期刊
FRONTIERS IN PHYSIOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2022.1018971
关键词
MG53; ischemia/reperfusion injury (I/R injury); multiple organs; protective; review
类别
资金
- Key Research and Development Program of Shandong Province
- National Natural Science Foundation of China [2019GSF108142]
- Science and Technology Program of Yantai City [81900310]
- [2021MSGY042]
- [2021MSGY044]
Ischemia/reperfusion (I/R) injury is a common clinical problem that can lead to cell damage and death. MG53, a protein highly expressed in mouse skeletal and cardiac muscle, has been found to repair cell membrane damage and protect multiple oxygen-dependent organs from I/R injury.
Ischemia/reperfusion (I/R) injury is a common clinical problem after coronary angioplasty, cardiopulmonary resuscitation, and organ transplantation, which can lead to cell damage and death. Mitsugumin 53 (MG53), also known as Trim72, is a conservative member of the TRIM family and is highly expressed in mouse skeletal and cardiac muscle, with minimal amounts in humans. MG53 has been proven to be involved in repairing cell membrane damage. It has a protective effect on I/R injury in multiple oxygen-dependent organs, such as the heart, brain, lung, kidney, and liver. Recombinant human MG53 also plays a unique role in I/R, sepsis, and other aspects, which is expected to provide new ideas for related treatment. This article briefly reviews the pathophysiology of I/R injury and how MG53 mitigates multi-organ I/R injury.
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