Wenchao Zhang et al.

JOURNAL OF CANCER (2020)

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Article Respiratory System

Extracellular vesicles from mast cells induce mesenchymal transition in airway epithelial cells

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RESPIRATORY RESEARCH (2020)

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Mast cells-derived MiR-223 destroys intestinal barrier function by inhibition of CLDN8 expression in intestinal epithelial cells

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BIOLOGICAL RESEARCH (2020)

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Tumor Cell-associated Exosomes Robustly Elicit Anti-tumor Immune Responses through Modulating Dendritic Cell Vaccines in Lung Tumor

Ce Wang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

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Article Gastroenterology & Hepatology

Exosomal Interferon-Induced Transmembrane Protein 2 Transmitted to Dendritic Cells Inhibits Interferon Alpha Pathway Activation and Blocks Anti-Hepatitis B Virus Efficacy of Exogenous Interferon Alpha

Ying Shi et al.

HEPATOLOGY (2019)

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Review Biochemistry & Molecular Biology

Exosomes and the Future of Immunotherapy in Pancreatic Cancer

Ines A. Batista et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Oncology

Macrophages derived exosomes deliver miR-223 to epithelial ovarian cancer cells to elicit a chemoresistant phenotype

Xiaolan Zhu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Effects of exosomes on pre-metastatic niche formation in tumors

Yaxin Guo et al.

MOLECULAR CANCER (2019)

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Review Cell Biology

Role of Exosomes in the Regulation of T-Cell Mediated Immune Responses and in Autoimmune Disease

Alberto Anel et al.

CELLS (2019)

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Intercellular Vesicular Transfer by Exosomes, Microparticles and Oncosomes - Implications for Cancer Biology and Treatments

Ritu Jaiswal et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Cell Biology

Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells

Fei Chen et al.

NATURE CELL BIOLOGY (2019)

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Article Oncology

Expression levels of MRP1, GST-π, and GSK3β in ovarian cancer and the relationship with drug resistance and prognosis of patients

Xiaojing Tong et al.

ONCOLOGY LETTERS (2019)

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Review Cell & Tissue Engineering

Genetic communication by extracellular vesicles is an important mechanism underlying stem cell-based therapy-mediated protection against acute kidney injury

Lingfei Zhao et al.

STEM CELL RESEARCH & THERAPY (2019)

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Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes

Sangiliyandi Gurunathan et al.

CELLS (2019)

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The Vicious Cross-Talk between Tumor Cells with an EMT Phenotype and Cells of the Immune System

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CELLS (2019)

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Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma

Malgorzata Czystowska-Kuzmicz et al.

NATURE COMMUNICATIONS (2019)

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Article Multidisciplinary Sciences

Toll-like Receptor-4 Activation Boosts the Immunosuppressive Properties of Tumor Cells-derived Exosomes

Rossana Domenis et al.

SCIENTIFIC REPORTS (2019)

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Article Medicine, Research & Experimental

Long-Chain Non-Coding RNA (lncRNA) MT1JP Suppresses Biological Activities of Lung Cancer by Regulating miRNA-423-3p/Bim Axis

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MEDICAL SCIENCE MONITOR (2019)

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Inhibition of the NKp44-PCNA Immune Checkpoint Using a mAb to PCNA

Kiran Kundu et al.

CANCER IMMUNOLOGY RESEARCH (2019)

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Review Biochemistry & Molecular Biology

Exosomes promote pre-metastatic niche formation in ovarian cancer

Wenlong Feng et al.

MOLECULAR CANCER (2019)

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Role of the Exosome in Ovarian Cancer Progression and Its Potential as a Therapeutic Target

Koji Nakamura et al.

CANCERS (2019)

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The release of tryptase from mast cells promote tumor cell metastasis via exosomes

Hui Xiao et al.

BMC CANCER (2019)

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Ovarian cancer circulating extracelluar vesicles promote coagulation and have a potential in diagnosis: an iTRAQ based proteomic analysis

Wei Zhang et al.

BMC CANCER (2019)

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CircPLEKHM3 acts as a tumor suppressor through regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis in ovarian cancer

Lei Zhang et al.

MOLECULAR CANCER (2019)

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Article Chemistry, Multidisciplinary

Isolation and Profiling of Circulating Tumor-Associated Exosomes Using Extracellular Vesicular Lipid-Protein Binding Affinity Based Microfluidic Device

Yoon-Tae Kang et al.

SMALL (2019)

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CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity

Wenyan Fu et al.

