期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.1018772
关键词
immuno-cardio-oncology; inflammation; immune cell dysbalance; repurposed therapies; patient stratification; interdisciplinarity
类别
This review discusses the immunological aspects connecting cancer and cardiovascular disease, and the opportunities and challenges of integrating immunotherapies and anti-inflammatory therapies in both diseases. It also discusses the use of advanced therapies like chimeric antigen receptor T cells to address the burden of cancer and cardiovascular disease. The review emphasizes the importance of using biomarkers to guide therapeutic interventions in cardiology.
Inflammation and a dysregulated immune system are common denominators of cancer and cardiovascular disease (CVD). Immuno-cardio-oncology addresses the interconnected immunological aspect in both cancer and CVD and the integration of immunotherapies and anti-inflammatory therapies in both distinct disease entities. Building on prominent examples of convergent inflammation (IL-1ss biology) and immune disbalance (CD20 cells) in cancer and CVD/heart failure, the review tackles both the roadblocks and opportunities of repurposed use of IL-1ss drugs and anti-CD20 antibodies in both fields, and discusses the use of advanced therapies e.g. chimeric antigen receptor (CAR) T cells, that can address the raising burden of both cancer and CVD. Finally, it is discussed how inspired by precision medicine in oncology, the use of biomarker-driven patient stratification is needed to better guide anti-inflammatory/immunomodulatory therapeutic interventions in cardiology.
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