Enhanced Anti-Skin Aging Effects of Fermented Black Ginseng (Panax ginseng CA Meyer) by Aspergillus niger KHNT-1

Review Plant Sciences

Pharmacological potential of ginseng and its major component ginsenosides

Zubair Ahmed Ratan et al.

Summary: Ginseng, as a traditional herb in Asian countries, has been used for thousands of years and contains a variety of active ingredients with numerous benefits, but further high-quality evidence is needed to prove its medicinal value.

JOURNAL OF GINSENG RESEARCH (2021)

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Review Dermatology

Skin pigmentation and its control: From ultraviolet radiation to stem cells

Joseph Michael Yardman-Frank et al.

Summary: This review provides an overview of skin pigmentation mechanisms, including melanocytes, tanning pathways, vitiligo, follicular pigmentation, and hair greying. It highlights the importance of future research and potential intervention points in these areas.

EXPERIMENTAL DERMATOLOGY (2021)

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Article Engineering, Chemical

Cumulative Production of Bioactive Rg3, Rg5, Rk1, and CK from Fermented Black Ginseng Using Novel Aspergillus niger KHNT-1 Strain Isolated from Korean Traditional Food

Jin Kyu Park et al.

Summary: Through studying the isolation and characteristics of components obtained by a shorter steaming cycle from white ginseng to fermented black ginseng, an increase in the bioactive degree of Rg3 was effectively achieved, resulting in enhanced pharmacological activity of the converted fermented black ginseng.

PROCESSES (2021)

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Article Engineering, Chemical

In Vitro Anti-Wrinkle and Skin-Moisturizing Effects of Evening Primrose (Oenothera biennis) Sprout and Identification of Its Active Components

Tae Heon Kim et al.

Summary: The study showed that Oenothera biennis sprout extract (OBS-E) has antioxidant, anti-wrinkle, and moisturizing activities, with polyphenolic acids and flavonoid glycosides playing key roles in these effects. OBS-E significantly increased hyaluronic acid levels and the expression of moisturizing genes, leading to improved skin hydration.

PROCESSES (2021)

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Review Dermatology

Environmentally-Induced (Extrinsic) Skin Aging: Exposomal Factors and Underlying Mechanisms

Jean Krutmann et al.

Summary: The skin, as a barrier organ, is an ideal model for studying environmentally-induced aging. This review explains how exposure to specific exposomal factors can lead to extrinsic skin aging, involving interactions between these factors and genetic modifications, ultimately causing macromolecular damage and changes in fibroblasts in the dermal compartment of the skin.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Article Engineering, Chemical

Ginsenosides Conversion and Anti-Oxidant Activities in Puffed Cultured Roots of Mountain Ginseng

Jian Yu Pu et al.

Summary: The study introduced a single step puffing method with high temperature and pressure to accelerate the conversion of major to minor ginsenosides in CRMG, resulting in higher levels of bioactive compounds. Puffed CRMG exhibited increased contents of phenolics, flavonoids, and minor ginsenosides, as well as enhanced antioxidant properties. This process also showed low toxicity on HaCaT cells and significant reduction of ROS levels, indicating the potential use of puffed CRMG in functional foods and cosmeceuticals.

PROCESSES (2021)

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Article Plant Sciences

The Metabolite Profile in Culture Supernatant of Aster yomena Callus and Its Anti-Photoaging Effect in Skin Cells Exposed to UVB

Woo Sik Kim et al.

Summary: The study demonstrated the potential of Aster yomena extract in reducing photoaging effects on human keratinocytes, and improving skin conditions related to inflammation, skin damage recovery, and moisture retention. This suggests the use of AYC-CS-E as a cosmetic ingredient for various skin diseases caused by photoaging, highlighting the commercial potential of the callus culture system for cosmetic ingredients supply.

PLANTS-BASEL (2021)

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Review Biochemistry & Molecular Biology

microRNAs in the Regulation of Melanogenesis

Yekatsiaryna Hushcha et al.

Summary: Melanogenesis is a complex biological process regulated by internal and external factors, as well as epigenetic factors such as miRNAs, which ultimately affect melanin synthesis by regulating key factors such as MITF. Understanding the role of miRNAs in melanogenesis can provide insights into the regulation mechanism of this biological process.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Chemistry, Applied

Oxidative stress in the skin: Impact and related protection

Juanjuan Chen et al.

Summary: Skin is exposed to oxidative stress from both exogenous and endogenous sources, leading to issues such as uneven skin tone, pigmentary disorder, roughness, and wrinkles. The balance of skin microbiota plays a crucial role in maintaining skin health. Antioxidants like vitamin C, resveratrol, and ferulic acid are effective in treating hyperpigmentation caused by oxidative stress, and strategies can be implemented to prevent skin pigmentation and aging induced by oxidative stress.