NATURE COMMUNICATIONS (2019)

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Review Immunology

Natural Killer Cells in Myeloid Malignancies: Immune Surveillance, NK Cell Dysfunction, and Pharmacological Opportunities to Bolster the Endogenous NK Cells

Mattias Carlsten et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Oncology

Mechanisms and Management of Chimeric Antigen Receptor T-Cell Therapy-Related Toxicities

Bhagirathbhai R. Dholaria et al.

BIODRUGS (2019)

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Exosomes: Versatile Nano Mediators of Immune Regulation

Qi Li et al.

CANCERS (2019)

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Review Oncology

Tumorigenesis, diagnosis, and therapeutic potential of exosomes in liver cancer

Hongbo Wang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Review Oncology

Clinical significance of exosomal miRNAs and proteins in three human cancers with high mortality in China

Li-Man Li et al.

ONCOLOGY LETTERS (2019)

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Article Multidisciplinary Sciences

Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity

Michela Capello et al.

NATURE COMMUNICATIONS (2019)

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Article Oncology

Inhibition of miR-214-3p Aids in Preventing Epithelial Ovarian Cancer Malignancy by Increasing the Expression of LHX6

Changwon Yang et al.

CANCERS (2019)

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Article Multidisciplinary Sciences

The TreaT-Assay: A Novel Urine-Derived Donor Kidney Cell-Based Assay for Prediction of Kidney Transplantation Outcome

Constantin J. Thieme et al.

SCIENTIFIC REPORTS (2019)

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Review Biochemistry & Molecular Biology

The roles of exosomal miRNAs and lncRNAs in lung diseases

Yang Li et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2019)

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Design strategies and application progress of therapeutic exosomes

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THERANOSTICS (2019)

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Article Medicine, Research & Experimental

Ovarian cancer cell-secreted exosomal miR-205 promotes metastasis by inducing angiogenesis

Liuqing He et al.

THERANOSTICS (2019)

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Review Oncology

Chimeric antigen receptor T-cell therapy - assessment and management of toxicities

Sattva S. Neelapu et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Review Cell Biology

Revisiting ovarian cancer microenvironment: a friend or a foe?

Boyi Zhang et al.

PROTEIN & CELL (2018)

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Review Biochemistry & Molecular Biology

MicroRNAs as potential liquid biopsy biomarkers in colorectal cancer: A systematic review

Yuji Toiyama et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2018)

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Review Pharmacology & Pharmacy

Role of IncRNAs in ovarian cancer: defining new biomarkers for therapeutic purposes

Manish K. Tripathi et al.

DRUG DISCOVERY TODAY (2018)

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A preliminary origin-tracking study of different densities urinary exosomes

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ELECTROPHORESIS (2018)

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Article Biochemical Research Methods

Simultaneous isolation and preconcentration of exosomes by ion concentration polarization

Steven Marczak et al.

ELECTROPHORESIS (2018)

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Review Pharmacology & Pharmacy

The potential theragnostic (diagnostic plus therapeutic) application of exosomes in diverse biomedical fields

Yong-Seok Kim et al.

KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2018)

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Review Biochemistry & Molecular Biology

Emerging role of exosome-derived long non-coding RNAs in tumor microenvironment

Zhenqiang Sun et al.

MOLECULAR CANCER (2018)

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Review Oncology

Dendritic Cell-Based Immunotherapy for Solid Tumors

Nam-Chul Jung et al.

TRANSLATIONAL ONCOLOGY (2018)

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Article Biotechnology & Applied Microbiology

Identification of differentially expressed genes and signaling pathways in ovarian cancer by integrated bioinformatics analysis

Xiao Yang et al.

ONCOTARGETS AND THERAPY (2018)

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Review Biotechnology & Applied Microbiology

Advances of exosome in the development of ovarian cancer and its diagnostic and therapeutic prospect

Jiayu Shen et al.

ONCOTARGETS AND THERAPY (2018)

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Article Multidisciplinary Sciences

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

Thomas Duhen et al.

NATURE COMMUNICATIONS (2018)

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Review Biotechnology & Applied Microbiology

Extracellular Vesicles: A New Perspective in Tumor Therapy

Yan-Zi Sun et al.

BIOMED RESEARCH INTERNATIONAL (2018)

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Review Gastroenterology & Hepatology

MicroRNAs as Immunotherapy Targets for Treating Gastroenterological Cancers

Yixin Yang et al.

CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2018)

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Review Immunology

Recent Advances in Targeting CD8 T-Cell Immunity for More Effective Cancer Immunotherapy

Aurelie Durgeau et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

γδ T Cells and Tumor Microenvironment: From Immunosurveillance to Tumor Evasion

Elena Lo Presti et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Oncology

Dual effect of DLBCL-derived EXOs in lymphoma to improve DC vaccine efficacy in vitro while favor tumorgenesis in vivo

Zhenzhen Chen et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

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Review Medicine, General & Internal

Altered long noncoding RNAs and survival outcomes in ovarian cancer: A systematic review and meta-analysis (PRISMA Compliant)

Li Ning et al.

MEDICINE (2018)

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Article Oncology

Prediction of candidate RNA signatures for recurrent ovarian cancer prognosis by the construction of an integrated competing endogenous RNA network

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ONCOLOGY REPORTS (2018)

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Review Chemistry, Analytical

Lab-on-Chip for Exosomes and Microvesicles Detection and Characterization

Maria Serena Chiriaco et al.

SENSORS (2018)

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Review Oncology

The Tumor Microenvironment of Epithelial Ovarian Cancer and Its Influence on Response to Immunotherapy

Galaxia M. Rodriguez et al.

CANCERS (2018)

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Review Biochemistry & Molecular Biology

The role of the interleukin (IL)-6/IL-6 receptor axis in cancer

Mustafa Yassin Taher et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2018)

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Article Immunology

Sialic Acid-Dependent Inhibition of T Cells by Exosomal Ganglioside GD3 in Ovarian Tumor Microenvironments

Gautam N. Shenoy et al.

JOURNAL OF IMMUNOLOGY (2018)

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Article Biochemistry & Molecular Biology

Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration

Xu Zhang et al.

MOLECULAR CANCER (2018)

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Integrated extracellular microRNA profiling for ovarian cancer screening

Akira Yokoi et al.

NATURE COMMUNICATIONS (2018)

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Review Biochemistry & Molecular Biology

The emerging roles and therapeutic potential of exosomes in epithelial ovarian cancer

Xiaoduan Li et al.

MOLECULAR CANCER (2017)

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Review Biochemistry & Molecular Biology

Role of exosomal proteins in cancer diagnosis

Weihua Li et al.

MOLECULAR CANCER (2017)

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Review Reproductive Biology

A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies

Lin Cheng et al.

JOURNAL OF OVARIAN RESEARCH (2017)

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Review Oncology

Tumor-derived exosomes in ovarian cancer - liquid biopsies for early detection and real-time monitoring of cancer progression

Shayna Sharma et al.

ONCOTARGET (2017)

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Review Oncology

The miR-200 family in ovarian cancer

Maria Koutsaki et al.

ONCOTARGET (2017)

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Article Multidisciplinary Sciences

Urinary Exosomes Contain MicroRNAs Capable of Paracrine Modulation of Tubular Transporters in Kidney

Tannia Gracia et al.

SCIENTIFIC REPORTS (2017)

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Review Oncology

Immune Cell Population in Ovarian Tumor Microenvironment

Dong Li Cai et al.

JOURNAL OF CANCER (2017)

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Article Multidisciplinary Sciences

IL-12 stimulates CTLs to secrete exosomes capable of activating bystander CD8+ T cells

Lei Li et al.

SCIENTIFIC REPORTS (2017)

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Review Biochemistry & Molecular Biology

Extracellular vesicles as emerging targets in cancer: Recent development from bench to bedside

Kerui Wu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2017)

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Review Immunology

Functions of Cancer-Derived Extracellular Vesicles in Immunosuppression

Liliana Czernek et al.

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2017)

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Article Cell Biology

Large-scale isolation and cytotoxicity of extracellular vesicles derived from activated human natural killer cells

Ambrose Y. Jong et al.

JOURNAL OF EXTRACELLULAR VESICLES (2017)

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Review Biochemistry & Molecular Biology

How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity

G. Daniel Grass et al.

BIOSCIENCE REPORTS (2016)

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Article Oncology

Ubiquitous Release of Exosomal Tumor Suppressor miR-6126 from Ovarian Cancer Cells

Pinar Kanlikilicer et al.

CANCER RESEARCH (2016)

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Review Biochemical Research Methods

Extracellular vesicles in ovarian cancer: applications to tumor biology, immunotherapy and biomarker discovery

Muhammad Nawaz et al.

EXPERT REVIEW OF PROTEOMICS (2016)

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Review Oncology

The biological significance and clinical applications of exosomes in ovarian cancer

Kalpana Deepa Priya Dorayappan et al.

