Apoptosis in megakaryocytes: Safeguard and threat for thrombopoiesis

Platelets, generated from precursor megakaryocytes (MKs), are central mediators of hemostasis and thrombosis. The process of thrombopoiesis is extremely complex, regulated by multiple factors, and related to many cellular events including apoptosis. However, the role of apoptosis in thrombopoiesis has been controversial for many years. Some researchers believe that apoptosis is an ally of thrombopoiesis and platelets production is apoptosis-dependent, while others have suggested that apoptosis is dispensable for thrombopoiesis, and is even inhibited during this process. In this review, we will focus on this conflict, discuss the relationship between megakaryocytopoiesis, thrombopoiesis and apoptosis. In addition, we also consider why such a vast number of studies draw opposite conclusions of the role of apoptosis in thrombopoiesis, and try to figure out the truth behind the mystery. This review provides more comprehensive insights into the relationship between megakaryocytopoiesis, thrombopoiesis, and apoptosis and finds some clues for the possible pathological mechanisms of platelet disorders caused by abnormal apoptosis.

Automated summary

This review discusses the controversy surrounding the role of apoptosis in platelet production. While some researchers believe that apoptosis is necessary for platelet generation, others argue that it is dispensable or even inhibited. The review also explores why there are conflicting conclusions regarding the role of apoptosis in thrombopoiesis and attempts to uncover the truth behind this mystery. By examining the relationship between apoptosis, megakaryocytopoiesis, and thrombopoiesis, the review provides comprehensive insights into the possible pathological mechanisms of platelet disorders caused by abnormal apoptosis.