Pacing interventions in non-responders to cardiac resynchronization therapy

Non-responders to Cardiac Resynchronization Therapy (CRT) represent a high-risk, and difficult to treat population of heart failure patients. Studies have shown that these patients have a lower quality of life and reduced life expectancy compared to those who respond to CRT. Whilst the first-line treatment for dyssynchronous heart failure is conventional biventricular epicardial CRT, a range of novel pacing interventions have emerged as potential alternatives. This has raised the question whether these new treatments may be useful as a second-line pacing intervention for treating non-responders, or indeed, whether some patients may benefit from these as a first-line option. In this review, we will examine the current evidence for four pacing interventions in the context of treatment of conventional CRT non-responders: CRT optimization; multisite left ventricular pacing; left ventricular endocardial pacing and conduction system pacing.

Automated summary

Non-responders to Cardiac Resynchronization Therapy (CRT) are a high-risk and challenging group of heart failure patients to treat. Research has shown that these patients have a lower quality of life and reduced life expectancy compared to those who respond to CRT. This review examines the current evidence for four pacing interventions as potential alternatives for treating non-responders to conventional CRT.