期刊
GENES
卷 13, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/genes13112055
关键词
myostatin; MSTN; muscle; strength; hypertrophy; hyperplasia; training; meta-analysis
资金
- Plekhanov Russian University of Economics [771]
This study conducted a systematic review and meta-analysis and found an association between MSTN gene polymorphism (K153R) and the strength phenotype of athletes. Athletes in the strength-oriented group had a higher frequency of the R minor variant compared to the control group.
Polymorphism (rs1805086), c.458A>G, p.Lys(K)153Arg(R), (K153R) of the myostatin gene (MSTN) has been associated with a skeletal muscle phenotype (hypertrophic response in muscles due to strength training). However, there are not enough reliable data to demonstrate whether MSTN rs1805086 K and R allelic variants are valid genetic factors that can affect the strength phenotype of athletes' skeletal muscles. The aim is to conduct a systematic review and meta-analysis of the association of MSTN rs1805086 polymorphism with the strength phenotype of athletes. This study analyzed 71 research articles on MSTN and performed a meta-analysis of MSTN K153R rs1805086 polymorphism in strength-oriented athletes and a control (non-athletes) group. It was found that athletes in the strength-oriented athlete group had a higher frequency of the R minor variant than that in the control group (OR = 2.02, P = 0.05). Thus, the obtained results convincingly demonstrate that there is an association between the studied polymorphism and strength phenotype of athletes; therefore, further studies on this association are scientifically warranted.
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