期刊
EXPERT REVIEW OF RESPIRATORY MEDICINE
卷 16, 期 11-12, 页码 1247-1256出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/17476348.2022.2147509
关键词
Compensatory response; gut microbiome; hypertension; Lachnospiraceae; obstructive sleep apnea; Ruminococcaceae
资金
- National Natural Science Foundation of China
- [82000096]
This study suggests that there is an interplay between obstructive sleep apnea (OSA) and hypertension affecting the gut microbiome. The results demonstrate a possible compensatory mechanism for gut microbiome changes in OSA pathophysiology. The increase in certain genera of Ruminococcaceae and Lachnospiraceae in OSA patients may represent an adaptive response to hypoxia.
BackgroundObstructive sleep apnea (OSA) and hypertension are interrelated diseases linked to gut dysbiosis. This study aimed to investigate the effect of OSA on the gut microbiome in the context of hypertension and vice versa.Research design and methodsOf 211 consecutively screened patients, 52 completed polysomnography study, medical history questionnaires, and fecal sample collection. 16S rRNA gene sequencing was performed on fecal samples, and diversity, richness, and microbial taxa were analyzed using bioinformatics.ResultsAlpha diversity showed slightly decreased diversity in OSA and hypertension groups without significant difference, and the hypoxia burden index (HBI) showed a weak positive correlation with Chao1 index (r = 0.342, p < 0.05) in OSA patients. Firmicutes-to-Bacteroidetes ratio was higher in patients with than without OSA. In hypertensive patients, those with OSA had higher Ruminococcus_1, Lachnoclostridium, Lachnospira, [Ruminococcus]_torques_group, and unidentified Lachnospiraceae levels than those without OSA. Conversely, in OSA patients, hypertensive patients had lower Faecalibacterium and Lachnospiraceae_NK4A136_group levels.ConclusionThe present study suggests a possible compensatory mechanism for gut microbiome changes in sleep apnea pathophysiology. The positive correlation between HBI and alpha diversity, and increase in certain genera of Ruminococcaceae and Lachnospiraceae in OSA patients may represent an adaptive response to hypoxia.
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