☆ 4.3 Review

Exploring predisposing factors and pathogenesis contributing to injuries of donor lungs

EXPERT REVIEW OF RESPIRATORY MEDICINE (2022)

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Article Surgery

Impact of ex vivo lung perfusion on brain-dead donor lung utilization: The French experience

Naissa Abdoul et al.

Summary: Donors whose lungs were transplanted after EVLP had similar profiles to those whose lungs were declined, but were quite different from donors with lungs transplanted without EVLP. Predictors for graft nonuse included age ≥ 50 years, smoking history, PaO2/FiO(2) ratio ≤ 300 mmHg, abnormal chest imaging, and purulent secretions. EVLP was found to increase the utilization of lungs from donors with a smoking history, PaO2/FiO(2) ratio ≤ 300 mmHg, and abnormal chest imaging.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

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Editorial Material Cardiac & Cardiovascular Systems

Successful Long-Term Outcome After Transplantation of Lungs Affected by Smoke Inhalation Injury

Jalal Moolji et al.

Summary: We report a case of a 43-year-old woman who underwent successful double lung transplantation from a donor with severe airway burns caused by a house fire. The recipient's lung function and quality of life remain excellent 24 months after the transplant. This is the first reported case of successful long-term outcomes in transplantation of lungs affected by smoke inhalation.

ANNALS OF THORACIC SURGERY (2022)

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Article Biotechnology & Applied Microbiology

Endothelin-Converting Enzyme 1 and Vascular Endothelial Growth Factor as Potential Biomarkers during Ex Vivo Lung Perfusion with Prolonged Hypothermic Lung-Sparing

Claudia Hernandez-Jimenez et al.

Summary: This study investigated the quantification of ECE-1 and VEGF in a swine model of EVLP with standard hypothermic preservation. The results showed that ECE-1 levels remained constant over time, while VEGF levels were initially higher after prolonged preservation but decreased during EVLP. Additionally, parameters such as hemodynamics, gas exchange, mechanical ventilation, and histology tended to improve after 12 hours of hypothermic preservation in the delayed initiation group.

DISEASE MARKERS (2022)

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Article Cardiac & Cardiovascular Systems

Safety of continuous 12-hour delivery of antimicrobial doses of inhaled nitric oxide during ex vivo lung perfusion

Vinicius S. Michaelsen et al.

Summary: This study aims to investigate the safety of continuous high-dose inhaled nitric oxide (iNO) during ex vivo lung perfusion (EVLP) for an extended period of 12 hours. The results suggest that continuous high-dose iNO delivered over 12 hours appears to be safe without inducing any significant pulmonary inflammation or deterioration in lung function.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2022)

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Review Respiratory System

Prognostic factors for development of acute respiratory distress syndrome following traumatic injury: a systematic review and meta-analysis

Alexandre Tran et al.

Summary: This study summarizes the prognostic associations between clinical risk factors and the development of ARDS following traumatic injury. The amount of crystalloid resuscitation within the first 24 hours of injury is identified as a modifiable factor, while increasing age, non-Hispanic White race, blunt mechanism of injury, presence of head injury, pulmonary contusion or rib fracture, and increasing chest injury severity are non-modifiable factors associated with the development of post-traumatic ARDS.

EUROPEAN RESPIRATORY JOURNAL (2022)

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Article Cardiac & Cardiovascular Systems

Effect of mode of intraoperative support on primary graft dysfunction after lung transplant

Gabriel Loor et al.

Summary: This study aimed to clarify the relationship between the use of extracorporeal life support during lung transplantation and severe primary graft dysfunction (PGD). The analysis of a multicenter international registry showed that venoarterial ECMO was associated with a higher risk of PGD compared to off-pump transplantation but lower risk than cardiopulmonary bypass (CPB). ECMO may be the preferable approach when extracorporeal life support is required during lung transplantation.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2022)

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Article Immunology

Specialized Proresolving Lipid Meditators Agonistic to Formyl Peptide Receptor Type 2 Attenuate Ischemia-reperfusion Injury in Rat Lung

Hiromi Oda et al.

Summary: Background. Lung ischemia-reperfusion injury (IRI) is a form of acute lung injury characterized by inflammation and lung edema. This study aimed to investigate the role of specialized proresolving lipid mediators (SPMs) in lung IRI. The results showed that endogenous SPMs decreased during lung IRI process and their effects were mediated through the ALX/FPR2 receptor. Administration of AT-RvD1 and AT-LXA(4) improved lung function and attenuated inflammation and lung injury via ALX/FPR2 activation.

TRANSPLANTATION (2022)

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Editorial Material Cardiac & Cardiovascular Systems

Successful Lung Transplantation From a Donor Who Had Recovered From Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia

Hye-Jin Kim et al.

Summary: During the COVID-19 pandemic, transplantation of lungs from donors who have recovered from COVID-19 infection is a critical issue. This study successfully transplanted lungs from a donor who had previously been infected with the virus into a patient with severe respiratory failure. The patient showed no evidence of COVID-19 transmission or graft dysfunction at the 3-month follow-up.

