☆ 4.8 Review

Fasting: From Physiology to Pathology

ADVANCED SCIENCE (2023)

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Article Nutrition & Dietetics

Effects of time-restricted feeding (16/8) combined with a low-sugar diet on the management of non-alcoholic fatty liver disease: A randomized controlled trial

Hamed Kord-Varkaneh et al.

Summary: This study investigated the effects of time-restricted feeding (TRF) combined with a low-sugar diet on patients with non-alcoholic fatty liver disease (NAFLD). The results showed that TRF combined with a low-sugar diet can reduce adiposity, improve liver function, lipid profile, and inflammatory markers in patients with NAFLD.

NUTRITION (2023)

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Review Pathology

The Immune Response in Multiple Sclerosis

Sofia Rodriguez Murua et al.

Summary: Multiple sclerosis is a chronic disease affecting the central nervous system, characterized by immune dysregulation and resulting in demyelination, neuronal damage, and degeneration. Genetic and environmental factors are believed to play a role in the onset and progression of this disease.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2022)

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Review Food Science & Technology

The role of short-chain fatty acids in immunity, inflammation and metabolism

Yao Yao et al.

Summary: Short-chain fatty acids (SCFAs) are important metabolites of gut microbiome and play a vital role in host health. They are key energy sources for colon and ileum cells, regulate intestinal epithelial barrier and defense functions, modulate the function of innate immune cells, regulate the differentiation of T cells and B cells, and also inhibit tumor cell proliferation and promote apoptosis.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

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Review Microbiology

A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders

Shokufeh Ghasemian Sorboni et al.

Summary: The human microbiome, consisting of bacteria, viruses, and fungi, plays a central role in the development of the immune system, the central nervous system, and the gastrointestinal tract. Imbalance in the gut microflora is associated with neurological disorders. Microbiome-based therapies show promise in treating these disorders.

CLINICAL MICROBIOLOGY REVIEWS (2022)

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Review Medicine, Research & Experimental

The ups and downs of caloric restriction and fasting: from molecular effects to clinical application

Sebastian J. Hofer et al.

Summary: Age-associated diseases are on the rise, leading to a need for efficient and low-cost methods. Caloric restriction (CR) is effective but implementation can be challenging, giving rise to CR-mimicking interventions. The advantages and disadvantages of these dietary interventions in humans must be carefully considered.

EMBO MOLECULAR MEDICINE (2022)

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Article Nutrition & Dietetics

Intermittent fasting and continuous energy restriction result in similar changes in body composition and muscle strength when combined with a 12 week resistance training program

Stephen J. Keenan et al.

Summary: The purpose of this study was to compare the effects of 12 weeks of resistance training combined with either 5:2 intermittent fasting or continuous energy restriction on body composition, muscle size and quality, and upper and lower body strength. The results showed that both interventions resulted in similar improvements in body composition, muscle quality, and strength, indicating that they can be effective strategies for individuals in enhancing their physical fitness.

EUROPEAN JOURNAL OF NUTRITION (2022)

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Article Pharmacology & Pharmacy

AgRP/NPY and POMC neurons in the arcuate nucleus and their potential role in treatment of obesity

Muhammad Sufyan Vohra et al.

Summary: Obesity is a major health crisis worldwide, regulated by specific neuronal populations in the brain's ARC region. Understanding the cellular and molecular mechanisms in ARC neurons is crucial for managing obesity and maintaining weight loss effectively. Targeting specific ARC circuits may offer a promising strategy for treating obesity with minimal or no side effects.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

Time-restricted feeding during the inactive phase abolishes the daily rhythm in mitochondrial respiration in rat skeletal muscle

Paul de Goede et al.

Summary: Shift-work disrupts circadian timing of glucose homeostasis, impairs muscle mitochondrial metabolism, and causes metabolic inflexibility, increasing the risk of developing T2DM.

FASEB JOURNAL (2022)

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Article Biochemistry & Molecular Biology

Alternate-day fasting alleviates high fat diet induced non-alcoholic fatty liver disease through controlling PPAR alpha/Fgf21 signaling

Xinlei Liu et al.

Summary: Alternate day fasting (ADF) attenuated high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) in mice by reducing hepatic inflammation and lipid accumulation. Fasting increased expression of serum and hepatic fibroblast growth Factor 21 (Fgf21) and prevented FFA-induced lipid storage in hepatocytes. Refeeding inhibited the increase in Fgf21 expression induced by fasting, suggesting a potential role of PPAR alpha/Fgf21 signaling in protecting against NAFLD.

MOLECULAR BIOLOGY REPORTS (2022)

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Article Biotechnology & Applied Microbiology

A microRNA checkpoint for Ca2+ signaling and overload in acute pancreatitis

Wenya Du et al.

Summary: This study discovers the crucial role of miR-26a in acute pancreatitis by inhibiting Ca2+ overload in pancreatic acinar cells. The study also reveals that during acute pancreatitis, SOCE channels are induced in pancreatic acinar cells, while the expression of miR-26a is reduced, and its expression is correlated with the severity of acute pancreatitis.

MOLECULAR THERAPY (2022)

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Editorial Material Endocrinology & Metabolism

Time-restricted feeding and circadian autophagy for long life

Hong Long et al.

Summary: A new study has shown that a novel intermittent time-restricted feeding (iTRF) dietary regimen can extend the healthy lifespan of Drosophila by driving a clock-dependent rise in autophagy each night.

NATURE REVIEWS ENDOCRINOLOGY (2022)

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Review Endocrinology & Metabolism

Clinical application of intermittent fasting for weight loss: progress and future directions

Krista A. Varady et al.

Summary: Intermittent fasting diets, which involve periods of fasting alternating with periods of eating, have gained popularity for their potential weight loss benefits. However, research on the health benefits of these diets in humans is limited, highlighting the need for further study in this area.

NATURE REVIEWS ENDOCRINOLOGY (2022)

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Review Clinical Neurology

Circadian rhythms in neurodegenerative disorders

Malik Nassan et al.

Summary: The circadian system governs physiological processes like sleep, alertness, and cognition, and disruptions in circadian homeostasis can have detrimental effects on human health, especially in neurodegenerative disorders. There is a bidirectional relationship between circadian function and neurodegeneration, highlighting the importance of studying circadian disruption in these disorders. Research in this field could lead to novel circadian-based therapeutic interventions for disabling conditions like Parkinson's, Alzheimer's, and other neurodegenerative diseases.

NATURE REVIEWS NEUROLOGY (2022)

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Review Pharmacology & Pharmacy

Lipopolysaccharide induced altered signaling pathways in various neurological disorders

Sukhdev Singh et al.

Summary: Neuroinflammation refers to the inflammatory response within the brain or spinal cord, which can be caused by various factors and lead to cognitive impairment and neurodegenerative diseases. Lipopolysaccharide (LPS), a component of gram-negative bacteria, stimulates the TLR4 receptors on glial cells and activates multiple signaling pathways, promoting neuroinflammation.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2022)

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Review Nutrition & Dietetics

Repercussions of intermittent fasting on the intestinal microbiota community and body composition: a systematic review

Flaydson C. S. Pinto et al.

Summary: This study provides a current survey of intermittent fasting (IF) protocols and their effects on the profile of the intestinal microbiota (IM) in obese organisms. It found that alternate-day fasting (ADF) and time-restricted feeding (TRF) are the most common protocols, and they have different mechanisms of metabolic signaling. Both protocols have the ability to remodel the IM and protect against the effects of weight gain.

NUTRITION REVIEWS (2022)

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Article Multidisciplinary Sciences

Caloric restriction in humans reveals immunometabolic regulators of health span

O. Spadaro et al.

Summary: Research indicates that a 14% caloric restriction in healthy individuals can improve immune cell generation and is associated with pathways regulating mitochondrial bioenergetics, anti-inflammatory responses, and longevity. The inhibition of the platelet activating factor acetyl hydrolase gene Pia2g7 may mediate the effects of reducing inflammation and extending healthy lifespan.

SCIENCE (2022)

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Article Medical Laboratory Technology

A systematic analysis of diet-induced nephroprotection reveals overlapping changes in cysteine catabolism

Felix C. Koehler et al.

Summary: Caloric restriction is an attractive strategy for organ protection in the clinic, but translating it to patients is complex. Tailored dietary regimens that modulate dietary composition show promise for increasing translatability. However, direct head-to-head comparisons between different dietary approaches for organ protection have not been conducted.

TRANSLATIONAL RESEARCH (2022)

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Article Multidisciplinary Sciences

Randomized controlled trial for time-restricted eating in healthy volunteers without obesity

Zhibo Xie et al.

Summary: Time-restricted feeding, both early (eTRF) and mid-day (mTRF), have been shown to have metabolic benefits. A randomized controlled trial comparing the effects of eTRF and mTRF in healthy non-obese individuals found that eTRF was more effective in improving insulin sensitivity and other metabolic parameters.

NATURE COMMUNICATIONS (2022)

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Article Oncology

Fasting- Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer

Claudio Vernieri et al.

Summary: Cyclic fasting or fasting-mimicking diets (FMD) enhance antineoplastic treatments by modulating systemic metabolism and boosting antitumor immunity. In a clinical trial, the five-day FMD was found to be safe and resulted in consistent decrease of blood glucose and growth factor concentration, recapitulating metabolic changes observed in preclinical experiments. The FMD also reshapes anticancer immunity and improves clinical outcomes in patients with cancer.

CANCER DISCOVERY (2022)

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Review Nutrition & Dietetics

Satiety Associated with Calorie Restriction and Time-Restricted Feeding: Peripheral Hormones

Debra K. M. Tacad et al.

Summary: Time-restricted feeding and continuous calorie restriction have similar effects on gut peptides involved in satiety, but the former may reduce hunger. Current research is still lacking, and more evidence and studies are needed to draw definitive conclusions.

ADVANCES IN NUTRITION (2022)

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Review Cardiac & Cardiovascular Systems

Ramadan fasting: recommendations for patients with cardiovascular disease

Abid Mohammed Akhtar et al.

Summary: Ramadan fasting, observed by most of the 1.8 billion Muslims worldwide, lacks specific guidance for patients with cardiovascular disease. Risk stratification into low, moderate, high, and very high-risk groups helps determine who can fast safely. Further studies are needed to clarify the benefits and risks of fasting on the cardiovascular system in patients with different cardiovascular conditions.

HEART (2022)

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Review Endocrinology & Metabolism

Time-restricted Eating for the Prevention and Management of Metabolic Diseases

Emily N. C. Manoogian et al.

Summary: Time-restricted feeding and time-restricted eating are emerging behavioral interventions based on circadian rhythms to improve health by limiting calorie intake within a specific time window. Animal and human studies have shown promising results in reducing the risk for obesity, diabetes, and cardiovascular diseases through this approach.