GYNECOLOGIC ONCOLOGY (2016)

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Article Oncology

Expression of PD-1, PD-L1 and PD-L2 is associated with differentiation status and histological type of endometrial cancer

Zhongfu Mo et al.

ONCOLOGY LETTERS (2016)

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Article Multidisciplinary Sciences

Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1

Chi Lam Au Yeung et al.

NATURE COMMUNICATIONS (2016)

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Article Oncology

HuR-regulated lncRNA NEAT1 stability in tumorigenesis and progression of ovarian cancer

Yiqing Chai et al.

CANCER MEDICINE (2016)

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Ovarian cancer

Ursula A. Matulonis et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

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Article Multidisciplinary Sciences

Human adipose mesenchymal stem cell-derived exosomal-miRNAs are critical factors for inducing anti-proliferation signalling to A2780 and SKOV-3 ovarian cancer cells

Abu Musa Md Talimur Reza et al.

SCIENTIFIC REPORTS (2016)

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Article Microbiology

Antigen Processing and Presentation Mechanisms in Myeloid Cells

Paul A. Roche et al.

MICROBIOLOGY SPECTRUM (2016)

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Article Cell Biology

Specific renal parenchymal-derived urinary extracellular vesicles identify age-associated structural changes in living donor kidneys

Anne E. Turco et al.

JOURNAL OF EXTRACELLULAR VESICLES (2016)

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Review Biochemistry & Molecular Biology

Prostate Cancer Detection and Prognosis: From Prostate Specific Antigen (PSA) to Exosomal Biomarkers

Xavier Filella et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Article Oncology

Dendritic and mast cell involvement in the inflammatory response to primary malignant bone tumours

Y. Inagaki et al.

CLINICAL SARCOMA RESEARCH (2016)

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Article Biochemical Research Methods

Molecular screening of cancer-derived exosomes by surface plasmon resonance spectroscopy

Luigino Grasso et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2015)

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Article Oncology

Increases urinary HMGA1 in serous epithelial ovarian cancer patients

Jun Zhou et al.

CANCER BIOMARKERS (2015)

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Article Oncology

Urinary microRNA-30a-5p is a potential biomarker for ovarian serous adenocarcinoma

Jun Zhou et al.

ONCOLOGY REPORTS (2015)

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Article Oncology

Evaluation of Cell-Free Urine microRNAs Expression for the Use in Diagnosis of Ovarian and Endometrial Cancers. A Pilot Study

Ludek Zavesky et al.

PATHOLOGY & ONCOLOGY RESEARCH (2015)

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Exosomes: Novel Biomarkers for Clinical Diagnosis

Jin Lin et al.

TheScientificWorldJOURNAL (2015)

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Article Oncology

Overexpression of MACC1 and the association with hepatocyte growth factor/c-Met in epithelial ovarian cancer

Hongyu Li et al.

ONCOLOGY LETTERS (2015)

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Review Oncology

Therapeutic potential of CAR-T cell-derived exosomes: a cell-free modality for targeted cancer therapy

Xiang-Jun Tang et al.

ONCOTARGET (2015)

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Exosomes: Novel Biomarkers for Clinical Diagnosis

Jin Lin et al.

Scientific World Journal (2015)

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Review Immunology

Emerging roles of exosomes in normal and pathological conditions: new insights for diagnosis and therapeutic applications

Julieta De Toro et al.

FRONTIERS IN IMMUNOLOGY (2015)

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Article Multidisciplinary Sciences

Isolation of Exosomes from Blood Plasma: Qualitative and Quantitative Comparison of Ultracentrifugation and Size Exclusion Chromatography Methods

Tamas Baranyai et al.

PLOS ONE (2015)

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Review Medicine, General & Internal

Extracellular vesicles: potential applications in cancer diagnosis, prognosis, and epidemiology

Mukesh Verma et al.

BMC CLINICAL PATHOLOGY (2015)

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Review Oncology

Stem cell-derived exosomes: roles in stromal remodeling, tumor progression, and cancer immunotherapy

Farah Fatima et al.

CHINESE JOURNAL OF CANCER (2015)

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Article Gastroenterology & Hepatology

CD44 but not CD24 expression is related to poor prognosis in non-cardia adenocarcinoma of the stomach

Xueyuan Cao et al.

