期刊
ADVANCED SCIENCE
卷 10, 期 3, 页码 -出版社
WILEY
DOI: 10.1002/advs.202204695
关键词
flexible side groups; large pi-conjugated molecules; photothermal performance; rigid molecular skeletons; second near-infrared fluorescent brightness
A versatile strategy is reported to enhance the fluorescence brightness and photothermal performance of near-infrared (NIR-II) window imaging-guided photothermal therapy probes by fabricating a large pi-conjugated molecule. The newly developed nanoprobe exhibits superior NIR-II imaging effect in vivo and high photothermal tumor inhibition rate, showing potential applications in precise cancer phototheranostics.
Second near-infrared (NIR-II, 1000-1700 nm) window fluorescence imaging-guided photothermal therapy probes are promising for precise cancer phototheranostics. However, most of the currently reported probes do not demonstrate high NIR-II fluorescent brightness (molar absorption coefficient (epsilon) x quantum yield (QY)) and photothermal performance (epsilon x photothermal conversion efficiency (PCE)) in a single molecule. Herein, a versatile strategy to solve this challenge is reported by fabricating a large pi-conjugated molecule (BNDI-Me) with a rigid molecular skeleton and flexible side groups. The proposed BNDI-Me nanoprobe boosts the epsilon and simultaneously optimizes its QY and PCE. Therefore, high NIR-II fluorescent brightness (epsilon x QY = 2296 m(-1) cm(-1)) and strong photothermal performance (epsilon x PCE = 82 000) are successfully incorporated in a single small molecule, and, to the best of knowledge, either of these two parameters is better than the best currently available fluorescent or photothermal probes. Thus, superior NIR-II imaging effect in vivo and high photothermal tumor inhibition rate (81.2%) at low systemic injection doses are obtained. The work provides further insights into the relationship of photophysical mechanisms and structures, and presents promising molecular design guidelines for the integration of more efficient multiple theranostic functions in a single molecule.
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