ENDOCRINE REVIEWS (2022)

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Editorial Material Cell Biology

Intermittent time-restricted feeding promotes longevity through circadian autophagy

Zhangyuan Yin et al.

Summary: Macroautophagy/autophagy plays a crucial role in aging and age-related diseases. A recent study showed that a newly designed dietary regimen, called intermittent time-restricted feeding (iTRF), can extend the healthspan and lifespan of flies through the circadian rhythm-dependent activation of autophagy. Specifically, the induction of autophagy during the night is both necessary and sufficient for the health benefits of iTRF. This study suggests that novel interventions promoting night-specific autophagy could be used to promote healthy aging.

AUTOPHAGY (2022)

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Review Biochemistry & Molecular Biology

AgRP neurons: Regulators of feeding, energy expenditure, and behavior

Jennifer D. Deem et al.

Summary: This review discusses the regulation of feeding drive and timing by AgRP neurons in the hypothalamic arcuate nucleus, as well as their integration with environmental cues to ensure optimal prioritization of behaviors. It also explores how classical feedback and anticipatory feedforward signals regulate these neurons, and examines how the integration of these signals may be disrupted in states of energy excess.

FEBS JOURNAL (2022)

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Article Nutrition & Dietetics

The daily caloric restriction and alternate-day fasting ameliorated lipid dysregulation in type 2 diabetic mice by downregulating hepatic pescadillo 1

Jielin Zhou et al.

Summary: This study investigates the role of PES1 in the effects of caloric restriction (CR) and alternate-day fasting (ADF) interventions on diabetes-related lipid dysregulation in mice. The results show that CR and ADF can improve lipid dysregulation in diabetic mice by downregulating hepatic levels of PES1. Mechanistically, the study suggests that this downregulation of PES1 may be mediated by increased binding of peroxisome proliferator-activated receptor alpha (PPAR-alpha) to the Pes1 promoter, leading to suppressed PES1 expression and reduced PES1-mediated ubiquitination of carnitine palmitoyltransferase 1A (CPT1A).

EUROPEAN JOURNAL OF NUTRITION (2022)

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Article Geriatrics & Gerontology

Antioxidant Potential, DNA Damage, Inflammation, Glycemic Control and Lipid Metabolism Alteration: A Mediation Analysis of Islamic Sunnah Intermittent Fasting on Cognitive Function among Older Adults with Mild Cognitive Impairment

T. C. Ooi et al.

Summary: This study found that oxidative stress, DNA damage, inflammation, and certain metabolic biomarkers may mediate the improvements in cognitive function among older adults with MCI who practice Islamic Sunnah intermittent fasting.

JOURNAL OF NUTRITION HEALTH & AGING (2022)

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Review Cell Biology

Molecular mechanisms of dietary restriction promoting health and longevity

Cara L. Green et al.

Summary: Dietary restriction with adequate nutrition is considered the gold standard for delaying ageing and extending healthspan and lifespan in various species, as it impacts key nutrient-sensing signalling pathways to promote healthy longevity.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

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Review Nutrition & Dietetics

Impact of Christian Orthodox Church dietary recommendations on metabolic syndrome risk factors: a scoping review

A. Kokkinopoulou et al.

Summary: Fasting among followers of different religions has been a long-standing practice. Christian Orthodox Church fasting is characterized by a vegetarian-type diet with occasional seafood and snails. Participants in COC fasting have healthier blood lipid profiles and reduced MetS risk factors such as total cholesterol, LDL-cholesterol, systolic blood pressure, body weight, and BMI after fasting periods.

NUTRITION RESEARCH REVIEWS (2022)

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Article Chemistry, Multidisciplinary

Suppression of Energy Metabolism in Cancer Cells with Nutrient-Sensing Nanodrugs

Jiayi Zhang et al.

Summary: This study demonstrates the potential of FMD-assisted nutrient-sensing nanodrugs for cancer therapy by enhancing the treatment effectiveness on tumor cells and inhibiting tumor growth.

NANO LETTERS (2022)

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Article Medicine, General & Internal

Study protocol for the Shifting Weight using Intermittent Fasting in night shift workers (SWIFt) study: a three-arm randomised controlled trial comparing three weight loss strategies in night shift workers with obesity

Michelle Rogers et al.

Summary: The aim of this study is to examine the effects of three weight loss strategies on weight loss and insulin resistance in night shift workers. The results of this study will be important for the health management of night shift workers.

BMJ OPEN (2022)

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Article Genetics & Heredity

Calorie restriction improves metabolic state independently of gut microbiome composition: a randomized dietary intervention trial

Solomon A. Sowah et al.

Summary: This study analyzed the changes in gut microbiota in overweight and obese adults under intermittent and continuous calorie restriction diets. The results showed that both diets led to weight loss, but there were no significant differences in gut microbiome composition between the two groups. Overall weight loss was associated with metabolic improvements, but not with changes in the gut microbiome. However, there were significant correlations between gut bacterial families and metabolic biomarkers, anthropometric measures, and dietary composition.

GENOME MEDICINE (2022)

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Article Microbiology

Effects of caloric restriction on the gut microbiome are linked with immune senescence

Julia Sbierski-Kind et al.

Summary: Caloric restriction can improve metabolic health, reduce body fat accumulation, and enhance glucose tolerance, while delaying immune senescence by reducing specific cellular immune responses. This suggests that modulation of the gut microbiome could lead to the development of new therapeutic options for metabolic diseases.

MICROBIOME (2022)

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Article Geriatrics & Gerontology

Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain

Gavin Yong-Quan Ng et al.

Summary: Intermittent fasting can modulate H3K9 trimethylation in the cerebellum and trigger transcriptomic changes associated with metabolic processes. Part of the epigenomic and transcriptomic modulations induced by IF can be preserved for at least 3 months post-IF, but termination of IF results in a loss of H3K9 trimethylation regulation of the transcriptome.

GEROSCIENCE (2022)

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Article Nutrition & Dietetics

Hepatic PPARα Is Destabilized by SIRT1 Deacetylase in Undernourished Male Mice

Ji Ho Suh et al.

Summary: This study identifies a new mechanism, regulated by SIRT1, that may contribute to the liver's failed metabolic responses in individuals with chronic undernutrition.

FRONTIERS IN NUTRITION (2022)

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Article Chemistry, Multidisciplinary

Enhanced Sensitivity of Tumor Cells to Autophagy Inhibitors Using Fasting-Mimicking Diet and Targeted Lysosomal Delivery Nanoplatform

Ruihao Qian et al.

Summary: This study presents a nanoplatform for targeted delivery of hydroxychloroquine (HCQ) to tumor cells using insulin-like growth factors 2 receptor (IGF2R)-targeted liposomes. By simulating fasting-mimicking diet and upregulating IGF2R expression, the nanoparticles efficiently accumulate at the tumor site and effectively inhibit tumor growth.

NANO LETTERS (2022)

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Article Endocrinology & Metabolism

Six-Month Periodic Fasting in Patients With Type 2 Diabetes and Diabetic Nephropathy: A Proof-of-Concept Study

Alba Sulaj et al.

Summary: This study aimed to evaluate the impact of periodic fasting on albumin-to-creatinine ratio in patients with type 2 diabetes and explore its potential mechanisms. The results showed that periodic fasting may have positive effects on microalbuminuria, insulin resistance, lipid oxidation, and senescence.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

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Article Medicine, Research & Experimental

A miRNA-mediated attenuation of hepatocarcinogenesis in both hepatocytes and Kupffer cells

Yan Tian et al.

Summary: miR-26a regulates hepatocellular carcinoma development by attenuating oncogenic signaling pathways and inflammatory response.

MOLECULAR THERAPY-NUCLEIC ACIDS (2022)

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Review Physiology

COMPLEX PHYSIOLOGY AND CLINICAL IMPLICATIONS OF TIME-RESTRICTED EATING

Max C. Petersen et al.

Summary: This review discusses the effects and current research status of time-restricted eating (TRE) in the human body. By integrating the results of studies on rodent models and humans, it provides a framework for future research directions and identifies the current knowledge gaps.

PHYSIOLOGICAL REVIEWS (2022)

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Article Medicine, General & Internal

Effectiveness of Early Time-Restricted Eating for Weight Loss, Fat Loss, and Cardiometabolic Health in Adults With Obesity A Randomized Clinical Trial

Humaira Jamshed et al.

Summary: This randomized clinical trial found that early time-restricted eating (eTRE) was more effective for weight loss, improving diastolic blood pressure, and mood disturbances compared to eating over a period of 12 or more hours.

JAMA INTERNAL MEDICINE (2022)

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Article Medicine, General & Internal

Intermittent calorie restriction alters T cell subsets and metabolic markers in people with multiple sclerosis

Kathryn C. Fitzgerald et al.

Summary: In people with multiple sclerosis, an intermittent calorie restriction diet is associated with reduction in memory T cell subsets and changes in certain lipid markers.

EBIOMEDICINE (2022)

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Article Nutrition & Dietetics

Effects of the 5:2 intermittent fasting diet on non-alcoholic fatty liver disease: A randomized controlled trial

Hamed Kord Varkaneh et al.

Summary: This study investigates the effects of the 5:2 intermittent fasting diet on patients with non-alcoholic fatty liver disease (NAFLD). The results demonstrate that adhering to the 5:2 intermittent fasting diet can improve anthropometric indices, hepatic steatosis, liver enzymes, triglycerides, and inflammatory biomarkers in NAFLD patients.

FRONTIERS IN NUTRITION (2022)

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Article Cell Biology

Feasibility of time-restricted eating and impacts on cardiometabolic health in 24-h shift workers: The Healthy Heroes randomized control trial

Emily N. C. Manoogian et al.

Summary: Over a quarter of the workforce in industrialized countries does shift work, increasing the risk for car-diometabolic disease. A study with firefighters showed that time-restricted eating (TRE) was feasible and beneficial, improving cardiometabolic health.

CELL METABOLISM (2022)

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Article Biochemistry & Molecular Biology

UBE2O promotes lipid metabolic reprogramming and liver cancer progression by mediating HADHA ubiquitination

Meilin Ma et al.

Summary: This study reveals the importance of UBE2O in the development of hepatocellular carcinoma (HCC). UBE2O is found to be highly expressed in HCC tumors and is associated with poor survival prognosis. It regulates lipid metabolic reprogramming by modulating the ubiquitination and degradation of HADHA, a mitochondrial enzyme. Furthermore, UBE2O deletion in mice inhibits hepatocarcinogenesis and reduces hepatic lipid accumulation.