ANNALS OF THORACIC SURGERY (2022)

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Editorial Material Cardiac & Cardiovascular Systems

Xenogeneic support for the recovery of human donor organs

John D. O'Neill et al.

Summary: The article discusses a novel method of cross-circulation ex-vivo lung perfusion using xenographic support, highlighting the potential benefits of enhancing recovery of donor organs and increasing the availability of donor lungs for transplant. The authors address ethical, biosafety, immunological, and logistical concerns, showcasing the potential advantages of this technique.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2022)

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Article Cardiac & Cardiovascular Systems

Ex vivo treatment of cytomegalovirus in human donor lungs using a novel chemokine-based immunotoxin

Rafaela V. P. Ribeiro et al.

Summary: This study demonstrates that using F49A-FTP in ex-vivo lung perfusion significantly reduces HCMV reactivation compared to controls, suggesting successful targeting of latent virus (median reduction of 76% in F49A-FTP vs 15% increase in controls, p = 0.0087). Furthermore, there were comparable cell death rates of the targeted cells between both groups, indicating no off-target effects. Ex-vivo lung function remained stable over 6 hours and no differences in key inflammatory cytokines were observed, demonstrating the safety of this novel treatment.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2022)

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Review Gastroenterology & Hepatology

HBV-positive and HIV-positive organs in transplantation: A clinical guide for the hepatologist

Francesco Paolo Russo et al.

Summary: Organ transplantation is a life-saving treatment for patients with end-stage organ disease, but it is limited by a shortage of available organs. In recent years, there have been explorations and attempts to transplant organs from HBV and HIV positive donors in some countries. However, post-transplant antiviral therapies are necessary to prevent virus reactivation, and intentional virus transmission has practical, ethical, and clinical implications.

JOURNAL OF HEPATOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Lungs from polytrauma donors with significant chest trauma can be safely used for transplantation

Stefan Schwarz et al.

Summary: The use of organs from polytrauma donors for lung transplantation yields similar short- and long-term outcomes as transplantation from nontrauma donors. The radiologic signs of lung contusion at the time of offer have no impact on primary graft function and long-term survival.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2022)

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Article Immunology

Challenging the Ex Vivo Lung Perfusion Procedure With Continuous Dialysis in a Pig Model

Julien De Wolf et al.

Summary: This study investigated the effects of normothermic ex vivo lung perfusion (EVLP) on the physiological, metabolic, and genome-wide response in a pig model. The results showed that the management of EVLP perfusate by periodic replacement and continuous dialysis had no significant effect on lung function nor on the gene expression profiles ex vivo, suggesting that the accumulation of dialyzable cell products does not significantly alter the lung cell response during EVLP, which has implications for EVLP management in the clinic.

TRANSPLANTATION (2022)

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Article Respiratory System

Underlying lung disease and exposure to terrestrial moderate and high altitude: personalised risk assessment

Kirsten Holthof et al.

Summary: This study focuses on the health risks of patients with pre-existing lung disease during altitude travel and summarizes personalized pre-travel assessments and protective measures for various lung diseases.

BMC PULMONARY MEDICINE (2022)

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Article Immunology

Lung donation and SARS-CoV-2 transmission: Missed detection versus missed opportunity?

Jan Van Slambrouck et al.

IMMUNITY INFLAMMATION AND DISEASE (2022)

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Article Anesthesiology

Massive intraoperative red blood cell transfusion during lung transplantation is strongly associated with 90-day mortality

Enora Atchade et al.

Summary: This study aimed to evaluate the impact of massive intraoperative transfusion (MIOT) on the 90-day survival of lung transplantation recipients. The results showed that MIOT was associated with increased early postoperative morbidity and mortality rates.

ANAESTHESIA CRITICAL CARE & PAIN MEDICINE (2022)

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Article Surgery

Trends in Donation After Circulatory Death in Lung Transplantation in the United States: Impact Of Era

Christopher M. Bobba et al.

Summary: The use of lungs donated after circulatory death (DCD) has increased, with similar survival rates compared to lungs donated after brain death (DBD). This supports further utilization of DCD lungs in transplantation, expanding the donor pool.

TRANSPLANT INTERNATIONAL (2022)

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Article Immunology

A Retrospective Analysis for Risk Factors and Early Prognosis of Delayed Withdrawal Extracorporeal Membrane Oxygenation After Lung Transplantation

Liu Minqiang et al.

Summary: This study found that poor preoperative cardiac function in LTx recipients and prolonged mechanical ventilation time in donors are independent risk factors for delayed weaning of ECMO. Compared to the early withdrawal group, the delayed withdrawal group had significantly higher rates of postoperative complications and mortality.

TRANSPLANTATION (2021)

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Article Immunology

The Impact of Donor Asphyxiation or Drowning on Pediatric Lung Transplant Recipients

Laura Seese et al.

