4.8 Review

Hepatocytes: A key role in liver inflammation

期刊

FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.1083780

关键词

hepatocyte; organelle damage; hepatic inflammation; extracellular vesicles; cytokines

向作者/读者索取更多资源

Hepatocytes, as the major cells in the liver, have significant roles in maintaining liver homeostasis. They can undergo organelle damage in response to liver insults and inflammatory signals, leading to the release of pro-inflammatory factors and initiation of an inflammatory response. This review summarizes the connection between hepatic organelle damage and liver inflammation, as well as introduces various hepatocyte-derived pro-inflammatory factors in chronic liver injury.
Hepatocytes, the major parenchymal cells in the liver, are responsible for a variety of cellular functions including carbohydrate, lipid and protein metabolism, detoxification and immune cell activation to maintain liver homeotasis. Recent studies show hepatocytes play a pivotal role in liver inflammation. After receiving liver insults and inflammatory signals, hepatocytes may undergo organelle damage, and further respond by releasing mediators and expressing molecules that can act in the microenvironment as well as initiate a robust inflammatory response. In this review, we summarize how the hepatic organelle damage link to liver inflammation and introduce numerous hepatocyte-derived pro-inflammatory factors in response to chronic liver injury.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据