ONCOGENE (2022)

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Article Multidisciplinary Sciences

Time-restricted feeding mitigates obesity through adipocyte thermogenesis

Chelsea Hepler et al.

SCIENCE (2022)

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Article Nutrition & Dietetics

Twelve Months of Time-Restricted Feeding Improves Cognition and Alters Microbiome Composition Independent of Macronutrient Composition

Abbi R. Hernandez et al.

Summary: Time-restricted feeding may be a feasible alternative for enhancing late life cognitive and physical health. Regardless of dietary composition, time-restricted-fed rats had better cognitive performance than ad libitum-fed rats, which is associated with gut microbiome diversity and composition.

NUTRIENTS (2022)

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Article Biochemistry & Molecular Biology

Optimization of miR-22 expression cassette for rAAV delivery on diabetes

Li Yang et al.

Summary: This study successfully designed a series of expression cassettes for miR-22 using recombinant adeno-associated virus (rAAV) delivery. The optimal approach for efficient overexpression of miR-22 in vivo was determined by selecting appropriate promoters and longer primary miR-22. Overexpression of miR-22 in diabetic mice showed significant improvement in insulin sensitivity.

MOLECULAR BIOMEDICINE (2022)

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Review Oncology

Developing dietary interventions as therapy for cancer

Samuel R. Taylor et al.

Summary: This Review discusses metabolic alterations and vulnerabilities in different types of cancer, and suggests using dietary interventions in combination with pharmacologic therapies to target these changes. However, diet studies in cancer patients are rare and lack robust evidence. The article also explores how dietary strategies can be combined with pharmacological therapies in treating cancer.

NATURE REVIEWS CANCER (2022)

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Review Biochemistry & Molecular Biology

Molecular regulations of circadian rhythm and implications for physiology and diseases

Francesca Fagiani et al.

Summary: Circadian rhythms are endogenous oscillations with a ca. 24-hour period associated with the earth's daily rotation and light/dark cycle. The circadian clock, consisting of transcription factors, not only generates rhythms but also controls physiological functions and intracellular pathways in tissues and organs. Disruption of circadian rhythms can impact human diseases and understanding this field represents a significant challenge in establishing precision medicine.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Article Food Science & Technology

Effects of orthodox religious fasting versus combined energy and time restricted eating on body weight, lipid concentrations and glycaemic profile

Spyridon N. Karras et al.

Summary: The study found that the Orthodox Fasting diet had superior lipid-lowering effects compared to the time-restricted eating pattern. Both groups experienced reductions in BMI, but only the OF group showed significant reductions in total and low-density lipoprotein-cholesterol levels. Glycaemic and inflammatory parameters did not show significant differences between the two groups.

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2021)

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Article Nutrition & Dietetics

Effects of time-restricted feeding on body weight, body composition and vital signs in low-income women with obesity: A 12-month randomized clinical trial

Isabele Rejane de Oliveira Maranhao Pureza et al.

Summary: This study aimed to investigate the long-term effects of time-restricted feeding (TRF) on body weight, body composition, and vital signs in low-income women with obesity. The results showed that TRF did not have a significant impact on weight loss, but there were improvements in waist circumference and body fat percentage. This suggests that TRF may be helpful in long-term obesity management in this population. Further research is needed to explore the findings related to axillary temperature.

CLINICAL NUTRITION (2021)

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Article Gastroenterology & Hepatology

An Endoplasmic Reticulum Stress-MicroRNA-26a Feedback Circuit in NAFLD

Haixia Xu et al.

Summary: This study identified a negative feedback loop involving hepatic ER stress and miR-26a in the pathogenesis of NAFLD. MiR-26a induction by ER stress is critical for cells to cope with stress, and its deficiency exacerbates ER stress, lipid accumulation, inflammation and hepatic steatosis. Restoring miR-26a in hepatocytes may serve as a promising therapeutic strategy for NAFLD.

HEPATOLOGY (2021)

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Review Nutrition & Dietetics

A review of fasting effects on the response of cancer to chemotherapy

Mehdi Sadeghian et al.

Summary: Fasting may improve the response of tumor cells to chemotherapy through multiple mechanisms, protect normal cells, and enhance the effectiveness of chemotherapy. However, with limited human trials, more human studies with sufficient sample size and follow-ups are needed to confirm these findings.

CLINICAL NUTRITION (2021)

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Article Endocrinology & Metabolism

Effects of Intermittent Fasting or Calorie Restriction on Markers of Lipid Metabolism in Human Skeletal Muscle

Bo Liu et al.

Summary: Intermittent fasting (IF) has different effects on lipid metabolism compared to caloric restriction (CR), leading to more weight and fat loss, but also reduced expression of antioxidant enzymes. However, fasting can cause insulin resistance and increased PLIN5 expression, possibly reflecting transient lipid storage.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

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Article Biochemistry & Molecular Biology

Intermittent caloric restriction with a modified fasting-mimicking diet ameliorates autoimmunity and promotes recovery in a mouse model of multiple sclerosis

Meijuan Bai et al.

Summary: Intermittent caloric restriction through a modified fasting-mimicking diet was effective in treating autoimmune encephalomyelitis (EAE) by reducing disease severity, immune cell infiltration, and demyelination, while promoting tissue recovery.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2021)

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Review Microbiology

Gut microbiota in human metabolic health and disease

Yong Fan et al.

Summary: The intestinal microbiota plays a significant role in human metabolic health, potentially contributing to the development of common metabolic disorders when dysregulated. Current research is shifting towards cause-and-effect studies and utilizing high-throughput human multi-omics data to identify potential molecular mechanisms behind these associations.

NATURE REVIEWS MICROBIOLOGY (2021)

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Article Oncology

The effect of caloric restriction and fasting on cancer

Mona Alidadi et al.

Summary: Caloric restriction (CR) and fasting have shown potential anticancer effects by reducing tumor progression, enhancing death of cancer cells, and elevating the effectiveness and tolerability of chemo- and radiotherapies. However, clinical studies on the potential of CR and fasting in cancer treatment are scarce and inconsistent, requiring further investigation to clarify their impact.

SEMINARS IN CANCER BIOLOGY (2021)

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Review Nutrition & Dietetics

Cardiometabolic Benefits of Intermittent Fasting

Krista A. Varady et al.

Summary: Intermittent fasting can reduce blood pressure, insulin resistance, and oxidative stress, benefiting cardiometabolic health. However, its effects on LDL cholesterol and triglycerides vary. Other health benefits include improved appetite regulation and changes in gut microbiome diversity, but evidence is limited.

ANNUAL REVIEW OF NUTRITION, VOL 41, 2021 (2021)

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Article Endocrinology & Metabolism

Dietary Intake Regulates White Adipose Tissues Angiogenesis via Liver Fibroblast Growth Factor 21 in Male Mice

Lun Hua et al.

Summary: Obesity and related metabolic disorders are epidemic, with intermittent fasting shown to promote adipose tissue angiogenesis and have an anti-obesity effect. FGF21 acts as a potent regulator of VEGF levels in WAT, and long-term intermittent fasting can improve obesity-related metabolic disorders by inducing WAT angiogenesis through interorgan FGF21 signaling.

ENDOCRINOLOGY (2021)

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Article Cell Biology

Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape

Giulia Salvadori et al.

Summary: The study demonstrates that a fasting-mimicking diet activates starvation escape pathways in TNBC cells and reduces stemness markers in CSCs, leading to decreased cell numbers and improved mouse survival. Additionally, the diet activates different survival/growth pathways in differentiated cancer cells, which can be targeted by drugs to promote tumor regression.

CELL METABOLISM (2021)

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Article Agriculture, Multidisciplinary

Lactobacillus plantarum KLDS1.0344 and Lactobacillus acidophilus KLDS1.0901 Mixture Prevents Chronic Alcoholic Liver Injury in Mice by Protecting the Intestinal Barrier and Regulating Gut Microbiota and Liver-Related Pathways

Huizhen Li et al.

Summary: The Lactobacillus mixture improved intestinal permeability, reduced serum levels of lipopolysaccharides (LPS), and inhibited liver lipid accumulation, oxidative stress, and inflammation by regulating key pathways. Additionally, the Lactobacillus mixture modulated the gut microbiota, increasing SCFA producers and decreasing Gram-negative bacteria, thereby protecting the liver from alcohol-induced damage.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Letter Gastroenterology & Hepatology

Gut Microbiota-Derived Propionate Production May Explain Beneficial Effects of Intermittent Fasting in Experimental Colitis

Junhong Su et al.

JOURNAL OF CROHNS & COLITIS (2021)

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Article Endocrinology & Metabolism

Early or delayed time-restricted feeding prevents metabolic impact of obesity in ice

Prashant Regmi et al.

Summary: Time-restricted feeding (TRF) implemented early during the dark phase can prevent metabolic consequences of a high-fat diet in rodents. Delaying the initiation of TRF may limit weight benefits and induce a phase delay in the hepatic clock, but improve metabolic health. Providing more flexibility in when TRF is initiated could increase its translational potential in humans.

JOURNAL OF ENDOCRINOLOGY (2021)

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Article Oncology

Neurotoxicities associated with immune checkpoint inhibitor therapy

Sophie L. Duong et al.

Summary: This study investigated 18 patients with ICI-mediated neurotoxicities and found a diverse spectrum of neurotoxicities affecting the CNS, PNS, and neuroendocrine system. Early diagnosis and targeted treatment can significantly reduce morbidity and mortality rates for patients.

JOURNAL OF NEURO-ONCOLOGY (2021)

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Article Nutrition & Dietetics

Intermittent Fasting Alleviates Cognitive Impairments and Hippocampal Neuronal Loss but Enhances Astrocytosis in Mice with Subcortical Vascular Dementia

Faris Rizky Andika et al.

Summary: The study aimed to investigate the effects of intermittent fasting (IF) on cognitive impairments and cerebrovascular pathologies in a subcortical vascular dementia (SVaD) mouse model. Results showed that SVaD mice on the IF regimen exhibited improved cognitive performance and higher hippocampal neuronal density compared to SVaD mice fed ad libitum. However, SVaD-IF mice also showed increased astrocytosis in the hippocampus. The findings suggest that IF could be a potential nonpharmacological remedy for SVaD and other neurovascular diseases.

JOURNAL OF NUTRITION (2021)

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Article Medicine, Research & Experimental

Effects of time-restricted feeding in weight loss, metabolic syndrome and cardiovascular risk in obese women

Jessica D. Schroder et al.

Summary: TRF is an effective dietary approach for weight loss and reduction of cardiovascular risk in obese middle-aged women. It helps in reducing body weight and waist circumference, with no changes in biomarkers associated with Metabolic Syndrome.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

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Article Surgery

Effect of Fasting-Mimicking Diet or Continuous Energy Restriction on Weight Loss, Body Composition, and Appetite-Regulating Hormones Among Metabolically Healthy Women with Obesity: a Randomized Controlled, Parallel Trial

Mehdi Sadeghian et al.

