Insights into the Effect of Catalytic Intratumoral Lactate Depletion on Metabolic Reprogramming and Immune Activation for Antitumoral Activity

Article Chemistry, Multidisciplinary

Tailoring Aggregation Extent of Photosensitizers to Boost Phototherapy Potency for Eliciting Systemic Antitumor Immunity

Hao Zhao et al.

Summary: A discretely integrated nanofabrication (DIN) platform has been developed to optimize phototherapy efficacy and enhance antitumor immunity.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Microbiotic nanomedicine for tumor-specific chemotherapy-synergized innate/adaptive antitumor immunity

Wencheng Wu et al.

Summary: This study reports a novel microbiotic nanomedicine LOD/TPZ@Lips-LA, which combines lactate oxidase (LOD) and prodrug tirapazamine (TPZ) loaded liposomes anchored on lactobacillus (LA) surface for chemotherapy-synergized antitumor immunity. The nanomedicine induces tumor cell apoptosis through in situ ROS generation and TPZ activation based on LA metabolism, resulting in strong immunogenic cell death (ICD). By regulating biomarker expression, it promotes anti-tumorigenic M1 polarization of innate tumor-associated macrophages and infiltration of adaptive cytotoxic CD8+ T cells, synergistically enhancing the tumor inhibition effects.

NANO TODAY (2022)

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Review Biotechnology & Applied Microbiology

Targeting cancer metabolism in the era of precision oncology

Zachary E. Stine et al.

Summary: In the past century, there have been significant advancements in targeting cancer metabolism, but progress in the past decade has been limited. Some metabolism-based drugs for cancer have been successfully developed and are in clinical trials. However, consideration of the metabolism of non-cancer cells is crucial for successful treatment of cancer.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Article Cell Biology

Notch-mediated lactate metabolism regulates MDSC development through the Hes1/MCT2/c-Jun axis

Jun-Long Zhao et al.

Summary: Activated Notch signaling regulates lactate metabolism and is involved in MDSC differentiation and TAM maturation. By reducing lactate levels, Notch signaling inhibits G-MDSC differentiation and enhances TAM maturation.

CELL REPORTS (2022)

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Article Chemistry, Multidisciplinary

Metal-Phenolic Network-Enabled Lactic Acid Consumption Reverses Immunosuppressive Tumor Microenvironment for Sonodynamic Therapy

Zhan Zhang et al.

Summary: The constructed nanocomplex can remodel the immunosuppressive tumor microenvironment and achieve effective inhibition of tumors through sonodynamic therapy, while alleviating tumor hypoxia and acidic environment.

ACS NANO (2021)

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Review Engineering, Biomedical

Nanomedicine enables spatiotemporally regulating macrophage-based cancer immunotherapy

Yong-Dan Zhao et al.

Summary: Cancer immunotherapy faces challenges due to tumor immune evasion, with tumor associated macrophages playing crucial roles in cancer progression. Nanomaterials have the potential to provide superior spatial and temporal control over immunomodulation.

BIOMATERIALS (2021)

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Review Chemistry, Multidisciplinary

Biomedicine Meets Fenton Chemistry

Zhongmin Tang et al.

Summary: This review provides a comprehensive overview of the importance and representative applications of Fenton chemistry in the field of biomedicine, as well as future directions for development, which is essential for further advancement in this field.

CHEMICAL REVIEWS (2021)

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Review Chemistry, Multidisciplinary

Metal-Organic Framework-Based Enzyme Biocomposites

Weibin Liang et al.

Summary: Enzymes play a crucial role in chemical synthesis and biotechnology, but their activity can be easily affected by external stressors. Metal-organic frameworks (MOFs) offer protection to enzymes through encapsulation or infiltration, allowing them to maintain activity under challenging conditions.

CHEMICAL REVIEWS (2021)

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Article Nanoscience & Nanotechnology

Considerations for designing preclinical cancer immune nanomedicine studies

Wen Jiang et al.

Summary: Cancer immune nanomedicine faces complexities and challenges in practice, requiring researchers to consider factors such as tumor response complexity and immunotherapy comprehensively. Researchers need to delve into the internal and external influencing factors of tumors to better design experiments in cancer immune nanomedicine.

NATURE NANOTECHNOLOGY (2021)

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Review Chemistry, Multidisciplinary

Antitumor Agents Based on Metal-Organic Frameworks

Peng Gao et al.