Summary: This study evaluated the impact of drowning or asphyxiation donors in pediatric lung transplant recipients and found similar rates of complications and survival in a propensity-matched cohort.

TRANSPLANTATION (2021)

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Article Cardiac & Cardiovascular Systems

National Trends in Extended Criteria Donor Utilization and Outcomes for Lung Transplantation

Ian G. Christie et al.

Summary: This study examined trends in the use of extended criteria donor lungs for lung transplantation and found that the use of extended criteria lungs has increased over time. However, the use of extended criteria donor lungs did not compromise recipient survival outcomes, with both ECD and standard criteria organs showing similar 1-year survival rates.

ANNALS OF THORACIC SURGERY (2021)

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Article Cardiac & Cardiovascular Systems

Clinical Outcomes of Lung Transplants From Donors With Unexpected Pulmonary Embolism

Yuriko Terada et al.

Summary: Incidentally detected pulmonary embolism in lung transplantation donors may result in a higher incidence of acute cellular rejection in recipients, as well as reduced survival free from chronic lung allograft dysfunction. Surgeons should exercise caution when transplanting lungs with incidentally discovered pulmonary embolism, and further studies are needed to confirm these preliminary findings.

ANNALS OF THORACIC SURGERY (2021)

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Article Cardiac & Cardiovascular Systems

Cell-free DNA in human ex vivo lung perfusate as a potential biomarker to predict the risk of primary graft dysfunction in lung transplantation

Takashi Kanou et al.

Summary: This study found that levels of cfDNA, particularly nuDNA, in EVLP perfusate were higher in the severe PGD group (PGD3) compared to the non-PGD group. This suggests that analyzing cfDNA levels in EVLP perfusate can help estimate donor lung damage before implantation. Larger studies are needed to confirm this concept.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2021)

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Review Biochemistry & Molecular Biology

Sterile inflammation in thoracic transplantation

C. Corbin Frye et al.

Summary: Sterile inflammation after organ transplantation, caused by necrotic cell death and release of endogenous ligands, including DAMPs and alarmins, is a significant contributor to graft damage. Understanding the mechanistic basis of sterile inflammation is critical for identifying personalized therapies to prevent or interrupt this vicious cycle and mitigate allograft dysfunction.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Mitochondria as Therapeutic Targets in Transplantation

Kourosh Saeb-Parsy et al.

Summary: Advancements in surgical techniques, technology, and immune suppression have revolutionized organ transplantation, however, the metabolic changes during transplantation have been overlooked. Understanding the metabolic changes, especially those associated with mitochondria, could lead to improvements in transplanted grafts' function and longevity, ultimately increasing the pool of available organs for transplantation.

TRENDS IN MOLECULAR MEDICINE (2021)

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Article Engineering, Biomedical

Extracorporeal Membrane Oxygenation for Primary Graft Dysfunction After Lung Transplantation

Takashi Harano et al.

Summary: In patients requiring ECMO for PGD after lung transplantation, earlier initiation of ECMO and timely recognition of PGD may help improve patient survival rates.

ASAIO JOURNAL (2021)

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Article Biochemistry & Molecular Biology

Protective effects of anti-HMGB1 monoclonal antibody on lung ischemia reperfusion injury in mice

Kentaro Nakata et al.

Summary: The neutralizing anti-HMGB1 monoclonal antibody shows therapeutic potential in alleviating lung IR injury by reducing inflammatory responses and apoptosis, improving oxygenation capacity, and reducing tissue damage through lowering plasma HMGB1 levels and inhibiting proinflammatory factors.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Immunology

Overcoming the Limits of Reconditioning: Seventeen Hours of EVLP With Successful Transplantation From Uncontrolled Circulatory Death Donor

Alessandro Palleschi et al.

Summary: Uncontrolled donation after circulatory death (DCD) donors present a potential source of increased lung transplantation resources, but pose challenges due to warm ischemia and organ preservation issues. Utilizing ex vivo lung perfusion (EVLP) for lung evaluation and reconditioning can help extend the storage time of potentially transplantable lungs.

TRANSPLANTATION (2021)

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Editorial Material Critical Care Medicine

Successful double-lung transplantation from a donor previously infected with SARS-CoV-2

Laurens J. Ceulemans et al.

LANCET RESPIRATORY MEDICINE (2021)

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Article Surgery

Lung transplantation from swimming pool drowning victims: A case series

Sarah Tsou et al.

Summary: The use of donor lungs from victims of drowning is rare and there is limited literature on the outcomes, with most focusing on cases from natural bodies of water. However, three cases of successful bilateral lung transplantation from donors who drowned in swimming pools demonstrate the potential for good short- and long-term outcomes, suggesting that drowned donor lungs may offer a feasible solution to the growing demand for donor organs.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Article Surgery

Donor to recipient transmission of SARS-CoV-2 by lung transplantation despite negative donor upper respiratory tract testing

Daniel R. Kaul et al.