Summary: This study found that there was no significant difference in weight loss between FMD and CER. However, FMD was more effective at reducing insulin resistance, regulating appetite-regulating hormones, and preserving muscle mass and BMR.

OBESITY SURGERY (2021)

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Article Multidisciplinary Sciences

Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models

Manasi Das et al.

Summary: Obesity and its associated metabolic changes, including hyperinsulinemia and aberrant circadian rhythms, increases the risk for a variety of cancers including postmenopausal breast cancer. Here, the authors show that restricting when mice eat, but not what or how much they eat, delays breast cancer initiation and reduces tumor growth in obese mice in addition to improving insulin sensitivity and restoring circadian rhythms.

NATURE COMMUNICATIONS (2021)

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Review Nutrition & Dietetics

Mechanisms Underlying the Cognitive and Behavioural Effects of Maternal Obesity

Kyoko Hasebe et al.

Summary: The consumption of 'western'-style diets and sedentary lifestyles have led to a global epidemic of obesity, with maternal obesity, overnutrition, and unhealthy dietary patterns having lasting adverse effects on offspring's physical and mental health. Studies suggest that maternal overnutrition may disrupt offspring cognitive function, affective state, and psychosocial behavior through mechanisms such as neuroinflammation, disrupted neuronal circuities, dysregulated brain hormones, and changes in gut microbiota. Further research is needed to explore the specific pathways shaping abnormal behavior in offspring in the context of maternal obesogenic diet exposure.

NUTRIENTS (2021)

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Article Nutrition & Dietetics

Observational Study of Lipid Profile and C-Reactive Protein after a Seven-Day Fast

Valeria Galetti et al.

Summary: A study on the effects of a seven-day fast in a non-medical center in the Swiss Alps showed an increase in high-density lipoprotein cholesterol and insulin-like growth factor-1, while other blood parameters remained stable. However, on the seventh day of fasting, total cholesterol, triglycerides, and CRP increased, indicating a possible stress reaction that warrants further investigation.

NUTRIENTS (2021)

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Article Endocrinology & Metabolism

Neonatal overfeeding during lactation rapidly and permanently misaligns the hepatic circadian rhythm and programmes adult NAFLD

Francesc Ribas-Aulinas et al.

Summary: Childhood obesity is a strong risk factor for adult obesity, type 2 diabetes, and cardiovascular disease. A mouse model of early adiposity was developed through litter size reduction, with mice reared in small litters experiencing obesity, insulin resistance, and hepatic steatosis during adulthood. The study found that the liver played a major role in the development of the disease, with the circadian rhythm being a key factor in the long-term programming of metabolic health.

MOLECULAR METABOLISM (2021)

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Article Geriatrics & Gerontology

Fasting and fasting-mimicking diets for chemotherapy augmentation

Sebastian Brandhorst

Summary: The aging population in developed countries is likely to experience aging-related chronic diseases, including cancer. In addition to genetic and environmental factors, lifestyle choices play a crucial role in disease onset and progression.Studies show promising results for cancer patients and survivors using prolonged fasting and fasting-mimicking diets.

GEROSCIENCE (2021)

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Review Cell Biology

Effects of caloric restriction on the antagonistic and integrative hallmarks of aging

Begun Erbaba et al.

Summary: Caloric restriction is a non-genetic intervention that extends lifespan and healthspan by promoting cell survival, reducing cell proliferation, inducing stem cell quiescence, and preserving stem cell reserve for extreme needs. This protective mechanism induced by diet may involve downregulation of crucial cell cycle-related transcription activators and could offer new targets for treatments against neurodegenerative diseases.

AGEING RESEARCH REVIEWS (2021)

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Review Biochemistry & Molecular Biology

Adapting the proteostasis capacity to sustain brain healthspan

Claudio Hetz

Summary: Maintaining neuronal proteostasis is crucial for brain function throughout our lifespan. As we age, the decline in proteostasis network activity may increase the risk of neurodegenerative diseases characterized by abnormal protein aggregates.

CELL (2021)

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Article Food Science & Technology

Improvement of Non-Alcoholic Fatty Liver Disease in Mice by Intermittent Use of a Fasting-Mimicking Diet

Jingyu Zhao et al.

Summary: The intermittent application of a FMD, with low carbohydrate/protein content and high dietary fiber, can reduce obesity and glucose intolerance induced by a high-fat high-sucrose diet in mice. It also decreases adipocyte size, increases expression of lipolysis genes and HSL protein in white adipose tissue, and reduces HFHSD-induced lipid accumulation in the liver. RNA sequencing shows elevated expression of genes involved in fatty acid oxidation with FMD intervention.

MOLECULAR NUTRITION & FOOD RESEARCH (2021)

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Article Multidisciplinary Sciences

Circadian autophagy drives iTRF-mediated longevity

Matt Ulgherait et al.

Summary: Studies have shown that intermittent Time-restricted feeding (iTRF) extends the lifespan of fruit flies and delays aging markers, with circadian-regulated autophagy playing a crucial role in this process.

NATURE (2021)

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Review Rheumatology

The non-coding RNA interactome in joint health and disease

Shabana A. Ali et al.

Summary: Non-coding RNAs play distinct regulatory roles in joint diseases such as osteoarthritis and rheumatoid arthritis, regulating signaling pathways and biological processes important for normal joint development. Their specific expression profiles in disease states support their roles as promising candidate biomarkers and potential therapeutic targets. A better understanding of the non-coding RNA interactome could lead to new therapies for joint diseases.

NATURE REVIEWS RHEUMATOLOGY (2021)

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Article Biochemistry & Molecular Biology

Five Days Periodic Fasting Elevates Levels of Longevity Related Christensenella and Sirtuin Expression in Humans

Stephanie Lilja et al.

Summary: The study found that periodic fasting not only changed the composition of the gut microbiota, making it more diverse, but also affected SIRT expression in humans. Fasting triggered a significant switch in metabolism and increased gut microbiota diversity, showing a significant correlation between SIRT1 gene expression and the abundance of certain bacterial species.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

Reduced insulin/IGF1 signaling prevents immune aging via ZIP-10/bZIP-mediated feedforward loop

Yujin Lee et al.

Summary: Genetic inhibition of the DAF-2/insulin/IGF-1 receptor in Caenorhabditis elegans can enhance immunocompetence in old age by up-regulating anti-aging transcription factors and preventing immune aging. This study may lead to the development of strategies against immune aging in humans, as many functions are conserved across phyla.

JOURNAL OF CELL BIOLOGY (2021)

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Article Nutrition & Dietetics

Time-restricted feeding improves blood glucose and insulin sensitivity in overweight patients with type 2 diabetes: a randomised controlled trial

Tingting Che et al.

Summary: Time-restricted feeding is a promising dietary intervention for overweight patients with type 2 diabetes, leading to improved glycemic control, weight loss, reduced medication use, and enhanced quality of life. It may also offer cardiovascular benefits by lowering atherosclerotic lipid levels.

NUTRITION & METABOLISM (2021)

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Review Endocrinology & Metabolism

The regulation of food intake by insulin in the central nervous system

Caitlin S. Mitchell et al.

Summary: Insulin plays a crucial role in regulating food intake and energy balance through its actions on different neuronal subpopulations in the hypothalamus, impacting the expression of neuropeptides involved in appetite control. Additionally, insulin activity in the amygdala is implicated in modulating food intake and stress-induced obesity, highlighting the central role of this brain region in insulin signaling and energy homeostasis.

JOURNAL OF NEUROENDOCRINOLOGY (2021)

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Review Gastroenterology & Hepatology

Circadian clocks in the digestive system

Anneleen Segers et al.

Summary: The circadian system controls various physiological processes in the body, including digestion, motility, hormone secretion, barrier function, and gut microbiota, through the coordination between the master clock and peripheral clocks. External cues, such as feeding time, also play a role in synchronizing peripheral clocks. This system helps prepare the body for predictable environmental changes and influences glucose and lipid metabolism in the digestive system.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Does the weight loss efficacy of alternate day fasting differ according to sex and menopausal status?

Shuhao Lin et al.

Summary: This study found no significant difference in weight loss and metabolic benefits of alternate day fasting (ADF) according to sex or menopausal status in adults with obesity. Energy intake on fast days exceeded prescribed values, with no differences between groups.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2021)

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Article Psychology, Biological

Time-restricted feeding attenuates gluconeogenic activity through inhibition of PGC-1α expression and activity

Yuqing She et al.

Summary: The study found that Time-Restricted Feeding (TRF) can reduce hepatic gluconeogenic activity in obese mice by inhibiting the p38 MAPK/SIRT1/PGC-1 alpha signaling pathway, leading to improvements in glucose intolerance, hyperglycemia, and insulin resistance induced by a high-fat diet.

PHYSIOLOGY & BEHAVIOR (2021)

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Review Endocrinology & Metabolism

Old Paradoxes and New Opportunities for Appetite Control in Obesity

Lea Montegut et al.

Summary: In obese individuals, there are changes in the concentrations of various circulating appetite regulators. Most appetite-inhibitory hormones are elevated while appetite stimulatory hormones are reduced, possibly due to inefficient feedback circuitries. Identifying appetite regulators with convergent rather than paradoxical behavior is important for understanding and treating obesity through supplementation or neutralization of these hormones.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2021)

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Article Cell Biology

Proteomics analysis of adipose depots after intermittent fasting reveals visceral fat preservation mechanisms

Dylan J. Harney et al.

Summary: Intermittent fasting, particularly every-other-day fasting, results in increased mitochondria protein content and fatty acid synthesis enzymes in subcutaneous and visceral white adipose tissue in mice. It also downregulates lipolysis specifically in visceral WAT and reduces inflammatory collagen IV, leading to improved insulin sensitivity.

CELL REPORTS (2021)

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Review Immunology

Dietary Intervention Impacts Immune Cell Functions and Dynamics by Inducing Metabolic Rewiring

Takuma Okawa et al.

Summary: Nutrient metabolism is closely associated with immune cell differentiation and function, with interventions like intermittent fasting potentially manipulating immune cell functions. Nutritional status also influences immune cell subset dynamics, offering new therapeutic strategies for immunological disorders.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Pharmacology & Pharmacy

Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson's disease

Kai Zhang et al.

Summary: Parkinson's disease is a common neurodegenerative disease that can be accelerated by impaired autophagy, which may lead to neuron death. Targeting autophagy with small-molecule compounds is considered a promising strategy in PD treatment.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Endocrinology & Metabolism

Time-Restricted Eating, Intermittent Fasting, and Fasting-Mimicking Diets in Weight Loss

Maura Fanti et al.

