期刊
AMB EXPRESS
卷 12, 期 1, 页码 -出版社
SPRINGER
DOI: 10.1186/s13568-022-01490-y
关键词
Bacillus megaterium; Iron oxide; Nano-biomimetic; Hyperthermia
This study focuses on the synthesis of iron nanoparticles from the bacterial source of Bacillus megaterium for applications in diagnosis and drug delivery. The method has advantages such as reduced environmental and biological hazards, low toxicity, high biocompatibility, and the potential for industrial-scale production. The iron oxide nanoparticles synthesized using this method have suitable structural characteristics for magnetic hyperthermia therapy and pharmaceutical nanocarriers.
Keypoints Synthesis of iron nanoparticles for simultaneous diagnostic and therapeutic applications Production of magnetic iron oxide nanoparticles by magnetotactic bacteria with uniform size Using the synthesis pattern in Bacillus megatrium to produce nano-field iron oxide The suitable structural characteristics of magnetic nanoparticles have resulted in their widespread use in magnetic hyperthermia therapy. Moreover, they are considered a proper and operational choice for pharmaceutical nanocarriers. Using the biomimetic method, we were able to produce iron oxide magnetic nanoparticles from the bacterial source of PTCC1250, Bacillus megaterium, for therangostic diagnosis systems and targeted drug delivery. Some of the benefits of this method include mitigated environmental and biological dangers, low toxicity, high biocompatibility, cheap and short-term mass production possibilities in each synthesis round compared to other biological sources, simple equipment required for the synthesis; and the possibility of industrial-scale production. Bacillus megaterium is a magnetotactic bacteria (MTB) that has a magnetosome organelle capable of orienting based on external magnetic fields, caused by the mineralization of magnetic nanocrystals. Utilizing this capability and adding an iron nitrate solution to the bacterial suspension, we synthesized iron oxide nanoparticles. The extent of synthesis was measured using UV-visible spectrophotometry. The morphology was evaluated using FESEM. The crystallized structure was characterized using RAMAN and XRD. The size and distribution of the nanoparticles were assessed using DLS. The surface charge of the nanoparticles was measured using zeta potential. The synthesis of iron oxide nanoparticles was confirmed using FT-IR, and the magnetic property was measured using VSM. This study is continued to identify industrial and clinical applications.
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