Summary: This case report highlights a proven transmission of SARS-CoV-2 from a lung donor to recipient, with sequence analysis confirming the donor origin of infection in both the recipient and a healthcare worker. It emphasizes the importance of testing lower respiratory tract specimens from potential lung donors and enhancing personal protective equipment for healthcare workers involved in lung procurement and transplantation.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Article Biotechnology & Applied Microbiology

VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction

Siyi Wu et al.

Summary: Lung ischemia reperfusion injury (LIRI) is a complex pathophysiological process characterized by endothelial barrier dysfunction. The study demonstrated that VX765, a caspase-1 inhibitor, can effectively alleviate LIRI-induced endothelial pyroptosis and barrier dysfunction, providing protective effects against lung I/R.

BIOMED RESEARCH INTERNATIONAL (2021)

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Article Critical Care Medicine

Assessing Patients for Air Travel

Amy L. Bellinghausen et al.

Summary: It is important for physicians, especially primary care providers and pulmonary specialists, to advise patients before air travel, especially those with underlying pulmonary disease. Assessment tools and strategies are available to assess preflight risk and minimize potential harm, with specific conditions prompting a more thorough preflight workup.

CHEST (2021)

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Review Surgery

Current status and further potential of lung donation after circulatory death

Jonas P. Ehrsam et al.

Summary: Chronic organ shortage is the main limiting factor in lung transplantation, with donation after circulatory death (DCD) being introduced as a potential solution. Controlled-DCD lungs have shown to be effective and safe, with comparable outcomes to donation after brain death (DBD). Promoting controlled-DCD lung donation could significantly decrease mortality on the waiting list.

CLINICAL TRANSPLANTATION (2021)

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Review Respiratory System

Advanced considerations in organ donors

Hailey M. Shepherd et al.

Summary: The increasing demand for lung transplantation has not been matched by the availability of suitable lung allografts, leading to limitations in the number of transplantations performed each year in the US. Various methods have been proposed to address this issue, but there is significant disparity in acceptance and utilization of these practices among transplant centers. Addressing barriers in donor evaluation, management, and accessibility is crucial for maximizing the number of lungs available for transplantation within the existing donor pool.

JOURNAL OF THORACIC DISEASE (2021)

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Article Critical Care Medicine

Electricity Induced Burns and Lung Injury: A Rare Autopsy Observation

Tanuj Kanchan et al.

Summary: Electrocution injuries are frequently encountered in domestic and occupational settings, often leading to significant morbidity and mortality globally. Autopsy diagnosis of electrocution is typically based on gross and histopathological changes in entry and exit wounds, but not all cases exhibit visible wound changes. In such cases, examining histopathological changes in internal organs along the current path can be helpful in diagnosis. This highlights the importance of autopsy pathology in identifying electrocution as a cause of death.

JOURNAL OF BURN CARE & RESEARCH (2021)

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Review Cardiac & Cardiovascular Systems

Inflammatory responses in lungs from donation after brain death: Mechanisms and potential therapeutic targets

Aaron Wong et al.

Summary: The utilization of lungs donated after brain death is low due to brain death-induced lung injury, with elevated inflammatory responses and cell death pathways. Research suggests that improving donor management and developing novel treatment strategies may enhance the transplantation outcomes of DBD lungs.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2021)

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Review Surgery

The potential of ex vivo lung perfusion on improving organ quality and ameliorating ischemia reperfusion injury

Jasper Iske et al.

Summary: Allogeneic lung transplantation is the treatment of choice for advanced lung diseases, but ischemia reperfusion injury remains a crucial issue during the transplant process. Ex vivo lung perfusion technique can reduce the incidence of primary graft dysfunction and improve organ quality.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Article Surgery

Aggressive pursuit and utilization of non-ideal donor lungs does not compromise post-lung transplant survival

Samantha E. Halpern et al.

Summary: It was found that the attitudes of organ procurement organizations towards non-ideal donors can affect post-transplant outcomes for lung transplant recipients, but the most aggressive and least aggressive OPOs actually achieve similar patient survival rates and short-term post-transplant outcomes.

CLINICAL TRANSPLANTATION (2021)

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Review Biochemistry & Molecular Biology

Attenuation of ventilator-induced lung injury through suppressing the pro-inflammatory signaling pathways: A review on preclinical studies

Mojdeh Monjezi et al.

Summary: Mechanical ventilation is commonly used in ICU patients, but may lead to ventilator-induced lung injury (VILI). The pathogenesis of VILI involves inflammatory mediators, damage-associated molecular patterns, and pattern recognition receptors. Therefore, blocking these signaling pathways may help reduce the progression of VILI.

MOLECULAR IMMUNOLOGY (2021)

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Article Cell Biology

Static lung storage at 10°C maintains mitochondrial health and preserves donor organ function

Aadil Ali et al.