Summary: Dietary interventions, such as time-restricted eating, intermittent fasting, and fasting-mimicking diets, have shown potential for weight loss, but long-term efficacy remains uncertain and requires further research to validate.

CURRENT OBESITY REPORTS (2021)

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Article Multidisciplinary Sciences

PER2 mediates CREB-dependent light induction of the clock gene Per1

Andrea Brenna et al.

Summary: Light influences various physiological processes in mammals, and PER2 has been identified as a co-factor of CREB to facilitate the formation of a transactivation complex on the Per1 gene regulatory region in response to light stimulation.

SCIENTIFIC REPORTS (2021)

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Article Nutrition & Dietetics

The effect of intermittent energy restriction on weight loss and diabetes risk markers in women with a history of gestational diabetes: a 12-month randomized control trial

Kristy L. Gray et al.

Summary: This study found that intermittent energy restriction (IER) produces comparable weight loss to continuous energy restriction (CER) over 12 months in overweight women with previous gestational diabetes. However, the high dropout rate in the study is a limitation in interpreting these results, and larger studies are needed to confirm the noninferiority of IER compared to CER.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2021)

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Article Nutrition & Dietetics

Remodeling of the gut microbiome during Ramadan-associated intermittent fasting

Junhong Su et al.

Summary: Intermittent fasting, particularly observed during Ramadan, was found to increase gut microbiome diversity and upregulate specific bacterial families such as Lachnospiraceae and Ruminococcaceae. These changes in microbiome composition returned to baseline after cessation of intermittent feeding, and alterations in Lachnospiraceae concentrations were correlated with changes in physiological parameters provoked by intermittent fasting. The study suggests that the upregulation of butyric acid-producing Lachnospiraceae may play a role in the health benefits associated with intermittent fasting.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2021)

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Article Endocrinology & Metabolism

Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction

Sandra S. Hammer et al.

Summary: Intermittent fasting (IF) can effectively prevent microvascular and bone marrow dysfunction in diabetes patients by activating the SIRT1 signaling pathway, aiding in improving metabolic health and visual function impairment.

DIABETOLOGIA (2021)

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Article Medicine, Research & Experimental

Eight-hour time-restricted feeding improves endocrine and metabolic profiles in women with anovulatory polycystic ovary syndrome

Chunzhu Li et al.

Summary: The research showed that time-restricted feeding can help women with anovulatory PCOS to lose weight, reduce body fat, improve menstrual irregularity, hyperandrogenemia, insulin resistance, and chronic inflammation.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

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Article Nutrition & Dietetics

Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4+ T Cell Responsiveness

Kim Han et al.

Summary: Intermittent fasting and fasting mimetic diets can ameliorate inflammation by affecting serum protein levels, which play a crucial role in immune modulation.

NUTRIENTS (2021)

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Article Multidisciplinary Sciences

Time-restricted feeding rescues high-fat-diet-induced hippocampal impairment

Jennifer A. Davis et al.

Summary: Changing meal timing can rescue the cognitive and hippocampal impairments induced by HFD, even without altering body composition and total caloric intake. This suggests that short-term time-restricted feeding is an effective intervention for HFD-induced cognitive deficits and hippocampal dysfunction.

ISCIENCE (2021)

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Article Cell Biology

Aging and neuroinflammation: Changes in immune cell responses, axon integrity, and motor function in a viral model of progressive multiple sclerosis

Leyre Mestre et al.

Summary: Aging has been shown to have an impact on immune cells and neuroinflammatory processes in the CNS of both healthy and infected mice. Microglia and macrophages in old mice showed opposite response to CNS viral infection, with increased programmed death-ligand 1 expression in microglia. The study suggests the need for new or adapted pharmacological strategies for elderly MS patients.

AGING CELL (2021)

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Article Oncology

Intermittent fasting in the prevention and treatment of cancer

Katherine K. Clifton et al.

Summary: Intermittent fasting (IF) has gained popularity as a potential anticarcinogenic strategy, but its effects on cancer patients remain unclear without high-quality randomized clinical trials. More research is needed to determine the risks and benefits of IF for cancer patients before it can be recommended outside of clinical trials.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Biochemistry & Molecular Biology

The microbiota coordinates diurnal rhythms in innate immunity with the circadian clock

John F. Brooks et al.

Summary: The study found that the intestinal microbiota generates diurnal rhythms in innate immunity that synchronize with feeding rhythms to anticipate microbial exposure. This synchronization activates an immunological circuit triggering oscillations in epithelial STAT3 expression and activation that produce rhythmic antimicrobial protein expression, causing resistance to bacterial infection to vary across the day-night cycle.

CELL (2021)

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Review Biochemical Research Methods

Beyond calorie restriction: aging as a biological target for nutrient therapies

Steven N. Austad et al.

Summary: The important discovery that reducing food intake can extend life and improve health is being challenged by research showing that protein restriction, intermittent fasting, and the timing of eating also impact health. This suggests that optimizing human diets will require a personalized approach.

CURRENT OPINION IN BIOTECHNOLOGY (2021)

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Article Sport Sciences

Twelve Months of Time-restricted Eating and Resistance Training Improves Inflammatory Markers and Cardiometabolic Risk Factors

Tatiana Moro et al.

Summary: The study demonstrates that long-term time-restricted eating combined with resistance training is feasible, safe, and effective in reducing inflammatory markers and risk factors related to cardiovascular and metabolic diseases.

MEDICINE & SCIENCE IN SPORTS & EXERCISE (2021)

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Review Biochemistry & Molecular Biology

Macroautophagy and aging: The impact of cellular recycling on health and longevity

Jose L. Nieto-Torres et al.

Summary: Autophagy is a cellular recycling process that declines with age, playing important roles in physiological aging and age-related diseases. Enhancement of autophagy has beneficial effects on healthspan and lifespan, while defects in autophagy promote age-related diseases.

MOLECULAR ASPECTS OF MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho

Gisele Pereira Dias et al.

Summary: The study showed that intermittent fasting improves long-term memory retention, increases neurogenesis in the hippocampus, and enhances cognition by upregulating the longevity gene Klotho, particularly through enhancing adult hippocampal neurogenesis.

MOLECULAR PSYCHIATRY (2021)

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Review Cardiac & Cardiovascular Systems

PPAR control of metabolism and cardiovascular functions

David Montaigne et al.

Summary: Novel PPAR agonists offer new opportunities for managing metabolic and cardiovascular diseases by regulating gene expression, lipid metabolism, insulin sensitivity, glucose metabolism, and cardiovascular health. Activation of PPARs by specific ligands can have antiatherogenic, anti-inflammatory, and metabolic benefits, making them important therapeutic targets in the treatment of various diseases.

NATURE REVIEWS CARDIOLOGY (2021)

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Review Nutrition & Dietetics

Time-restricted feeding regulates molecular mechanisms with involvement of circadian rhythm to prevent metabolic diseases

Falak Zeb et al.

Summary: Time-restricted feeding (TRF) regulates the circadian rhythm of food intake to prevent metabolic diseases, optimize nutrient utilization, and coordinate circadian clock components and nutrient-sensing pathways to protect metabolic health.

NUTRITION (2021)

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Article Nutrition & Dietetics

Eight weeks of intermittent fasting versus calorie restriction does not alter eating behaviors, mood, sleep quality, quality of life and cognitive performance in women with overweight

Xiao Tong Teong et al.

Summary: Intermittent fasting (IF) and calorie restriction (CR) are both effective for weight loss, with IF showing greater reductions in weight and body fat. Both IF and CR resulted in improved cognitive performance, while having no significant impact on eating behaviors, mood, sleep quality, and quality of life.

NUTRITION RESEARCH (2021)

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Article Multidisciplinary Sciences

Time-restricted feeding protects the blood pressure circadian rhythm in diabetic mice

Tianfei Hou et al.

Summary: The study reveals that restricting the timing of food intake can prevent nondipping blood pressure in diabetic mice and effectively restore disrupted blood pressure circadian rhythm.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Cell Biology

A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults

Iain Templeman et al.

Summary: This study found that daily fasting is less effective in reducing body fat mass compared to a matched degree of daily energy restriction, with no evidence of fasting-specific effects on metabolic regulation or cardiovascular health.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Editorial Material Cell Biology

Time to eat reveals the hierarchy of peripheral clocks

Zhihui Zhang et al.

Summary: Meal timing can reset cellular circadian clocks in the body, with clocks in different tissues being reset to varying degrees by feeding rhythms, and modulated by the central clock and the liver clock. Tissue-specific regulation and intercellular signaling play essential roles in clock synchronization.

TRENDS IN CELL BIOLOGY (2021)

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Article Multidisciplinary Sciences

Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis

Xiaolong Tang et al.

Summary: The combination of intermittent fasting and chemotherapy can improve treatment efficacy, with the GSK3β-SIRT7 axis playing a crucial role. This mechanism is likely regulated by AMPK and GSK3β.

NATURE COMMUNICATIONS (2021)

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Article Nutrition & Dietetics

Four Weeks of 16/8 Time Restrictive Feeding in Endurance Trained Male Runners Decreases Fat Mass, without Affecting Exercise Performance

Ashley P. Tovar et al.

Summary: The study showed that adhering to a 4-week 16/8 TRF dietary intervention resulted in decreased fat mass and maintained fat-free mass in trained male endurance runners, without affecting running performance.

NUTRIENTS (2021)

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Article Nutrition & Dietetics

A Smartphone Intervention to Promote Time Restricted Eating Reduces Body Weight and Blood Pressure in Adults with Overweight and Obesity: A Pilot Study

Malini Prasad et al.

Summary: This study demonstrates the feasibility and efficacy of time restricted eating (TRE) administered via a smartphone in adults with overweight and obesity. Participants successfully reduced their eating window and daily eating occasions, leading to decreases in body weight, waist circumference, and systolic blood pressure.

NUTRIENTS (2021)

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Article Environmental Sciences

Effects of Time-Restricted Feeding on Supramaximal Exercise Performance and Body Composition: A Randomized and Counterbalanced Crossover Study in Healthy Men

Joana M. Correia et al.

Summary: In this study, the effects of short- and long-term time-restricted feeding on performance and body composition in well-trained men were explored. It was found that after four weeks of TRF, there was an increase in WnT mean power and total work output, as well as an increase in fat-free mass. However, there was no correlation between change in fat-free mass and WnT mean power after TRF. TRF did not elicit any changes in WnT performance or body composition one week post-intervention.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Oncology

Safety and Feasibility of Fasting-Mimicking Diet and Effects on Nutritional Status and Circulating Metabolic and Inflammatory Factors in Cancer Patients Undergoing Active Treatment

Francesca Valdemarin et al.

