Comprehensive analysis of anoikis-related long non-coding RNA immune infiltration in patients with bladder cancer and immunotherapy

Article Biochemistry & Molecular Biology

Comprehensive Analysis of Necroptosis-Related Long Noncoding RNA Immune Infiltration and Prediction of Prognosis in Patients With Colon Cancer

Li Liu et al.

Summary: This study identified necroptosis-related lncRNAs in colon cancer patients and found that these lncRNAs can predict patient survival and tumor immunity. They may have implications for personalized cancer therapy.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Article Genetics & Heredity

A Novel Necroptosis-Related lncRNA Signature Predicts the Prognosis of Lung Adenocarcinoma

Yinliang Lu et al.

Summary: A signature consisting of 7 necroptosis-related lncRNAs was constructed as an independent predictor for LUAD patients, showing a close relationship between the predictive signature and immune status of LUAD patients.

FRONTIERS IN GENETICS (2022)

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Article Biochemical Research Methods

Expression profile of immune checkpoint genes and their roles in predicting immunotherapy response

Fei-Fei Hu et al.

Summary: The study identified expression patterns of ICGs and their correlations with patient response to immune checkpoint blockade therapy, providing insights into the mechanisms of ICGs in anticancer treatments. A model using ICG expression features showed robust performance in predicting patient responses and outperformed other mRNA-based predictors.

BRIEFINGS IN BIOINFORMATICS (2021)

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Article Oncology

Immunogenomic Gene Signature of Cell-Death Associated Genes with Prognostic Implications in Lung Cancer

Pankaj Ahluwalia et al.

Summary: This study identified a novel 21-gene cell death signature in lung cancer patients, which significantly correlates with patient survival. Patients with higher expression of this genomic signature were found to have increased risk of early mortality. Additionally, the study revealed perturbations in cytokine expression, immune cell infiltration, and immune checkpoint molecule expression in high-risk patients, suggesting a potential for personalized immunotherapies targeting these pathways.

CANCERS (2021)

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Review Oncology

Outcome of patients with advanced upper tract urothelial carcinoma treated with immune checkpoint inhibitors: A systematic review and meta-analysis

Melissa Bersanelli et al.

Summary: The systematic review and meta-analysis of clinical studies on advanced UTUC patients treated with ICI did not show statistically significant effects in reducing the risk of death compared to standard chemotherapy. Subgroup analyses from randomized clinical trials are needed to provide more conclusive evidence.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2021)

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Article Oncology

Development of Biomarker Signatures Associated with Anoikis to Predict Prognosis in Endometrial Carcinoma Patients

Shan Chen et al.

Summary: This study identified seven anoikis-related genes for developing a prognostic signature for endometrial carcinoma patients, which accurately classified cases with different clinical outcomes and reflected specific immune status. The findings suggest that patients with high expression of this signature may not benefit from immunotherapy.

JOURNAL OF ONCOLOGY (2021)

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Article Oncology

Identification and Validation of m6A-Related lncRNA Signature as Potential Predictive Biomarkers in Breast Cancer

Wenchang Lv et al.

Summary: This study identified 6 m6A-related lncRNAs, constructed a prognostic-predicting model, and divided BC patients into high-risk and low-risk groups based on risk score. The risk score of the model was found to be an excellent independent prognostic factor, providing supplemental screening method for precisely judging BC prognosis.

FRONTIERS IN ONCOLOGY (2021)

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Article Multidisciplinary Sciences

Epigenetic regulation of triple negative breast cancer (TNBC) by TGF-β signaling

Radhakrishnan Vishnubalaji et al.

Summary: TGF beta signaling in TNBC is complex and involves regulation of protein coding genes and long non-coding RNA. The study provides a comprehensive analysis of the transcriptional landscape in response to TGF beta activation and inhibition, revealing potential targets for TGF beta regulation in TNBC.

SCIENTIFIC REPORTS (2021)

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Article Genetics & Heredity

Construction and Analysis of the Dysregulated ceRNA Network and Identification of Risk Long Noncoding RNAs in Breast Cancer

Xiaojie Su et al.

Summary: The study constructed a dysregulated lncRNA-PCG co-expression network in BRCA based on miRNA-mediated relationships and co-expression information. 30 risk lncRNAs were identified for BRCA, and a four-lncRNA prognostic signature was developed. These lncRNAs mainly functioned in cell cycle and DNA-related processes, and the prognostic signature showed independent predictive value for BRCA survival.

FRONTIERS IN GENETICS (2021)

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Review Oncology

Advances in bladder cancer biology and therapy

Linda Tran et al.

Summary: Recent developments in bladder cancer research have focused on identifying mutated genes, understanding cellular aspects, and advancing non-invasive diagnostic methods. Immune checkpoint inhibitor therapeutics have shown significant therapeutic impact, providing patients with better monitoring options and hope for prolonged survival.

NATURE REVIEWS CANCER (2021)

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Review Biochemistry & Molecular Biology