期刊
ADVANCED SCIENCE
卷 10, 期 3, 页码 -出版社
WILEY
DOI: 10.1002/advs.202204801
关键词
antibacteria; biodegradable; implantable; triboelectric nanogenerator; ultrasound
This study proposes a new strategy of using an ultrasound-driven implantable vibrational nanogenerator to eliminate microorganisms in deep tissue.
To prevent surgical site infection (SSI), which significantly increases the rate morbidity and mortality, eliminating microorganisms is prominent. Antimicrobial resistance is identified as a global health challenge. This work proposes a new strategy to eliminate microorganisms of deep tissue through electrical stimulation with an ultrasound (US)-driven implantable, biodegradable, and vibrant triboelectric nanogenerator (IBV-TENG). After a programmed lifetime, the IBV-TENG can be eliminated by provoking the on-demand device dissolution by controlling US intensity with no surgical removal of the device from the body. A voltage of approximate to 4 V and current of approximate to 22 mu A generated from IBV-TENG under ultrasound in vitro, confirming inactivating approximate to 100% of Staphylococcus aureus and approximate to 99% of Escherichia coli. Furthermore, ex vivo results show that IBV-TENG implanted under porcine tissue successfully inactivates bacteria. This antibacterial technology is expected to be a countermeasure strategy against SSIs, increasing life expectancy and healthcare quality by preventing microorganisms of deep tissue.
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