INTERNATIONAL JOURNAL OF COSMETIC SCIENCE (2021)

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Article Biochemistry & Molecular Biology

Antiwrinkle and Antimelanogenesis Effects of Tyndallized Lactobacillus acidophilus KCCM12625P

Hye Yeon Lim et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Simultaneous Determination of Six Isoflavones from Puerariae Lobatae Radix by CPE-HPLC and Effect of Puerarin on Tyrosinase Activity

Limin Qu et al.

MOLECULES (2020)

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Article Biochemistry & Molecular Biology

Tyrosinase-Targeting Gallacetophenone Inhibits Melanogenesis in Melanocytes and Human Skin- Equivalents

Ji Young Lee et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Nutrition & Dietetics

Anti-Melanogenic Effect of Ethanolic Extract of Sorghum bicolor on IBMX-Induced Melanogenesis in B16/F10 Melanoma Cells

Hye Ju Han et al.

NUTRIENTS (2020)

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Review Biochemistry & Molecular Biology

Ginsenoside Compound K: Insights into Recent Studies on Pharmacokinetics and Health-Promoting Activities

Anshul Sharma et al.

BIOMOLECULES (2020)

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Article Environmental Sciences

Effects of anti-wrinkle and skin-whitening fermented black ginseng on human subjects and underlying mechanism of action

Jin Ju Park et al.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES (2020)

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Review Cell Biology

Mitochondria in skin health, aging, and disease

Annapoorna Sreedhar et al.

CELL DEATH & DISEASE (2020)

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Article Biotechnology & Applied Microbiology

Biotransformation of Protopanaxadiol-Type Ginsenosides in Korean Ginseng Extract into Food-Available Compound K by an Extracellular Enzyme from Aspergillus niger

Eun-Bi Jeong et al.

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2020)

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Review Biochemistry & Molecular Biology

Diversity of Ginsenoside Profiles Produced by Various Processing Technologies

Xiang Min Piao et al.

MOLECULES (2020)

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Article Biotechnology & Applied Microbiology

Change of Ginsenoside Profiles in Processed Ginseng by Drying, Steaming, and Puffing

Ji-Hye Shin et al.

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2019)

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Review Biochemistry & Molecular Biology

Black Ginseng and Its Saponins: Preparation, Phytochemistry and Pharmacological Effects

Ahmed M. Metwaly et al.

MOLECULES (2019)

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Article Agricultural Engineering

A new simple and fast approach to analyze chemical composition on white, red, and black ginseng

Na Guo et al.

INDUSTRIAL CROPS AND PRODUCTS (2019)

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Article Biology

Development of a Global Subjective Skin Aging Assessment score from the perspective of dermatologists

Punnapath Buranasirin et al.

BMC RESEARCH NOTES (2019)

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Article Biochemistry & Molecular Biology

Inhibitory role of silk cocoon extract against elastase, hyaluronidase and UV radiation-induced matrix metalloproteinase expression in human dermal fibroblasts and keratinocytes

Jadi Praveen Kumar et al.

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2019)

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Article Plant Sciences

Effects of fermented black ginseng on wound healing mediated by angiogenesis through the mitogen-activated protein kinase pathway in human umbilical vein endothelial cells

Jun Yeon Park et al.

JOURNAL OF GINSENG RESEARCH (2018)

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Review Cell & Tissue Engineering

Fighting against Skin Aging: The Way from Bench to Bedside

Shoubing Zhang et al.

CELL TRANSPLANTATION (2018)

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Article Food Science & Technology

Increase of content and bioactivity of total phenolic compounds from spent coffee grounds through solid state fermentation by Bacillus clausii

Jesus J. Rochin-Medina et al.

JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE (2018)

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Article Chemistry, Medicinal

Protective Effect of Sulfated Polysaccharides from Celluclast-Assisted Extract of Hizikia fusiforme Against Ultraviolet B-Induced Skin Damage by Regulating NF-κB, AP-1, and MAPKs Signaling Pathways In Vitro in Human Dermal Fibroblasts

Lei Wang et al.

MARINE DRUGS (2018)

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Article Food Science & Technology

Ginsenosides Rg5 and Rkl, the skin-whitening agents in black ginseng

Yan Jin et al.

JOURNAL OF FUNCTIONAL FOODS (2018)

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Article Food Science & Technology

Inhibitory effect of carvacrol on melanin synthesis via suppression of tyrosinase expression

Nam-Joo Jeon et al.