Summary: Metal-organic frameworks (MOFs) show great promise in biomedical applications, particularly in the design and application of anti-tumor drugs, with significant developments in the past two decades.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Nanoscience & Nanotechnology

Amplifying STING activation by cyclic dinucleotide-manganese particles for local and systemic cancer metalloimmunotherapy

Xiaoqi Sun et al.

Summary: Metalloimmunotherapy utilizes metal ions to amplify the anti-tumour immune response promoted by STING agonists, forming nanoparticles that effectively deliver STING agonists and achieve remarkable therapeutic efficacy in multiple tumour models. This work highlights the great potential of coordination nanomedicine for metalloimmunotherapy.

NATURE NANOTECHNOLOGY (2021)

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Article Multidisciplinary Sciences

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

McLane J. Watson et al.

Summary: T-reg cells exhibit broad heterogeneity in glucose metabolism within normal and transformed tissues, utilizing an alternative metabolic pathway to maintain their suppressive function and proliferation. Glucose uptake is correlated with poorer suppressive function and long-term instability, while high-glucose conditions impair T-reg cell function and stability. Additionally, T-reg cells upregulate pathways involved in the metabolism of lactic acid, with lactate uptake being dispensable for peripheral T-reg cells but required intratumorally for slowed tumor growth and increased response to immunotherapy.

NATURE (2021)

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Article Chemistry, Multidisciplinary

A Virus-Spike Tumor-Activatable Pyroptotic Agent

Sadia Nadeem et al.

Summary: The study presents a virus-spike tumor-activatable pyroptotic agent for cancer-specific therapy, which can induce pyroptosis in tumor cells. This agent can accumulate in tumors after systemic administration and be degraded by intracellular glutathione to activate inflammasomes and lead to pyroptotic cell death. This structure-dependent and tumor intracellular GSH activatable pyroptotic agent represents a novel paradigm for cancer-specific pyroptotic nanomedicine development.

SMALL (2021)

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Article Chemistry, Multidisciplinary

Dual-Depletion of Intratumoral Lactate and ATP with Radicals Generation for Cascade Metabolic-Chemodynamic Therapy

Feng Tian et al.

Summary: A multifunctional nanoagent designed for cascade metabolic-chemodynamic therapy efficiently depletes lactate and ATP in the tumor microenvironment, generating hydroxyl radicals for therapy. The nanoagent efficiently accumulates in tumors, showing evidence of anti-angiogenesis and anti-metastasis effects.

ADVANCED SCIENCE (2021)

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Article Engineering, Biomedical

Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets

Quanyin Hu et al.

Summary: The use of a hydrogel reservoir for local delivery of combination immunotherapy has shown promise in inhibiting tumor recurrence after surgery.

NATURE BIOMEDICAL ENGINEERING (2021)

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Review Chemistry, Multidisciplinary

Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects

Xianlong Zhang et al.

Summary: Multiple enzyme-driven biological catalytic cascades occur in living organisms, and efforts have been devoted to developing novel cascade catalytic systems mimicking these biological cascades. Nanozymes, as enzyme mimics, have significantly advanced the development of biomimetic cascade nanoreactors, leading to advancements in biosensing and biomedical applications. Progress in understanding and utilizing nanozyme-engineered biomimetic cascade catalytic nanoreactors for biosensing and biomedical applications is comprehensively covered in this article.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Advanced Cancer Starvation Therapy by Simultaneous Deprivation of Lactate and Glucose Using a MOF Nanoplatform

Jiantao Yu et al.

Summary: Recent research has shown that lactate is a major energy source for cells, prompting the development of a new strategy for cancer starvation therapy involving dual deprivation of lactate and glucose. Nanoplatforms are used to co-deliver CHC and GOx in order to achieve this, resulting in enhanced anti-tumor effects both in vitro and in vivo.

ADVANCED SCIENCE (2021)

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Review Chemistry, Multidisciplinary

Gadolinium theranostics for the diagnosis and treatment of cancer

Amy G. Robertson et al.

Summary: According to the World Health Organization, the number of new cancer cases and deaths is expected to rise in the next decade, calling for the development of new and effective cancer treatments and diagnostic tools. Theranostics, particularly those utilizing materials like gadolinium, are showing promise in personalized management of oncology patients, representing a new direction in cancer research.

CHEMICAL SOCIETY REVIEWS (2021)

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Review Oncology

Systemic immunity in cancer

Kamir J. Hiam-Galvez et al.