Summary: Cold static preservation at 10 degrees Celsius can lead to better preservation of donor lungs with improved mitochondrial health and metabolic protection. This approach has been successfully applied in clinical settings, allowing for extended preservation time and improved outcomes for lung transplant recipients. Preserving lungs at 10 degrees Celsius may become the new standard of care for prolonged pulmonary preservation.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Multidisciplinary Sciences

Heparanase inhibition preserves the endothelial glycocalyx in lung grafts and improves lung preservation and transplant outcomes

Kentaro Noda et al.

Summary: This study demonstrated the importance of protecting the endothelial glycocalyx (eGC) through heparanase inhibition in improving lung graft quality and function, reducing reperfusion-related damage.

SCIENTIFIC REPORTS (2021)

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Review Medicine, General & Internal

Patient-Self Inflicted Lung Injury: A Practical Review

Guillaume Carteaux et al.

Summary: This review details the main pathophysiological mechanisms by which the patient's respiratory effort could become deleterious, including excessive over-distension, inhomogeneous distribution of pressure variations across the lung, and increase in transvascular pressure leading to aggravated pulmonary edema. Harmful patient-ventilator interactions are also discussed, along with practical ways to detect situations at risk for P-SILI in clinical settings and personalize treatment strategies.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Cell Biology

Perfluorocarbon-Based Oxygen Carriers and Subnormothermic Lung Machine Perfusion Decrease Production of Pro-Inflammatory Mediators

Stephan Arni et al.

Summary: The study found that using PFCOC for EVLP at 28 degrees Celsius significantly improves lung donor physiology and alleviates lung tissue biochemical and inflammatory parameters. Compared to EVLP at 37 degrees Celsius, EVLP at 28 degrees Celsius not only improved dynamic compliance and pulmonary vascular resistance, but also reduced levels of inflammatory cytokines.

CELLS (2021)

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Article Respiratory System

Adiponectin ameliorates lung ischemia-reperfusion injury through SIRT1-PINK1 signaling-mediated mitophagy in type 2 diabetic rats

Tao Jiang et al.

Summary: The study demonstrated that adiponectin attenuated reperfusion-induced oxidative stress, inflammation, apoptosis, and mitochondrial dysfunction in diabetic lung ischemia-reperfusion injury through activation of the SIRT1-PINK1 signaling-mediated mitophagy.

RESPIRATORY RESEARCH (2021)

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Review Critical Care Medicine

Treatment of the lung injury of drowning: a systematic review

Ogilvie Thom et al.

Summary: The evidence for treating lung injury in drowning patients is limited, and there is a critical need for comparative studies to develop more effective therapeutic strategies.

CRITICAL CARE (2021)

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Review Cardiac & Cardiovascular Systems

Outcomes of marginal donors for lung transplantation after ex vivo lung perfusion: A systematic review and meta-analysis

Dong Tian et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2020)

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Review Physiology

PATHOGENESIS OF HIV-RELATED LUNG DISEASE: IMMUNITY, INFECTION, AND INFLAMMATION

Sushma K. Cribbs et al.

PHYSIOLOGICAL REVIEWS (2020)

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Article Critical Care Medicine

Prevention of viral transmission during lung transplantation with hepatitis C-viraemic donors: an open-label, single-centre, pilot trial

Marcelo Cypel et al.

LANCET RESPIRATORY MEDICINE (2020)

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Review Cardiac & Cardiovascular Systems

Role of Mitochondrial Calcium and the Permeability Transition Pore in Regulating Cell Death

Tyler M. Bauer et al.

CIRCULATION RESEARCH (2020)

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Letter Surgery

Hepatitis B surface antigen-positive donor to negative recipient lung transplantation

Sara Belga et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2020)

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Article Surgery

Viremic Hepatitis B Donors: A Case of Why It's Time to Further Expand the Donor Pool for Thoracic Transplant

E.M. Eichenberger et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2020)

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Review Biology

Current techniques and the future of lung preservation

Larissa J. Lautner et al.

CRYOBIOLOGY (2020)

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Review Transplantation

Redefining marginality: donor lung criteria

Jasleen Kukreja et al.

CURRENT OPINION IN ORGAN TRANSPLANTATION (2020)

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Review Respiratory System

Developments in lung transplantation over the past decade

Sophie C. van der Mark et al.

EUROPEAN RESPIRATORY REVIEW (2020)

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Review Medicine, General & Internal

Pulmonary embolism: update on management and controversies

Lisa Duffett et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Article Multidisciplinary Sciences

Clinical transplantation using negative pressure ventilation ex situ lung perfusion with extended criteria donor lungs

Max T. Buchko et al.

NATURE COMMUNICATIONS (2020)

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Article Cardiac & Cardiovascular Systems

Extended criteria donor lungs do not impact recipient outcomes in pediatric transplantation

Wiebke Sommer et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2019)

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Article Surgery

Transplantation of donor lungs with pulmonary embolism - a retrospective study

Wiebke Sommer et al.

