期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.1083462
关键词
HER-2 positive breast cancer; NK cells; ADCC; immunotherapy approach; monoclonal antibodies
类别
资金
- National Natural Science Foundation of China [81774308]
- High-level University Team Building Summit Plateau Innovation Team [601521D]
This review provides an overview of the role of natural killer (NK) cells and antibody-dependent cellular cytotoxicity (ADCC) in targeted therapy of HER2-positive breast cancer, as well as recent strategies to leverage our knowledge of NK cells and ADCC as an immunotherapy approach.
Human epidermal growth factor receptor 2 (HER2)-positive breast cancer has a high metastatic potential. Monoclonal antibodies (mAbs) that target HER2, such as trastuzumab and pertuzumab, are the cornerstone of adjuvant therapy for HER2-positive breast cancer. A growing body of preclinical and clinical evidence points to the importance of innate immunity mediated by antibody-dependent cellular cytotoxicity (ADCC) in the clinical effect of mAbs on the resulting anti-tumor response. In this review, we provide an overview of the role of natural killer (NK) cells and ADCC in targeted therapy of HER2-positive breast cancer, including the biological functions of NK cells and the role of NK cells and ADCC in anti-HER2 targeted drugs. We then discuss regulatory mechanisms and recent strategies to leverage our knowledge of NK cells and ADCC as an immunotherapy approach for HER2-positive breast cancer.
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