JOURNAL OF FUNCTIONAL FOODS (2018)

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Article Plant Sciences

The skin protective effects of compound K, a metabolite of ginsenoside Rb1 from Panax ginseng

Eunji Kim et al.

JOURNAL OF GINSENG RESEARCH (2018)

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Review Biochemistry & Molecular Biology

MC1R: Front and Center in the Bright Side of Dark Eumelanin and DNA Repair

Viki B. Swope et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Biochemistry & Molecular Biology

UPLC-QTOF/MS-Based Metabolomics Applied for the Quality Evaluation of Four Processed Panax ginseng Products

Jae Won Lee et al.

MOLECULES (2018)

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Article Biochemistry & Molecular Biology

A Potent Tyrosinase Inhibitor, (E)-3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one, with Anti-Melanogenesis Properties in alpha-MSH and IBMX-Induced B16F10 Melanoma Cells

Chang Seok Kim et al.

MOLECULES (2018)

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Article Medicine, Research & Experimental

Anti-wrinkle effect of fermented black ginseng on human fibroblasts

Quynh Lien Pham et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)

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Review Biochemistry & Molecular Biology

Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors

Thanigaimalai Pillaiyar et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2017)

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Review Plant Sciences

Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases

Ji Hye Kim et al.

JOURNAL OF GINSENG RESEARCH (2017)

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Review Biochemistry & Molecular Biology

Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis

Pavida Pittayapruek et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Article Plant Sciences

Comparative phenolic compound profiles and antioxidative activity of the fruit, leaves, and roots of Korean ginseng (Panax ginseng Meyer) according to cultivation years

Ill-Min Chung et al.

JOURNAL OF GINSENG RESEARCH (2016)

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Review Biochemistry & Molecular Biology

Signaling Pathways in Melanogenesis

Stacey A. N. D'Mello et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Review Environmental Sciences

Anticedants and natural prevention of environmental toxicants induced accelerated aging of skin

Tanuja Yadav et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2015)

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Review Biochemistry & Molecular Biology

Biological Mechanisms Underlying the Ultraviolet Radiation-Induced Formation of Skin Wrinkling and Sagging I: Reduced Skin Elasticity, Highly Associated with Enhanced Dermal Elastase Activity, Triggers Wrinkling and Sagging

Genji Imokawa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

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Article Plant Sciences

Effect of White, Red and Black Ginseng on Physicochemical Properties and Ginsenosides

Yan Jin et al.

PLANT FOODS FOR HUMAN NUTRITION (2015)

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Article Plant Sciences

Antimelanogenic effect of ginsenoside Rg3 through extracellular signal-regulated kinase-mediated inhibition of microphthalmia-associated transcription factor

Seung Jae Lee et al.

JOURNAL OF GINSENG RESEARCH (2015)

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Review Biochemistry & Molecular Biology

Oxidative Stress in Aging Human Skin

Mark Rinnerthaler et al.

BIOMOLECULES (2015)

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Article Pharmacology & Pharmacy

Stereoselectiye Skin Anti-photoaging Properties of Ginsenoside Rg3 in UV-B-Irradiated Keratinocytes

Chang-Jin Lim et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2014)

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Review Biochemistry & Molecular Biology

Ultraviolet Radiation, Aging and the Skin: Prevention of Damage by Topical cAMP Manipulation

Alexandra Amaro-Ortiz et al.

MOLECULES (2014)

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Review Multidisciplinary Sciences

Ginseng for Health Care: A Systematic Review of Randomized Controlled Trials in Korean Literature

Jiae Choi et al.

PLOS ONE (2013)

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Article Plant Sciences

The bioavailability of red ginseng extract fermented by Phellinus linteus

Jae Sik Ryu et al.

JOURNAL OF GINSENG RESEARCH (2013)

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Review Dermatology

Characteristics of the Aging Skin

Miranda A. Farage et al.

ADVANCES IN WOUND CARE (2013)

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Article Chemistry, Medicinal

Fermenting Red Ginseng Enhances Its Safety and Efficacy as a Novel Skin Care Anti-Aging Ingredient: In Vitro and Animal Study

Hyun-Sun Lee et al.

JOURNAL OF MEDICINAL FOOD (2012)

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Article Chemistry, Medicinal

Metabolism of Ginsenosides to Bioactive Compounds by Intestinal Microflora and Its Industrial Application

Journal of Ginseng Research (2010)

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Article Biochemistry & Molecular Biology

Effect of xanthohumol on melanogenesis in B16 melanoma cells

Jeung-Hyun Koo et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2008)

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Enhanced Anti-Skin Aging Effects of Fermented Black Ginseng (Panax ginseng CA Meyer) by Aspergillus niger KHNT-1

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