TRANSPLANT INTERNATIONAL (2019)

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Review Respiratory System

Pulmonary contusion

Szilard Rendeki et al.

JOURNAL OF THORACIC DISEASE (2019)

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Review Anesthesiology

Transfusion-related Acute Lung Injury in the Perioperative Patient

Mark J. McVey et al.

ANESTHESIOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Mesenchymal stromal cell therapy during ex vivo lung perfusion ameliorates ischemia-reperfusion injury in lung transplantation

Daisuke Nakajima et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2019)

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Article Surgery

Prone Positioning During Ex Vivo Lung Perfusion Influences Regional Edema Accumulation

Sofie Ordies et al.

JOURNAL OF SURGICAL RESEARCH (2019)

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Review Immunology

The Comparable Efficacy of Lung Donation After Circulatory Death and Brain Death: A Systematic Review and Meta-analysis

Jian Zhou et al.

TRANSPLANTATION (2019)

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Article Surgery

Total parenteral nutrition in ex vivo lung perfusion: Addressing metabolism improves both inflammation and oxygenation

Max T. Buchko et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2019)

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Article Respiratory System

Breathing lung transplantation with the Organ Care System (OCS) Lung: lessons learned and future implications

William Lightle et al.

JOURNAL OF THORACIC DISEASE (2019)

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Editorial Material Surgery

Expanding the Lung Donor Pool and Improving Outcomes Ex Vivo Lung Perfusion

Stephen Chiu et al.

JAMA SURGERY (2019)

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Article Surgery

Long-term Outcomes of Lung Transplant With Ex Vivo Lung Perfusion

Chandima Divithotawela et al.

JAMA SURGERY (2019)

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Letter Respiratory System

Neutrophil extracellular traps in ex vivo lung perfusion perfusate predict the clinical outcome of lung transplant recipients

Lindsay Caldarone et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

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Article Cardiac & Cardiovascular Systems

Feasibility of lung microdialysis to assess metabolism during clinical ex vivo lung perfusion

Anna Teresa Mazzeo et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2019)

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Article Cardiac & Cardiovascular Systems

Donation after circulatory death in lung transplantation-five-year follow-up from ISHLT Registry

Dirk Van Raemdonck et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2019)

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Article Surgery

Feasibility of lung transplantation from donors mechanically ventilated for prolonged periods

Seiichiro Sugimoto et al.

SURGERY TODAY (2019)

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Review Respiratory System

Preclinical and clinical studies of smoke-inhalation-induced acute lung injury: update on both pathogenesis and innovative therapy

Bingxin Guo et al.

THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE (2019)

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Article Cardiac & Cardiovascular Systems

α1-Anti-trypsin improves function of porcine donor lungs during ex-vivo lung perfusion

Huiqing Lin et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2018)

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Article Cardiac & Cardiovascular Systems

Negative pressure ventilation decreases inflammation and lung edema during normothermic ex-vivo lung perfusion

Nader S. Aboelnazar et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2018)

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Article Immunology

Effects of Warm Versus Cold Ischemic Donor Lung Preservation on the Underlying Mechanisms of Injuries During Ischemia and Reperfusion

Ilker Iskender et al.

TRANSPLANTATION (2018)

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Editorial Material Cardiac & Cardiovascular Systems

High positive end-expiratory pressure during ex vivo lung perfusion: recruiting rejected donor lungs

Kamal S. Ayyat et al.

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY (2018)

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Article Critical Care Medicine

Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study

Gregor Warnecke et al.

LANCET RESPIRATORY MEDICINE (2018)

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Article Immunology

Impact of donor lung pathogenic bacteria on patient outcomes in the immediate posttransplant period

Omar Ahmad et al.

TRANSPLANT INFECTIOUS DISEASE (2018)

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Article Medicine, General & Internal

Intracerebral haemorrhage: current approaches to acute management

Charlotte Cordonnier et al.

LANCET (2018)

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Article Biotechnology & Applied Microbiology

Safety and Efficacy of Ex Vivo Donor Lung Adenoviral IL-10 Gene Therapy in a Large Animal Lung Transplant Survival Model

Tiago N. Machuca et al.

HUMAN GENE THERAPY (2017)

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Article Cardiac & Cardiovascular Systems

Lung lavage and Surfactant Replacement During Ex Vivo Lung Perfusion for Treatment of Gastric Acid Aspiration-Induced Donor Lung Injury

Daisuke Nakajima et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2017)

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Article Cardiac & Cardiovascular Systems

Airway pressure release ventilation during ex vivo lung perfusion attenuates injury

J. Hunter Mehaffey et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2017)

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Article Cardiac & Cardiovascular Systems

Lungs donated after circulatory death and prolonged warm ischemia are transplanted successfully after enhanced ex vivo lung perfusion using adenosine A2B receptor antagonism

Eric J. Charles et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2017)

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Review Respiratory System

Primary graft dysfunction: pathophysiology to guide new preventive therapies

Ciara M. Shaver et al.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2017)

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Article Respiratory System

Evaluation and Management of the Potential Lung Donor

Andrew Courtwright et al.