Summary: Our study demonstrates that periodic cycles of a modified fasting regime are feasible and safe in cancer patients at low nutritional risk, without negatively affecting body composition. Additionally, this fasting regime can reduce fat mass, insulin production, and circulating IGF1 and leptin levels in cancer patients.

CANCERS (2021)

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Article Food Science & Technology

Intermittent fasting suppressed splenic CD205+ G-MDSC accumulation in a murine breast cancer model by attenuating cell trafficking and inducing apoptosis

Chenghao Fu et al.

Summary: Intermittent fasting selectively inhibits the accumulation of tumor-induced splenic CD205+ G-MDSCs, enhancing anti-tumor immunity through downregulation of CXCR4 and induction of apoptosis by altering glucose metabolism.

FOOD SCIENCE & NUTRITION (2021)

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Review Agriculture, Dairy & Animal Science

Gut microbiotada positive contributor in the process of intermittent fasting-mediated obesity control

Bohan Rong et al.

Summary: This paper focuses on the interaction between intermittent fasting and gut microbiota, highlighting the potential positive effects on host energy metabolism. It also discusses a potential recommended strain (Akkermansia muciniphila) and a regulatory pathway (circadian rhythm) for gut microbiota in improving host energy metabolism in IF.

ANIMAL NUTRITION (2021)

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Article Endocrinology & Metabolism

Fasting-induced FOXO4 blunts human CD4+ T helper cell responsiveness

Kim Han et al.

Summary: Research shows that fasting can reduce the responsiveness of CD4(+) T helper cells, with longer fasting having a more pronounced effect on CD4(+) T cell biology. Identification of FOXO4-FKBP5 as a new fasting-induced regulatory pathway provides insights into how fasting can blunt human CD4(+) T helper cell responsiveness.

NATURE METABOLISM (2021)

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Article Gastroenterology & Hepatology

Fecal microbiota composition associates with the capacity of human peripheral blood monocytes to differentiate into immunogenic dendritic cells in vitro

Dusan Radojevic et al.

Summary: The composition of gut microbiota in healthy donors is significantly correlated with the immunogenic properties of dendritic cells generated in vitro, indicating the important role of gut microbiota in donor precursor cells differentiation into immunogenic DCs suitable for cancer therapy.

GUT MICROBES (2021)

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Article Endocrinology & Metabolism

Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan

Amrendra Mishra et al.

Summary: Research shows that a monthly cycle of 5 days of a fasting-mimicking diet can prevent obesity and related detrimental effects on cardiometabolic health and lifespan in mice. The fasting-mimicking diet inhibits obesity by reducing fat accumulation and improves heart function and resistance to cardiotoxins. It also prevents issues like hyperglycemia, hypercholesterolemia, and hyperleptinemia, while improving glucose and insulin tolerance.

NATURE METABOLISM (2021)

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Article Gastroenterology & Hepatology

Treatment of NAFLD with intermittent calorie restriction or low-carb high-fat diet - a randomised controlled trial

Magnus Holmer et al.

Summary: For individuals with obesity and fatty liver, weight loss through diet can effectively improve liver conditions. This study demonstrates that both low-carb high-fat and the 5:2 diet are effective in treating fatty liver caused by obesity.

JHEP REPORTS (2021)

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Review Biochemistry & Molecular Biology

Targeting the ubiquitination/deubiquitination process to regulate immune checkpoint pathways

Jiaxin Liu et al.

Summary: The immune system acts as a fortress against pathogens and tumor cells, but excessive immune responses can lead to harmful effects. Therapeutic antibodies targeting immune checkpoints have made breakthroughs in cancer treatment, but the efficacy of immune checkpoint blockade remains unsatisfactory.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Biochemistry & Molecular Biology

Night-restricted feeding improves locomotor activity rhythm and modulates nutrient utilization to accelerate growth in rabbits

Yao Guo et al.

Summary: Night-restricted feeding (NRF) promotes growth and reduces fat content in rabbits models by improving circadian rhythm, enhancing metabolism, and preventing obesity. Research indicates that NRF can improve metabolic function by regulating protein synthesis and muscle formation.

FASEB JOURNAL (2021)

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Article Nutrition & Dietetics

Intermittent energy restriction is comparable to continuous energy restriction for cardiometabolic health in adults with central obesity: A randomized controlled trial; the Met-IER study

Ana M. Pinto et al.

CLINICAL NUTRITION (2020)

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Review Clinical Neurology

The gut microbiome in neurological disorders

John F. Cryan et al.

LANCET NEUROLOGY (2020)

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Review Cell Biology

Molecular mechanisms and physiological importance of circadian rhythms

Alina Patke et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Review Cell Biology

Ageing, age-related diseases and oxidative stress: What to do next?

Jiao Luo et al.

AGEING RESEARCH REVIEWS (2020)

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Review Cell Biology

Calorie restriction for enhanced longevity: The role of novel dietary strategies in the present obesogenic environment

James L. Dorling et al.

AGEING RESEARCH REVIEWS (2020)

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Article Nutrition & Dietetics

Intermittent fasting, Paleolithic, or Mediterranean diets in the real world: exploratory secondary analyses of a weight-loss trial that included choice of diet and exercise

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Article Cell Biology

Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome

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Article Environmental Sciences

Impact of pyrethroids and organochlorine pesticides residue on IGF-1 and CYP1A genes expression and muscle protein patterns of cultured Mugil capito

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Article Gastroenterology & Hepatology

Circadian Rhythms in the Pathogenesis and Treatment of Fatty Liver Disease

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GASTROENTEROLOGY (2020)

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Acute effects of time-restricted feeding in low-income women with obesity placed on hypoenergetic diets: Randomized trial

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Time-restricted feeding improves markers of cardiometabolic health in physically active college-age men: a 4-week randomized pre-post pilot study

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Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase

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Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment

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Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD)

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Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction

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Energy Restriction Enhances Adult Hippocampal Neurogenesis-Associated Memory after Four Weeks in an Adult Human Population with Central Obesity; a Randomized Controlled Trial

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Article Geriatrics & Gerontology

Short-term time-restricted feeding is safe and feasible in non-obese healthy midlife and older adults

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GEROSCIENCE (2020)

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Diversity, compositional and functional differences between gut microbiota of children and adults

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Lysine-specific demethylase 3A is important for autophagic occurrence

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Intermittent fasting increases adult hippocampal neurogenesis

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Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression

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Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers

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Intermittent fasting from dawn to sunset for 30 consecutive days is associated with anticancer proteomic signature and upregulates key regulatory proteins of glucose and lipid metabolism, circadian clock, DNA repair, cytoskeleton remodeling, immune system and cognitive function in healthy

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Long-Term Feeding of a High-Fat Diet Ameliorated Age-Related Phenotypes in SAMP8 Mice

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Multi-omics Analysis of the Intermittent Fasting Response in Mice Identifies an Unexpected Role for HNF4α

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Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders

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Time-restricted feeding is associated with changes in human gut microbiota related to nutrient intake

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Two weeks of early time-restricted feeding (eTRF) improves skeletal muscle insulin and anabolic sensitivity in healthy men

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Review Biochemistry & Molecular Biology

Calorie Restriction and Aging in Humans

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Impact of modified short-term fasting and its combination with a fasting supportive diet during chemotherapy on the incidence and severity of chemotherapy-induced toxicities in cancer patients - a controlled cross-over pilot study

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Study design of the Fasting In diabetes Treatment (FIT) trial: a randomised, controlled, assessor blinded intervention trial which examines the effect of intermittent use of a fasting mimicking diet in patients with type 2 diabetes

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Effects of 4-and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity

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Circadian Rhythms in Hormone-sensitive Lipase in Human Adipose Tissue: Relationship to Meal Timing and Fasting Duration

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Intermittent fasting promotes adult hippocampal neuronal differentiation by activating GSK-3β in 3xTg-AD mice

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Calorie restriction promotes remyelination in a Cuprizone-Induced demyelination mouse model of multiple sclerosis

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Fasting-mimicking diet and hormone therapy induce breast cancer regression

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Intermittent Fasting and Metabolic Health: From Religious Fast to Time-Restricted Feeding

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Peripheral circadian rhythms in the liver and white adipose tissue of mice are attenuated by constant light and restored by time-restricted feeding

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Fasting mimicking diet as an adjunct toneoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial

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Article Endocrinology & Metabolism

Fasting in diabetes treatment (FIT) trial: study protocol for a randomised, controlled, assessor-blinded intervention trial on the effects of intermittent use of a fasting-mimicking diet in patients with type 2 diabetes

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Intermittent Fasting and High-Intensity Exercise Elicit Sexual-Dimorphic and Tissue-Specific Adaptations in Diet-Induced Obese Mice

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Effects of Ramadan Intermittent Fasting on Gut Hormones and Body Composition in Males with Obesity

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INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

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Intermittent Fasting Improves Cardiometabolic Risk Factors and Alters Gut Microbiota in Metabolic Syndrome Patients

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Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression

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Intermittent Fasting Enhanced the Cognitive Function in Older Adults with Mild Cognitive Impairment by Inducing Biochemical and Metabolic changes: A 3-Year Progressive Study

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Does the Energy Restriction Intermittent Fasting Diet Alleviate Metabolic Syndrome Biomarkers? A Randomized Controlled Trial

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Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and Obesity The TREAT Randomized Clinical Trial

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JAMA INTERNAL MEDICINE (2020)

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Two-Week Isocaloric Time-Restricted Feeding Decreases Liver Inflammation without Significant Weight Loss in Obese Mice with Non-Alcoholic Fatty Liver Disease

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Time-restricted eating effects on performance, immune function, and body composition in elite cyclists: a randomized controlled trial

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Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting

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PROFAST: A Randomized Trial Assessing the Effects of Intermittent Fasting and Lacticaseibacillus rhamnosus Probiotic among People with Prediabetes

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Article Nutrition & Dietetics

Time-Restricted Feeding Reduces the Detrimental Effects of a High-Fat Diet, Possibly by Modulating the Circadian Rhythm of Hepatic Lipid Metabolism and Gut Microbiota

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Intermittent fasting from dawn to sunset for four consecutive weeks induces anticancer serum proteome response and improves metabolic syndrome

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Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer

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Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock

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Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories

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Time-restricted feeding causes irreversible metabolic disorders and gut microbiota shift in pediatric mice

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Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

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Type 2 Diabetes, but Not Insulin (Analog) Treatment, Is Associated With More Advanced Stages of Breast Cancer: A National Linkage of Cancer and Pharmacy Registries

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Metabolism-induced tumor activator 1 (MITA1), an Energy Stress-Inducible Long Noncoding RNA, Promotes Hepatocellular Carcinoma Metastasis

