期刊
CELL CYCLE
卷 14, 期 13, 页码 2022-2032出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2015.1044172
关键词
cell cycle; cyclin-dependent kinases; glycolysis; metabolism; nutrients; proliferation
类别
资金
- Netherlands Organization for Scientific Research (NWO)
- Dutch Cancer Society (KWF Kankerbestrijding)
The relationship between cellular metabolism and the cell cycle machinery is by no means unidirectional. The ability of a cell to enter the cell cycle critically depends on the availability of metabolites. Conversely, the cell cycle machinery commits to regulating metabolic networks in order to support cell survival and proliferation. In this review, we will give an account of how the cell cycle machinery and metabolism are interconnected. Acquiring information on how communication takes place among metabolic signaling networks and the cell cycle controllers is crucial to increase our understanding of the deregulation thereof in disease, including cancer.
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