CLINICS IN CHEST MEDICINE (2017)

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Article Cardiac & Cardiovascular Systems

Bronchodilator Inhalation During Ex Vivo Lung Perfusion Improves Posttransplant Graft Function After Warm Ischemia

Kyoko Hijiya et al.

ANNALS OF THORACIC SURGERY (2017)

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Article Surgery

Ex Vivo Perfusion Treatment of Infection in Human Donor Lungs

D. Nakajima et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2016)

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Article Anesthesiology

Increased Intraoperative Fluid Administration Is Associated with Severe Primary Graft Dysfunction After Lung Transplantation

Mariya A. Geube et al.

ANESTHESIA AND ANALGESIA (2016)

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Article Hematology

Influences of high-voltage electrical burns on the pulmonary microcirculation in rabbits

H. M. Zhou et al.

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION (2016)

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Review Surgery

Lung transplantation following death by drowning: a review of the current literature

Shravani Pasupneti et al.

CLINICAL TRANSPLANTATION (2016)

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Article Critical Care Medicine

Ventilator-related causes of lung injury: the mechanical power

L. Gattinoni et al.

INTENSIVE CARE MEDICINE (2016)

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Article Cardiac & Cardiovascular Systems

Impact of donor and recipient hepatitis C status in lung transplantation

Brian R. Englum et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2016)

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Review Cardiac & Cardiovascular Systems

Molecular mechanisms underlying hyperoxia acute lung injury

Francisca Dias-Freitas et al.

RESPIRATORY MEDICINE (2016)

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Review Surgery

New classification of donation after circulatory death donors definitions and terminology

Marie Thuong et al.

TRANSPLANT INTERNATIONAL (2016)

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Article Multidisciplinary Sciences

Neutrophil extracellular traps are indirectly triggered by lipopolysaccharide and contribute to acute lung injury

Shuai Liu et al.

SCIENTIFIC REPORTS (2016)

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Review Critical Care Medicine

The inflammatory response to extracorporeal membrane oxygenation (ECMO): a review of the pathophysiology

Jonathan E. Millar et al.

CRITICAL CARE (2016)

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Article Surgery

Solid Organ Transplantation From Hepatitis B Virus-Positive Donors: Consensus Guidelines for Recipient Management

S. Huprikar et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2015)

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Article Surgery

A Novel Dual Ex Vivo Lung Perfusion Technique Improves Immediate Outcomes in an Experimental Model of Lung Transplantation

Y. Tanaka et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2015)

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Article Cardiac & Cardiovascular Systems

β2-Adrenoreceptor Agonist Inhalation During Ex Vivo Lung Perfusion Attenuates Lung Injury

Takeshi Kondo et al.

ANNALS OF THORACIC SURGERY (2015)

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Article Critical Care Medicine

Management of the Potential Organ Donor in the ICU: Society of Critical Care Medicine/American College of Chest Physicians/Association of Organ Procurement Organizations Consensus Statement

Robert M. Kotloff et al.

CRITICAL CARE MEDICINE (2015)

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Review Transplantation

Update on ischemia-reperfusion injury in lung transplantation

Fengshi Chen et al.

CURRENT OPINION IN ORGAN TRANSPLANTATION (2015)

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Review Anesthesiology

How to minimise ventilator-induced lung injury in transplanted lungs The role of protective ventilation and other strategies

Andre Soluri-Martins et al.

EUROPEAN JOURNAL OF ANAESTHESIOLOGY (2015)

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Article Cardiac & Cardiovascular Systems

The effects of hydrogen gas inhalation during ex vivo lung perfusion on donor lungs obtained after cardiac death

Seokjin Haam et al.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2015)

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Review Critical Care Medicine

Pathogenetic Mechanisms of Neurogenic Pulmonary Edema

Jiri Sedy et al.

JOURNAL OF NEUROTRAUMA (2015)

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Editorial Material Immunology

Successful Repair of Donation After Circulatory Death Lungs With Large Pulmonary Embolus Using the Lung Organ Care System for Ex Vivo Thrombolysis and Subsequent Clinical Transplantation

Jessica G. Y. Luc et al.

TRANSPLANTATION (2015)

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Article Cardiac & Cardiovascular Systems

A neutrophil elastase inhibitor improves lung function during ex vivo lung perfusion

Masaaki Harada et al.

GENERAL THORACIC AND CARDIOVASCULAR SURGERY (2015)

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Article Medicine, Legal

Bone Marrow Embolism to the Lung in Electrocution Two Case Reports

Ryan Blumenthal et al.

AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY (2014)

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Article Physiology

Shear stress-related mechanosignaling with lung ischemia: lessons from basic research can inform lung transplantation

Shampa Chatterjee et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2014)

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Article Critical Care Medicine

Divergent Functions of Toll-like Receptors during Bacterial Lung Infections

Pankaj Baral et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)

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Article Cardiac & Cardiovascular Systems

Use of the Donor Lung After Asphyxiation or Drowning: Effect on Lung Transplant Recipients

Bryan A. Whitson et al.