BMC GASTROENTEROLOGY (2014)

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Article Oncology

Deregulated microRNAs in gastric cancer tissue-derived mesenchymal stem cells: novel biomarkers and a mechanism for gastric cancer

M. Wang et al.

BRITISH JOURNAL OF CANCER (2014)

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Article Multidisciplinary Sciences

Urinary Exosomes: A Novel Means to Non-Invasively Assess Changes in Renal Gene and Protein Expression

Silvia Spanu et al.

PLOS ONE (2014)

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Review Biotechnology & Applied Microbiology

MicroRNAs transported by exosomes in body fluids as mediators of intercellular communication in cancer

Ivan Salido-Guadarrama et al.

ONCOTARGETS AND THERAPY (2014)

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Review Reproductive Biology

Exosomes: an overview of biogenesis, composition and role in ovarian cancer

Allison Beach et al.

JOURNAL OF OVARIAN RESEARCH (2014)

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Review Immunology

Serum microRNAs as biomarkers of human lymphocyte activation in health and disease

Paola de Candia et al.

FRONTIERS IN IMMUNOLOGY (2014)

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Review Oncology

Functions and therapeutic roles of exosomes in cancer

Jacob A. Tickner et al.

FRONTIERS IN ONCOLOGY (2014)

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Review Chemistry, Multidisciplinary

Friend or foe: the role of microRNA in chemotherapy resistance

Haoran Li et al.

ACTA PHARMACOLOGICA SINICA (2013)

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Article Biochemical Research Methods

Characterization and proteomic analysis of ovarian cancer-derived exosomes

Bing Liang et al.

JOURNAL OF PROTEOMICS (2013)

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Review Biotechnology & Applied Microbiology

Ovarian Cancer Stem Cells: A New Target for Cancer Therapy

Qinglei Zhan et al.

BIOMED RESEARCH INTERNATIONAL (2013)

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Editorial Material Oncology

NK cell-released exosomes Natural nanobullets against tumors

Stefano Fais

ONCOIMMUNOLOGY (2013)

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Article Oncology

Elevated mRNA expression of CHAC1 splicing variants is associated with poor outcome for breast and ovarian cancer patients

G. Goebel et al.

BRITISH JOURNAL OF CANCER (2012)

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Review Pharmacology & Pharmacy

Steroid receptor coactivator-3 as a potential molecular target for cancer therapy

Jean Ching-Yi Tien et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2012)

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Editorial Material Oncology

Cancer immunotherapy Benefit and harm?

Dainius Characiejus

ONCOIMMUNOLOGY (2012)

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Article Oncology

Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic Niche

Cristina Grange et al.

CANCER RESEARCH (2011)

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Review Medicine, Research & Experimental

Tumor-infiltrating immune cells and prognosis: the potential link between conventional cancer therapy and immunity

Caroline Jochems et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2011)

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Article Oncology

Exosomes in the ascites of ovarian cancer patients: Origin and effects on anti-tumor immunity

Peng Peng et al.

ONCOLOGY REPORTS (2011)

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Article Multidisciplinary Sciences

Thermal- and Oxidative Stress Causes Enhanced Release of NKG2D Ligand-Bearing Immunosuppressive Exosomes in Leukemia/Lymphoma T and B Cells

Malin Hedlund et al.

PLOS ONE (2011)

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Article Hematology

Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells

Jihene Klibi et al.

BLOOD (2009)

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Article Oncology

Claudin-containing exosomes in the peripheral circulation of women with ovarian cancer

Jianghong Li et al.

BMC CANCER (2009)

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Article Oncology

Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes

Sascha Keller et al.

CANCER LETTERS (2009)

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Review Biochemistry & Molecular Biology

Tumor-induced modulation of dendritic cell function

Eva Gottfried et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2008)

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Article Immunology

NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy

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IMMUNITY (2008)

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Human tumor-derived exosomes selectively impair lymphocyte responses to interieukin-2

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Urinary mesothelin provides greater sensitivity for early stage ovarian cancer than serum mesothelin, urinary hCG free beta subunit and urinary hCG beta core fragment

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Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function

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Efficient inhibition of intra-peritoneal tumor growth and dissemination of human ovarian carcinoma cells in nude mice by anti-L1-cell adhesion molecule monoclonal antibody treatment

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Preparation of human ovarian cancer ascites-derived exosomes for a clinical trial

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Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses

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ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming

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Cytoplasmic CD24 expression in advanced ovarian serous borderline tumors

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The rationale for combined chemo/immunotherapy using a Toll-like receptor 3 (TLR3) agonist and tumour-derived exosomes in advanced ovarian cancer

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