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Neuroprotection of Fasting Mimicking Diet on MPTP-Induced Parkinson's Disease Mice via Gut Microbiota and Metabolites

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PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Diverse metabolic reactions activated during 58-hr fasting are revealed by non-targeted metabolomic analysis of human blood

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Glucose Activates Vagal Control of Hyperglycemia and Inflammation in Fasted Mice

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Loss of Hepatic Oscillatory Fed microRNAs Abrogates Refed Transition and Causes Liver Dysfunctions

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Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology

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Ets1-Mediated Acetylation of FoxO1 Is Critical for Gluconeogenesis Regulation during Feed-Fast Cycles

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Time-restricted Feeding Attenuates High-fat Diet-enhanced Spontaneous Metastasis of Lewis Lung Carcinoma in Mice

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Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

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Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time

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Nutrient Sensing by the Intestinal Epithelium Orchestrates Mucosal Antimicrobial Defense via Translational Control of Hes1

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NF-κB Shapes Metabolic Adaptation by Attenuating Foxo-Mediated Lipolysis in Drosophila

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Flash glucose monitoring for the safe use of a 2-day intermittent energy restriction in patients with type 2 diabetes at risk of hypoglycaemia: An exploratory study

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SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice

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Rhythmic Food Intake Drives Rhythmic Gene Expression More Potently than the Hepatic Circadian Clock in Mice

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Fermented Dairy Foods: Impact on Intestinal Microbiota and Health-Linked Biomarkers

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FRONTIERS IN MICROBIOLOGY (2019)

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Time-Restricted Eating to Prevent and Manage Chronic Metabolic Diseases

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Annual Review of Nutrition (2019)

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Early Time-Restricted Feeding Reduces Appetite and Increases Fat Oxidation But Does Not Affect Energy Expenditure in Humans

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Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption

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The Effects of Time Restricted Feeding on Overweight, Older Adults: A Pilot Study

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Review Nutrition & Dietetics

A Review of Various Antioxidant Compounds and their Potential Utility as Complementary Therapy in Multiple Sclerosis

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2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial

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Downregulation of mTOR Signaling Increases Stem Cell Population Telomere Length during Starvation of Immortal Planarians

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Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses

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Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans

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Mechanisms of Fasting-Mediated Protection against Renal Injury and Fibrosis Development after Ischemic Acute Kidney Injury

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Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

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Calorie restriction slows age-related microbiota changes in an Alzheimer's disease model in female mice

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Time-restricted feeding during childhood has persistent effects on mice commensal microbiota

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The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex

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Exploiting FAsting-mimicking Diet and MEtformin to Improve the Efficacy of Platinum-pemetrexed Chemotherapy in Advanced LKB1-inactivated Lung Adenocarcinoma: The FAME Trial

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Article Gastroenterology & Hepatology

Effects of alternate-day fasting on body weight and dyslipidaemia in patients with non-alcoholic fatty liver disease: a randomised controlled trial

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BMC GASTROENTEROLOGY (2019)

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Alteration in gut microbiota caused by time-restricted feeding alleviate hepatic ischaemia reperfusion injury in mice

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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Review Cell Biology

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Intermittent fasting exerts beneficial metabolic effects on blood pressure and cardiac structure by modulating local renin-angiotensin system in the heart of mice fed high-fat or high-fructose diets

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NUTRITION RESEARCH (2019)

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Effects of Intermittent Versus Continuous Energy Intakes on Insulin Sensitivity and Metabolic Risk in Women with Overweight

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Review Medicine, General & Internal

Effects of Intermittent Fasting on Health, Aging, and Disease

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NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Age-dependent changes and biomarkers of aging in Caenorhabditis elegans

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AGING CELL (2019)

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Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction

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NUTRIENTS (2019)

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Review Nutrition & Dietetics

The Effects of Calorie Restriction on Autophagy: Role on Aging Intervention

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Circadian clock network desynchrony promotes weight gain and alters glucose homeostasis in mice

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MOLECULAR METABOLISM (2019)

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Article Endocrinology & Metabolism

Intermittent Fasting Improves Glucose Tolerance and Promotes Adipose Tissue Remodeling in Male Mice Fed a High-Fat Diet

Bo Liu et al.

ENDOCRINOLOGY (2019)

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Article Multidisciplinary Sciences

Thermogenesis-independent metabolic benefits conferred by isocaloric intermittent fasting in ob/ob mice

Yun Hye Kim et al.

SCIENTIFIC REPORTS (2019)

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Article Oncology

The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study

Stephan P. Bauersfeld et al.

BMC CANCER (2018)

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Article Oncology

The interplay between noncoding RNAs and insulin in diabetes

Yan Tian et al.

CANCER LETTERS (2018)

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Review Biochemistry & Molecular Biology

The Human Gut Microbiome: From Association to Modulation

Thomas S. B. Schmidt et al.

CELL (2018)

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Article Cell Biology

Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes

Elizabeth F. Sutton et al.

CELL METABOLISM (2018)

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Article Cell Biology

Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota

Francesca Cignarella et al.

CELL METABOLISM (2018)

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Article Cell Biology

Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging

Leanne M. Redman et al.

CELL METABOLISM (2018)

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Article Cell & Tissue Engineering

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging

Maria M. Mihaylova et al.

CELL STEM CELL (2018)

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Article Biochemistry & Molecular Biology

Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension

James H. Catterson et al.

CURRENT BIOLOGY (2018)

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Article Endocrinology & Metabolism

Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice

Eleni Beli et al.

DIABETES (2018)

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Article Endocrinology & Metabolism

Type 2 Diabetes in Relation to the Risk of Renal Cell Carcinoma Among Men and Women in Two Large Prospective Cohort Studies

Rebecca E. Graff et al.

DIABETES CARE (2018)

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Article Endocrinology & Metabolism

Intermittent fasting in Type 2 diabetes mellitus and the risk of hypoglycaemia: a randomized controlled trial

B. T. Corley et al.

DIABETIC MEDICINE (2018)

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Review Endocrinology & Metabolism

Molecular Actions of PPARα in Lipid Metabolism and Inflammation

Nadia Bougarne et al.

ENDOCRINE REVIEWS (2018)

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Article Medicine, Research & Experimental

Intermittent fasting protects against the deterioration of cognitive function, energy metabolism and dyslipidemia in Alzheimer's disease-induced estrogen deficient rats

Bae Kun Shin et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2018)

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Article Biochemistry & Molecular Biology

Circadian clock-mediated regulation of blood pressure

Lauren G. Douma et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Article Medicine, Research & Experimental

Fasting-induced JMJD3 histone demethylase epigenetically activates mitochondrial fatty acid β-oxidation

Sunmi Seok et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Article Gastroenterology & Hepatology

The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis

Maheul Ploton et al.

JOURNAL OF HEPATOLOGY (2018)

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Article Immunology

A Pilot Study To Investigate the Immune-Modulatory Effects of Fasting in Steroid-Naive Mild Asthmatics

Kim Han et al.

JOURNAL OF IMMUNOLOGY (2018)

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Article Endocrinology & Metabolism

Restricted feeding for 9 h in the active period partially abrogates the detrimental metabolic effects of a Western diet with liquid sugar consumption in mice

Lauren N. Woodie et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2018)

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Article Neurosciences

Intermittent Fasting Alleviates the Increase of Lipoprotein Lipase Expression in Brain of a Mouse Model of Alzheimer's Disease: Possibly Mediated by β-hydroxybutyrate

Jingzhu Zhang et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

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Article Nutrition & Dietetics

Intermittent Fasting with or without Exercise Prevents Weight Gain and Improves Lipids in Diet-Induced Obese Mice

Robin A. Wilson et al.

NUTRIENTS (2018)

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Article Cell Biology

Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat

Shiki Okamoto et al.

CELL REPORTS (2018)

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Review Immunology

Age and Age-Related Diseases: Role of inflammation Triggers and Cytokines

Irene Maeve Rea et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Endocrinology & Metabolism

Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha

Guolin Li et al.

MOLECULAR METABOLISM (2018)

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Article Neurosciences

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease

Dagmar E. Ehrnhoefer et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2018)

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Article Nutrition & Dietetics

Time-restricted feeding mitigates high-fat diet-enhanced mammary tumorigenesis in MMTV-PyMT mice

S. Sundaram et al.

NUTRITION RESEARCH (2018)

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Article Multidisciplinary Sciences

SCFAs strongly stimulate PYY production in human enteroendocrine cells

P. Larraufie et al.

SCIENTIFIC REPORTS (2018)

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Review Cell Biology

Roles of the immune system in cancer: from tumor initiation to metastatic progression

Hugo Gonzalez et al.

GENES & DEVELOPMENT (2018)

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Article Nutrition & Dietetics

Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores beta cells and reconstructs gut microbiota in mice

Siying Wei et al.

NUTRITION & METABOLISM (2018)

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Review Multidisciplinary Sciences

A time to fast

Andrea Di Francesco et al.

SCIENCE (2018)

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Article Cell Biology

Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle

Kenichiro Kinouchi et al.

CELL REPORTS (2018)

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Article Endocrinology & Metabolism

Intermittent Fasting: Is the Wait Worth the Weight?

Mary-Catherine Stockman et al.

CURRENT OBESITY REPORTS (2018)

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Letter Cardiac & Cardiovascular Systems

Time-Restricted Feeding Improves Metabolic Health in Mice Lacking a Circadian Clock

Tracy Hampton

CIRCULATION (2018)

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Article Sport Sciences

Time-restricted feeding in young men performing resistance training: A randomized controlled trial

Grant M. Tinsley et al.

EUROPEAN JOURNAL OF SPORT SCIENCE (2017)

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Article Biochemistry & Molecular Biology

Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation

Zhigang Lu et al.

NATURE MEDICINE (2017)

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Review Biochemistry & Molecular Biology

Proteome Stability as a Key Factor of Genome Integrity

Sentiljana Gumeni et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Biochemistry & Molecular Biology

The microRNA machinery regulates fasting-induced changes in gene expression and longevity in Caenorhabditis elegans

Akiko Kogure et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

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Article Biochemistry & Molecular Biology

Relationship between FGF21 and UCP1 levels under time-restricted feeding and high-fat diet

Nava Chapnik et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2017)

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Article Cardiac & Cardiovascular Systems

The Importance of Breakfast in Atherosclerosis Disease

Irina Uzhova et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

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Letter Oncology

Fasting conditions in clinical oncology trials and drug labelling

Guo Yu et al.

LANCET ONCOLOGY (2017)

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Article Nutrition & Dietetics

Ramadan model of intermittent fasting for 28 d had no major effect on body composition, glucose metabolism, or cognitive functions in healthy lean men

Nina M. Harder-Lauridsen et al.

