期刊
GENES
卷 13, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/genes13112078
关键词
RNA-Seq; vitamin K; comorbidities; differentially expressed genes; variant analysis
资金
- SERB-DST [IRR/2018/000025]
This study focuses on exploring differentially expressed genes (DEGs) and variants associated with Vitamin K (VK) disease phenotypes (such as myocardial infarction, renal failure, and prostate cancer), aiming to find common pathogenic variants and discussing the role of long noncoding RNAs (lncRNAs) in the biogenesis of VK deficiencies.
Systems genetics is key for integrating a large number of variants associated with diseases. Vitamin K (VK) is one of the scarcely studied disease conditions. In this work, we ascertained the differentially expressed genes (DEGs) and variants associated with individual subpopulations of VK disease phenotypes, viz., myocardial infarction, renal failure and prostate cancer. We sought to ask whether or not any DEGs harbor pathogenic variants common in these conditions, attempt to bridge the gap in finding characteristic biomarkers and discuss the role of long noncoding RNAs (lncRNAs) in the biogenesis of VK deficiencies.
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