ANNALS OF THORACIC SURGERY (2014)

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Editorial Material Cardiac & Cardiovascular Systems

Successful Lung Transplantation After Donor Lung Reconditioning With Urokinase in Ex Vivo Lung Perfusion System

Ilhan Inci et al.

ANNALS OF THORACIC SURGERY (2014)

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Article Critical Care Medicine

Air Travel and Pneumothorax

Xiaowen Hu et al.

CHEST (2014)

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Review Urology & Nephrology

Donor-derived infection-the challenge for transplant safety

Jay A. Fishman et al.

NATURE REVIEWS NEPHROLOGY (2014)

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Article Surgery

Ex vivo lung perfusion to improve donor lung function and increase the number of organs available for transplantation

Franco Valenza et al.

TRANSPLANT INTERNATIONAL (2014)

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Article Immunology

Successful Lung Salvage by Ex Vivo Reconditioning of Neurogenic Pulmonary Edema: Case Report

P. G. Sanchez et al.

TRANSPLANTATION PROCEEDINGS (2014)

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Review Respiratory System

Advances in ventilator-associated lung injury: prevention is the target

Yuda Sutherasan et al.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2014)

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Article Critical Care Medicine

Clinical Risk Factors for Primary Graft Dysfunction after Lung Transplantation

Joshua M. Diamond et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)

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Review Allergy

Viral infection of the lung: Host response and sequelae

Jae-Kwang Yoo et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

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Article Cardiac & Cardiovascular Systems

Protective effect of plasmin in marginal donor lungs in an ex vivo lung perfusion model

Hideki Motoyama et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2013)

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Review Critical Care Medicine

Donor management and lung preservation for lung transplantation

Laveena Munshi et al.

LANCET RESPIRATORY MEDICINE (2013)

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Article Engineering, Biomedical

Donor Lungs With Pulmonary Embolism Evaluated with Ex Vivo Lung Perfusion

Chase R. Brown et al.

ASAIO JOURNAL (2012)

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Article Respiratory System

The clinical potential of ex vivo lung perfusion

Marcelo Cypel et al.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2012)

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Review Physiology

What do we know about mechanical strain in lung alveoli?

Esra Roan et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2011)

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Article Cardiac & Cardiovascular Systems

The Value of Pulmonary Contusion Volume Measurement With Three-Dimensional Computed Tomography in Predicting Acute Respiratory Distress Syndrome Development

Shaohua Wang et al.

ANNALS OF THORACIC SURGERY (2011)

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Article Endocrinology & Metabolism

Endocrine changes in brain death and transplantation

Aaron M. Ranasinghe et al.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2011)

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Article Critical Care Medicine

Aspiration-induced lung injury

Krishnan Raghavendran et al.

CRITICAL CARE MEDICINE (2011)

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Article Immunology

The Consumption of Glucose During Ex Vivo Lung Perfusion Correlates With Lung Edema

F. Valenza et al.

TRANSPLANTATION PROCEEDINGS (2011)

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Review Critical Care Medicine

Bench-to-bedside review: Damage-associated molecular patterns in the onset of ventilator-induced lung injury

Maria T. Kuipers et al.

CRITICAL CARE (2011)

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Review Cardiac & Cardiovascular Systems

Lung ischemia-reperfusion injury: a molecular and clinical view on a complex pathophysiological process

Willem A. den Hengst et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2010)

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Article Cardiac & Cardiovascular Systems

Guidelines for Donor Lung Selection: Time for Revision?

Karl G. Reyes et al.

ANNALS OF THORACIC SURGERY (2010)

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Article Cardiac & Cardiovascular Systems

Early institution of extracorporeal membrane oxygenation for primary graft dysfunction after lung transplantation improves outcome

Christopher H. Wigfield et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2007)

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Review Medicine, General & Internal

Electrocution and life-threatening electrical injuries

Christian Spies et al.

ANNALS OF INTERNAL MEDICINE (2006)

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Article Cardiac & Cardiovascular Systems

Unexpected donor pulmonary embolism affects early outcomes after lung transplantation: A major mechanism of primary graft failure?

T Oto et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2005)

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Article Surgery

Hyperinflation during lung preservation and increased reperfusion injury

MR Patel et al.

JOURNAL OF SURGICAL RESEARCH (2005)

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Article Cardiac & Cardiovascular Systems

Bacterial colonization of the donor lower airways is a predictor of poor outcome in lung transplantation

VS Avlonitis et al.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2003)

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Review Cardiac & Cardiovascular Systems

A review of lung transplant donor acceptability criteria

JB Orens et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2003)

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Article Cardiac & Cardiovascular Systems

Liberalization of donor criteria may expand the donor pool without adverse consequence in lung transplantation

SM Bhorade et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2000)

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