NUTRITION (2017)

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Article Neurosciences

Mitochondrial function in hypoxic ischemic injury and influence of aging

P. Benson Ham et al.

PROGRESS IN NEUROBIOLOGY (2017)

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Article Cell Biology

Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease

Min Wei et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

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Article Multidisciplinary Sciences

Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice

Kan Xie et al.

NATURE COMMUNICATIONS (2017)

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Article Cell Biology

Adipose KLF15 Controls Lipid Handling to Adapt to Nutrient Availability

Keiichiro Matoba et al.

CELL REPORTS (2017)

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Article Cell Biology

Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage

Hong Wang et al.

CELL REPORTS (2017)

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Article Medicine, General & Internal

Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults A Randomized Clinical Trial

John F. Trepanowski et al.

JAMA INTERNAL MEDICINE (2017)

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Article Neurosciences

Intermittent Fasting Protects against Alzheimer's Disease Possible through Restoring Aquaporin-4 Polarity

Jingzhu Zhang et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)

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Article Cell Biology

Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway

Haiyan Liu et al.

AUTOPHAGY (2017)

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Article Cell Biology

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota

Guolin Li et al.

CELL METABOLISM (2017)

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Review Cell Biology

Calorie restriction in rodents: Caveats to consider

Donald K. Ingram et al.

AGEING RESEARCH REVIEWS (2017)

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Article Biochemistry & Molecular Biology

Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes

Chia-Wei Cheng et al.

CELL (2017)

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Article Cell Biology

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

Ji-Man Park et al.

AUTOPHAGY (2016)

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Article Pharmacology & Pharmacy

Fasting protects against the side effects of irinotecan treatment but does not affect anti-tumour activity in mice

Sander A. Huisman et al.

BRITISH JOURNAL OF PHARMACOLOGY (2016)

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Article Oncology

Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

Stefano Di Biase et al.

CANCER CELL (2016)

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Article Biochemistry & Molecular Biology

mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction

Masaki Igarashi et al.

CELL (2016)

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Review Cell Biology

Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

Valter D. Longo et al.

CELL METABOLISM (2016)

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Article Gastroenterology & Hepatology

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

Alexandra Montagner et al.

GUT (2016)

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Article Medicine, Research & Experimental

Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males

Tatiana Moro et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2016)

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Article Endocrinology & Metabolism

A Randomized Pilot Study Comparing Zero-Calorie Alternate-Day Fasting to Daily Caloric Restriction in Adults with Obesity

Victoria A. Catenacci et al.

OBESITY (2016)

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Review Pharmacology & Pharmacy

Gut microbiome in health and disease: Linking the microbiome-gut-brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases

Shivani Ghaisas et al.

PHARMACOLOGY & THERAPEUTICS (2016)

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Review Biochemistry & Molecular Biology

The Warburg Effect: How Does it Benefit Cancer Cells?

Maria V. Liberti et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

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Article Cell Biology

A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms

In Young Choi et al.

CELL REPORTS (2016)

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Article Cell Biology

A Long Non-coding RNA, IncLGR, Regulates Hepatic Glucokinase Expression and Glycogen Storage during Fasting

Xiangbo Ruan et al.

CELL REPORTS (2016)

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Article Cell Biology

SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent Fasting

Marie Boutant et al.

CELL REPORTS (2016)

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Article Cell Biology

A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism

Yanlin He et al.

CELL REPORTS (2016)

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Article Medicine, General & Internal

Effect of Calorie Restriction on Mood, Quality of Life, Sleep, and Sexual Function in Healthy Nonobese Adults The CALERIE 2 Randomized Clinical Trial

Corby K. Martin et al.

JAMA INTERNAL MEDICINE (2016)

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Article Oncology

Prolonged Nightly Fasting and Breast Cancer Prognosis

Catherine R. Marinac et al.

JAMA ONCOLOGY (2016)

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Review Biochemistry & Molecular Biology

Regulation of Ketone Body Metabolism and the Role of PPARα

Maja Grabacka et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Article Oncology

The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study

Stefanie de Groot et al.

BMC CANCER (2015)

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Article Oncology

Prolonged Nightly Fasting and Breast Cancer Risk: Findings from NHANES (2009-2010)

Catherine R. Marinac et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2015)

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Article Cell Biology

Fasting protects against the side effects of irinotecan but preserves its anti-tumor effect in Apc15lox mutant mice

Sander A. Huisman et al.

CELL CYCLE (2015)

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Article Cell Biology

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

Sebastian Brandhorst et al.

CELL METABOLISM (2015)

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Article Cell Biology

A Smartphone App Reveals Erratic Diurnal Eating Patterns in Humans that Can Be Modulated for Health Benefits

Shubhroz Gill et al.

CELL METABOLISM (2015)

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Review Medicine, Research & Experimental

mTOR: a pharmacologic target for autophagy regulation

Young Chul Kim et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

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Article Biochemistry & Molecular Biology

Proteostasis and aging

Susmita Kaushik et al.

NATURE MEDICINE (2015)

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Article Multidisciplinary Sciences

Time-restricted feeding attenuates age-related cardiac decline in Drosophila

Shubhroz Gill et al.

SCIENCE (2015)

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Article Oncology

Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models

Giovanna Bianchi et al.

ONCOTARGET (2015)

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Article Endocrinology & Metabolism

The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents

A. Psichas et al.

INTERNATIONAL JOURNAL OF OBESITY (2015)

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Review Cell Biology

Fasting: Molecular Mechanisms and Clinical Applications

Valter D. Longo et al.

CELL METABOLISM (2014)

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Article Cell & Tissue Engineering

Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression

Chia-Wei Cheng et al.

CELL STEM CELL (2014)

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Article Gastroenterology & Hepatology

Fasting protects liver from ischemic injury through Sirt1-mediated downregulation of circulating HMGB1 in mice

Andreas Rickenbacher et al.

JOURNAL OF HEPATOLOGY (2014)

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Review Genetics & Heredity

Mechanisms of epigenetic memory

Agustina D'Urso et al.

TRENDS IN GENETICS (2014)

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Review Neurosciences

Interventions that Improve Body and Brain Bioenergetics for Parkinson's Disease Risk Reduction and Therapy

Mark P. Mattson

JOURNAL OF PARKINSONS DISEASE (2014)

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Article Cell Biology

Impact of fasting on the rhythmic expression of myogenic and metabolic factors in skeletal muscle of adult mice

T. Shavlakadze et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2013)

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Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

CELL (2013)

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Article Geriatrics & Gerontology

Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast

John P. Aris et al.

EXPERIMENTAL GERONTOLOGY (2013)

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Article Biochemistry & Molecular Biology

Altered mitochondrial functioning induced by preoperative fasting may underlie protection against renal ischemia/reperfusion injury

Marielle Verweij et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2013)

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Review Endocrinology & Metabolism

Neuroinflammation and neurodegeneration in overnutrition-induced diseases

Dongsheng Cai

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2013)

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Article Cell Biology

A Fasting-Responsive Signaling Pathway that Extends Life Span in C. elegans

Masaharu Uno et al.

CELL REPORTS (2013)

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Article Neurosciences

Ghrelin Regulates the Hypothalamic-Pituitary-Adrenal Axis and Restricts Anxiety After Acute Stress

Sarah J. Spencer et al.

BIOLOGICAL PSYCHIATRY (2012)

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Article Cell Biology

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

Megumi Hatori et al.

CELL METABOLISM (2012)

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Article Gastroenterology & Hepatology

Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver

Wei-Dong Chen et al.

HEPATOLOGY (2012)

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Article Neurosciences

Glucagon-Like Peptide 1 (GLP-1) Can Reverse AMP-Activated Protein Kinase (AMPK) and S6 Kinase (P70S6K) Activities Induced by Fluctuations in Glucose Levels in Hypothalamic Areas Involved in Feeding Behaviour

Veronica Hurtado-Carneiro et al.

MOLECULAR NEUROBIOLOGY (2012)

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Review Gastroenterology & Hepatology

The role of the gut microbiota in nutrition and health

Harry J. Flint et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2012)

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Article Nutrition & Dietetics

Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women

Monica C. Klempel et al.

NUTRITION JOURNAL (2012)

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Article Cell Biology

The Gut Hormones PYY3-36 and GLP-17-36 amide Reduce Food Intake and Modulate Brain Activity in Appetite Centers in Humans

Akila De Silva et al.

CELL METABOLISM (2011)

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Review Cell Biology

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

Maria M. Mihaylova et al.

NATURE CELL BIOLOGY (2011)

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Article Multidisciplinary Sciences

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

Shomit Sengupta et al.

NATURE (2010)

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Article Biochemistry & Molecular Biology

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

Eric E. Zhang et al.

NATURE MEDICINE (2010)

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Article Oncology

Effect of intermittent fasting on prostate cancer tumor growth in a mouse model

J. A. Thomas et al.

PROSTATE CANCER AND PROSTATIC DISEASES (2010)

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Article Multidisciplinary Sciences

Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C-elegans

Sakiko Honjoh et al.

NATURE (2009)

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Article Multidisciplinary Sciences

Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression

Christopher Vollmers et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Article Multidisciplinary Sciences

Starvation Protects Germline Stem Cells and Extends Reproductive Longevity in C-elegans

Giana Angelo et al.

SCIENCE (2009)

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Article Multidisciplinary Sciences

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

Katja A. Lamia et al.

SCIENCE (2009)

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Article Biochemistry & Molecular Biology

The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

Yasukazu Nakahata et al.

CELL (2008)

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Article Biochemistry & Molecular Biology

SIRT1 regulates circadian clock gene expression through PER2 deacetylation

Gad Asher et al.

CELL (2008)

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Article Multidisciplinary Sciences

Starvation-dependent differential stress resistance protects normal but not cancer COS against high-dose chemotherapy

Lizzia Raffaghello et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Article Cell Biology

Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21

Takeshi Inagaki et al.

CELL METABOLISM (2007)

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Article Neurosciences

Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease

Veerendra Kumar Madald Halagappa et al.

NEUROBIOLOGY OF DISEASE (2007)

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Article Biochemistry & Molecular Biology

Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma

James B. Johnson et al.

FREE RADICAL BIOLOGY AND MEDICINE (2007)

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Review Cell Biology

The biology of incretin hormones

DJ Drucker

CELL METABOLISM (2006)

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Article Oncology

A conserved, extended chromatin opening within α-globin locus during development

XH Fu et al.

EXPERIMENTAL CELL RESEARCH (2005)

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Article Multidisciplinary Sciences

Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

WZ Duan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Article Multidisciplinary Sciences

Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides

T Shimokawa et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

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