Summary: Understanding systemic immune landscape beyond the tumour microenvironment is crucial in assessing the effectiveness of immunotherapy in cancer treatment. Despite the potential of immunotherapy to induce new immune responses, compromised immune responses in individuals with tumors may limit its efficacy.

NATURE REVIEWS CANCER (2021)

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Review Oncology

The metabolism of cancer cells during metastasis

Gabriele Bergers et al.

Summary: This review discusses the metabolic rewiring in cancer cells during the metastatic cascade and the distinct metabolic features of primary tumors and metastases. Metastasis is the leading cause of death in most cancer patients, and targeting metastatic seeding and colonization remains a significant challenge. Adjusting metabolism may provide therapeutic opportunities to prevent or reduce metastasis, and targeting the new metabolic traits in established metastases could lead to their eradication.

NATURE REVIEWS CANCER (2021)

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Review Immunology

Lactate modulation of immune responses in inflammatory versus tumour microenvironments

Michelangelo Certo et al.

Summary: The microenvironments of cancerous tissues and tissues affected by chronic inflammatory diseases exhibit different immune states but similar metabolic states. Understanding the metabolic signature allows for therapeutic intervention to reset metabolite availability and correct dysregulated immune states.

NATURE REVIEWS IMMUNOLOGY (2021)

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Review Multidisciplinary Sciences

Metabolic reprogramming and cancer progression

Brandon Faubert et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Bacterial Template Synthesis of Multifunctional Nanospindles for Glutathione Detection and Enhanced Cancer-Specific Chemo-Chemodynamic Therapy

Yan-Wen Bao et al.

RESEARCH (2020)

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Article Nanoscience & Nanotechnology

Dual-Modal Therapeutic Role of the Lactate Oxidase-Embedded Hierarchical Porous Zeolitic Imidazolate Framework as a Nanocatalyst for Effective Tumor Suppression

Xi Zhou et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Immunomodulation-Enhanced Nanozyme-Based Tumor Catalytic Therapy

Bolong Xu et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Openwork@Dendritic Mesoporous Silica Nanoparticles for Lactate Depletion and Tumor Microenvironment Regulation

Jie Tang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Chemistry, Physical

Tunable catalytic activity of gadolinium-doped ceria nanoparticles for pro-oxidation of hydrogen peroxide

Anuja Bhalkikar et al.

NANO RESEARCH (2020)

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Destruction of Metal-Organic Frameworks: Positive and Negative Aspects of Stability and Lability

Liang Feng et al.

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Editorial Material Chemistry, Multidisciplinary

Chemiluminescent Nanosystems for Imaging Cancer Chemodynamic Therapy

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Nanoplatform-based cascade engineering for cancer therapy

Jiajie Chen et al.

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Metabolism of immune cells in cancer

Robert D. Leone et al.

NATURE REVIEWS CANCER (2020)

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Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications

Yanyan Huang et al.

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Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment

Ningqiang Gong et al.

NATURE NANOTECHNOLOGY (2019)

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The Nano-Bio Interactions of Nanomedicines: Understanding the Biochemical Driving Forces and Redox Reactions

Yaling Wang et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

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Targeting metabolism to regulate immune responses in autoimmunity and cancer

Chirag H. Patel et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Mechanisms and Implications of Metabolic Heterogeneity in Cancer

Jiyeon Kim et al.

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Catalytically Selective Chemotherapy from Tumor-Metabolic Generated Lactic Acid

Zhimin Tian et al.

SMALL (2019)

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Intra/Extracellular Lactic Acid Exhaustion for Synergistic Metabolic Therapy and Immunotherapy of Tumors

Fan Gao et al.

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Enhanced Activity of Enzymes Encapsulated in Hydrophilic Metal-Organic Frameworks

Weibin Liang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II)

Jiangjiexing Wu et al.

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Nanozyme: new horizons for responsive biomedical applications

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In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy

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A ribonucleoprotein octamer for targeted siRNA delivery

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Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD plus Depletion in Cancer Cells

Don Benjamin et al.

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Lactate Metabolism in Human Lung Tumors

Brandon Faubert et al.

CELL (2017)

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Highly sensitive and robust peroxidase-like activity of porous nanorods of ceria and their application for breast cancer detection

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Metabolic Reprogramming of Immune Cells in Cancer Progression

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Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

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Low pressure induced porous nanorods of ceria with high reducibility and large oxygen storage capacity: synthesis and catalytic applications

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Insights into the Effect of Catalytic Intratumoral Lactate Depletion on Metabolic Reprogramming and Immune Activation for Antitumoral Activity

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